This is my book review that came out on 24th Sunday 2017 in the EJOST(European Journal of Orthopaedic Surgery and Traumatology),which I have sent as an attachment.
K.Mohan Iyer(25/9/2017)
this presentation focus on a specific problem for patients with multiple hereditary exostosis who suffered from forearm deformity . It introduce a new technique to correct the deformity while preserving the epipyseal plate to maintain the growth of the bone.It avoids the complex surgery of distraction osteogenesis.
To investigate the geometric development of the
wrist in relation to the changes in its ossification pattern;
the study will help the treating surgeon to identify early deviations
from normal in children with musculoskeletal disorders
and provide a template for anatomic reduction after trauma
scenarios.
Background:
The anterolateral ligament (ALL) is a true well-defined ligament in the knee first described in 1879 by Segond. After the work of Claes et al., several studies were conducted about biomechanics and its role in stability of the knee. The anatomical existence of the ALL has been studied by and various radiographic diagnostic modalities and in cadavers. It originates from lateral femoral epicondyle and is inserted between Gerdy’s tubercle and the fibular head. There has been controversy about the existence of ALL in pediatric patients. The aim of this work was to confirm the presence of ALL in pediatric patients by using MRI.
Materials and Methods:
We reviewed the knee MRI scans of 100 pediatric patients (ages between one and 12 yr) who had no knee injury or congenital deformity and had been evaluated by an expert radiologist.
Results:
The ALL was detected in 90% of the pediatric patients with the use of MRI.
Conclusions:
The main finding of this study was that ALL can be seen in pediatric patients using MRI. Despite numerous studies, additional research is needed to further define the role of the ALL in knee function.
Level of Evidence:
Level IV.
this presentation focus on a specific problem for patients with multiple hereditary exostosis who suffered from forearm deformity . It introduce a new technique to correct the deformity while preserving the epipyseal plate to maintain the growth of the bone.It avoids the complex surgery of distraction osteogenesis.
To investigate the geometric development of the
wrist in relation to the changes in its ossification pattern;
the study will help the treating surgeon to identify early deviations
from normal in children with musculoskeletal disorders
and provide a template for anatomic reduction after trauma
scenarios.
Background:
The anterolateral ligament (ALL) is a true well-defined ligament in the knee first described in 1879 by Segond. After the work of Claes et al., several studies were conducted about biomechanics and its role in stability of the knee. The anatomical existence of the ALL has been studied by and various radiographic diagnostic modalities and in cadavers. It originates from lateral femoral epicondyle and is inserted between Gerdy’s tubercle and the fibular head. There has been controversy about the existence of ALL in pediatric patients. The aim of this work was to confirm the presence of ALL in pediatric patients by using MRI.
Materials and Methods:
We reviewed the knee MRI scans of 100 pediatric patients (ages between one and 12 yr) who had no knee injury or congenital deformity and had been evaluated by an expert radiologist.
Results:
The ALL was detected in 90% of the pediatric patients with the use of MRI.
Conclusions:
The main finding of this study was that ALL can be seen in pediatric patients using MRI. Despite numerous studies, additional research is needed to further define the role of the ALL in knee function.
Level of Evidence:
Level IV.
Open debridement and radiocapitellar replacement in primary and post-traumati...Alberto Mantovani
Background: Postmortem and clinical studies have shown an early and prevalent involvement of the radiohumeral
joint in primary and secondary arthritis of the elbow. The lateral resurfacing elbow (LRE) prosthesis
has recently been developed for the treatment of lateral elbow arthritis. However, few data have been
published on LRE results.
Materials and methods: A prospective multicenter study was designed to assess LRE preliminary results.
There were 20 patients (average age, 55 years). Preoperative diagnosis were primary osteoarthritis in 11
and post-traumatic osteoarthritis in 9. All patients underwent open debridement and LRE prosthesis.
Patients were evaluated preoperatively and postoperatively with the Mayo Elbow Performance Score
(MEPS), modified American Shoulder Elbow Surgeons (m-ASES) elbow assessment, and the Quick
Disabilities of the Arm, Shoulder and Hand (Quick-DASH). Mean follow-up was 22.6 months.
Results: At the last follow-up, the mean improvement of MEPS and m-ASES was 35 (P ¼ .001) and 34
(P ¼ .001) respectively; the average Quick DASH decreased by 29 (P ¼ .001). Average range of motion
was improved by 35 (P ¼.001). MEPI results were excellent in 12 patients, good in 2, and fair and poor in
3 each. Mild overstuffing was observed in 5 patients, and an implant malpositioning in 3. The implant
survival rate was 100%.
Conclusion: LRE showed promising results in this prospective investigation. Most patients had an
uneventful postoperative course and have shown a painless elbow joint, with satisfactory functional
recovery at short-term follow-up. Further studies with longer follow-up are warranted.
Leiomyoma is a benign tumor that originates from smooth
muscle cell. The most common sites are the uterus, gastrointestinal tract & skin. Leiomyoma is a relatively uncommon smooth muscle tumor rarely found in the head and neck. Enzinger and Weiss (1995), analyzed a total of 7748 leiomyomas, 95% of the tumors occurred in the female genitalia (uterus), 3% in the skin, 0.9% in the gastrointestinal tract and the remainder at various sites including skull base.
Abstract Background and introduction: Our work aimed to compare and evaluate CT arthrography
(CTA) and MR arthrography (MRA) techniques in diagnosing glenohumeral joint instabilities,
also help the clinician to choose the ideal diagnostic modalities CTA & MRA either separately or
combined to reach the early and accurate diagnosis of glenohumeral joint instability.
Patient and methods: The study included 96 patients: 72 males, 24 females. Their age ranged from
14 to 51 years (mean =33), complaining of shoulder dislocation whether traumatic or nontraumatic
with glenohumeral instability.
For every patient, intra-articular contrast injection was done followed by CT and MRI arthrography
(CTA & MRA).
Results: Preliminary results showed the role of CTA & MRA in diagnosing the causes of instability.
Correlation between CTA and MRA may have a role in more accurate diagnosis of glenohumeral
instability.
Conclusion: The combination of CT arthrography and MR arthrography is a promisable one in
defining the type of instability
ΣΥΝΔΕΣΜΟΠΛΑΣΤΙΚΗ ΠΡΟΣΘΙΟΥ ΧΙΑΣΤΟΥ ΣΥΝΔΕΣΜΟΥ ΜΕ ΜΟΝΗ ΔΕΣΜΗ ΣΕ ΑΝΑΤΟΜΙΚΗ ΘΕΣΗ. ...STAVROS ALEVROGIANNIS
(Παρουσίαση σε Διεθνές Συνέδριο Εταιρείας Αρθροσκόπησης & Χειρουργικής Γόνατος της Πολωνίας, POZNAN 2011).
FREE HAND NOVEL ANATOMIC SINGLE BAND TECHNIQUE FOR ACLR
(X/O BUTTON,CONMED,LINVATEC,USA).PRELIMINARY RESULTS.
(POZNAN 2011)
The role of radiation diagnostic methods in pathological changes of the hip j...SubmissionResearchpa
Endoprosthesis replacement-operational treatment of diseases and damages of hip joint. The problem of prevention of complications and their negative effects is extremely actual today. However the role of different beam techniques in identification of adverse effects and complications of endoprosthesis replacement of joints is studied insufficiently. Results of clinic and diagnostic and beam researches of 40 patients with pathology of hip joint are analyzed. The used beam methods of research - roentgenography, multispiral computed tomography. At presurgical stage the main objective was detection of pathology of joint, definition of indications and planning of operative measure. Situation and relationship of components of endoprosthesis, condition of bone tissue, and also bone cement round cup and leg of prosthesis were key parameters of radiological assessment of outcomes of endoprosthesis replacement. Complex use of radiological techniques (roentgenography and spiral computed tomography) allows to specify and add semiotics of changes of bone tissue at the level of acetabular hollow and proximal department of femur after endoprosthesis replacement. by Janibekov J. J 2020. The role of radiation diagnostic methods in pathological changes of the hip joint before and after endoprosthetics. International Journal on Integrated Education. 3, 11 (Dec. 2020), 203-205. DOI:https://doi.org/10.31149/ijie.v3i12.918. https://journals.researchparks.org/index.php/IJIE/article/view/918/866 https://journals.researchparks.org/index.php/IJIE/article/view/918
Open debridement and radiocapitellar replacement in primary and post-traumati...Alberto Mantovani
Background: Postmortem and clinical studies have shown an early and prevalent involvement of the radiohumeral
joint in primary and secondary arthritis of the elbow. The lateral resurfacing elbow (LRE) prosthesis
has recently been developed for the treatment of lateral elbow arthritis. However, few data have been
published on LRE results.
Materials and methods: A prospective multicenter study was designed to assess LRE preliminary results.
There were 20 patients (average age, 55 years). Preoperative diagnosis were primary osteoarthritis in 11
and post-traumatic osteoarthritis in 9. All patients underwent open debridement and LRE prosthesis.
Patients were evaluated preoperatively and postoperatively with the Mayo Elbow Performance Score
(MEPS), modified American Shoulder Elbow Surgeons (m-ASES) elbow assessment, and the Quick
Disabilities of the Arm, Shoulder and Hand (Quick-DASH). Mean follow-up was 22.6 months.
Results: At the last follow-up, the mean improvement of MEPS and m-ASES was 35 (P ¼ .001) and 34
(P ¼ .001) respectively; the average Quick DASH decreased by 29 (P ¼ .001). Average range of motion
was improved by 35 (P ¼.001). MEPI results were excellent in 12 patients, good in 2, and fair and poor in
3 each. Mild overstuffing was observed in 5 patients, and an implant malpositioning in 3. The implant
survival rate was 100%.
Conclusion: LRE showed promising results in this prospective investigation. Most patients had an
uneventful postoperative course and have shown a painless elbow joint, with satisfactory functional
recovery at short-term follow-up. Further studies with longer follow-up are warranted.
Leiomyoma is a benign tumor that originates from smooth
muscle cell. The most common sites are the uterus, gastrointestinal tract & skin. Leiomyoma is a relatively uncommon smooth muscle tumor rarely found in the head and neck. Enzinger and Weiss (1995), analyzed a total of 7748 leiomyomas, 95% of the tumors occurred in the female genitalia (uterus), 3% in the skin, 0.9% in the gastrointestinal tract and the remainder at various sites including skull base.
Abstract Background and introduction: Our work aimed to compare and evaluate CT arthrography
(CTA) and MR arthrography (MRA) techniques in diagnosing glenohumeral joint instabilities,
also help the clinician to choose the ideal diagnostic modalities CTA & MRA either separately or
combined to reach the early and accurate diagnosis of glenohumeral joint instability.
Patient and methods: The study included 96 patients: 72 males, 24 females. Their age ranged from
14 to 51 years (mean =33), complaining of shoulder dislocation whether traumatic or nontraumatic
with glenohumeral instability.
For every patient, intra-articular contrast injection was done followed by CT and MRI arthrography
(CTA & MRA).
Results: Preliminary results showed the role of CTA & MRA in diagnosing the causes of instability.
Correlation between CTA and MRA may have a role in more accurate diagnosis of glenohumeral
instability.
Conclusion: The combination of CT arthrography and MR arthrography is a promisable one in
defining the type of instability
ΣΥΝΔΕΣΜΟΠΛΑΣΤΙΚΗ ΠΡΟΣΘΙΟΥ ΧΙΑΣΤΟΥ ΣΥΝΔΕΣΜΟΥ ΜΕ ΜΟΝΗ ΔΕΣΜΗ ΣΕ ΑΝΑΤΟΜΙΚΗ ΘΕΣΗ. ...STAVROS ALEVROGIANNIS
(Παρουσίαση σε Διεθνές Συνέδριο Εταιρείας Αρθροσκόπησης & Χειρουργικής Γόνατος της Πολωνίας, POZNAN 2011).
FREE HAND NOVEL ANATOMIC SINGLE BAND TECHNIQUE FOR ACLR
(X/O BUTTON,CONMED,LINVATEC,USA).PRELIMINARY RESULTS.
(POZNAN 2011)
The role of radiation diagnostic methods in pathological changes of the hip j...SubmissionResearchpa
Endoprosthesis replacement-operational treatment of diseases and damages of hip joint. The problem of prevention of complications and their negative effects is extremely actual today. However the role of different beam techniques in identification of adverse effects and complications of endoprosthesis replacement of joints is studied insufficiently. Results of clinic and diagnostic and beam researches of 40 patients with pathology of hip joint are analyzed. The used beam methods of research - roentgenography, multispiral computed tomography. At presurgical stage the main objective was detection of pathology of joint, definition of indications and planning of operative measure. Situation and relationship of components of endoprosthesis, condition of bone tissue, and also bone cement round cup and leg of prosthesis were key parameters of radiological assessment of outcomes of endoprosthesis replacement. Complex use of radiological techniques (roentgenography and spiral computed tomography) allows to specify and add semiotics of changes of bone tissue at the level of acetabular hollow and proximal department of femur after endoprosthesis replacement. by Janibekov J. J 2020. The role of radiation diagnostic methods in pathological changes of the hip joint before and after endoprosthetics. International Journal on Integrated Education. 3, 11 (Dec. 2020), 203-205. DOI:https://doi.org/10.31149/ijie.v3i12.918. https://journals.researchparks.org/index.php/IJIE/article/view/918/866 https://journals.researchparks.org/index.php/IJIE/article/view/918
ACKNOWLEDGE PUBLICATION - IJSCR ACKNOWLEDGEMENT - Dr. RAHUL VC TIWARI, SIBAR INSTITUTE OF DENTAL SCIENCES, GUNTUR, ANDHRA PRADESH, INDIA. PUBLISHED LITERATURE
Dr. Ahmed M. Adawy
Professor Emeritus, Dept. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
The term “blow out” refers to partial herniation of the orbital contents through one of its walls. This usually occurs via blunt force trauma to the eye. Most often, the orbital floor is fractured in conjunction with the inferior orbital rim “impure” blowout fracture, but “pure” orbital floor fractures, with intact orbital rim can be seen. An extensive and careful history, physical examination, together with CT scans is vital for the diagnosis of orbital floor fractures. The timing of treatment, surgical approaches, and reconstruction of the orbital floor are presented.
Crimson Publishers-Management of Heterotopic Ossification of the Elbow in Pat...CrimsonPublishersOPROJ
Management of Heterotopic Ossification of the Elbow in Patients with Elbow and Brain Injury a Retrospective Study by V Psychoyios in Orthopedic Research Online Journal
Surgery is the best method for treatment of cancer. Dr. Martin Malawer uses the finest surgical methods to treat the sarcoma cancer in patients. He had got specialization in the field of limb sparing surgery.
The presentation discusses evidence based medicine in the stream of Orthopaedics. Here I have discussed a case of Ipsilateral Intertronchanteric and Femoral shaft Fracture and its various treatment modalities. The presentation was done at J.N. Medical College Belagavi, India. Lets share, discuss and keep learning.
Abstract
Objective: To assess the outcome of arthroscopic release in patients with cronicalchronic lateral epicondylitis. Materials and methods: Arthroscopic release in three patients with lateral epicondylitis was performed. The Mayo Elbow Performance Index (or Mayo Elbow Performance score) was used pre and post surgical treatment. Sample: Two females and one male. The patients were principal labourers and not athletes. Patients had significant pain and pain was the principal symptom that affected the score of the performance index.
Results: Scores on the performance index improved after surgery. No neurological complications were reported and early return to normal daily activities was noted.
Conclusion: Arthroscopic treatment was an alternative safe and effective method for treating chronic lateral epicondiyitis in three cases. This method makes it possible to simultaneously scan the articulation to diagnostic and treatment associated diseases. It is necessary most wide assays and comparative studies for establish sure treatment protocols.
A comparative study on the clinical and functional outcome of limb salvage su...NAAR Journal
The aim of this study was to analyze the survival, recurrence, complications as well as the quality of life (QOL) in tibial osteosarcoma (OSA) patients managed by limb salvage surgery (LSS), either by a prosthesis, resection or graft or by amputation. 106 tibial osteosarcoma patients were enrolled where 39 had custom-designed endoprosthetic arthroplasty (LSS1), 36 underwent resection and bone graft (LSS2) while only 31 underwent amputation. A Comparison was done based on post-operative survival rates, postoperative recurrence, and complications. The impact of the patient’s QOL was also evaluated.
A less-invasive-approach-of-medial-meniscectomy-in-rat-a-model-to-target-earl...science journals
The existing medial meniscectomy (MMx) procedure in rodents involves transection of MCL and wide opening of the knee capsule followed by meniscus transection.
1.The best way for the anterior approach to the hip on a standard operating table using a leg holder with a combined spinal anaesthetic and general anaesthetic, as written by John O’Donnell, Melbourne, Australia, in 2018.
2.The chapter on total hip replacement as a day case, which is an evolution in total hip replacement, has been written by authors from Frankfurt, Germany, mentioning their schedule in detail in 2018.
3.The principles of anterior approach for total hip arthroplasty have been discussed in detail by authors from Italy in 2018. Their technique involves choice of patients; superficial and deep dissection, exhibiting each step through excellent figures; and dedicated surgical instruments along with the use of intra-operative imaging.
4. Chapter from formerly Hip Preservation Fellow, Research Fellow at Warwick Medical School, UK now based in Sri Lanka discussing how the Direct Anterior approach to the Hip in 2018 can be done on the plain table with supporting explaining figures which is useful in countries in Asia like India without the use of special operating tables and dedicated surgical instruments for the same.
5.An additional chapter on DAA ,written by Dr Kirubakaran Pattabiraman, assistant professor, Department of Orthopedics, JIPMER, Puducherry, India, has been added in the book because his contribution is the most unique as it provides extensive details on DAA.
6.The main aim of this book is for the upcoming postgraduates in orthopedics anywhere in the world to be well versed in the direst anterior approach (DAA) to the hip joint.
K.MohanIyer[15/8/2023]
Piriformis Syndrome:
Table of contents
1.Introduction.
2.Epidemiology of Piriformis Syndrome.
3.Predisposing Factors.
4.Aetiology of Piriformis Syndrome.
5.Specific tests for the Piriformis Syndrome.
6.Pathophysiology
7.Differential Diagnosis
8.Imaging
9.Electro-diagnostic studies
10.Intrapelvic Causes of Sciatica in Piriformis Syndrome
11.Pyomyositis of the Piriformis Muscle
12.Bipartitite Piriformis giving rise to sciatic nerve entrapment
13.Hydrodissection of Piriformis Syndrome
14.Composite Anatomical Variations between the Sciatic
Nerve and the Piriformis Muscle
15.Epidemiology.Clinical Diagnosis of Piriformis Syndrome
16. Peroneal Neuropathy in Piriformis Syndrome
17. Physiotherapy for Piriformis syndrome
18.Treatment of Piriformis Syndrome
19.Complications with Prognosis.
The foreword has been given by Mr Dipen K Menon,MS(Orth), FRCS (Eng Et Glasg), MCh(Orth), FRCS(Tr Et Orth) Consultant Orthopaedic Surgeon, Kettering General Hospital,NHS Foundation Trust (Affiliated to University of Leicester), United Kingdom.
"Piriformis Syndrome" is currently planned to be published by 29.10.2023.
K.Mohan Iyer[1/8/2023]
Modified Posterior Approach to the Hip Joint.pdfnew.pdfKrishnamohan Iyer
Modified Posterior Approach to the Hip Joint[2nd edition]
Table of contents
This is more complex as the entire manuscript is based on my original research that I had done in 1981,which I have been following since then till today with my references.
Chapter no.1: Introduction Posterior Approach(PA) by
Ahmed Zaghloul, Assistant Lecturer,
Orthopaedic department, Faculty of
Medicine, Mansoura University, Egypt.
Chapter no.2: Additional version of PA by Kemal Şibar and
Alper Öztürk,Ankara,Turkey.
Chapter no.3: Direct Anterior Approach to the Hip by Prof.
John O'Donnell,Melbourne,Australia.
Chapter no.4:Principles of Direct Anterior Approach to the
Hip by Alessandro Geraci,Orthopaedic
Department, CaFoncello Hospital,Treviso, Italy
Chapter no.5:Anterior Minimally Invasive Surgery (AMIS) by
Hiran Amarasekera,Consultant Orthopaedic
Surgeon, Neville Fernando Teaching Hospital,
Malabe, Sri Lanka
Chapter no.6: DAA by Kirubakaran Pattabiraman,
Department of Orthopedics,JIPMER,
Puducherry,INDIA and Prof Thomas
Mullner,Austria.
Chapter no.7:DAA[Direct Anterior Approach to the Hip Joint]
by Calllum McBryde et al [Consultant Young
Adult Hip Surgeon, Department of Trauma &
Orthopaedics, Royal Orthopaedic Hospital NHS
Trust, Birmingham, UK]
Chapter no.8:Direct Anterior Approach for Total Hip
Arthroplasty by Rajesh Malhotra and Deepak
Gautam
"Modified Posterior Approach to the Hip Joint 2nd ed." is tentatively planned to be published by 24.09.2023.
K.Mohan Iyer[1/8/2023]
Revised final table of contents:
1.Introduction.
2.Epidemiology of Piriformis Syndrome.
3.Predisposing Factors.
4.Aetiology of Piriformis Syndrome.
5.Specific tests for the PS
6.Pathophysiology
7.Differential Diagnosis
8.Imaging
9.Electro-diagnostic studies
10.Intrapelvic Causes of Sciatica in Piriformis Syndrome
11.Pyomyositis of the Piriformis Muscle
12.Bipartitite Piriformis giving rise to
sciatic nerve entrapment
13.Hydrodissection of Piriformis Syndrome
14.Composite Anatomical Variations between the Sciatic
Nerve and the Piriformis Muscle
15.Epidemiology.Clinical Diagnosis of Piriformis Syndrome
16. Peroneal Neuropathy in Piriformis Syndrome
17. Physiotherapy for Piriformis syndrome
18.Treatment of Piriformis Syndrome
19.Complications with Prognosis.
20. References
21.References for further reading[9 chapters]
K.Mohan Iyer[6/7/2023]
Modified Posterior Approach to the Hip Joint,2nd Edition,
The Surgery for the Hip Joint has evolved considerably in different parts of the world.This evolution dates back to as early as 1883 and is still occuring in many parts of the world.Dr,K.Mohan Iyer started with his research in 1981 and is seen in many textbooks of repute.It has reached a new dimension to include
1. Posterior Approach to Hip Joint.
2. Southern Posterior Approach of the Hip
3. Direct Anterior Approach to the Hip Joint
4. Principles of the Anterior Approach for Total Hip
Arthroplasty
5. Anterior Minimally Invasive Surgery
6. The Direct Anterior Approach
7. Direct Anterior Approach to the Hip Joint
8. Direct Anterior Approach for Total Hip Arthroplasty.
The best part of his research is its feasibility in third world countries when it can be done in an indegenious way as shown in detail in chapter 8 of this book.
This book is being published by Springer Nature[Switzerland] and should be released in 2023.
K.Mohan Iyer[10/6/2023]
My ebook titled Posterior Approaches to the Hip Joint should be available by ...Krishnamohan Iyer
Citations in textbooks of repute
Original Research work done: A New Posterior Approach to the Hip Joint – K. Mohan Iyer, Injury, 13, 76-80, 1981.
1 Campbell’s Textbook of Operative Orthopaedics,12th Edition,by S.Terry Canale and James H.Beaty,Page No.331.
2. The Year Book of Orthopaedics 1982-Mark B.Coventry, Pages:371-373.
3.The Hip: ISBN 10:0812113020/ISBN 13:9780812113020
My original work has been quoted on page no.90.
4. Surgery of the Hip, Elsevier, Mosby/Saunders, Volume 2, by Daniel J.Berry and Jay R.Lieberman, Page No.269.
5. The Adult Hip by John J Callaghan MD, Aaron G Rosenberg MD, Harry E Rubash. Volume 1, Callaghan, Rosenberg and Rubash, ISBN:078175092X, Pages:700-701,718.
6. Surgery of the Hip Edited by Raymond G. Tronzo; Ref.no.187:(Page no.333):Fractures of the Hip in Adults: My original research on the Hip Joint has been quoted.
7. Minially Invasive Total Joint Arthroplasty by William J Hozak,Martin Kirsmer,Michael Hogler,Peter M Bonutti,Franz Rachbauer,Jonathan L Scaffer,William J Donnelly(Editors).
My original work(1981) is also referred to in this book Total
Hip Arthroplasty Arch Orthop Trauma Surg 102:225-229 at reference no.24[pages 115 -229]
This is my next book after which I will be publishing my book “Hip Joint in Adults: Advances and Developments” following my book THE HIP JOINT.by PanStanford,Singapore.(17/7/2017)
Detailed programme of the Global Ortho Congress at Philadelphia,USA where my presentation is on 8/11/2016 at 3.15 to 3.35 pm as seen in this attachment.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
1. 1 23
European Journal of Orthopaedic
Surgery & Traumatology
ISSN 1633-8065
Volume 27
Number 7
Eur J Orthop Surg Traumatol (2017)
27:1027-1028
DOI 10.1007/s00590-017-1923-y
K. Mohan Iyer (Ed.): The Hip Joint
Pierre Kehr
2. 1 23
Your article is protected by copyright and
all rights are held exclusively by Springer-
Verlag France. This e-offprint is for personal
use only and shall not be self-archived
in electronic repositories. If you wish to
self-archive your article, please use the
accepted manuscript version for posting on
your own website. You may further deposit
the accepted manuscript version in any
repository, provided it is only made publicly
available 12 months after official publication
or later and provided acknowledgement is
given to the original source of publication
and a link is inserted to the published article
on Springer's website. The link must be
accompanied by the following text: "The final
publication is available at link.springer.com”.
3. BOOK ANALYZES
K. Mohan Iyer (Ed.): The Hip Joint
Pan Stanford Publishing Pte. Ltd., CRC Press, 510 Pages, 15 Color & 188 B/W
illustrations, £ 159.00, ISBN 978-981-4745-14-7 (Hardcover), ISBN 978-981-4745-15-4
(eBook)
Pierre Kehr1
Received: 15 January 2017 / Accepted: 27 January 2017 / Published online: 7 February 2017
Ó Springer-Verlag France 2017
This monumental volume, of which K. Mohan lyer is the
editor, was written by several authors. It contains more
than 500 pages and provides comprehensive cover of the
hip joint in 15 broad chapters. After a rather brief embry-
ological and anatomical description, the author studies the
biomechanics defining the forces applied to the femoral
head in particular. Each chapter ends with a rich reference
list.
The clinical examination is written by K. Mohan Iyer
himself. While medical imaging is gaining increasing
importance both among surgeons and patients, it is essen-
tial as the author does to recall the clinical features which
begin from the exterior aspect and gait examination. The
neurological examination as well as specific testing is then
detailed.
Imaging begins with standard X-ray studies with its
classical landmarks and then MRI with beautiful images in
order to identify in detail anatomical elements and muscles.
Anatomical structures may even be observed with
ultrasonography.
The following chapters will allow for the study of dif-
ferent hip pathologies, beginning with child and adolescent
conditions, from septic arthritis in the infant, to dysplasia
and congenital dislocation, irritable hip (i.e. transient syn-
ovitis) and coxa vara, as well as excessive anteversion,
epiphysiolysis and osteochondritis (i.e. Legg–Calve´–
Perthes disease). Each condition is studied thoroughly with
its clinical diagnosis, epidemiology, pathogenesis, diag-
nosis and classifications, including the recommended
treatments and complications. An inclusive and extensive
reference list can be found at the end of this broad chapter.
Chapter 6 is about hip traumas. Fractures of the femoral
head in children and adults as well as hip dislocations and
periprosthetic fractures are dealt with in succession. Each
sub-chapter is comprehensively covered with its classifi-
cations and surgical treatments. Illustrations and drawings
are of high quality.
Chapter 7 deals with non-traumatic hip conditions in
adults. The study begins with a thorough coverage of
osteoarthritis of the hip (including diagnostic and radio-
logical examinations, treatments, surgical approaches,
arthroplasties as well as complications); the next sections
are on rheumatoid arthritis, hip tuberculosis, metabolic and
nutritional disorders of the hip; haemophilia, Paget’s dis-
ease, meralgia, types of bursitis (great trochanter, psoas,
snapping hip) and aseptic necrosis of the femoral head are
also described.
Chapter 8 is devoted to hip arthroplasty providing at the
very beginning a wide historical background (from
Charnley and the cobalt-chrome alloy, to the brothers
Judget and acrylic cement, as well as Moore and Thomp-
son). Then indications are detailed based on clinical and
imaging findings. The different types of total hip prostheses
are described, including anterior and posterior approaches,
minimally invasive surgery, complications, advantages and
drawbacks of the various approaches. Hip prostheses
reoperations are presented in detail, in particular compli-
cations in ceramic-on-ceramic implants, loss of bone stock,
as well as the different surgical approaches, including
removal of cemented and uncemented femoral implants, of
acetabular components, femoral reconstruction in case of
cemented prosthesis, bone grafting, results and complica-
tions. The option of a one-step or two-step surgical pro-
cedure is also presented. A clinical case is described
& Pierre Kehr
pierre.kehr@gmail.com
1
Strasbourg, France
123
Eur J Orthop Surg Traumatol (2017) 27:1027–1028
DOI 10.1007/s00590-017-1923-y
Author's personal copy
4. thoroughly in order to demonstrate the procedure, and
numerous colour pre- and post-operative pictures are pre-
sent. Chapter 8 ends with a gigantic list of bibliographical
references over the last thirty years.
Girdlestone resection arthroplasty of the hip, sometimes
the only option in reoperations, is the focus of chapter 9,
while chapter 10 deals with osteotomies around the hip.
They are classified according to their indications, location,
the main area of pain and the neurological conditions. The
authors provide full description of osteotomies, among
which Salter osteotomy, Pemberton osteotomy, innominate
Steel osteotomy, periacetabular (Ganz) osteotomy, Staheli
osteotomy, Chiari osteotomy, Schanz osteotomy, Lorenz
osteotomy, varus- and valgus-production osteotomy,
osteotomy for Blount’s disease, Sarmiento valgus osteot-
omy, McMurray’s osteotomy, Sugioka’s osteotomy are
also described.
Chapter 11 describes surface replacement techniques.
Chapter 12 covers minimally invasive hip arthroplasty
with an overview of patient-specific instrumentation,
potential advantages for the patient and selection of
patients eligible for these treatments; surgical approaches
are superbly illustrated with preoperative colour pho-
tographs. Extensive reference sections spanning between
the years 2001 and 2004 are included at the end of the
chapter.
Navigation is the focus of the short chapter 13. Methods
for navigation are described with their indications in total
arthroplasty or in surface replacement, as well as their
limitations.
Chapter 14 deals with tumours around the hip, presented
as follows: osteogenic tumours (such as bone islands,
osteoid osteoma, conventional osteosarcoma, periosteal
osteosarcoma and secondary or telangiectatic), comprising
Ewing sarcoma, cartilaginous tumours (osteochondroma
and chondrosarcoma), giant-cell tumours, fibrogenic
tumours, aneurysmal cyst, also focusing on Jaffe-Lichten-
stein fibrous dysplasia, angiosarcoma, hemangioma, mye-
loma, lymphoma, metastases and brown tumours. Paget’s
disease, alveolar soft part sarcomas and chordoma are also
reviewed. All these paragraphs are enriched with demon-
strative radiographs.
The book ends with chapter 15 illustrating hip arthro-
scopy, its description and indications, and a number of
examples are also given.
In conclusion, this book is truly a bible of the current
medical and surgical state of knowledge regarding hip
joint. It should be on the shelves of every specialist in the
field: orthopaedic surgeons, trauma surgeons, rheumatolo-
gists, may they be senior or in training, or at least it should
be accessible electronically.
In the electronic version examined, we regret the
absence of an index which would enable prompt access
according to keywords.
Compliance with ethical standards
Conflict of interest None.
1028 Eur J Orthop Surg Traumatol (2017) 27:1027–1028
123
Author's personal copy