Aung citt nyein
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This study evaluated the efficacy and toxicity of a complex combination biochemotherapy regimen for 25 patients with advanced metastatic melanoma. A complete response was seen in 2 patients, partial response in 2 patients, and stable disease in 9 patients. The most common toxicities were lethargy, fever, nausea, vomiting, thrombocytopenia, leukopenia, and neutropenia. Doses of vindesine, cisplatin, and IL-2 often had to be reduced due to toxicities. The regimen showed an objective response rate of 16% with an 8% complete response rate, but dose reductions were frequently required due to treatment-related side effects.
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Smart radiotherapy aims to precisely target tumor cells while sparing healthy cells. New techniques described in the document include using hypoxic cell sensitizers to target hypoxic tumor regions, anti-angiogenic agents to inhibit tumor blood vessels, and nanoparticles to enhance radiation dose and selectively deliver drugs. Molecular imaging helps optimize treatment by identifying tumor characteristics. Combining radiotherapy with immunotherapy or targeted depletion of host cells may also improve outcomes. Overall, the document discusses developing more precise radiation approaches through better understanding of tumor biology and microenvironment.
Immunotherapy for cancer
In this presentation, I discuss a new standard of treatment in cancers which is immunotherapy. I also discuss the few cancers for which it has been approved.
Dr. Thomas Chen, UCI grand rounds 7-28-2010
The document discusses new treatments being developed for malignant gliomas. It describes research into targeting the endoplasmic reticulum stress response pathway to induce apoptosis in glioma cells. Several new drug candidates and delivery methods are discussed, including an implantable pump being developed to provide continuous metronomic chemotherapy delivery directly to the brain tumor. Gene therapy using replication-competent retroviruses and improved immunotherapy approaches are also mentioned as promising new treatment strategies.
Antibiotics And Leukopenia
Several classes of antibiotics can potentially cause neutropenia by decreasing production or destroying neutrophils in the peripheral blood. The incidence of neutropenia varies by antibiotic and dose, with onset typically occurring after 1-3 weeks of treatment. Most cases of antibiotic-induced neutropenia are reversible by discontinuing the causative drug. Doctors should monitor white blood cell counts in patients receiving antibiotics long-term to promptly identify and treat neutropenia.
Antibiotics And Leukopenia
Several classes of antibiotics can potentially cause neutropenia by decreasing neutrophil production or destroying neutrophils. The incidence of neutropenia varies by antibiotic and dose, with onset typically occurring after 1-3 weeks of treatment. Symptoms usually resolve within a few days to a few weeks after discontinuing the offending antibiotic. Doctors should monitor white blood cell counts in patients receiving antibiotics long-term or high doses to promptly identify and treat neutropenia.
9th non hodgkin's
This document provides information on Non-Hodgkin's lymphoma (NHL), including its subtypes, risk factors, presentation, classification, staging, diagnostic workup, prognostic factors, and treatment approaches. It discusses the most common subtypes of NHL - diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) - in more detail. For DLBCL, it outlines treatment protocols based on stage, prognostic factors, and management of relapsed/refractory disease. For FL, it discusses grading, clinical features, treatment based on stage including immunochemotherapy regimens and radiation therapy options. It also summarizes marginal zone lymphomas regarding clinical features, treatment including antibiotics for gastric M
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Treatment approaches of Lethal midline granuloma , a type of NK/T cell NHL .One of the deadliest of midline destructive lesions of the Nose and PNS.
Multiple myeloma and plasmacytoma
This document provides an overview of the management of plasma cell neoplasms including multiple myeloma and plasmacytoma. It discusses the clinical spectrum, epidemiology, etiology, pathogenesis, clinical features, evaluation, staging systems, imaging, and management approaches including treatment regimens for newly diagnosed, relapsed, and transplant eligible or ineligible patients. It also reviews treatment of complications such as bone disease, anemia, renal failure, and infections. Management involves risk-stratified chemotherapy, stem cell transplantation, radiation, surgery, bisphosphonates, and palliative care.
Oral Cancer
The document discusses oral cancer and its management. It covers the molecular changes involved in carcinogenesis including mutations in proto-oncogenes and tumor suppressor genes. Treatment options for oral cancer depend on the tumor stage and site and may involve surgery, radiation therapy, chemotherapy, or palliative care. Complications of cancer therapy include acute reactions like mucositis as well as chronic issues involving fibrosis, vascular changes, and loss of salivary gland function. Pain management is important and involves a multimodal approach.
Anti tb drugs
This document provides information about anti-tuberculosis therapy. It begins by listing the learning objectives, which include describing primary and secondary anti-tuberculosis drugs, the phases of TB treatment, mechanisms of action and side effects of drugs, defining multi-drug resistant TB, and the role of vaccines in prevention. It then discusses specifics of TB as a global health problem, treatment regimens, first and second-line drugs, mechanisms of action of isoniazid and rifampin, and side effects of isoniazid. The document aims to educate about best practices for treating TB through use of combination drug therapy.
Emerging Role of PRRT.pdf
1. Peptide receptor radionuclide therapy (PRRT) involves administering radiolabeled peptides like octreotide that target somatostatin receptors overexpressed on neuroendocrine tumors.
2. PRRT with beta-emitting radionuclides like yttrium-90 and lutetium-177 is an effective treatment for inoperable or metastatic neuroendocrine tumors.
3. PRRT has shown symptomatic improvement, tumor growth control, and regression in around 30% of patients with neuroendocrine tumors.
Common principles of treatment of TB patients
Common principles of treatment of TB patients. Antimycobacterial preparations. Standard treatment regimens of patients with tuberculosis.
Effectiveness of gefitinib as additional radiosensitizer to conventional chem...
This randomized controlled study evaluated the effectiveness of adding the tyrosine kinase inhibitor gefitinib to conventional chemoradiation for locally advanced head and neck squamous cell carcinoma. 104 patients were randomized to receive either gefitinib plus cisplatin-based chemoradiation (experimental arm) or cisplatin-based chemoradiation alone (control arm). The study found a statistically significant difference in overall response rates favoring the gefitinib arm, as well as improved disease-free survival. However, the gefitinib arm also resulted in higher rates of manageable toxicities like dermatitis, mucositis, and diarrhea.
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This document discusses prognostic factors in epithelial ovarian cancer. It analyzes data from 55 patients treated with primary surgery and chemotherapy between 2005-2009. The key findings are:
1. Significant prognostic factors in univariate analysis included age, histology, FIGO stage, and ascites.
2. Patients aged 70 or older and with FIGO stage IV cancer had poorer prognoses, with a 31-month survival time. Patients with endometrioid or clear cell histology had longer survival, at 51 months.
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Pyae phyo aung's thesis (breast cancer)
This study examined the significance of HER-2 and hormonal receptor status in patients with locally advanced breast cancer treated with neoadjuvant systemic therapy. It found that hormonal receptor status has a significant prognostic effect on both overall survival and progression-free survival. HER-2 receptor status was found to have a significant prognostic effect on overall survival. No significant association was found between receptor status and clinical response to neoadjuvant chemotherapy. The study was limited by its small sample size and retrospective design.
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This study compared the effectiveness of two chemotherapy regimens, BEACOPP and COPP-ABVD, for treating advanced Hodgkin's lymphoma. 49 patients received either BEACOPP (25 patients) or COPP-ABVD (24 patients). The rate of freedom from treatment failure at 5 years was higher for BEACOPP at 76% compared to 69% for COPP-ABVD. Overall survival rates at 5 years were also higher for BEACOPP at 88% versus 83% for COPP-ABVD. While BEACOPP resulted in better tumor control and survival, it also had more acute toxicity including grade 4 leukopenia in some cycles.
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This study compared the efficacy and toxicities of gemcitabine/cisplatin combination chemotherapy and paclitexal/carboplatin combination chemotherapy as first-line treatment for 53 patients with stage IIIB or IV non-small cell lung cancer. The study found that gemcitabine/cisplatin combination resulted in better response rates but not statistically significantly so. It also found that gemcitabine/cisplatin combination resulted in more hematological toxicities. Patient demographics were not significantly different between the two treatment arms. The study concluded that platinum-based combinations are effective for non-small cell lung cancer but require proper premedications.
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The document presents findings from a study comparing CHOP chemotherapy alone versus CHOP plus rituximab in elderly patients with diffuse large B cell lymphoma. The study found that adding rituximab to CHOP chemotherapy significantly increased complete response rates, decreased treatment failure and relapse rates, and improved event-free and overall survival compared to CHOP alone, without significantly increasing toxicity.
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- 14. Patients Characteristics (No. of organ affected)
- 15. Patients Characteristics (Previous Therapy)
- 16. Tumour response to therapy CR -complete remission : PR -partial remission : SD -stable disease : PD -disease progression
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