Cutaneous involvement is very common in the different types of vasculitis. Skin lesions may be the only manifestation or may occur in the context of systemic disease
Lecture on varicose veins for medical student. Encompasses basic sciences, classifications, principles and tips on management for this relatively common disorder.
Cutaneous involvement is very common in the different types of vasculitis. Skin lesions may be the only manifestation or may occur in the context of systemic disease
Lecture on varicose veins for medical student. Encompasses basic sciences, classifications, principles and tips on management for this relatively common disorder.
• Pathophysiology
• Clinical manifestations PCCM p 279
• Arterial ulcers
• Venous ulcers
• Diagnosis
• Management
• Compression
o Pressure bandages PCCM p 280
o When to apply pressure bandage
o Contra-indications for bandages
• Debridement
• Topical therapy
• Wound dressing
• Essential health information
• Leg ulcers in the elderly p 1060/p 1089
updated definitions of pressure ulcer injury wound coding per 2016,non-pressure wounds, how to code, best practice treatments,quiz on coding stages. Lecture notes visible in note view once downloaded
Cardiovascular history taking is an important skill that is often assessed in bedside teaching . It’s important to have a systematic approach to ensure you don’t miss any key information. The guide below provides a framework to take a thorough cardiovascular history.
• Pathophysiology
• Clinical manifestations PCCM p 279
• Arterial ulcers
• Venous ulcers
• Diagnosis
• Management
• Compression
o Pressure bandages PCCM p 280
o When to apply pressure bandage
o Contra-indications for bandages
• Debridement
• Topical therapy
• Wound dressing
• Essential health information
• Leg ulcers in the elderly p 1060/p 1089
updated definitions of pressure ulcer injury wound coding per 2016,non-pressure wounds, how to code, best practice treatments,quiz on coding stages. Lecture notes visible in note view once downloaded
Cardiovascular history taking is an important skill that is often assessed in bedside teaching . It’s important to have a systematic approach to ensure you don’t miss any key information. The guide below provides a framework to take a thorough cardiovascular history.
History taking (History of Physical Examination)pankaj rana
A History of Physical Examination Texts and the Conception of Bedside Diagnosis. ... Throughout this paper we construct a difference between a “bedside diagnosis,” made when the physician and patient are in each other's presence, and a “remote diagnosis,” made when the patient and physician are separated.
Patiwnt notes, history taking systematic screwing if patients to arrive at impression. Examination guide on assessment of patient normal anatomy and physiology by review of the body systems, central nervous system, Gastrointestinal , Cardiopulmonary , Genitourinary and Muskuloskeleal system review and examination
Basic principles, interview style, various components and their significance, how to take history of present illness, past history,family and personal history, substance history, premorbid personality
S.O.A.PDr. Quazi Ibtesaam HumaMPT NeurosciencesAsst Prof
Objectives
At the end of the lecture students should be able understand
What is SOAP?
Introduction
Aims
Structure
Its application in the field of Physiotherapy
What is SOAP??
S- Subjective
O- Objective
A- Assessment
P- Plan of care
Developed in the 1960s at the University of Vermont by Dr. Lawrence Weed as part of the Problem-oriented medical record (POMR)
Method of documentation for healthcare providers.
To document in a structured and organized way.
Structure- Subjective (First heading of the SOAP note)
Documentation under this heading comes from the “subjective” experiences, personal views or feeling of a patient or someone close to them.
CHIEF COMPLAINT
The CC or presenting problem is reported by the patient.
This can be a symptom, condition, previous diagnosis or another short statement that describes why the patient is presenting today.
The CC is similar to the title of a paper, allowing the reader to get a sense of what the rest of the document will entail.
CHIEF COMPLAINT- Cont’d
Examples: chest pain, decreased appetite, shortness of breath.
However, a patient may have multiple CC’s, and their first complaint may not be the most significant one.
Thus, physicians should encourage patients to state all of their problems, while paying attention to detail to discover the most compelling problem.
Identifying the main problem must occur to perform effective and efficient diagnosis.
HISTORY OF PRESENT ILLNESS (HOPI)
The HOPI begins with a simple one line opening statement including the patient's age, sex and reason for the visit.
Example: 47-year old female presenting with PAIN AT RIGHT SHOULDER .
This is the section where the patient can elaborate on their chief complaint. An acronym often used to organize the HOPI is termed “OLDCARTS”:
“OLDCARTS”
ONSET: When did the CC begin?
LOCATION: Where is the CC located?
DURATION: How long has the CC been going on for?
CHARACTERIZATION: How does the patient describe the CC?
ALLEVIATING AND AGGRAVATING FACTORS: What makes the CC better? Worse?
RADIATION: Does the CC move or stay in one location?
TEMPORAL FACTOR: Is the CC worse (or better) at a certain time of the day?
SEVERITY: Using a scale of 1 to 10, 1 being the least, 10 being the worst, how does the patient rate the CC?
HISTORY
Medical history: Pertinent current or past medical conditions
Surgical history: Try to include the year of the surgery and surgeon if possible.
Family history: Include pertinent family history. Avoid documenting the medical history of every person in the patient's family.
Social History: An acronym that may be used here is HEADSS which stands for Home and Environment; Education, Employment, Eating; Activities; Drugs; Sexuality; and Suicide/Depression.
REVIEW OF SYSTEM
This is a system based list of questions that help uncover symptoms not otherwise mentioned by the patient.
General: Weight loss, decreased appetite
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Outline
• Introduction
• The Calgary-Cambridge consultation guide
• Gathering the information.
• Guides on starting physical examination
• Explanation, planning and closing the Session
3. The Medical Interview
• History taking
Asking questions to obtain information and aid diagnosis
• It is gathering data both objective and subjective for the purpose
of:
generating differential diagnosis
Evaluating progress following specific treatment
Evaluating change in the patients condition/impact of a specific disease
process.
• Its an art that one has to practice frequently
• It is estimated that 70-80% of diagnoses are based on history
taking alone.
(Kings College London 2013)
4. Calgary-Cambridge Consultation Guide
(Kurtz et al. 2005)
Closing the Session
Explanation and Planning
Physical Examination
Gathering Information
Initiating the Session
4
Providing
structure
Building
relationships
5. Initiating the Session
• Greet the patient
• Introduce yourself
• Get consent
• Ensure patient comfort and privacy
3 types of questions
OPEN
-Always start with an open ended
question
“How can I help you?”
CLOSED
-theses clarify and focus on the
concerns raised by the patient.
“Are you still vomiting?’
LEADING
-based on your assumptions that
leads the patient to the answer you
want to hear.
“You are not allergic to anything are
you?
6. Demographics
• Name
• Age
• Sex
• Address
• Ethnicity
• Occupation
• Religion
• Marital status.
• Date of Clerkship
7. Presenting Complaint
• The main reason why the patient is visiting the hospital.
• Use Open ended questions
• Complaints should be recorded in the patients own words
• Chronological order ( from oldest complaint, to the most recent ones)
8. History of presenting complaint
• Explore symptoms brought up in the presenting complaint, again in
chronological order, ask when the patient last felt well.
• Onset, Duration, Progress, periodicity, Aggravating factors, Relieving
Factors, Associated symptoms, severity.
• Exhaust all other symptoms of the system in question, highlighting
important positives and negatives.
• All risk factors of the possible diagnoses should be explored i.e.
Medical comorbidities, lifestyle factors.
• Previous Hospital admissions due to the same presenting ailments,
how it was treated.
9. Systemic Enquiry
• This is a guide not to miss anything
• Any significant finding should be moved to History of presenting
complaint.
10. General Cardiovascular GI Urinary Respiratory CNS MSK
•Weakness
•Fatigue
•Anorexia
•Change of
weight
•Fever/chills
•Lumps
•Night sweats
Chest pain
Paroxysmal
Nocturnal
Dyspnoea
Orthopnoea
Short Of
Breath(SOB)
Cough/sputum
(pinkish/frank
blood)
Swelling of
ankle(SOA)
Palpitations
Cyanosis
Appetite
(anorexia/weigh
t change)
Diet
Nausea/vomitin
g
Regurgitation/he
art
burn/flatulence
Difficulty in
swallowing
Abdominal
pain/distension
Change of bowel
habit
Haematemesis,
melaena,
haematochaezia
Jaundice
Frequency
Dysuria
Urgency/strangu
ry
Hesitancy
Terminal
dribbling
Nocturia
Back/loin pain
Incontinence
Character of
urine:color/
amount
(polyuria) &
timing
Fever
Cough(productiv
e/dry)
Sputum (colour,
amount, smell)
Haemoptysis
Chest pain
SOB/Dyspnoea
Tachypnoea
Hoarseness
Wheezing
Visual/Smell/Tas
te/Hearing/Spee
ch problem
Head ache
Fits/Faints/Black
outs/loss of
consciousness(L
OC)
Muscle
weakness/numb
ness/paralysis
Abnormal
sensation
Tremor
Change of
behaviour or
psyche.
Pariesis.
Pain – muscle,
bone, joint
Swelling
Weakness/move
ment
Deformities
Gait
11. Past Medical History
• Existing Medical conditions
• IHD/DM/Asthma/Hypertension/RHD, TB// Epilepsy :E.g. if diabetic- mention time
of diagnosis, current medication, clinic check up.
HIV Status.
• HIV: Viral load, CD4 count
• Previous hospitalizations
• Blood Transfusions
• Allergies
• Obstetric and Gynae history for female patients: Parity, LNMP
12. Drug History
• Any drugs or medication that the patient is currently on and their
doses.
• Use of alternative medicines i.e. Traditional /Herbal medicine &
alternative medicine.
• ART: what regimen the patient is on, if it has been ever changed,
reasons why it was changed.
13. Surgical history
• What type of operation.
• Indication
• Time and place
• Type of anaesthesia
• Complications
14. Family History
• Any familial diseases e.g. breast cancer, IHD, DM, schizophrenia,
Hypertension, asthma, albinism, haemoglobinopathies, Haemophilias
etc.
• Infections going around family as TB, Leprosy.
• Cholera, typhoid in case of epidemics.
15. Social History
• Smoking history - amount, duration & type. Calculate pack years
• Alcohol history - amount, duration & type.
• Travelling history
• Socioeconomic status
Home conditions as:
• Water supply.
• Type of house, number of inhabitants
• Sanitation status at home & surrounding.
• Animals / birds in his/her house.
16. Summarize History
• Name, Age,Sex, Presenting complaint, comorbidities. Important
positives and Important Negatives.
“This Mr X is a 27 year old male, RVD non reactive, presented with a 3
week history of a productive cough and a 1 week history of global
headaches. Only constitutional symptom he presented with is weight
loss. Patient was previously treated for pulmonary TB at age 5yrs and
has a 5 pack year history of smoking”
• Have a working diagnosis and well as differentials, that will help in
guiding your physical examination.
17. Physical Examination
• The third Calgary-Cambridge stage concerns physical
examination.
• Explanation of the procedure
• Consent sought
• Privacy and dignity maintained
• Chaperone (if required)
17
18. Explanation, planning and closing the Session
• Ensuring appropriate point of closure:
• Explain and give information to the patient about the status quo and
the way forward ( investigations, treatment modalities etc).
• Summarise consultation briefly (with the patient), clarifying plan of
care.
• Final check that the patient agrees and is comfortable with the plan,
and asks for any corrections, questions and other items to discuss.
18
19. References
• Clinical Examination: a systemic guide to physical diagnosis. Talley and
O’Connor
• Kings College London (2013) Introduction to History Taking. [On-line].
http://www.kcl.ac.uk/health/study/facilities/chantler/docs/PatientEd
ucation/HistoryTakingNOTES.doc [Accessed 15 June 2017].
• Kumar and Clark