Awake and Asleep are the first natural health products designed to mitigate the effects of circadian rhythm disruption.

1. The first natural
health products
designed to
mitigate the effects
of circadian
rhythm disruption

2. “ My vision is the preservation of shift workers’
health with preventative medicine.”
Introduced by
Dr Pushpa Chandra, RN, ND

3. • Critical care nurse working shifts
for over 25 years
• Competitive extreme
ultramarathoner for over 30 years
• Over 500 marathons including
Everest, Antarctica, North Pole and
Sahara Desert
• User of Awake and Asleep
ingredients for over 30 years
• Ingredients of Awake and Asleep
are the cornerstone of my health
and performance
My story

4. Our natural biological clock
If we try to operate outside of this natural rhythm by working nights or staying up late,
our bodies cannot adjust and we suffer
Circadian Rhythm Disruption.

5. Circadian rhythm
disruption:
Errors
3rd leading cause of death
in Canadian and US hospitals
BMJ 2016;353:i2139
>4,000 Doctor-related
deaths in Canada alone
University of Health Network (UHN)
- Dr Peter Pisters (president and CEO)

6. Circadian rhythm
disruption:
Errors
5 times more likely
on night shift
The Canadian Adverse Events Study:
the incidence of adverse events among hospital patients in Canada
The space shuttle Challenger disaster, Chernobyl, Three
Mile Island, Exxon Valdez and other notable disasters were
discovered to have shift work fatigue as a significant causal
factor.

7. Circadian rhythm
disruption:
Health effects
Breast cancer and deaths
among workers in their 30s
WHO – Carcinogen. International Agency for Research on Cancer (IARC)
Ranks as 2A (same as DDT & lead).
Cognition deficit
prevents self-care
Chronic effects of shift work on cognition:
findings from the VISAT longitudinal study

8. Circadian rhythm
disruption:
Health effects
Obesity increased
Fertility decreased
Longevity decreased
The Impact of Sleep and Circadian Disturbance on Hormones and
Metabolism: Kim, Jeong & Hong
CRD has a systemic adverse health effect. Every organ in
the body is affected.

9. Circadian rhythm
disruption:
Accidents & fatalities
Worse than drunk driving
US News & World Report: https://cars.usnews.com

10. Why choose Awake & Asleep
• Professional grade product formulated
by a doctor who was a shiftworker
• Evidence-based quality ingredients
with high potency
• All natural, caffeine-free
and non-addictive
• Produced in Canada in a
Good Manufacturing Practices facility
• Health Canada approved

11. Why choose Awake & Asleep together
The only natural products designed
to work together as a 24-hour system
to boost overall vitality
by enhancing the body’s functioning
during wakefulness and helping
to ensure proper restorative rest.

12. Elite class of herbs in Awake and Asleep
• helps the body adapt to biological
and psychological stress promoting
homeostasis.
• has a balancing effect on
Hypothalamic Pituitary Adrenal (HPA
– Axis)
• This stress-protecting effect
rebalances cortisol, realigns other
hormones and overall vitality

13. Performance
Stamina
Rejuvination

14. Support for shift workers
Sports enhancement
and training
Restore and refresh
naturally

15. Ingredients
Siberian ginseng (Eleutherococcus) immune restorative
and neuroprotective. Protects from mental and physical
stress.
Rhodiola nootropic anti-fatigue agent, promotes
physical and cognitive vitality. Mental focus tonic,
protects against cognitive decline in shift workers.
L glutamine promotes healthy immune cells.
Schisandra premium brain tonic and energy booster.
Renowned for antiaging, longevity and memory.
Bacopa monnieri enhances focus, memory and
cognitive function.
L tyrosine promotes mental alertness and focus.
Marigold antioxidant for eyes.
Vitamin D3 guards immunity.

16. Siberian ginseng: Eleutherococcus Senticosus
‘The king’ – the most disease-preventative herb
• Enhances mental acuity and physical endurance during work hours and
throughout your exercise regime or sport. Improves oxygen uptake by
exercising muscles, enabling longer workouts and quicker recovery time.
• Anabolic effect; stimulates protein synthesis in the pancreas, liver, and
adrenal cortex.
• Increases noradrenalin and serotonin for quicker recovery from acute
stress.
• Nootropic (SMART HERB). IMPROVES learning and memory.
• Protects against environmental pollutants and radiation.
• Normalizes body temperature – can be used to prevent hypothermia.
Key ingredients: detail

17. Eleutherococcus Senticosus: contd
“The king” – the most disease-preventative herb
• Regulates blood-sugar levels (leaf extract is more effective than the root).
• Protects the liver and enhances its ability to break down and eliminate
drugs from the body. Anti-alcoholic.
• Immune restorative/enhancing agent. Increases the body’s ability to resist
infection; prevents colds and flu, and shortens recovery time.
• Anticancer effects through homeostasis. Decreases the side effects of
toxic therapies like chemotherapy and radiation.
• Strong antioxidant against free radicals and antilipid peroxidative
activities.
• Improves circadian biorhythm.
Key ingredients: detail

18. Rhodiola Rosea
Cognitive Vitality
• Nootropic (Smart Herb)
• Brain tonic – Top herb for shift workers. After a 2 week trial in night shift
emergency rooms, Physicians experienced improved cognition, increased
energy and reaction times.
• improves short-term memory and learning, and increases mental
working capacity, efficacy (decreased number of errors) and speed of
information processing.
• Regulates key chemicals such as serotonin and other ”feel good opioids”
• Promotes physical, mental and cognitive vitality. Neuroprotective - used
a lot to treat alzheimers.
Key ingredients: detail

19. Rhodiola Rosea: contd
Cognitive Vitality
• Reduces fatigue and exhaustion in prolonged stressful situations.
• Offers generalized resistance against physical, chemical and biological
stressors in animal studies. Makes body resistant to toxins.
• Top herbs for endurance athletes (including Olympians) – increases
oxygen carrying capacity. Amps your energy, vitality and stamina during
stress.
• Evidence also suggests cardioprotective, anticancer, antiviral,
hepatoprotective , antioxidative, antidiabetic, and antidepressant
effects.
Key ingredients: detail

20. Schisandra chinensis
Longevity and anti-aging
• 5 flavored berry sour, salt, sweet, bitter and pungent
• Most renowned for promoting longevity and anti-aging through its
potent antioxidant effects on detox pathways and as immune booster.
• Top liver protective herb, boosts liver function by regenerating liver cell ,
GSH production and is top herb for hepatitis
• improves mental efficacy and increases physical stamina, especially in
fatigued subjects. In one study, working capacity was increased by 222%
when compared to the control group.
• premium brain tonic, reproductive tonic, energy booster and digestion
• Improves eyesight
Key ingredients: detail

21. Bacopa Monneiri
Nootropic Brain tonic
• Not an adaptogenic compound but a potent antioxidant for the brain.
• Oxidative stress - most important factor in chronic inflammation and
in age related illness.
• Bacopa tops free radical scavenging action in the most metabolically
active organ (the brain).
• Neural tonic that increases cell to cell communication and increases
blood flow to brain, improving learning, memory and motivation.
Key ingredients: detail

22. Bacopa Monneiri: contd
Nootropic Brain tonic
• Sanskrit scholars used this to memorize lengthy sacred documents
and scriptures.
• Most researched in relation to neurodegenerative diseases (such as
Alzheimer's), and is proven to be a safer choice than its
pharmacological counterpart for treatment.
• Longevity, cognitive enhancement, memory, neural tonic and a
smart herb.
Key ingredients: detail

23. Eleuthro, Rhodiola and Schisandra
Together, they are stress protective and restorative
• Active components of rhodiola, schisandra and eleuthero are structurally
similar to catecholamines—primary regulators of stress—and other
components resembling corticosteroids that help to inactivate a stress
response.
• Rhodiola is the most active of the three substances, taking effect 30
minutes after administration, with beneficial effects lasting for at least 4
hours.
• A single dose of the three herb combination significantly improved the
speed and accuracy of cognitive performance and improved attention in
healthy people suffering from chronic stress when they performed
stressful cognitive tasks.
Key ingredients: detail

24. Indications
• Anyone using caffeine for energy or to stay awake
• Preventative approach to help resist stressors of all
kinds including physical, chemical or biological
• Tonic to help boost immunity, stamina and helps
adrenal fatigue.
• All shiftworkers or anyone working non traditional
work hours such as pilots
• Athletes for physical and mental stamina
• Students

25. Dosing
Adults: two capsules one time per day.
Take at the beginning of a work shift or as indicated
by a healthcare practitioner.
Take with a meal containing oil/fat.
Do not use if you are pregnant

26. Ingredients
Ashwagandha Somnifera: Natural sleep inducer.
Rejuvenates vitality by activating body's natural
immunity.
Melatonin: Natural hormone that improves sleep quality
and duration, reducing daytime fatigue. Mitigates jet lag
effects.
GABA: Promotes mental calmness and relaxation.
L-Theanine: Enhances sleep quality and recovery from
exhaustion.
Taurine: Induces muscle relaxation.
Magnesium bisglycinate: Relaxes muscles and nerves,
promoting restful sleep.
Vitamin D3: Guards immunity.
Vitamin B12: Regulates the sleep/wake cycle.

27. Withania Somnifera (ashwagandha)
‘Indian Winter cherry’ or ‘Indian Ginseng’
• Most highly acclaimed Ayurvedic adaptogen. Among the Ayurvedic
Rasayana herbs, ashwagandha holds the most prominent place.
• Nervine tonic benefits – the only adaptogen that you can take at night. It
has a sedating effect. Best adaptogen for the tired and wired at night.
You’ll feel rejuvenated upon waking.
• Ashwagandha is alternately translated as the ‘strength’, ‘sweat’ and ‘smell’
of a horse and is compared well with Eleutherococcus senticosus.
• Ashwagandha is one of Ayurveda’s few natural ojas builders, which means
it supports vitality, immunity, sleep, physical strength and health, and
spirituality.
Key ingredients: detail

28. • multiple pharmacological actions such as:
• anti-stress, neuroprotective, antitumor, anti-arthritic, analgesic and
anti-inflammatory etc. It is useful for different types of diseases like
Parkinson, dementia, memory loss, stress induced diseases, malignoma
and others.
• Stamina, endurance (better swim time in rats).
• Adjunct to standard chemo for breast cancer patients (fatigue related to
chemo).
Withania Somnifera (ashwagandha): contd
‘Indian Winter cherry’ or ‘Indian Ginseng’
Key ingredients: detail

29. • Exhibits an antidepressant effect, comparable with that induced by
imipramine.
• Powerful anti-inflammatory for arthritic conditions, such as rheumatoid
arthritis, osteoarthritis and gout. Its powerful anti-arthritic properties are
now widely accepted and documented.
• Analgesic that soothes nervous system from pain response.
• Safe with children.
• Safe with alcohol.
Withania Somnifera (ashwagandha): contd
‘Indian Winter cherry’ or ‘Indian Ginseng’
Key ingredients: detail

30. Melatonin
• Initially considered as an exclusive sleep hormone secreted by the pineal
gland; however, over the last few years, we’ve discovered that the GI tract,
retina, and immune system also produce melatonin.
• Now see it as more as an immune-boosting and anti-aging hormone.
• Its molecular mechanisms involve several actions:
• Anti-aging effects: counteracts atrophy of the thymus gland to restore
the organ's youthful ability to generate mature T-cells.
• Immune-boosting effects: increases interleukin-2 (IL-2) production and
improves the effectiveness of natural killer cells - two important
components of the immune system.
• Used in large doses to treat breast cancer.
Key ingredients: detail

31. • Melatonin is a powerful and versatile antioxidant produced within the
body. Melatonin protects both lipids and proteins against damage, and
can scavenge some of the most dangerous free radicals in the body—
including hydroxyl radicals and hydrogen peroxide.
• Many studies show that melatonin’s antioxidant properties prevents the
shortening of telomeres. Antiaging effect of melatonin.
• Unlike other antioxidants, melatonin easily diffuses into all cells, and even
crosses the blood-brain barrier to protect the delicate brain.
Melatonin: contd
Key ingredients: detail

32. Indications
• Shiftworkers / jet lag
• Problem falling asleep or staying asleep
• Wired and tired
• Insomnia from stress
• Immune health
• Arthritis pain / inflammation

33. Dosing
Adults: two capsules one time per day.
Do not drive or use machinery for five hours after
use.
Take at or before bedtime.