Advances in biochemistry and molecular biology have helped to understand the genetic basis of inherited diseases.
Gene therapy was once considered a fantasy (imaginary).
It was a dream of the researchers to replace the defective genes with good ones and cure the genetic disorders.
Advances in biochemistry and molecular biology have helped to understand the genetic basis of inherited diseases.
Gene therapy was once considered a fantasy (imaginary).
It was a dream of the researchers to replace the defective genes with good ones and cure the genetic disorders.
This is grand rounds presentation about the role of MIC-A antibodies in renal transplantation. I gave this presentation back in 2008, during the second year of my fellowship at the University of Pittsburgh Medical Center.
Melatonin is produced by the pineal gland from the essential amino acid L-tryptophan and declines significantly when a person reaches age 40. Melatonin also controls the circadian rhythm as well as deep stages of sleep. Learn more about this powerful sleep hormone and its benefits.
Antibody mediated rejection of solid organ allograftstashagarwal
Objectives:
Introduction of Antibody mediated rejection AMR
Role of C4d in transplant rejection
Donor specific antibodies DSA
Presentation of AMR in kidney, liver, lung and heart.
Transplantation basics explained with history . For details look at the subtext for every slide. Immune suppression drugs. Body reaction to grafts are all explained
Diploma nursing Extension student International institute of health science jinja,Uganda presenting the Antineoplastic drugs, the main objectives is
1.definition.
2.classes of Antineoplastic drugs.
3.Different types of drugs in each class.
4Different forms,dosage,indication,Adverse effects of some common Antineoplastic.
Nursing interventions in Antineoplastic drugs.
Immunotherapeutic drugs can be broadly classified into four types: checkpoint inhibitors, cytokines, monoclonal antibodies, and vaccines. However, immunotherapeutic drugs still have some problems, such as off-target side effects and poor pharmacokinetics.
Monoclonal Antibodies and it's applications.pptxAfroj Shaikh
SlideShare Description: Monoclonal Antibodies and Their Applications
In the rapidly advancing field of biotechnology, monoclonal antibodies have emerged as powerful tools with diverse applications. This SlideShare presentation provides a comprehensive overview of monoclonal antibodies and their wide-ranging uses in various fields, including medicine, research, and diagnostics.
The presentation begins by explaining the fundamental concept of monoclonal antibodies, highlighting their unique structure and production process. It delves into the significance of hybridoma technology, which allows for the generation of large quantities of identical antibodies derived from a single parental cell line.
Moving on, the SlideShare explores the applications of monoclonal antibodies in the field of medicine. It elucidates how these antibodies are employed in targeted therapies, such as cancer immunotherapy. The presentation highlights the remarkable specificity of monoclonal antibodies in recognizing and binding to specific targets, thereby enabling precise and tailored treatment approaches. It also discusses the role of monoclonal antibodies in autoimmune diseases, infectious diseases, and organ transplantation.
Furthermore, the presentation sheds light on the use of monoclonal antibodies in research and diagnostics. It explains how these antibodies are utilized as indispensable tools in laboratory research, facilitating the identification and characterization of various biomarkers and molecules. It also showcases their utility in techniques such as enzyme-linked immunosorbent assays (ELISA), flow cytometry, and immunohistochemistry.
The SlideShare emphasizes the impact of monoclonal antibodies on the development of novel therapeutic modalities, including antibody-drug conjugates and bispecific antibodies. It touches upon the challenges and future prospects in the field, highlighting ongoing research efforts and advancements in antibody engineering.
With visually appealing slides, concise and informative content, this SlideShare presentation on monoclonal antibodies provides a valuable resource for scientists, healthcare professionals, students, and anyone interested in understanding the significance and applications of these remarkable biotechnological innovations.
This slideshare conatins detailed overview of immunotheraphy,humanisation of antibodies and its clinical application
this is the topic from cellular and molecular pharmacology of m pharmacy first year
immunotheraphy is further classified to its various types which has been discussed individually
its also conatins various immunotheraphy drugs which has other clinical advantages
this slide contain information about antibody mediated anti-cancer therapy like antibody drug conjugates (ADC), Bispecific monoclonal antibody, Immuno-checkpoint therapy, biomarkers, mechanism of action of all 3 therapies, approved drugs of each category
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Ocular injury ppt Upendra pal optometrist upums saifai etawah
Monoclonal Antibodies As Therapeutic Agents In Oncology And
1.
2. Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy Misbahul_ferdous@yahoo.com
3. PRESENATATION BY DR MISBAHUL FERDOUS MBBS - 2007 FMD (USTC) 2009 PGT (CARDIOLOGY) 2008 NICVD NATINAL INSTITUTE OF CARDIOVASCULAR DISEASES AND HOSPITAL. DHAKA .BANGLADESH MD,CARDIOLOGY (COURSE) SHANDONG UNIVERSITY School of medicine CHINA
9. What is a monoclonal antibody A monoclonal antibody is a laboratory-produced molecule that's carefully engineered to attach to specific defects in your cancer cells. Monoclonal antibodies are proteins produced in the laboratory from a single clone of a B cell, the type of cells of the immune system that make antibodies
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12. How do monoclonal antibody drugs work? 1.Make the cancer cell more visible to the immune system: The immune system attacks foreign invaders in your body, but it doesn't always recognize cancer cells as enemies. A monoclonal antibody can be directed to attach to certain parts of a cancer cell. In this way, the antibody marks the cancer cell and makes it easier for the immune system to find. 2. Block growth signals
13. 3.Deliver radiation to cancer cells: By combining a radioactive particle with a monoclonal antibody, doctors can deliver radiation directly to the cancer cells.
14. Side effects of monoclonal antibody In general, the more common side effects caused by monoclonal antibody drugs include: Allergic reactions, such as hives or itching Flu-like symptoms, including chills, fatigue, fever, and muscle aches and pains Nausea Diarrhea Skin rashes
15. Rare, but more serious side effects of monoclonal antibody therapy may include: Infusion reactions. Severe allergy-like reactions can occur and in very few cases lead to death. Dangerously low blood cell counts. Low levels of red blood cells, white blood cells and platelets may lead to serious complications. Skin problems Bleeding. Some of the monoclonal antibody drugs are designed to stop cancer from forming new blood vessels. There have been reports that these medications can cause bleeding.
16. Gene therapy GENE THERAPY is a field of medicine in which genes are introduced into the body to cure diseases. It invovelves : Detection of gene 2) Determination & its role 3) Isolation & cloning 4) Introducing the gene by proper way. it is of two types : (a) germline gene therapy [done in germcells] (b) somatic gene therapy [done in somatic cells]
17. humanized monoclonal antibody A type of antibody made in the laboratory by combining a human antibody with a small part of a mouse or rat monoclonal antibody. The mouse or rat part of the antibody binds to the target antigen, and the human part makes it less likely to be destroyed by the body's immune system.
26. Men710,040 Women662,870 2005 Estimated US Cancer Cases 32% Breast 12% Lung / bronchus 11% Colon / rectum 6% Uterine corpus 4% Non-Hodgkin’s 4% Melanoma of skin 3% Ovary 3% Thyroid 2% Urinary bladder 2% Pancreas 21% All Other Sites Prostate 33% Lung / bronchus 13% Colon / rectum 10% Urinary / bladder 7% Melanoma of skin 5% Non-Hodgkin’s 4% Kidney 3% Leukemia 3% Oral Cavity 3% Pancreas 2% All Other Sites 17% *Excludes basal and squamous cell skin cancers and in situ carcinomas except urinary bladder. Source: American Cancer Society, 2005.
27. Spontaneous UV and ionizing radiation Chemical carcinogens Tumour induction Genetic abnormalities (XP) Virus-induced (HepC, EBV, HPV) Immunosuppression Causative agents
28. History of monoclonal antibody The discovery of monoclonal antibodies (mAbs) in 1975 by Kohler and Milstein ushered in cancer treatment to a modern era of targeted therapy . Therapeutic antibodies have become a major strategy in cancer therapy due to their ability to specifically bind to primary and metastatic cancer cells with high affinity
29. The approval of nine mAbs by the FDA for clinical tumor therapy signifies important progress in antibody study. They include rituximab (Rituxan®), ibritumomab (Zevalin®), 131I-tositumomab (Bexxar®), gemtuzumabozogamicin(Mylotarg alemtuzumab (Campath®), trastuzumab (Herceptin®) bevacizumab (Avastin®), cetuximab (Erbitux®) panitumumab (Vectibix®).
30. These 9 mAbs can be dividedinto two groups according to their targets The first group is directed against antigens that are either specifically expressed by tumor cells, such as the HER-2/neu protein on breast cancer and other carcinomas, or are shared with normal cells, such as differential antigens (CD20, CD52,CD19, etc.). The aim of using this type of antibodies is to induce tumor death by neutralizing the effect of a growth factor, or by inducing apoptosis, or by activating effector mechanisms of the host.
31. The second group of therapeutic mAbs targets the stroma-tumor interactions. A leading example of this group is, an mAb that neutralizes vascular endothelial growth factor (VEGF), VGEF is a tumor-derived growth factor that increases neo-angiogenesis and thus supports tumor growth. mABs Neutralize the VEGF and finally blocks angiogenesis and leads to tumor starvation
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33. Since 1997 there have been nine commercially available therapeutic mAbs approved by the FDA among which five are being used for treatment of hematologic malignancies the other four for solid tumors
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35. Rituximab (Rituxan®) the commercially most successful anti-cancer drug of all mABs Rituximab, which targets the CD20 surface receptor, that is strongly over expressed in most B-cell lymphomas, This Rituximab is a chimeric, monoclonal IgG1 antibody that induces apoptosis, antibody-dependent cell cytotoxicity and complement-dependent cytotoxicity.
37. Rituximab has recently been approved to be administered as either a 4- or 8-dose weekly regimen in patients who have previously responded to rituximab, and in patients who have bulky tumors (>10 cm). The overall response rate (ORR) was 50%, with 6% complete response (CR) and 44% partial response (PR) rates
38. Chop followed by rituximab the combination of six cycles of chemotherapy consisting of CHOP (cyclophosphamide, adriamycin, oncovin and prednisone) with concurrently administered rituximab in 40 patients with predominantly untreated follicular lymphoma greatly increased the response rate. 55% CR 40% PR
39. Side effect of the rituximab The main toxicities associated with rituximab included infusion-related chills, fever, nausea, vomiting and general fatigue. Bone marrow suppression was not a significant side effect in patients treated with rituximab
40. The combination of anti-angiogenesis mAbs and chemotherapy resulting in synergistic anti-tumor efficacy Three distinct mechanisms may help to explain the chemosensitizing activity of anti-angiogenicmAbs: 1.Normalizing tumor vasculature 2. preventing rapid increase in tumor cell population 3. augmenting the antivascular effects of chemotherapy.
41. Antibody gene therapy as a new strategy for cancer treatment Although nine mAbs have been approved by the FDA,wider application of mAbs is limited due to the following reasons: (1) high dose and purity required for antibody protein treatment increase the production cost (2) the relatively large molecular weight of full-length antibody and high pressure within the tumor make it difficult for full-length antibody to penetrate into large-volume solid tumors, thus greatly reducing the therapeutic effect
42. Why mABs can not penetrate the solid tumours the large molecule full-length antibody has great difficulty entering solid tumors, due to : 1.compacted stroma within the tumors 2. high intra-tumor pressure produced by lymphatic return barrier. Therefore, the anti-tumor efficacy of conventional antibody therapy is greatly reduced in treating large-volume solid tumors
43. Why adenovirus approved for gene therapy we chose adenovirus as the antibody gene transfer vector for the following reasons (1) adenovirus has been used in more than 5000 clinical patients without significant adverse effects and toxicity, exhibiting the conclusive safety and efficacy as an in vivo vector (2) adenoviral manufacture technologies are easy, convenient and simple (3) adenovirus is the only commercial product approved in the world for gene therapy
44. 4. this adenovirus-mediated antibody expressing system could be a new approach for antibody therapy 5. the complicated, expensive and time-consuming antibody protein preparation and purification procedures could be replaced by using adenovirus as an antibody expression tool for its technical simplicity and low cost
45. Strategy for improving antibody’s anti-tumor effect by exploiting mesenchymal stem cells mesenchymal stem cells (MSCs) can recognize the emitting signal from tumors and help to construct matrix or junction tissues for tumor growth, it would be an interesting attempt to use MSCs as a vehicle to deliver full-length antibody to tumors. In our study, the bone marrow derived primary mesenchymal stem cells (mBMSCs) were used as a vehicle to target tumor cells (our unpublished data)
46. using MSCs carrying a full-length antibody gene, could overcome the disadvantages of low antibody penetration into solid tumors, markedly enhancing the anti-tumor efficacy and hence it has the potential to be developed into a safe, efficient, low cost and targeting therapeutic system.
47. Antibody gene therapy is less time consuming and more economical compared with traditional antibody protein therapy, its potential drawbacks are as follows: (1) antibodies from gene therapy are presumably produced in liver and lung cells that are efficiently infected by the viral vector. It is unknown whether some other somatic cells will also express the antibodies (2) host antibodies against Adenovirus may decrease the anti-tumor efficacy of virus-mediated full-length antibody gene therapy
48. (3) when this approach is applied to humans, the administration routes, the desired antibody gene expression time and possible inflammation response need to be investigated. There is still a long way to go before antibody gene therapy could be put into clinical use.