Professor Serge Jurasunas' upcoming presentation: "A New Way to Approach Cancer". This presentation is for the Medicine Week Congress in Baden Baden Germany, October 30 thru November 3rd, 2019.

1. How to Boost NK Cell Activity by using Rice Bran Arabinoxylan/BioBran and
Other Natural Compounds in the Treatment of Cancer
30.10 – 3.11.2019
Medizinische Woche
Krebskongress
Baden – Baden
Germany
NEW MODERN WAY TO APPROACH CANCER
Speaker: Serge Jurasunas N.D. M.D (Hc) M.D. (Hom)
Professor of Naturopathic Oncology
www.sergejurasunas.com

2. Serge Jurasunas, N. D. , M. D. (Hom)
• Over 50 years of practice.
• 35 years using integrative cancer methods.
• Interest in Nutrition, Live Blood Analytics, Oxidative dried blood testing,
Iridology, Detox, Oxidative Stress
• Developed several innovative cancer therapies.
• During the past 12 years involved in the research and practical application of 53
tumor suppressor genes and other apoptotic players.
• Runs a large clinic in Lisbon over 38 years.
• Published over 150 papers, conferences articles.
• Author of 8 books and several booklets
blog: https://naturopathiconcology.blogspot.com
email: sergejurasunas@gmail.com
2

3. BOOKS
3

4. Video from a Researcher at the University of Singapore
(From My Science Work)
A number of recent articles published in various countries have shown that
reactivating the immune system to treat cancer is now attracting Oncologists.
4
Reactivating the Immune System Against Cancer: A Role for Natural Compounds

6. NK Cell- Based Immunotherapy in Cancer Metastasis
NK Cells are our First
Line of Defence
Against Cancer

7. • NK cells are component of the innate immune
response against viruses and malignant cells.
• NK cells were first described in early 1970 on a
functional basis according to their ability to kill
tumor cells directly in the absence of stimulation.
• NK cells are bone-marrow derived and they
represent only 5-15% of the total lymphocyte
population.
• NK cells have anti-tumor targeting enabling them
to migrate to sites of metastasis and eliminate
malignant cells but spare normal cells.

8. NATURAL KILLER CELLS

9. NATURAL KILLER CELLS = OUR FIRST LINE OF DEFENCENATURAL KILLER CELLS = OUR FIRST LINE OF DEFENCENATURAL KILLER CELLS = OUR FIRST LINE OF DEFENCENATURAL KILLER CELLS = OUR FIRST LINE OF DEFENCE
AGAINST CANCERAGAINST CANCERAGAINST CANCERAGAINST CANCER
• NK cells patrol in the blood and lymphatic system at a resting state.
• NK cells became more active in presence of cancer cells and in response to
cytokines.
• NK cells when activated destroy a cancer cell in 5 minutes and repeat this
process up to 27 times in its lifetime.

10. “Individuals having low NK cell activity
are at risk to develop cancer.”₁
₁ Tmai K., Matsuyama S., Miyake S., Suga K., Nakachi K.
Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: An 11-
year follow-up study of a general population – Lancet . 2000.356 - 1795-1799

12. - Breakthrough in Immuno-Oncology.
- Boost NK cell activity.
- Using a Arabinoxylan compound/ BioBran derived from
modified rice bran.
- BioBran/MGN-3 = a biological response modifier.
- Developed in 1 990 by Daiwa Japan.
ONE OF THE SAFEST SUPPLEMENTS AVAILABLE TODAY

13. 13
5th International BioBran Workshop, 9-11, June 2017, Krakow, Poland
Oncologist Joseph Brenner M.D., Hegyi Gabriela M.D., Prof.Jurasunas
N.D., Prof. Tibor Hajto, Immuno-Oncologist Prof. Rupert Handgretinger

14. BioBran: A Biological Response ModifierBioBran: A Biological Response ModifierBioBran: A Biological Response ModifierBioBran: A Biological Response Modifier
Rice Bran ArabinoxylanRice Bran ArabinoxylanRice Bran ArabinoxylanRice Bran Arabinoxylan
• BioBran is produced by enzymatic hydrolysis of Hemicellulose
B a dietary fiber found in rice bran containing Arabinoxylan
as its main component.
• It consists of a highly branched and complicated sugar
composition of mainly Arabinose and Xylose obtained from
modified rice bran.
• The long polysaccharide molecules are broken into small
ones after being heated with a Shiitake mycelia mushroom
enzyme.

15. • Before this process the long polysaccharide molecules
cannot be digested and are usually eliminated from the
colon.
The result is an Arabinoxylan derivative with strong
immunomodulatory properties:
STRUCTURE

16. RICE BRAN SHIITAKE MUSHROOM
MYCELIA CULTURE
Extraction with hot water
HEMICELLULOSE B
Shiitake mushroom mycelia removed
CARBOHYDRATE HYDROLYSIS
ENZYME COMPLEX
ACTIVATION
BBioBran
Rice Bran Arabinoxylan

17. DIGESTION, ABSORPTION AND FUNCTION OF BioBran
Dietary fibers are eliminated by the intestine but BioBran is absorbed in the
small intestine practically undigested entering in the blood to become a
nutritional food which activates NK cells optimizing immune function when
taken orally.

19. Cancer patients have the following defects along with
decreasing cytotoxic activity, compared to healthy
individuals.
- Decreased production of perforin and granzymes.
- Decreased binding capacity.
- Defective cytokine production.
- Decreased cytotoxicity.

20. A Strong Link Exists Between Breast Cancer and Natural Killer
(NK) Cells:
Commenting on a 116 patients healed with surgery -
“The more NK cells that are active in the week
following surgery, the better the chances of long
term survival.”
Professor Ronald B. Herberman (Natural Cancer Institute)
Director Institute of Oncology
University of Pittsburg - USA

21. BioBran Increases the Curve of NK cells
If you prescribe 2g of BioBran to
volunteers then you can see a curve of NK
cells increasing about 60% after two
weeks. But if you continue, you can
achieve up to 200 even 300% or more in
NK cell numbers and activity.
Control:
NK cells were here but not activated to
release their toxic enzymes (perforin)
through the membrane of cancer cells.
Ghoneum M. “Enhancement of Human natural killer cells activity by modified
arabinoxylan from rice bran. (MGN-3) Int. Immunotherapy 1998. XIV.89-99

22. Treatment with BioBran causes a remarkable increase in NK cells activity including increase
and release of perforin and granzyme content in cancer patients after 2 weeks.
PERCENTAGE OF REDUCTION
Breast cancer = 154% - 332%
Leukemia = 100% - 240%
Cervical cancer = 100% - 275%
Prostate = 174% - 385%
Multiple Myeloma= 100% - 537%
“ Enhancement of NK cells activity continue to rise at 3-6 months after treatment. “
Ghoneum M. Narmatalla G. N.K Immunomodulatory function in 27 cancer patients by MGN-3, a modified arabinoxylan
from rice bran - The abstract of 87th Annual Meeting of the American Ass. for cancer Research. Wah. D.C April 20-24.1996.

24. BioBran is superior to other immune supplements like mushroom, Arabinoxylan, Maitake
Mushroom – D. Fraction, A H-CC

25. Effect on long-term administration of Immunomodulatory Food (1) on cancer patients
completing conventional therapy- H. Tsunekawa, Tsunekawa Gastrointestinal Clinic.
16 cancer patients mainly in
stage IV, had just undergone
surgery, chemotherapy and
radiotherapy.
Daily diet was based on modern
dietetic food, grains, vegetables,
1-5 kinds of functional food per
day.
BioBran dosage: 3g per day at
each meal.
(1) Maeda H.- The food function of Modified Arabinoxylan from rice bran (MGN-3) Packing of food, 33-
1:2001

26. 26
NK Immunorestoration of Cancer Patients by BioBran/MGN-3
Figure 3: Cytocentrifuge preparation of
two K562 tumor cells undergoing
destruction by one NK cell. NK cells were
activated by MGN-3
a) First step in the process represented by
the binding of an NK cell to tumor cells.
(Giema, X740)
b) Preparation showing one tumor cell is
dead. (Giema, X740)
c) Preparation showing both tumor cells
are dead while an NK cell in between is
still alive. (Giema, X740)
d) Cytocentrifuge preparation showing NK
cell has detached itself from the dead
tumor cells. (Giema, X740)

28. BioBran Enhances the Effect of Chemotherapy Leading to
Effective Treatment at Low Dosage with Less Toxic Effect and More
Results

30. Swiss albino mice were inoculated with Ehrlich Ascites Carcinoma (EAC) cells- the RBAC graph
received 40mg/kg body weight of RBAC intravenously three times a week for a period of 3
weeks, starting after the 8th inoculation of EAC- the control group received phosphate-
buffered saline (PBS)- after the treatment, the result showed a significant reduction in Tumor
size showing tumor regression

31. BioBran MGN-3 reduced side-effects of
chemotherapy for patients with breast cancer,
Nisbitar hospital.
Study: 50 breast cancer patients were investigated
on the effect of BioBran with a daily dose of 3gr:
• Nausea
• Vomiting
• Appetite
• Fatigue
• Weight loss
• Anorexia
80% of women who took BioBran typically benefit
from a significant reduction in side effects.

35. 15g mg/kg/day. Two fold increase in NK cytotoxicity after 1 month of treatment
30g mg/kg/day. Significant enhancement of NK activity. (310% over baseline) after one week and continue to increase. Peak response observed in 2 months of treatment where
NK activity increase fivefold.
Increase to 45 mg/kg/day demonstrate a similar increasing trend in NK activity but the values were higher in magnitude than those of 30 mg/kg/day. Discontinuation of treatment
result in a decline of NK activity.
Treatment of cancer patient: 3gr per day during 2/3 months and reduce to 2 gr per day

36. ADVANTAGEADVANTAGEADVANTAGEADVANTAGESSSS OF TAKING BioBran/ARABINOXYLAN RICE BRANOF TAKING BioBran/ARABINOXYLAN RICE BRANOF TAKING BioBran/ARABINOXYLAN RICE BRANOF TAKING BioBran/ARABINOXYLAN RICE BRAN
•Non-toxic
•Easily absorbed
•Non hyper responsive
•Fast acting
•Natural and GMO free
Supported by intensive scientific and clinical research, chemical trials,
in-vitro and in-vivo in Japan, USA and Europe.

37. Conclusion:
BioBran/MGN-3 Arabinoxylan Rice Bran
 Increases NK cell activity and other immune cells.
 Increases chemotherapy effectiveness with less side effects.
 Reduces tumor size (faster) alone or together.
 Prevents metastasis and cancer reoccurrence.
 Increased lifespan expectation with better quality of life in
advanced cancers.
 Contributes to faster decrease – Antigen Tumor Markers.
 Works in synergy with other natural agents such as curcumin.
 Can be taken long term without toxicity for up to (7 years).

39.  BioBran/Arabinoxylan Rice Bran unlike any other compound
has been the subject of many human trials, tests and
publications in medical journals for over 20 years.
BioBran has been researched in many hospitals and
universities in Japan and the USA. Over 700 hospitals in Japan
use BioBran as a support for chemotherapy.
Studies : Cambridge University, Tokyo Medical and Dental University, Chiba
University, Kobe Women´s College, Kyushu University, Kyoto University, et
al.

40. Why BioBran/Arabinoxylan Rice Bran
When treating a cancer patient the main goal is to first
choose a very efficient, high quality natural compound
with scientific evidence that you can use with safety and
show positive results with your patients.
You may combine two or three components working in
synergy with each other and with chemotherapy to
obtain quicker and better results. - S. Jurasunas

41. BIOBRAN + CURCUMIN

44. Curcumin potentiates the
cytotoxicity of Paclitaxel
toward breast cancer cells.
Curcumin inhibits human
breast cancer cells in
culture.

45. Apoptotic effects of MGN-3 (BioBran) and curcumin on U266 cells-
U266 cells were cultured with MGN-3 (50u/m) and curcumin (2.5.5.0. or 10u/m) for 3 days- curcumin
alone increase apoptosis in U266 cells- however when MGN-3 was combined with curcumin the levels
of apoptosis were remarkerly increased by 20.22 and 24% at a curcumin concentration of 2.5.5 and
10u/m representing a 200%-220% and 247% increase in cancer cell apoptosis as compared to the
controlled unhealed cells with either alternative (alone or in combination).

46. Combination TherapiesBoth MGN-3
Arabinoxylan Rice Bran
and curcumin have the
ability to activate
different immune cells
such as NK cells, T-cells,
B-cells, macrophages,
Dendritic cells while
both can restrict Treg
cells recruited by the
tumor to inhibit immune
cells activity (1).
(1) M. Ghoneum, S. Gollapudi- Synergistic apoptotic effect of Arabinoxylan Rice
Bran (MGN-3/BioBran) and curcumin (Tumeric) on human multiple myeloma
cell line U266 in vitro - Neoplasma-58-2.2011

48. Synergistic Effects of BioBran/Arabinoxylan Rice Bran with
Other Natural Components to Target Cancer
CURCUMIN (1)
GENISTEIN (2)
IL-2 (3)
(1) M. Ghoneum, S. Gollapudi- Synergistic apoptotic effect of Arabinoxylan Rice Bran (MGN-3/BioBran) and
curcumin (Tumeric) on human multiple myeloma cell line U266 in vitro - Neoplasma-58-2.2011
(2) Janet M. Pavese, Rebecca L. Farmer- Inhibition of cancer cell invasion and metastasis by genistein- cancer
metastasis- Rev (2 010) 29-465-482
(3) M. Ghoneum and A. Jeweet- Synergistic effect of modified Arabinoxylane (MGN-3) and Low Dose of
recombinant IL-2 on human NK cell activity and TNF-A production - 1998-East Cast Conference - Board
Certification – Exam.15.16.August 1998

50. Genistein Curcumin
• Proapoptotic
• Antiangiogenic potential
• Immunomodulatory
• Inhibit Glycolysis
• Improve Microbiota
• Decrease Telomerase Activity
• Downregulation of TGFB
• Proapoptotic (P53, BAX)
• Antiangiogenic Potential
• Immune Stimulation
• Inhibit NF.K.B. Activity
• Inhibit COX-2 Expression
• Inhibit HER 2/Neu
• Decrease Telomerase Activity
APOPTOSIS
• Antiestrogen Effect – Inhibits EGF and EGFR mediated signaling pathway overexpressed in
breast cancer; involved in cancer progression.
• Aromatase Modulation.
• Interfere with HR2 Signaling Pathway.
Active Dietary Compounds in Breast Cancer

51. Breast cancer stage IV with multiple metastasis to liver, pleura,
bone and right lung:
Recurrence -
After 4 months of chemotherapy scan shows more
dissemination of metastasis.
Treatment: BioBran, Curcumin, Coenzyme-Q10
After 3 months: 60 % improvement
Extract from my book: ‘Cancer Treatment Breakthrough-Immuno-Oncology U sing Rice Bran Arabinoxylan Compound ’

52. F.41 Years – Asympthomatic Prime Lesions 18 cm –
Secondary Lesions 8 cm
Combination of chemotherapy with our complementary treatment
that targets apoptosis, angiogenesis, immune activity – Anticancer
Diet
52
Advanced Gastric Cancer - Results of Blood Analysis
July 2015 April 2015 July 2015 April 2015
Lesion of
30,1 mm
Lesion of
48,7 mm
Lesion of
18 cm

54. X Ray of the Spine
After 3 months of combined
therapy + chemotherapy.
Total elimination of very large
lesions in the illium and spine.
Jurasunas Serge, ND

55. Blog: https://naturopathiconcology.blogspot.com/
email: sergejurasunas@gmail.com
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Serge Jurasunas