Antisocial personality disorder is characterized by gross and guiltless disregard for others' rights from age 15 into adulthood. People with ASPD tend to behave in deceitful, impulsive, irresponsible, reckless, irritable, and remorseless ways that cause discomfort to others or violate social norms and laws. Risk factors include childhood conduct disorder, family history of personality disorders, and childhood abuse or neglect. Treatment may include family or group psychotherapy to change destructive patterns and teach new skills, as well as cognitive and behavior therapies.

1. ANTISOCIAL PERSONALITY
DISORDER
By
ARINDAM SAIN(CSIR-JRF), M.Sc. (Human
Physiology)
PHYSIOLOGY NEWS

2. Antisocial personality disorder
 Antisocial personality disorder is a mental condition in which a
person consistently shows no regard for right and wrong and
ignores the rights and feelings of others
 People with antisocial personality disorder tend to antagonize,
manipulate or treat others harshly or with callous indifference
 They show no guilt or remorse for their behaviour
 Individuals with antisocial personality disorder often violate the law,
becoming criminals
 They may lie, behave violently or impulsively, and have problems
with drug and alcohol use
PHYSIOLOGY NEWS

3. PHYSIOLOGY NEWS
Antisocial personality disorder (ASPD) is characterized by gross and
guiltless disregard for and violation of others’ rights, present since age
15 and persisting in adulthood. Diagnostic and Statistical Manual of
Mental Disorders (5th ed.; DSM-5; American Psychiatric Association
2013) criteria include:
 Nonconformity to social norms, unlawful behaviour.
 Deceitful, impulsive, irresponsible, and reckless behaviour.
 Irritability and aggressiveness, with no remorse.

4. Symptoms:
People with antisocial personality disorder tend to have
few symptoms. Rather, they cause discomfort or distress
to others through socially unacceptable behaviour and
by being:
 Deceitful
 Impulsive
 Aggressive or irritable
 Reckless
 Irresponsible
 Remorseless
PHYSIOLOGY NEWS

5. PHYSIOLOGY NEWS
RISK FACTORS:
Certain factors seem to increase the risk of developing antisocial
personality disorder, such as:
a) Diagnosis of childhood conduct disorder
b) Family history of antisocial personality disorder or other
personality disorders or mental illness
c) Being subjected to abuse or neglect during childhood
d) Unstable, violent or chaotic family life during childhood

6. PHYSIOLOGY NEWS
1. The pathophysiology of ASPD remains unclear
2. Reduced grey matter volume in the frontal cortex is seen in most
cases
3. About 50% of the total liability to developing ASPD has been
attributed to genetic factors
4. Single-nucleotide polymorphisms at 6p21.2 and at 6p21.32 at the
human leukocyte antigen (HLA) region is related to ASPD
5. In humans, LINC00951 and LRFN2 are both expressed in the
frontal cortex
6. Both of these genes are associated with the reduced grey matter
volume in ASPD

7. GWAS study identified genetic
abnormality (SNPs) in ASPD
PHYSIOLOGY NEWSM-R Rautiainen et al.

8. Antisocial populations differ on bio-cognitive dimensions
PHYSIOLOGY NEWSI.A. Brazil et al.

9. TREATMENT:
 In younger people, family or group psychotherapy may help to
change destructive patterns of behaviour, teach new vocational and
relationship skills, and reinforce a person's social support
 Psychotherapy also may help a person with this disorder learn to be
more sensitive to the feelings of others and encourage new, socially
acceptable and productive ways of thinking about one's goals and
aims
 Cognitive therapy attempts to change sociopathic ways of thinking
 Behaviour therapy uses reward and punishment to promote good
behaviour

10. THANK YOU