This document discusses mechanisms of anticancer drug resistance and approaches to overcome resistance. It covers several key points: 1. Cancer cells can develop resistance to chemotherapy drugs through various mechanisms like drug inactivation, target alteration, drug efflux, DNA damage repair, heterogeneity, and inhibiting cell death. 2. Nanomedicine is a promising therapeutic approach to overcome resistance by improving drug distribution, efficacy and reducing side effects. Nanoparticles can be activated by light to heat and kill cancer cells. 3. Various types of nanoparticles are being studied for cancer treatment including lipid-based, polymer-based, dendrimers, carbon-based, and metallic/magnetic nanoparticles. Understanding resistance mechanisms and safety/efficacy