The document describes the Avea ventilator. It can be used from the neonatal ICU to adult ICU to treat patients with conditions ranging from acute respiratory distress syndrome to home care. Key features include closed loop oxygen control to maintain optimal oxygen levels, integrated heliox delivery without external devices, and advanced pulmonary monitoring tools like transpulmonary pressure monitoring and volumetric capnography to optimize ventilation settings. The ventilator has intuitive operation, multiple ventilation modes, and integrated communications and monitoring capabilities to support patients.

1. Avea® Ventilator Delivering your highest standard of care Delivering your highest standard of care Reginald Samuel Sales Consultant Virtus Trading L.L.C www.virtusuae.com

2. Viasys range of Ventilaters Sub Acute Care IMC, ER Adult/Ped. AcuteCare ICU, PICU HomeCare Neo Acute Care NICU Avea Avea Vela LTV1200 3100A (HFOV) 3100B (HFOV) SiPAP

3. Neonatal to Adult Volume 2.0 ml to 2.5 liter - suitable for neonates to adults 1 to 150 bpm (neonatal), 1 to 120 bpm (pediatric I adult) Closed loop FiO2 Integrated Heliox Delivery Advanced Pulmonary Mechanics Volumetric CO2 Touch Screen Controls (TTT) Avea® Overview

4. Closed loop FiO2 SpO2 FiO2

5. Current procedure for SpO2 Control

6. SpO2 FiO2 Current procedure for SpO2 Control

7. Closed loop FiO2 CLiO

8. SpO2 FiO2 Routine (4h) Automated (4h) Closed loop FiO2 CLiO

9. University of Miami patented / licensed algorithms Avea Long-life blender Improves blender longevity and accuracy Accumulator isolation valve Improves response Add pulse oximeter module (Masimo) Technology

11. No need for the user to titrate FiO2 Significant 40% work load of the nurses is reduced SpO2 Leave is well maintained according to the clinician ’s desire Neonate is safe from complications of Hyperoxia affects like Detached Retina Advantages of CLiO

12. Integrated HelioxDelivery No need to attach external device to provide Heliox delivery Easy to switch between medical gas and Heliox Avea® automatically sense which gas control to initiate

13. To set optimal PEEP only two measurements are required Transpulmonary Plateau Pressure (Ptp Plat) Transpulmonary PEEP (Ptp PEEP) Setting optimal ventilatory pressures reduces ventilation days Reducing ventilation days reduces the risk of infection Placing an esophageal catheter is as easy as placing a naso-gastric tube Advanced Pulmonary Mechanics technology Transpulmonary Pressure Monitoring

14. One of four automated assessment maneuvers for obtaining recruit able lung tissue. Both high and low inflection points are calculated and displayed. Pflex Advanced Mechanics

15. ARDS and ALI lungs need relatively high levels of PEEP High PEEP can have severe effects on: Cardiac Output Perfusion Perfusion/Ventilation Match Volumetric Capnography is the ideal tool to monitor: Perfusion Ventilation Perfusion/Ventilation Match Deadspace0.8 cc Volumetric CO2

16. Advanced mainstream sampling of airway providing following volumetric Capnography features Evaluation of changes in anatomic, alveolar and physiologic dead space Evaluation of the effectiveness of ventilation Measurement of C02 elimination / production Evaluation of EtC02 Trends in ventilation Monitors: End Tidal C02 (ETC02), VC02, VtC02 Waveforms & Loops: Capnogram, Single Breath PC02 vs. Vte loop Volumetric Capnography Advanced Mechanics

17. Transpulmonary Pressure (Ptp) Enables the setting of optimal ventilatory pressures Volumetric Capnography (VCO2) Enables the testing for perfusion/ventilation mismatch ONLY the AVEA offers these diagnostics tools ONLY the blood gases value take sep The AVEA brings Ptp and VCO2 together Advanced Mechanics

18. Display of Rapid Shallow Respiratory Breathing Index(RSBI), Maximum Inspiratory Pressure (MIP), Respiratory Drive (P100), Dynamic Compliance & Resistance weaning parameters Advanced Mechanics

19. 24hr trends 24hr trends of 54 monitored parameter

20. Dedicated Monitoring Configurable monitoring screen allows user to monitor 15 parameter in one screen for 54 monitored parameter

21. Color Coded Touch Screen User can easily identify patient triggered breaths at a glance

22. Revolutionary Compressor Unique scroll pump compressor is so small and is built into the AVEA. During power failure the compressor can work on standard internal battery for 30 minutes. This enables the ventilator to be unplugged and moved with the patient easily.

23. Heated Expiratory Filter System AVEA’s Heated Filter System helps maintain flow sensor performance and helps reduce airborne pathogens in patient’s room, such as SARS, Avian Flu and MRSA.

24. The HEPA filtration element filters the expired gas to 0.3 microns. With a 99.999+% bacterial and viral efficiency rating providing the best environment for staff and patients. Single patient use 60% lower resistance compared to Pall Microbial Filter Single Piece Combi: No need for current cartridge with Pall Microbial Filter and separate water trap Disposable Expiratory Filter/Water Trap

25. Volume Controlled Ventilation Volume Assist Control (AlC) Mode Volume SIMV Mode Pressure Support Ventilation Pressure Assist Control (AlC) Mode Pressure SIMV Airway Pressure Release Ventilation (APRV I Biphasic/Bilevel/BiPAP) Pressure Regulated Volume Control (PRVC) SIMV Mode Pressure Regulated Volume Control (PRVC) Assist Control (A/C) Mode TCPL SIMV Mode (time cycle pressure limit) TCPL Assist Control (AlC) Mode Neonatal Nasal nCPAP Mode Continuous Positive Airway Pressure with Pressure Support Ventilation (CPAP/PSV) Apnea Back up Ventilation Standby Breath Types and Modes

26. Communications AVEA offers a selection of protocols compatible with many patient monitoring and hospital information systems. A VGA output for training and a parallel port for printing

27. Intuitive Operation & Display Mode, screen and status indicators are easy to see at a distance Selectable, full color graphics improve breath phase recognition (Red, Blue & Yellow) Five monitored values are visible to the user at all times: each is selectable from a menu of 54 options The intuitive “touch-turn-touch tm “ design reduces training time and enhances clinician confidence Valuable information is displayed to assist the practitioner with clinical decisions

28. Patient Safety