Anticholinergic drugs act as competitive antagonists at muscarinic receptors. They block the effects of the neurotransmitter acetylcholine (Ach) and thus reduce parasympathetic nervous system activity. Key points:
- Atropine and scopolamine are examples of naturally occurring anticholinergic drugs. Synthetic muscarinic antagonists include benztropine, hyoscyamine, and oxybutynin.
- They have therapeutic effects in the eyes (mydriasis, cycloplegia), gastrointestinal tract (reducing motility), respiratory tract (reducing secretions), and central nervous system (treating extrapyramidal side effects).
- Potential adverse effects include dry