Adaptogens are natural substances that increase nonspecific resistance to stress by regulating homeostasis. They modulate the stress response and production of eicosanoids to help the body adapt. Some examples of adaptogens include ashwagandha, tulsi, ginseng, amla, neem, and shatavari. Ashwagandha and tulsi are discussed in more detail, with ashwagandha noted to improve brain function, immunity, stress resilience, and antioxidant effects, while tulsi protects against chemical, physical, infectious and emotional stresses.

1. KHAN MOHAMMAD USAMA
M.TECH(PHARM) PROCESS CHEMISTRY
NIPER HYDERABAD
*ADAPTOGENS AND
THEIR EXAPLES

2. *
 Adaptogens are those natural substances which
increases the non specific resistance of
organisms against different types of stressors.
 The drug induced state of resistance against
aversive stimuli is termed as adaptogenic
activity.
 They are the metabolic regulators which
enhances the ability of organisms to adapt the
environmental factors.
 They are also called as anti stress drugs.

3.  Adaptogens increase the ability of the stress
system to respond to stress stimuli in a manner
that tends to preserve homeostasis, particularly
by modulating the biosynthesis of eicosanoids—
including prostaglandins E2 and F2, 5-
hydroxyeicosatetraenoic acid (5-HETE), 12HETE,
and leukotriene B4.
 Adaptogens also appear to regulate the basal
level of the arachidonic acid that is these
substances’precursor, and to also do this under
various stressful conditions, such as
immobilization,heavy physical exercise,and
radiation injury.

4. Adaptogens are relatively safe to consume but it’s
important to note that they are unregulated by the
U.S. Food and Drug Administration (FDA).
They are suitable for long-term consumption and
support a healthy and balanced diet.
The Benefits of Adaptogens:
Different adaptogens have varying characteristics
and qualities but they are generally high in
antioxidants, help reduce cellular damage and
inflammation, and boost energy and
immunity. Rhodiola, in particular, may also help
increase serotonin levels and improve mood.

5. Adaptogens have been studied in both animals and
isolated neuronal cells. Researchers have found they
have several effect on body,
 neuroprotective property,
 anti-fatigue properties,
 antidepressive effects,
 stimulant for central nervous system,
 increase mental work capacity,
 enhance attention,
 prevent stress and fatigue.

6. *EXAMPLES OF ADAPTOGENS
Ashwagandha,
Tulsi,
Ginseng,
Amla,
Neem,
Shatavari,
Myrobalan,

7. *
Ashwagandha (Withania somnifera, fam.
Solanaceae) is commonly known as “Indian Winter
cherry” or “Indian Ginseng”. It is one of the most
important herb of Ayurveda (the traditional system
of medicine in India) used for millennia as a
Rasayana and adaptogen for its wide ranging health
benefits.It is known as “Sattvic Kapha Rasayana”
Herb.
Ashwagandha is commonly available as a churna, a
fine sieved powder that can be mixed with water,
ghee (clarified butter) or honey.

8. It enhances the function of the brain and nervous
system and improves the memory.
It improves the function of the reproductive
system promoting a healthy sexual and
reproductive balance.
Being a powerful adaptogen, it enhances the
body's resilience to stress. Ashwagandha improves
the body's defense against disease by improving
the cell-mediated immunity.
It also possesses potent antioxidant properties
that help protect against cellular damage caused
by free radicals.

9. The biologically active chemical constituents
of Withania somnifera include
 Alkaloids
 steroidal lactones
 saponins
Sitoindosides and acylsterylglucosides in
Ashwagandha are anti-stress agents.
Active principles of Ashwagandha, for instance
the sitoindosides VII-X and Withaferin-A, have
been shown to have significant anti-stress activity
against acute models of experimental stress.
Many of its constituents support
immunomodulatory actions.

10. Tulsi is an aromatic shrub in the basil family
Lamiaceae (tribe ocimeae) that is thought to have
originated in north central India and now grows
native throughout the eastern world tropics.
Within Ayurveda, tulsi is known as “The
Incomparable One,” “Mother Medicine of Nature”
and “The Queen of Herbs,” and is revered as an
“elixir of life” that is without equal for both its
medic inal and spiritual properties.
TULSI

11. Considered as a potent adaptogen, tulsi has a
unique combination of pharmacological actions
that promote wellbeing and resilience.
The medicinal properties of tulsi have been
studied in hundreds of scientific studies including
in vitro, animal and human experiments.
pharmacological actions of Tulsi help the body and
mind cope with a wide range of chemical,
physical, infectious and emotional stresses and
restore physiological and psychological function.

12. Tulsi has been found to protect organs and
tissues against chemical stress from industrial
pollutants and heavy metals, and physical stress
from prolonged physical exertion, ischemia,
physical restraint and exposure to cold and
excessive noise.
Tulsi has also been shown to counter metabolic
stress through normalization of blood glucose,
blood pressure and lipid levels,
and psychological stress through positive effects
on memory and cognitive function and through
its anxiolytic and anti-depressant properties.

13. THANK YOU......