Professor Serge Jurasunas - New Modern Way to Approach Cancer - Biobran Workshop - Zagreb Croatia 2-27-2018

How to treat cancer with immunotherapy utilizing BioBran and through
the microbiome. Clinical cases.
27 February, 2018
Zagreb
Croatia
NEW MODERN WAY TO APPROACH CANCER:
•Speaker: Serge Jurasunas N.D. M.D (h.c) M.D.(Hom)
Professor of Naturopathic Oncology
www.sergejurasunas.com

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Serge Jurasunas N.D., M.D. (Hom)
Pioneer in Natural Medicine and Naturopathic Oncology
Practitioner – Researcher – Author – 50 years of practice

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International Publication of
Articles by Serge Jurasunas
in Various Health Magazines:
 USA
 Germany
 Japan
 Lithuania
 Belgium

New Modern Way to Treate Cancer - Strategic
Immunotherapy, Apoptosis and Angiogenesis
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5th International BioBran Workshop, 9-11, June 2017, Krakow, Poland
Oncologists Joseph Brenner M.D., Hegyi Gabriela M.D., Prof.Jurasunas N.D.,
Prof. Tibor Hajto, Immuno-Oncologist Prof.Rupert Handgretinger

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Declaration signed December 23rd,
1971 with the promise to have
cancer cured within the next 5
years. Since then, nearly $ 300
billion has been spent with no cure
yet!!!
1971 Declaration of War on Cancer by US
President Richard M. Nixon signing the National
Cancer Act

Where are We Today with Cancer ?
Despite progress in Oncology
and some benefit in the gold
standard of palliative therapy,
surgery and radiation,
conventional treatment has not
achieved the hope and
expectation to cure cancer.
In metastasic cancer, Oncology
is no better than 30 years ago.
There has been no significant
change in the survival rate.
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Problems of Conventional Oncology
→ Chemotherapy is toxic, induces adverse
effects and can be fatal to patients
→ Resistance of cancer to chemo-radiation
→ Induces adverse eﬀects including death
→ Many anticancer drugs show little or no
efficacy
→ Chemotherapy and radiation are carcinogenic
by themselves; responsible for secondary cancer
→ Metastasis cancer is incurable and responsible
for 95% of deaths
→ Recurrence is sƟll too high
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Cancer cannot be attacked only in one direction,
but requires several simultaneous directions.
You need more than one arrow to kill the tumor.

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New Modern way to Approach Cancer:: Strategic immunotherapy,
Apoptosis and Angiogenesis.

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p53 Mutations in Cancer
■ p53 is the most commonly
mutated gene harbored in
more than half of all
cancers.
■ Inactivated or mutated
p53 appears necessary to
develop many forms of
cancer.
■ Restoring p53 WT
function or activation may
offer a therapeutic benefit.
Read: Serge Jurasunas - The p53 Tumor Supressor Gene Understanding p53 Based
Anticancer Therapies Utilizing Dietary Agents. Townsend Letter – August/Sept 2015

New Modern Way to Approach Cancer:
Strategic Immunotherapy, Apoptosis and Angiogenesis
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P-53 Tumor suppressed gene:
Understanding P53 based Anticancer
Therapies utilizing Dietary Agents
By Serge Jurasunas
Published in Townsend Letter, The Examiner of
Alternative Medicine USA ( August/Sept 2015

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New Modern Way to Treat Cancer - Strategic

Video from Researcher , Dr. Marc Diederich
from the University of Singapore
(From My Science Work)
A number of recent articles published in various countries have
shown that reactivating the immune system to treat cancer is now
attracting oncology theories.
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Reactivating the Immune System Against Cancer: A Role for Natural Compounds

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New Modern way to treate cancer, Strategic,

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Biobran a Biological Response Modifier
Biobran is a hemicellulose complex, a dietary fiber containing
Arabinoxylan as a major component which is produced from modified rice
bran and enzymatically treated with an extract from mycellia shitake
mushroom.
Before the process
Arabinoxylan itself has
no immunostimulating
activity until the long
polyssacharides
molecules are broken up
into smaller components.
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Digestion, Absorption and Function of Biobran
Most dietary fibers are eliminated by the intestine but Biobran is absorbed in
the small intestine practically undigested entering into the blood to become
a nutritional food that activates N.K.cells and optimizes immune function
when taken orally.
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Biobran Increases the Curve of NK cells
If you prescribe 2g of Biobran
to volunteers you can then
see a curve of NK cells
increasing about 60% after
two weeks. But if you
continue, you can even
achieve up to 200 even 300%
or more NK cell numbers and
greater activity.
NK cells are here but not
activated to release their toxic
enzymes (perforin) through
the membrane of cancer cells.
Ghoneum M. “Enhancement of Human natural killer cells activity by
modified arabinoxylan from rice bran. (Mgn3) Int. Immunotherapy
1998. XIV.89-9922

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Treatment with BioBran causes a remarkable increase in NK cell activity
in various cancers after 2 weeks.
PERCENTAGE OF INDUCTION
Breast cancer = 154 -332%
Leukemia = 100-240%
Cervical cancer = 100-275%
Prostate = 174-385%
Multiple Myeloma = 100-537%
Enhancement of NK cells activity continue to rise at 3-6 months
after treatment. (1)
(1) Ghoneum M. Narmatalla G. N.K Immunomodulatory function in 27 cancer patients by Mgn3, a modified
arabinoxylan from rice bran.
(1) The abstract of 87th Annual Meeting of the American Assn. f or cancer Research. Wash. D.C April 20-24.1996.

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RICE BRAN ARABINOXYLAN COMPOUND
(Biobran MGN-3)
We have incorporated BioBran in our treatment of cancer
patients with a few thousand cases so far of all types and grades
and have use several combinations included in our protocol.
We also noticed that BioBran is superior to other immune
supplements like arabinoxylan and mushrooms including
Maitake Mushroom D-Fraction, AHCC by making comparisons
between each product and in the our patient’s protocols.
When treating a cancer patient the main goal is to first chose the
best quality and efficient compounds, combining the best two or
three working in synergy that have more efficacy when targeting
the cancer mechanism!

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Effect of Biobran on Macrophage Activation

-Cancer patients on chemotherapy have a depressed NK cell
activity attributed to a decrease or absence of perforin and
granzyme (1).
-Mgn3 Biobran studies have shown that the treatment causes
an increase in the granular content (perforin and granzymes)
of NK cells.
-It also results in an increased NK cell binding capacity to
cancer cells.
(1) Culler S.P. Brunet M., Martin S.J. – Granzymes in cancer and immunity – Cell Death Differ.
2010.17-616-623
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NK Immunorestoration of Cancer Patients by Biobran/Mgn3
Cytocentrifuge preparation of two K562 tumor cells
undergoing destruction by one NK cell. NK cells
were activated by MGN-3
a) First step in the process represented by the
binding of an NK cell to tumor cells. (Giema,
X740)
b) Preparation showing one tumor cell is dead.
(Giema, X740)
c) Preparation showing both tumor cells are dead
while an NK cell in between is still alive.
(Giema, X740)
d) Cytocentrifuge preparation showing NK cell
has detached itself from the dead tumor cells.
(Giema, X740)

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NK Cells Killing Cancer Cells

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Schematic representation of NK Cell Activity
In MGN-3 Treatment for a Longer Period of Time
as Compared with Other BRMs.

Significant Synergism
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Biobran Enhances the Effect of Chemotherapy Leading to Effective
Treatment at Low Dosage with Less Toxic Effect and More Results

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NK Cell activity increases survival of cancer patients.
In different types of human tumors including
melanoma, breast cancer, bladder, colon, prostate,
ovary, rectum and glioblastoma longer survival has
been observed in patients with a higher number of
lymhocytes and NK cells.
References: Jass J.R. Lymphocytic infiltration and survival in rectal cancer J.Clin.Pathol. 1986-19-585-589
Clemente CG et al. Prognosis value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous
melanoma. Cancer. 1996 – 77 -1303-1310

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Patient Survival, Recurrence and Tumor Reduction
After Treatment with CT alone vs CT and Rice Bran
Arabinoxylan Compound (Mgn3)
with CT Alone vs CT and BioBran.

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BIOBRAN (MGN-3 arabinoxylan compound).
CONCLUSION:
In human studies BioBran has been shown to be the most
effective in activating NK cells and optimizing immune
function when taken Orally before or after meals.

CURCUMIN – A Potent Anticancer Agent
(Yellow ingredient derived from curcuma longa.l one of the most
extensively investigated phytochemical compounds with ANTICANCER
properties. (1)
(1) Anticancer potential of curcuma. An old spice with new targets. Bharat B. Aggarwal Ph.D. University of
Texas M.D. Anderson Cancer Center. Houston. TX.USA
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Effects of Curcumin on the Interaction with Multiple
Cell Signaling Proteins, Cancer and Chemotherapy
Apoptosis Induction Downregulated BcL2-Survivin, increased p53 gene
expression, Bax and P21 gene expression,
Stimulation of caspases 3-7 activity. Inhibits NFKB
Inhibition of the Cell Cycle
Progression
G2/M arrests (also GO, G1) (pathway of many
anticancer agents)
Inhibition of Angiogenesis Inhibition of VEGF, NFKB activity
Inhibition of Metastasis and
Invasion
Inhibition of MMP’s 3,6,7,8 expression or activity.
Anti-Inflammatory Suppression of COX2 expression or activity,
downregulate Nuclear Factor Kappa B (NFKB) itself
is responsable for tumor growth, metastasis
invasion, suppress ion of immune function and
activated VEGF. MMP’s favor angiogenesis
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Human Melanoma Cell Line SK-MEL-37 Cells have been Treated with 15uM
and 20uM of Curcumin for 24 hours: (B and D) Entering into Apoptosis. (A
and C Untreated Cells).
These cells have demonstrated to be resistant to doxorubicin, cisplatin in
culture but sensitive to curcumin treatment.
Marcella Lemos Carneiro – Morphological alterations and Go/G1 cell cycle arrest induced by curcumin in human SK-
MEL-37 melanoma cells. Braz.arch.Biol. Technol.Vol.53 n.2.Curitiba.April.2010
Curcumin potentializes
chemotherapy effectiveness
in a variety of cancers
including breast, ovarian,
colon and pancreatic and
could become a promising
tool.
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Curcumin Increases the Sensitivity of Drug Treatment in
Breast, Ovarian, Cervical, Pancreas and Colon Cancer
- 5 Fu
- Taxol
- Pactitaxel
- Cisplatin
- Adramycin
- Daunorubicin
Koo J.Y. et al, 2002, VBS et al. 2003, Chan M.M., 2003, Chuang S.E. et al, 2002

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 Both BioBran and curcumin can block T-regulatory,
lymphocytes, Treg cells ( or CD4 + CD25 + Lymphocytes)
increase in a tumor microenvironment and are highly
immunosuppressive
 Treg cells have a suppressive effect on NK cell activity,
dendritic cells and macrophages producing
immunosuppressant cytokines such as the TGFB and TC10.
Smyth. M.J. Treg MWL, Swann J. Kyarissoundes K,
Godfrey DY. , CD4 + CD25 T regulatory cells suppress NK cell- mediated immunotherapy of cancer – J. Tusmund 2006-
176-1582-1587

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T regulatory T- cells ( Tregs) in the Tumor Microenviroment

A Study in Breast Cancer
(Bayet-Robert and Collegues 2010)
Oral curcumin and docetaxel administered to
INOPERABLE breast cancer patients with advanced
tumors and metastasis, became OPERABLE after the
combination therapy.
Patients had LOWERED tumor MARKERS and V.E.G.F.
levels indicating REDUCED cancer cell SURVIVAL and
ANGIOGENESIS, tumor SIZE and inflammation. (1)
(1) Serge Jurasunas – Complementary Approach to Breast Cancer. A Case with Multiple Liver
Metastasis is Free from Disease. Townsend Letter August/September 2015.
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Synergetic Effect of Biobran MGn3 and Curcumin
in Cancer Treatment with Chemotherapy
- Faster reduction and/or elimination of secondary
nodules in cancer recurrence.
- Significant reduction of large tumors when
taken together with chemotherapy.
- Advanced cancers with multiple metastasis
(Liver, lung, etc.), having received poor
prognosis with a combination of chemotherapy,
have resulted in prolongation of lifespan (6-8
years) with maintenance, along with an improved
quality of life (QOL). 50

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Microbiome:
A New Target in Immuno-oncology.
Stronger Immune Response to Kill Cancer Cells.

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Distribution and Abundance of Bacteria in the Human
Gastro-Intestinal Tract

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TOP KNOWN BENEFITS of the HUMAN MICROBIOME
(Commensals bacteria)
 Preventing infection by pathogens bacteria
 Development of the immune system
 Digestion of food
 Vitamin production ( B2, B12, K, Folic acid)
 Toxin degradation

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Chemotherapy and Intestinal bacteria
Cyclophosphamide and Oxaliplatin
increase intestinal permeability and
stimulate translocation of specific gram
positive commensal bacteria into the lymph
nodes and blood circulation by stimulating
the production of PTH17 antitumor cells
which reinforce the action of chemotherapy.
References.
Iida N, N, Dzutsev A, Steward CA, Smith I, Bouladoux N, Weingarten RA et al. Commensal
bacteria control cancer response to therapy modulating the tumor microenvironment. Science,
2013. 342, 467-70.
Viands S, Saccheri F, Mignot G, Yamazuki T, Dailliere R, Hanneni D, et al. The intestinal
microbiota modulate the anticancer immune effects of cyclophosphamide.
Science. 2013-342, 971-6
.

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The Intestinal Flora (microbiota) Reinforce
Chemotherapy Effectiveness
REPORT. GUSTAVE ROUSSY INSTITUT (VILLEJUIF-
FRANCE)
NATIONAL INSTITUTE OF CANCER (USA)
Bacterial phytogenetic tree that supports the
mucous colon of rats.
Red ball, Bacteria that stimulate the immune system
Green ball, Bacteria that inhibit the immune response.

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Antibiotics Interfere with the Microbiome and
Decrease Immunotherapy Efficacy

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Immunotherapy induces adverse effects, often very serious
With no benefits for the patients.
30% to 60% of patients have been resistant to the treatment
Immunotherapy is efficient only between in about 10-20 % patients.
Therefore it requires additional support such as improving
the microbiota with selected Probiotics, selected food and some
Immunomodulators to obtain better results such as:
RICE BRAN ARABINOXYLAN COMPOUND BIOBRAN MGN-3

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New Modern Way to Approach Cancer:.
Protocol for Cancer Patients:
Symbioflore I.II.III. Made from Autolysate of human bacteria to develop or boost
the Microbiome and the Immune System. (sublingual 10-20 drops per day)
Biobran, 1 bag of 1gr 3 times per day, 20 min. after meals.
Curcumin. 1 bag of 1500 mg liquid diluted in water to take
3 times per day between meal.
Additionally as support to nutritional need, detoxification,
boosting Mitochondria function and activating ATP energy.
Enzyme Yeast cells (Zell-Oxygen)
Anticancer diet, cocktails of fresh vegetable juice

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10/11/2005 – Bad physical condition – metastasis to bone skeleton – PSA 354 nl/ml
Treatment – L.C.E. (Comitris) – Immunomodulator (Biobran) 3g per day
12/01/2006 - PSA 53.6 nl/ml - After 3 months PSA 1.4 nl/ml
After 5 months elimination of almost all the bone metastasis.
Patient Male – 73 years old – Prostate Cancer
Clinical story: Adenocarcinoma of the Prostate – Gleason 7 (3+4) -
Advanced case – No Surgery or Chemotherapy/Radiation.

A Few Interesting Case Histories
We Don’t Cure All the Cancers but…
-Many cases after 25-30 years are alive and doing well.
-Several have had a 10 year extension.
-Several advanced cases have improved their quality of life with a life
spent up to 7 years , including prostate cancer, multiple myeloma,
breast cancer and pancreatic cancer.
-Unfortunately many cases come in too late that end up as fatalities
from excess chemotherapy.
-Overall our treatments have demonstrated efficacy, help the patient
by reducing toxic effects, improve chemotherapy effectiveness,
quality of life and increase life expectancy.
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F.41 years – Asympthomatic Prime Lesions 18 cm –
Secondary Lesions 8 cm
Combination of chemotherapy with our complementary treatment that
targets apoptosis, angiogenesis and improves immune activity – Anticancer
Diet
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Advanced Gastric Cancer - Results of Blood Analysis
July 2015 April 2015 July 2015 April 2015
Lesion of
30,1 mm
Lesion of
48,7 mm
Lesion of
18 cm

p53 Gene Expression
p53 Protein Level
mutated
p53 Protein Level
normal
58 units/µl of plasma
35,4 units/µl of plasma
1 unit/µl of plasma
Reference range:
10-50 units/µl of plasma
Reference range:
0,10 – 1,00 units/µl of plasma
Reference range:
5 - 15 units
Tumor Marker 2 – Pyruvate Kinase
TM2.PK
Advanced Gastric Cancer - Results of Blood Analysis
1st Test: 28/04/2015 2nd Test: 26/06/2015
p53 Gene Expression
p53 Protein Level n
normal
p53 Protein Level
mutated
Not detectable
Tumor Marker 2 – Pyruvate Kinase
TM2.PK
Comment: We significantly increased about 4 times the expression of p53 gene and increased
only to a certain extent normal p53 protein. We reversed the production of mutant protein to
a normal wild type. TM2.PK activity decreased to an almost normal range.
After the applied therapy
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Advanced Gastric Cancer - Photo taken on May, 2017

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Breast Cancer with Multiple Metastasis to Liver
Complete Case Published in the Townsend Letter August/Sept 2014 or
online at www.sergejurasunas.com
Patient female, 44 years old diagnosed in October 2011 with a stage III left breast
cancer, with dissemination of about 30 lesions to the liver; up to 1,5cm size for many
localized in the left lobe, and segment III and IV of the right lobe.
Breast tumor was about 3.5cm with inflammation spread to neighboring tissues; many
swollen lymph nodes were diagnosed on the left part of the neck. Chemotherapy was
suggested before surgery to reduce the tumor and the inflammation.
January 2012 – The patient came into our clinic suffering from adverse side effects
having had very little response from chemotherapy. She felt tired, nausea, loss of
appetite, anxiety. We had taken 3 different tests: Live Blood Analysis, Oxidative Dried
Blood Test and Molecular Markers Testing. These tests showed very high BCL2
activity, low BAX gene activity and especially very high VEGF levels showing activated
angiogenesis in the solid tumor.
Treatment – L.C.E., Biobran MGN-3, Curcumin and Anticancer Diet
After 2 months of treatment the inflammation was almost gone, in the same way as
the swallowed ganglions and reduced tumor. Surgery was done followed by
chemotherapy and our treatment. In 2003 a new scan showed total elimination of the
30 liver nodules and complete remission. In 2017 the patient was still in remission but
still comes in regularly for our check up exams.

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Breast Carcinoma Stage IV with Multiple Metastasis to Ganglions,
Liver, Bone, Pleura and One Nodule to Right Lung
Patient female – 42 years old – Breast carcinoma stage IV with multiple metastasis
to ganglions, liver, bone, pleura and one nodule to right lung.
The patient underwent a radical mastectomy and started chemotherapy on October
2015. A February, 2016 scan showed more dissemination of metastasis, which
increased in April, with poor physical condition. There was strong resistance from
cancer cells to chemotherapy with more dissemination of metastasis.
The patient came to us in May 2016 and immediatly started our treatment.
Biobran MGN-3, 3 gr per day – Curcumin, 4,5 gr per day – Enzyme yeast cells
preparation, 40 ml per day – Coenzyme Q10, 300 mg per day followed by an
aggressive anticancer diet and plenty of vegetable juices which is important in any
cancer treatment.
August 2016, a new scan showed major improvement, about a 70% reduction in nodule
size, demonstrating synergy with our combination therapy with chemotherapy by
increasing effectiveness by targeting apoptosis, angiogenesis and immune cell activity.
Results in the next slide reveal the patient got worse from chemotherapy alone, but after 3
months had a much better scan after our complementary therapy.

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Breast Carcinoma Stage IV with Multiple Metastasis to Ganglions,
Liver, B one, Pleura and One Nodule to the Right Lung

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Advanced Prostate Cancer (1)
Patient male – 71 years old – Advanced prostate cancer.
The patient was diagnosed in 2005 with a prostate cancer with
dessimination of bone metastasis. Very high PSA 1.260 ng/ml. No surgery,
chemotherapy or radiation was suggested but only a hormonal therapy,
but without result. The patient was in a very bad condition.
2006 – The patient started our alternative treatment.
L.C.E. Biobran Mgn-3, prostasol (herbal composition) Imupros (vitamins,
trace elements, lycopene, ginseng, etc…) together with an anticancer diet.
After 4 months the patient felt better and gradually started to improve. PSA
decreased to 328 ng/ml. After 8 months to 58 ng/ml and to 2.8 ng/ml and
final to 1.58 ng/ml.
After 6 months of treatment a new bone scan showed a 50% decrease of
bone lesions and after one year a total elimination. The treatment was
followed during the whole year.

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Colon Cancer with Metastasis to the Lungs and Liver
Patient female – 56 years old – Diagnosed in May 2010 with colon cancer, stage IV
with metastasis spread to liver.
Surgery and Chemotherapy.
June 2012 - New scan had shown more metastasis to the liver. Patient was
submitted to more chemotherapy with a period of remission.
September 2013 - Recurrence and dessimination of metástases to lung, ganglions
and liver. High tumor marker level Ca 19.9 848 U/ml. CEA 260 ng/ml. The patient
came in our clinic in a desesperate condition.
Treatment: Biobran, Mgn-3, Curcumin, L.C.E., SOD, Alpha lipoic acid, followed by an
aggressive anticancer diet, cocktails of vegetable juice.
2015 - Patient was in bad physical condition, anemic, much coughing from lung
metastasis, felt tired, had chest pains and some difficulty breathing.

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Cancer of the Colon with Metastasis to the Lungs and Liver
The Patient in March 2017

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Cancer of the Colon with Metastasis to the Lungs and Liver

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The same patient 7 months later in October 2017
with a good physical prospect, good quality of life,
happy despite the “death sentence” given to her by her
doctors nearly 5 years ago. She was taking BioBran from
the beginning alone with other supplements.

Patient female – 50 years old with a metastasic recurrence from
breast cancer (2000) in 2004 with multiple lesions disseminated in the
skeleton. Strong pains and after one year of the new protocol of
chemotherapy a new bone scan (May 2005) showed more
disseminated lesions in comparison to 2004. Poor response and
evolution of the disease. The complete case fully illustrated is
available in English and French.
X Ray of the Spine
After 3 months of
combined therapy +
chemotherapy.
Total elimination of the
very large lesions in the
illium and spine.
Jurasunas Serge, ND

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Tumor Marker – CA 15.3
113U/ml
55.2 U/ml
23.6 U/ml
June
2005
August
2005
January
2006

Old Case
Breast Cancer Survivor
1994 – Age 36 years.
Bad prognostic of 18 ganglions
with metastasis – Liver and
bone metastasis.
June 2008 – Age 50 years
Participating as a witness in
our psychological support
group meetings for our cancer
patients – 2017 – The patient is
still in remission at 59 years
old.

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My Next Book:
New Modern Way to Treat Cancer
Breakthrough in Immuno-Oncology
RICE BRAN ARABINOXYLAN COMPOUND / BioBran

Thank You for
Your Attention!
Don’t Let the Cancer Kill You, but Rather Kill the Cancer !
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Professor Serge Jurasunas - New Modern Way to Approach Cancer - Biobran Workshop - Zagreb Croatia 2-27-2018

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