This is my book review that came out on 24th Sunday 2017 in the EJOST(European Journal of Orthopaedic Surgery and Traumatology),which I have sent as an attachment.
K.Mohan Iyer(25/9/2017)
This is my book review that came out on 24th Sunday 2017 in the EJOST(European Journal of Orthopaedic Surgery and Traumatology),which I have sent as an attachment.
K.Mohan Iyer(25/9/2017)
Musculoskeletal Masqeuraders - Rolling the 'Clinical Dice'Steve Nawoor
I recently delivered this presentation on 'MSK Masqueraders' at the National Exhibition Center (NEC) in Birmingham for the 2015 Therapy Expo conference.
Basically this was a brief insight and overview of MSK Masqueraders and the impact on clinical practice. The context of each slide was expanded during the conference session and hopefully the presentation below gives you a flavour of the topics I covered. Be mindful that this presentation is a snippet of what I would usually cover so, is not a complete overview of the topic of Masqueraders, which is a challenging area of clinical practice.
Having knowledge of conditions that can masquerade as MSK pathology is a key aspect of the physiotherapist’s clinical development. More and more roles and opportunities are arising where we are responsible for first line assessment and care, which means we must have an ability to screen effectively, systematically and understand when the patient is presenting with symptoms that don't quite fit with an MSK presentation.
Index of suspicion, pattern recognition and understanding when and how to streamline you assessment to ascertain clarity on the next steps for a patient that you are concerned about can be challenging but is vital.
Twitter Handle: @stevenawoor
The Musculoskeletal System under the Unit HUMAN BODY
~now active with hyperlinks.
Please note that this presentation will be more appreciated if your computer is under Microsoft 2013. Kindly consider the compatibility for more convenient and pleasing slides.
An apt yet detailed description of Polyarthritis for undergraduate level with basic definitions, classification, concept, clinical features along with descriptive images, diagnosis & assessment with distinguishing features along with differential diagnosis.
Musculoskeletal Masqeuraders - Rolling the 'Clinical Dice'Steve Nawoor
I recently delivered this presentation on 'MSK Masqueraders' at the National Exhibition Center (NEC) in Birmingham for the 2015 Therapy Expo conference.
Basically this was a brief insight and overview of MSK Masqueraders and the impact on clinical practice. The context of each slide was expanded during the conference session and hopefully the presentation below gives you a flavour of the topics I covered. Be mindful that this presentation is a snippet of what I would usually cover so, is not a complete overview of the topic of Masqueraders, which is a challenging area of clinical practice.
Having knowledge of conditions that can masquerade as MSK pathology is a key aspect of the physiotherapist’s clinical development. More and more roles and opportunities are arising where we are responsible for first line assessment and care, which means we must have an ability to screen effectively, systematically and understand when the patient is presenting with symptoms that don't quite fit with an MSK presentation.
Index of suspicion, pattern recognition and understanding when and how to streamline you assessment to ascertain clarity on the next steps for a patient that you are concerned about can be challenging but is vital.
Twitter Handle: @stevenawoor
The Musculoskeletal System under the Unit HUMAN BODY
~now active with hyperlinks.
Please note that this presentation will be more appreciated if your computer is under Microsoft 2013. Kindly consider the compatibility for more convenient and pleasing slides.
An apt yet detailed description of Polyarthritis for undergraduate level with basic definitions, classification, concept, clinical features along with descriptive images, diagnosis & assessment with distinguishing features along with differential diagnosis.
Advancement in Scaffolds for Bone Tissue Engineering: A Reviewiosrjce
In last decade, Tissue Engineering has moved a way ahead and has proposed solutions by replacing
the permanently or severely damaged tissues of our body. The field has expanded to tissue regeneration of
cartilage, bone, blood vessels, skin, etc. The domain of tissue engineering is very wide and is the combination of
bioengineering, biology & biochemistry. This review is focus on recent research advancement in bone tissue
engineering. Bone grafting techniques are used to replace the severely damaged due to any accident, trauma or
any disease. These are either allograft, autologous or synthetic bone properties similar to bone. Bone Tissue
Engineering is part of a synthetic technique and overcome the limitations faced in other two mentioned
techniques. Bone Tissue engineering is rapidly developing field and has become important due to its remarkable
therapeutic properties. Mesenchymal stem cells are used as starting cells in tissue regeneration. These cells get
differentiated into bone cells and start multiplying to form bone. One inevitable requirement of these growing
human cells is a strong support which helps in the proper growth. This support is known as scaffold, in tissue
engineering. For proper regeneration of cells scaffold materials plays vital importance in the field of bone tissue engineering. This review attempts is illustrate the biology of natural bone, various desirable properties of scaffold, biomaterials used for fabrication of scaffold and various fabrication techniques with examples of bone regenerate.
Role of polycystin 1 in bone remodeling- orthodontic tooth movement study in ...EdwardHAngle
Objective: To test the hypothesis that polycystin-1 (PC1) is involved in orthodontic tooth movement as a mechanical sensor.
Materials and Methods: The response to force application was compared between three mutant and four wild-type 7-week-old mice. The mutant mice were PC1/Wnt1-cre, lacking PC1 in the craniofacial region. An orthodontic closed coil spring was bonded between the incisor and the left first molar, applying 20 g of force for 4 days. Micro–computed tomography, hematoxylin and eosin staining, and tartrate-resistent acid phosphatase (TRAP) staining were used to study the differences in tooth movement among the groups.
Results: In the wild-type mice the bonded molar moved mesially, and the periodontal ligament (PDL) was compressed in the compression side. The compression side showed a hyalinized zone, and osteoclasts were identified there using TRAP staining. In the mutant mice, the molar did not move, the incisor tipped palatally, and there was slight widening of the PDL in the tension area. Osteoclasts were not seen on the bone surface or on the compression side. Osteoclasts were only observed on the other side of the bone—in the bone marrow.
Conclusions: These results suggest a difference in tooth movement and osteoclast activity between PC1 mutant mice and wild-type mice in response to orthodontic force. The impaired tooth movement and the lack of osteoclasts on the bone surface in the mutant working side may be related to lack of signal from the PDL due to PC1 deficiency.
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Ossifying fibroma vs fibrous dysplasia of the jaw/rotary endodontic courses b...Indian dental academy
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay
Similar to Ap 50 11-12 1 orthopedic pathology (20)
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
5. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Fig. 28 A synovial joint, on section.
6. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Rigid endoskeleton
- Supports the body
- Protects viceral organ
- Provides attachments for muscles
Metabolism of calcium and other minerals
Contains hematopoietic marrow
Function of Bone
7. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Fig. 2.1 Embryonic development of a long bone during the first six months
22. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Bone
marrow
hematopoieti
c lineage
Bone marrow
stromal cell
lineage
BONEBONE
23. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Bone marrow
hematopoietic lineage
CFM-GM ( colony forming unit
granulocyte-macrophage )
monobl
ast promonocy
te
mon
ocyte
Tissue
macropha
ge
osteoclast
24. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Bone marrow
stromal cell
lineage
( mesenchymalstem cell )CFU-F(Colony forming
unit fibroblast)
Stromal
osteoblast
precursor cell
Transitory osteoblast
Secretory osteoblast
Osteoblast
( bone lining cell )
25. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
( Receptor activator for
nuclear factor Kappa B)
( Rank ligands )
Osteobl
ast-
osteocla
st
interacti
on
38. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Histology of Synovium
•Intimal layer: A thin layer
of synovial cells or
synoviocytes
•Subintimal layer:
arterioles, fat and other
connective tissue cells
such as fibroblasts,
42. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Congenital
anomalies
Developmental
abnormalities:
complex,
variable, genetic
based and
manifest during
43. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Developmenta
l anomalies1) Defect in nuclear proteins and
transcription factor ( dysostosis)
2) Mutations in the hormone and
signal transduction ( dysplasia )
3) Defect in extracellular
structural proteins
49. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
OSTEOGENESIS IMPERFECTA
A group of distinct clinical syndromes with
various modes of inheritance and having in
common an increased propensity to fracture.
51. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Osteogenesis
ImperfectaAbnormal secretion type I
collagen
Decreased synthesis type I
collagen Decreased
Deletion 1(I) gene
Matrix
59. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Direct inoculations following
compound fracture
Osteomyelitis : caused by
Hematogenous spreading
(staphylococcus aureus, Salmonella)
61. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
OsteomyelitisOsteomyelitis
Involu
crum:
New bone
formation i
n periosteu
m
Seques
trum:
Dead bone
70. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Figure 231. Tuberculous osteomyelitis.Figure 231. Tuberculous osteomyelitis.
A sagittal section of a portion of the
vertebral column. Two vertebrae are involved an
d have collapsed, causing kyphotic angulation w
ith compression of the spinal cord.
71. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Spinal tuberculosis (Pott’s disease)
Psoas abscess
Disc destruction
Vertebral collapse
Paraplegia
75. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Commonly affects the spine
Spreads usually from pulmonary
disease via blood stream
Tuberculosis
77. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
A
B
Figure 244. Congenital syphilis. A, There are
radiolucent defects adjacent to the zones of
provisional calcification and periosteal new
bone around the diaphysis. The defect in the
proximal tibia is symmetrical (Wimberger’s
sign). B, Reexamination of the forearm three
weeks later reveals evidence of healing of the
metaphyseal lesions.
80. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Simple fracture
Impacted fracture
Comminuted fracture
Stress fracture
Greenstick fracture
Trauma to normal bone
81. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Osteoporosis
Osteomalacia
Hyperparathyroidism
Paget’s disease
Osteogennesis imperfecta
Tumors
Pathological fracture
90. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Avascular
necrosis
•Synonym:
Aseptic
necrosisosteonecr
osis
91. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Cause of osteonecrosis
• Idiopathic
• Post fracture
• Fat embolism
• Legg-Calves Perthes
disease
• Steroid induce
• Alcohol
96. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Rheumatoid arthritis
• Self-perpetuating , inflammatory joint
disease
• Initially characterized by swelling in
several joints and stiffness
• Roentgenographically show a chronic
inflammatory destruction of the joint
• Laboratory findings: Rheumatoid
factor, ESR
98. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Terminology in Rheumatoid
arthritis
•Pannus:
inflammed
synovium
attaching on
articular cartilage
100. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
PATHOLOGY OF SYNOVIUM in
rheumatoid arthritis
101. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Proposed mechanism for
rheumatoid diseases
Robbins and Cotran ( 7th
.
Ed) p. 137
106. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Histologic typing
of bone tumorBone-forming
tumorsCartilage forming
tumorsGiant cell
tumorsBone
marrow tum
ors
107. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Bone forming tumors
•Benign : OSTEOMA
• Malignant:
OSTEOSARCOMA
108. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Cartilage-forming tumors
• Benign : OSTEOCHONDROMA,
ENCHONDROMA, CHONDROBLASTOMA,
CHONDROMYXOID FIBROMA
• Malignant : CHONDROSARCOMA
109. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Bone marrow-
forming tumors
• Ewing’s
sarcoma
148. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Metabolic bone diseases
- Matrix
- Mineralization
- Deposition of waste product
formation
resorption
149. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Matrix formation defect
- Osteogenesis imperfecta
- Paget’s disease
- Mucopolysaccharidosis
150. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Matrix resorption defect
Hyperparath
yroidism
Osteopetrosi
s
165. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Table 1. Comparison of two types of involutional osteoporosis.
From Riggs and Melton(1986)with permission.
Type IType I Type IIType II
Age (years) 51-75 > 70
Sex ratio (female : male) 6:1 2:1
Type of bone loss Mainly cancellous Cancellous and compact
Rate of bone loss Accelerated Not accelerated
Fracture site Vertebrae (crush) and Vertebrae (wedge)
distal radius and hip
Parathyroid function Decreased Increased
Calcium absorption Decreased Decreased
Metabolism of 25-OH-D to Secondary decrease Primary decrease
1.25(OH)2D
Main causes Factors related to Factors related to
menopause ageing
25-OH-D = 25-hydroxyvitamin D ; 1.25(OH)2D = dihydroxyvitamin D.
166. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
PATHOGENESIS OF OSTEOPOROSISPATHOGENESIS OF OSTEOPOROSIS
ModelModel
Figure 4. Conceptual model of the pathogenesis of fractures relate to osteoporosis.
Modified from Riggs (1988).
167. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital…..
Deposition of waste product
- Pseudo - gout
- Gout
- Oxalosis
- Ochronosis
5 phases:Phase 1= osteoclastic resorption; phase 2=mononuclear resorption; phase 3=preosteoblastic and differentiation into osteoblasts; phase 4=osteoblastic matrix formation; phase 5= mineralization; phase 6= end product of remodeling in cancellous bone
