Excellent results without side-effects are achieved when Ashwagandha is used with other Complementary and Alternative Medicine therapies.

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2. Modern life is full of challenges such as:
 meeting deadlines
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3. One of the best Integrative medicine
resources for CAM practitioners is a
supplement calledAshwagandha.

4.  Ashwagandha or Withania somnifera is
commonly known as “Indian Winter cherry”
or “Indian Ginseng”
 It is and is one of the most frequently used
herbs in Ayurvedic Medicine

5. The Biologically Active
Constituents of Ashwagandha

7. Characteristics of
Ashwagandha

8.  Tonic
 Aphrodisiac
 Narcotic
 Diuretic
 Anthelmintic
 Astringent
 Thermogenic
 Stimulant

9.  Ashwagandha is also referred to as a
rasayana in Ayurvedic medicine
 This Sanskrit term means preventing aging
and disease

10. Ashwagandha orWithania has the following
properties:
 Free radical scavenging activity
 Antioxidant activity
 Supports immune system

11. Brain Function Pharmacology

12.  Provides potent antioxidant protection
 Stimulates the activation of immune system
cells; lymphocytes and phagocytes
 Is a proven adaptogenic
 Both Withania and Diazepam have been
shown to act as a mood stabilizer in
comparative in-vivo studies
 Research studies have also shown that
Ashwaghanda has anxiolytic effects

13.  Induces dendrite extension in a human
neuroblastoma cell line
 Attenuates hippocampal neuronal cell
damage in mice
 Possess GABA-mimetic activity

14. Mechanism of Action

15.  Ashwagandha is primarily known inWestern
medicine as an Adaptogen
 The active constituents are possibly due to
Withanoside IV
 Inhibits nitric oxide production
 Down regulation of nNOS
 Suppresses corticosterone release
 Activates cholineacetyltransferase, which in turn
increase serotonin level in hippocampus to
inhibit NADPH-d (stress-related hormone)

16.  GABA mimetic activity
 Prevents stress-related hormones such as
NADPH diaphosphorase and cortisol from
increasing
 Comparable calming anxiolytic effect to the
drug Lorazepam in rat maize test
 Both Ashwagandha and Lorazepam reduces
rat brain levels of tribulin, an endocoid
marker of clinical anxiety

17. Clinical Study

18.  Cohort of 64 subjects with a history of chronic stress
 Serum cortisol measured
 Standard stress-assessment questionnaires utilised
 Participants were randomized to either the placebo control
group or the study drug treatment group for a period of 60
days
 The treatment group consumed a capsule containing 300
mg of high-concentration full-spectrum extract from the
root of the Ashwagandha plant
 During the treatment period (on Day 15, Day 30 and Day 45),
a follow-up telephone call was made to all subjects to check
for treatment compliance and to note any adverse reactions.
 Final safety and efficacy assessments were done on Day 60

19.  Serum cortisol (stress hormone) levels were
substantially reduced in the treated group
 Ashwagandha effectively improves an
individual's resistance towards stress
Study limitations:
 Low sample size
 Time duration of study

20. Excellent results without side-effects are achieved when
Ashwagandha is used with other Complementary and
Alternative Medicine therapies such as:
Yoga Acupuncture
Homeopathy Cognitive Behaviour
Therapy
LifelineTechnique ExerciseTherapy
Hypnotherapy Spiritual Counselling
Tai Chi Meditation
MassageTherapy Aromatherapy

21.  Complementary medicine recommendations
 Complementary therapy recommendations
(if required)
 Specific dietary advice
 Lifestyle plans
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23. I worked for over 14 years with eminent scientists as a
front line medical researcher for a top-flight
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In the last 12 years I have been working with medical
doctors as a practitioner of Ayurveda, Remedial
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and Spiritual Counseling in Integrated Medicine
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