Malaria is spread by mosquitoes and causes hundreds of thousands of deaths each year, especially among young children in Africa. It is estimated that 198 million people contracted malaria in 2013, resulting in over 600,000 deaths. The most at-risk groups include young children, pregnant women, individuals with HIV/AIDS, foreigners, and those returning to high-risk areas. Prevention methods include insecticide-treated bed nets, indoor insecticide spraying, and antimalarial medicines, but resistance to insecticides and drugs poses ongoing challenges.