Chapter -13, Anti-neoplastic drugs (one page notes).pptx
•Download as PPTX, PDF•
1 like•45 views
Content regarding antineoplastic drugs as per PCI syllabus for D.Pharm students.
Report
Share
Report
Share
Recommended
Chemotherapy of cancer
Chemotherapy of cancer -it consists of cell-cycle and classification of anticancer drugs,mechanism of anticancer drugs,radiation of anticancer drugs.
RECENT ADVANCES IN CANCER TREATMENT.pptx
Introduction, Types, Causes,
Symptoms of cancer
Anti-cancer drug &
Recent advances in cancer treatment included Newer drug carrier systems, Nanotechnology, Carbon nanotubes, Cancer Vaccine, Antigen Vaccines, Dendritic Cell Vaccines, DNA Vaccines.
AntineoplasticAgentsby KEMISA. HASSEN ZAINABU
Diploma nursing Extension student International institute of health science jinja,Uganda presenting the Antineoplastic drugs, the main objectives is
1.definition.
2.classes of Antineoplastic drugs.
3.Different types of drugs in each class.
4Different forms,dosage,indication,Adverse effects of some common Antineoplastic.
Nursing interventions in Antineoplastic drugs.
Anticancer drugs
This document discusses chemotherapy and neoplastic drugs. It begins by defining neoplasms and tumors, describing benign and malignant tumors. It then covers cancer characteristics and classifications such as carcinoma, sarcoma, lymphoma, and leukemia. The document discusses genetic and environmental causes of cancer. Methods of cancer diagnosis and various treatment approaches are outlined, including surgery, chemotherapy, radiation therapy, and palliative care. Common chemotherapeutic drug classes like alkylating agents, antimetabolites, plant alkaloids, and their mechanisms and uses are also summarized.
Anticancer drugs persentation
This document provides information about cancer including:
- Cancer is characterized by abnormal, uncontrolled cell growth.
- Lung cancer is the most common cancer in men and breast cancer is most common in women.
- Cancers can be benign or malignant tumors and are classified into broad groups like carcinomas and sarcomas.
- Cancers are caused by physical, biological, chemical and genetic factors like viruses, radiation, and lifestyle habits.
- Diagnosis involves biopsies, imaging tests, and analyzing tumor markers in blood. Staging determines how advanced a cancer is.
- Treatment includes surgery, radiation, immunotherapy, chemotherapy and other drugs that target cell growth pathways.
Anti-tumor drugs PPT Dr. Shahid Rasool.ppt
The learning Objectives are
1. To understand tumor, its types, causes and cell cycle of normal cell.
2. To learn and comprehend the pharmacognostic features of various plant and marine derived drugs having anticancer activity.
3. To know the anti cancer mechanism of these natural drugs.
Recent advances in anticancer agents
This document discusses various types of anticancer drugs, including their classification, mechanisms of action, and examples. It describes five main classes of anticancer agents: cytotoxic drugs like alkylating agents and antimetabolites that directly kill cancer cells; natural anticancer agents such as vinca alkaloids and taxanes that interfere with cell division; antibiotics that intercalate DNA; miscellaneous agents discovered through random synthesis; and drugs that act on hormones to manipulate the endocrine system and inhibit cancer growth. Recent FDA-approved drugs for various cancer types are also mentioned.
Anti-cancer drug.pptx
The document discusses various types of cancer, tumors, and anti-cancer drugs. It defines cancer and different types such as carcinoma, sarcoma, lymphoma, and leukemia. It describes characteristics of cancer like uncontrolled cell proliferation and metastasis. It then discusses different classes of anti-cancer drugs like alkylating agents, antimetabolites, plant alkaloids, and antibiotics. It provides details on specific drugs like cyclophosphamide, methotrexate, doxorubicin, bleomycin, paclitaxel, vincristine, and cytarabine. It explains the mechanism of action, indications, side effects, contraindications, and dosages of these drugs.
Recommended
Chemotherapy of cancer
Chemotherapy of cancer -it consists of cell-cycle and classification of anticancer drugs,mechanism of anticancer drugs,radiation of anticancer drugs.
RECENT ADVANCES IN CANCER TREATMENT.pptx
Introduction, Types, Causes,
Symptoms of cancer
Anti-cancer drug &
Recent advances in cancer treatment included Newer drug carrier systems, Nanotechnology, Carbon nanotubes, Cancer Vaccine, Antigen Vaccines, Dendritic Cell Vaccines, DNA Vaccines.
AntineoplasticAgentsby KEMISA. HASSEN ZAINABU
Diploma nursing Extension student International institute of health science jinja,Uganda presenting the Antineoplastic drugs, the main objectives is
1.definition.
2.classes of Antineoplastic drugs.
3.Different types of drugs in each class.
4Different forms,dosage,indication,Adverse effects of some common Antineoplastic.
Nursing interventions in Antineoplastic drugs.
Anticancer drugs
This document discusses chemotherapy and neoplastic drugs. It begins by defining neoplasms and tumors, describing benign and malignant tumors. It then covers cancer characteristics and classifications such as carcinoma, sarcoma, lymphoma, and leukemia. The document discusses genetic and environmental causes of cancer. Methods of cancer diagnosis and various treatment approaches are outlined, including surgery, chemotherapy, radiation therapy, and palliative care. Common chemotherapeutic drug classes like alkylating agents, antimetabolites, plant alkaloids, and their mechanisms and uses are also summarized.
Anticancer drugs persentation
This document provides information about cancer including:
- Cancer is characterized by abnormal, uncontrolled cell growth.
- Lung cancer is the most common cancer in men and breast cancer is most common in women.
- Cancers can be benign or malignant tumors and are classified into broad groups like carcinomas and sarcomas.
- Cancers are caused by physical, biological, chemical and genetic factors like viruses, radiation, and lifestyle habits.
- Diagnosis involves biopsies, imaging tests, and analyzing tumor markers in blood. Staging determines how advanced a cancer is.
- Treatment includes surgery, radiation, immunotherapy, chemotherapy and other drugs that target cell growth pathways.
Anti-tumor drugs PPT Dr. Shahid Rasool.ppt
The learning Objectives are
1. To understand tumor, its types, causes and cell cycle of normal cell.
2. To learn and comprehend the pharmacognostic features of various plant and marine derived drugs having anticancer activity.
3. To know the anti cancer mechanism of these natural drugs.
Recent advances in anticancer agents
This document discusses various types of anticancer drugs, including their classification, mechanisms of action, and examples. It describes five main classes of anticancer agents: cytotoxic drugs like alkylating agents and antimetabolites that directly kill cancer cells; natural anticancer agents such as vinca alkaloids and taxanes that interfere with cell division; antibiotics that intercalate DNA; miscellaneous agents discovered through random synthesis; and drugs that act on hormones to manipulate the endocrine system and inhibit cancer growth. Recent FDA-approved drugs for various cancer types are also mentioned.
Anti-cancer drug.pptx
The document discusses various types of cancer, tumors, and anti-cancer drugs. It defines cancer and different types such as carcinoma, sarcoma, lymphoma, and leukemia. It describes characteristics of cancer like uncontrolled cell proliferation and metastasis. It then discusses different classes of anti-cancer drugs like alkylating agents, antimetabolites, plant alkaloids, and antibiotics. It provides details on specific drugs like cyclophosphamide, methotrexate, doxorubicin, bleomycin, paclitaxel, vincristine, and cytarabine. It explains the mechanism of action, indications, side effects, contraindications, and dosages of these drugs.
Natural therapy aganist cancer
This document discusses cancer biology and natural therapies against cancer. It provides an overview of the cell cycle, genetics of cancer, tumour biology, and characteristics of cancer cells. It then discusses reasons for cancer development and side effects of conventional cancer treatment. The document outlines 7 steps to beat cancer naturally and lists 10 cancer facts. It discusses several natural compounds that have anti-cancer activity, including curcumin, compounds in ginger and eggplant, and cruciferous vegetables. Natural cancer therapies aim to strengthen immunity and create an unfavorable environment for cancer growth.
Anticancer drugs: Classification , general toxicity and Alkylating agents.
Neoplasm or cancer is one of the dangerous condition. Here we discuss about cancer and it's drug classification, general toxicity and brief description about Alkylating agents.
Basics of Cancer.pptx
This document provides information about the basics of cancer treatment. It defines cancer as abnormal cells that divide uncontrollably and are able to invade other tissues and spread. It describes the main characteristics of tumors. It also covers the types of genes linked to cancer development including tumor suppressor genes and oncogenes. The document discusses the different modalities used to treat cancer, including surgery, chemotherapy, radiation therapy, hormonal therapy, and targeted therapy. It provides details on the various classes and examples of chemotherapy drugs and hormonal therapies used to treat breast and prostate cancer.
Cancer.pptx
Cancer is caused by genetic mutations that cause cells to grow uncontrollably and spread. There are two major classes of cancer genes - oncogenes which stimulate cell growth, and tumor suppressor genes which normally limit cell growth. Cancer can be caused by genetic, infectious, chemical, or physical factors that cause these mutations. Treatment involves surgery, radiation, chemotherapy, hormone therapy, or targeted therapy depending on the cancer type and stage. Chemotherapy uses drugs to destroy cancer cells and works through several mechanisms including alkylating DNA, interfering with cell division, damaging DNA, or stopping cell division.
Cancer Basics.pptx
Cancer is caused by genetic mutations that cause cells to grow uncontrollably and spread. There are two major classes of cancer genes - oncogenes which stimulate cell growth, and tumor suppressor genes which normally limit cell growth. Cancer can be caused by genetic, infectious, or environmental factors. Treatment may involve surgery, radiation, chemotherapy, hormone therapy, or targeted therapy. Chemotherapy uses drugs to destroy cancer cells and works in different phases of the cell cycle. Common drug classes include alkylating agents, antimetabolites, anti-tumor antibiotics, topoisomerase inhibitors, mitotic inhibitors, and corticosteroids.
anticancer agents
This document provides an overview of antineoplastic agents and recently approved drugs used to treat cancer. It defines cancer and describes the main types. The classification of anticancer drugs is discussed, including drugs that act directly on cells like alkylating agents, antimetabolites, natural products, antibiotics, and miscellaneous drugs. Drugs that act on hormones are also summarized. Recently approved drugs by the FDA from 2013-2016 for cancers like lung cancer, breast cancer, and leukemia are listed with their uses. References are included from medical pharmacology textbooks and FDA websites.
Principles of cancer chemotherapy (2) (2)
This document provides an overview of cancer chemotherapy. It discusses the goals of cancer chemotherapy as being cure, control, or palliation depending on the cancer stage. It then reviews some key developments in cancer chemotherapy over time, including the 1940s-50s seeing the first successful chemotherapy drugs and the 1970s being considered the "Golden Age" with the development of drug combinations and new classes of drugs. The rest of the document discusses various aspects of chemotherapy drugs and mechanisms, including specific drug classes and examples, cell cycle phases, drug combinations, and newer targeted therapies and immunotherapies.
Cancer things to know pptx
No, I have not heard of cancer occurring in red blood cells or heart muscle cells. Cancer is generally considered a disease of epithelial cells (cells that line surfaces in the body) and other cell types like lymphocytes and bone marrow cells. Red blood cells and cardiac muscle cells do not typically undergo cell division, which is required for cancer development. So while it is theoretically possible, it is extremely rare to have cancers originate from these cell types.
Chemotherapy of cancer
This document summarizes different types of chemotherapy used to treat cancer. It discusses how chemotherapy works by interfering with rapidly dividing cancer cell growth. The main types covered are alkylating agents, antimetabolites, antitumor antibiotics, plant alkaloids, and miscellaneous agents. For each type, 1-2 specific drug examples are provided along with a brief overview of their mechanism of action and effects on DNA, RNA, or other cell processes critical to cell division. Hormonal agents are also summarized as targeting certain hormone-sensitive cancers. The document aims to explain the biological basis and classifications of various chemotherapy drugs.
Pharmacognosy chapter plants Anti cancer plants.pdf
This document discusses tumor inhibitors derived from plants. It begins by defining key terms like tumors, neoplasia, benign and malignant tumors, and metastasis. It then discusses several types of tumors including adenomas, carcinomas, and sarcomas. The rest of the document discusses various plant-derived compounds that have anti-tumor properties, including vinca alkaloids extracted from Catharanthus roseus, podophyllum and podophyllum resin, and their mechanisms of action in inhibiting tumor growth and cancer progression.
Basic concept of Cancer and cancer cell.
Cancer is a genetic disease caused by alterations in genes that can result from mutations during cell division, exposure to external agents, or randomly. There are four main types of cancer - carcinomas, sarcomas, lymphomas, and leukemias. Cancer is characterized by cellular changes that promote uncontrolled growth. Some key cancer genes include oncogenes that promote growth and tumor suppressor genes that normally inhibit growth. Examples are discussed like MYC, RAS, P53, and RB. New strategies to treat cancer focus on immunotherapy, inhibiting cancer-promoting proteins, and blocking angiogenesis within tumors.
Cancer
This document provides information on various types of cancer treatments including immunotherapy, prodrug therapy, and targeted therapies. It discusses how immunotherapy works to boost the immune system's natural defenses to fight cancer. Examples of immunotherapy approaches include monoclonal antibodies, cancer vaccines, and non-specific immunotherapies like cytokines. Prodrugs are inactive compounds that are metabolized into active drugs inside the body. Targeted therapies work by interfering with specific proteins that help tumors grow and spread.
Anti Cancer drugs I.ppt
This document provides an overview of anticancer drugs and chemotherapy. It discusses the general approach to cancer therapy, including killing cancer cells and modifying their growth. The main modalities of cancer treatment are described as chemotherapy, surgery, and radiation. The goals of chemotherapy are cure, prolonged remission, or palliation. Common anticancer drug classes are also summarized, including their mechanisms of action, examples, and toxicities.
Cancer treatment
The document discusses various cancer treatment methods including surgery, radiotherapy, immunotherapy, hormone therapy, chemotherapy, and combination/adjuvant chemotherapy. It provides details on each method such as how surgery is used for diagnosis and removal of tumors, how different types of radiation are used in radiotherapy, and how chemotherapy works by destroying cancer cells. The document also covers natural compounds that can induce apoptosis in cancer cells, including plant extracts, flavonoids, and curcumin which suppresses prostaglandin formation through COX-2 inhibition. Nanoparticles are also discussed as a means of targeted drug delivery to cancer cells to reduce side effects.
anticancer ppt.pptx
This document discusses mechanisms of anticancer drug resistance and approaches to overcome resistance. It covers several key points:
1. Cancer cells can develop resistance to chemotherapy drugs through various mechanisms like drug inactivation, target alteration, drug efflux, DNA damage repair, heterogeneity, and inhibiting cell death.
2. Nanomedicine is a promising therapeutic approach to overcome resistance by improving drug distribution, efficacy and reducing side effects. Nanoparticles can be activated by light to heat and kill cancer cells.
3. Various types of nanoparticles are being studied for cancer treatment including lipid-based, polymer-based, dendrimers, carbon-based, and metallic/magnetic nanoparticles. Understanding resistance mechanisms and safety/efficacy
Anticancer drug screening
The document describes screening methods for new anticancer drugs. It discusses how cancer arises from genetic mutations and different cancer types. Current treatments include chemotherapy, surgery and radiation. There is a need for more selective anticancer agents due to drug resistance and side effects. Various in vitro and in vivo screening assays are described to test compounds for cytotoxicity against cancer cells and tumors in animal models. The goal is to develop more effective and safer anticancer drugs.
TAXANES AND PODOPHYLLOTOXINS
TAXANES AND PODOPHYLLOTOXINSCollege of Pharmacy,Sri Ramakrishna Institute of Paramedical Sciences,Coimbatore
The document discusses natural products taxanes and podophyllotoxins that have led to new anti-cancer drugs. It describes how over 60% of anti-cancer drugs originate from natural products. Taxanes such as paclitaxel and docetaxel stabilize microtubules, preventing cell division and causing cancer cell death. Podophyllotoxins like etoposide and teniposide inhibit topoisomerase and DNA synthesis in cancer cells. Both classes are effective against various cancer types with side effects like low blood counts and hair loss that require careful treatment. Natural products continue providing leads for developing new anti-cancer pharmaceuticals.ANTICANCER NEW.pptx
This document discusses various natural anticancer drugs, including taxanes like paclitaxel and docetaxel derived from yew trees, and podophyllotoxins like etoposide and teniposide derived from podophyllum hexandrum. It explains their mechanisms of action involving microtubule stabilization or inhibition of topoisomerase enzymes, and their clinical applications in treating several cancer types. Over 60% of anticancer drugs originate from natural products, and natural products continue providing leads for developing novel and selective anticancer agents.
Anti neoplastic agents
This document discusses anti-neoplastic agents used to treat cancer. It begins by introducing malignant disease and cancer treatment options such as surgery, radiotherapy, chemotherapy, immunotherapy and gene therapy. It then categorizes anti-cancer drugs according to their chemical structure, mechanism of action, and cell cycle specificity. Examples of major drug classes discussed include alkylating agents, platinum compounds, antimetabolites, and plant extracts. Common mechanisms of action and adverse effects are also summarized for several representative drugs.
Alkylating anticancers
Cancer is caused by uncontrolled cell growth and can be due to environmental or genetic factors. Chemotherapy uses drugs to stop or slow the growth of cancer cells and works by targeting fast-growing cells. The main types of chemotherapy drugs are alkylating agents, such as platinum-based drugs and nitrogen mustards, which damage DNA and prevent cell replication. Alkylating agents work by introducing alkyl groups onto DNA through covalent bonding, causing cross-linking that interferes with cell division. Cyclophosphamide is a commonly used alkylating agent that requires metabolic activation to form an active metabolite. Cisplatin forms DNA cross-links that trigger apoptosis and is used to treat various cancer types.
Chapter -12, Antibiotics (One Page Notes).pdf
This is a notes for the D.Pharm students and related to the antibiotic drugs.
MakeIntern IIT Delhi CADD Presentation.pdf
It includes
-Drug discovery process
-Trajectory of computer aided drug design
-Data source
-Drug design for benign prostatic hyperplasia
-Target identification
-Ligand design
-Docking score
-Result and conclusion
#CADD #Drug research #prostrate cancer #new research panel #advance research #computer aided drug design
More Related Content
Similar to Chapter -13, Anti-neoplastic drugs (one page notes).pptx
Natural therapy aganist cancer
This document discusses cancer biology and natural therapies against cancer. It provides an overview of the cell cycle, genetics of cancer, tumour biology, and characteristics of cancer cells. It then discusses reasons for cancer development and side effects of conventional cancer treatment. The document outlines 7 steps to beat cancer naturally and lists 10 cancer facts. It discusses several natural compounds that have anti-cancer activity, including curcumin, compounds in ginger and eggplant, and cruciferous vegetables. Natural cancer therapies aim to strengthen immunity and create an unfavorable environment for cancer growth.
Anticancer drugs: Classification , general toxicity and Alkylating agents.
Neoplasm or cancer is one of the dangerous condition. Here we discuss about cancer and it's drug classification, general toxicity and brief description about Alkylating agents.
Basics of Cancer.pptx
This document provides information about the basics of cancer treatment. It defines cancer as abnormal cells that divide uncontrollably and are able to invade other tissues and spread. It describes the main characteristics of tumors. It also covers the types of genes linked to cancer development including tumor suppressor genes and oncogenes. The document discusses the different modalities used to treat cancer, including surgery, chemotherapy, radiation therapy, hormonal therapy, and targeted therapy. It provides details on the various classes and examples of chemotherapy drugs and hormonal therapies used to treat breast and prostate cancer.
Cancer.pptx
Cancer is caused by genetic mutations that cause cells to grow uncontrollably and spread. There are two major classes of cancer genes - oncogenes which stimulate cell growth, and tumor suppressor genes which normally limit cell growth. Cancer can be caused by genetic, infectious, chemical, or physical factors that cause these mutations. Treatment involves surgery, radiation, chemotherapy, hormone therapy, or targeted therapy depending on the cancer type and stage. Chemotherapy uses drugs to destroy cancer cells and works through several mechanisms including alkylating DNA, interfering with cell division, damaging DNA, or stopping cell division.
Cancer Basics.pptx
Cancer is caused by genetic mutations that cause cells to grow uncontrollably and spread. There are two major classes of cancer genes - oncogenes which stimulate cell growth, and tumor suppressor genes which normally limit cell growth. Cancer can be caused by genetic, infectious, or environmental factors. Treatment may involve surgery, radiation, chemotherapy, hormone therapy, or targeted therapy. Chemotherapy uses drugs to destroy cancer cells and works in different phases of the cell cycle. Common drug classes include alkylating agents, antimetabolites, anti-tumor antibiotics, topoisomerase inhibitors, mitotic inhibitors, and corticosteroids.
anticancer agents
This document provides an overview of antineoplastic agents and recently approved drugs used to treat cancer. It defines cancer and describes the main types. The classification of anticancer drugs is discussed, including drugs that act directly on cells like alkylating agents, antimetabolites, natural products, antibiotics, and miscellaneous drugs. Drugs that act on hormones are also summarized. Recently approved drugs by the FDA from 2013-2016 for cancers like lung cancer, breast cancer, and leukemia are listed with their uses. References are included from medical pharmacology textbooks and FDA websites.
Principles of cancer chemotherapy (2) (2)
This document provides an overview of cancer chemotherapy. It discusses the goals of cancer chemotherapy as being cure, control, or palliation depending on the cancer stage. It then reviews some key developments in cancer chemotherapy over time, including the 1940s-50s seeing the first successful chemotherapy drugs and the 1970s being considered the "Golden Age" with the development of drug combinations and new classes of drugs. The rest of the document discusses various aspects of chemotherapy drugs and mechanisms, including specific drug classes and examples, cell cycle phases, drug combinations, and newer targeted therapies and immunotherapies.
Cancer things to know pptx
No, I have not heard of cancer occurring in red blood cells or heart muscle cells. Cancer is generally considered a disease of epithelial cells (cells that line surfaces in the body) and other cell types like lymphocytes and bone marrow cells. Red blood cells and cardiac muscle cells do not typically undergo cell division, which is required for cancer development. So while it is theoretically possible, it is extremely rare to have cancers originate from these cell types.
Chemotherapy of cancer
This document summarizes different types of chemotherapy used to treat cancer. It discusses how chemotherapy works by interfering with rapidly dividing cancer cell growth. The main types covered are alkylating agents, antimetabolites, antitumor antibiotics, plant alkaloids, and miscellaneous agents. For each type, 1-2 specific drug examples are provided along with a brief overview of their mechanism of action and effects on DNA, RNA, or other cell processes critical to cell division. Hormonal agents are also summarized as targeting certain hormone-sensitive cancers. The document aims to explain the biological basis and classifications of various chemotherapy drugs.
Pharmacognosy chapter plants Anti cancer plants.pdf
This document discusses tumor inhibitors derived from plants. It begins by defining key terms like tumors, neoplasia, benign and malignant tumors, and metastasis. It then discusses several types of tumors including adenomas, carcinomas, and sarcomas. The rest of the document discusses various plant-derived compounds that have anti-tumor properties, including vinca alkaloids extracted from Catharanthus roseus, podophyllum and podophyllum resin, and their mechanisms of action in inhibiting tumor growth and cancer progression.
Basic concept of Cancer and cancer cell.
Cancer is a genetic disease caused by alterations in genes that can result from mutations during cell division, exposure to external agents, or randomly. There are four main types of cancer - carcinomas, sarcomas, lymphomas, and leukemias. Cancer is characterized by cellular changes that promote uncontrolled growth. Some key cancer genes include oncogenes that promote growth and tumor suppressor genes that normally inhibit growth. Examples are discussed like MYC, RAS, P53, and RB. New strategies to treat cancer focus on immunotherapy, inhibiting cancer-promoting proteins, and blocking angiogenesis within tumors.
Cancer
This document provides information on various types of cancer treatments including immunotherapy, prodrug therapy, and targeted therapies. It discusses how immunotherapy works to boost the immune system's natural defenses to fight cancer. Examples of immunotherapy approaches include monoclonal antibodies, cancer vaccines, and non-specific immunotherapies like cytokines. Prodrugs are inactive compounds that are metabolized into active drugs inside the body. Targeted therapies work by interfering with specific proteins that help tumors grow and spread.
Anti Cancer drugs I.ppt
This document provides an overview of anticancer drugs and chemotherapy. It discusses the general approach to cancer therapy, including killing cancer cells and modifying their growth. The main modalities of cancer treatment are described as chemotherapy, surgery, and radiation. The goals of chemotherapy are cure, prolonged remission, or palliation. Common anticancer drug classes are also summarized, including their mechanisms of action, examples, and toxicities.
Cancer treatment
The document discusses various cancer treatment methods including surgery, radiotherapy, immunotherapy, hormone therapy, chemotherapy, and combination/adjuvant chemotherapy. It provides details on each method such as how surgery is used for diagnosis and removal of tumors, how different types of radiation are used in radiotherapy, and how chemotherapy works by destroying cancer cells. The document also covers natural compounds that can induce apoptosis in cancer cells, including plant extracts, flavonoids, and curcumin which suppresses prostaglandin formation through COX-2 inhibition. Nanoparticles are also discussed as a means of targeted drug delivery to cancer cells to reduce side effects.
anticancer ppt.pptx
This document discusses mechanisms of anticancer drug resistance and approaches to overcome resistance. It covers several key points:
1. Cancer cells can develop resistance to chemotherapy drugs through various mechanisms like drug inactivation, target alteration, drug efflux, DNA damage repair, heterogeneity, and inhibiting cell death.
2. Nanomedicine is a promising therapeutic approach to overcome resistance by improving drug distribution, efficacy and reducing side effects. Nanoparticles can be activated by light to heat and kill cancer cells.
3. Various types of nanoparticles are being studied for cancer treatment including lipid-based, polymer-based, dendrimers, carbon-based, and metallic/magnetic nanoparticles. Understanding resistance mechanisms and safety/efficacy
Anticancer drug screening
The document describes screening methods for new anticancer drugs. It discusses how cancer arises from genetic mutations and different cancer types. Current treatments include chemotherapy, surgery and radiation. There is a need for more selective anticancer agents due to drug resistance and side effects. Various in vitro and in vivo screening assays are described to test compounds for cytotoxicity against cancer cells and tumors in animal models. The goal is to develop more effective and safer anticancer drugs.
TAXANES AND PODOPHYLLOTOXINS
TAXANES AND PODOPHYLLOTOXINSCollege of Pharmacy,Sri Ramakrishna Institute of Paramedical Sciences,Coimbatore
The document discusses natural products taxanes and podophyllotoxins that have led to new anti-cancer drugs. It describes how over 60% of anti-cancer drugs originate from natural products. Taxanes such as paclitaxel and docetaxel stabilize microtubules, preventing cell division and causing cancer cell death. Podophyllotoxins like etoposide and teniposide inhibit topoisomerase and DNA synthesis in cancer cells. Both classes are effective against various cancer types with side effects like low blood counts and hair loss that require careful treatment. Natural products continue providing leads for developing new anti-cancer pharmaceuticals.ANTICANCER NEW.pptx
This document discusses various natural anticancer drugs, including taxanes like paclitaxel and docetaxel derived from yew trees, and podophyllotoxins like etoposide and teniposide derived from podophyllum hexandrum. It explains their mechanisms of action involving microtubule stabilization or inhibition of topoisomerase enzymes, and their clinical applications in treating several cancer types. Over 60% of anticancer drugs originate from natural products, and natural products continue providing leads for developing novel and selective anticancer agents.
Anti neoplastic agents
This document discusses anti-neoplastic agents used to treat cancer. It begins by introducing malignant disease and cancer treatment options such as surgery, radiotherapy, chemotherapy, immunotherapy and gene therapy. It then categorizes anti-cancer drugs according to their chemical structure, mechanism of action, and cell cycle specificity. Examples of major drug classes discussed include alkylating agents, platinum compounds, antimetabolites, and plant extracts. Common mechanisms of action and adverse effects are also summarized for several representative drugs.
Alkylating anticancers
Cancer is caused by uncontrolled cell growth and can be due to environmental or genetic factors. Chemotherapy uses drugs to stop or slow the growth of cancer cells and works by targeting fast-growing cells. The main types of chemotherapy drugs are alkylating agents, such as platinum-based drugs and nitrogen mustards, which damage DNA and prevent cell replication. Alkylating agents work by introducing alkyl groups onto DNA through covalent bonding, causing cross-linking that interferes with cell division. Cyclophosphamide is a commonly used alkylating agent that requires metabolic activation to form an active metabolite. Cisplatin forms DNA cross-links that trigger apoptosis and is used to treat various cancer types.
Similar to Chapter -13, Anti-neoplastic drugs (one page notes).pptx (20)
Anticancer drugs: Classification , general toxicity and Alkylating agents.
Anticancer drugs: Classification , general toxicity and Alkylating agents.
Pharmacognosy chapter plants Anti cancer plants.pdf
Pharmacognosy chapter plants Anti cancer plants.pdf
More from Kartik Tiwari
Chapter -12, Antibiotics (One Page Notes).pdf
This is a notes for the D.Pharm students and related to the antibiotic drugs.
MakeIntern IIT Delhi CADD Presentation.pdf
It includes
-Drug discovery process
-Trajectory of computer aided drug design
-Data source
-Drug design for benign prostatic hyperplasia
-Target identification
-Ligand design
-Docking score
-Result and conclusion
#CADD #Drug research #prostrate cancer #new research panel #advance research #computer aided drug design
Diuretic, Hypoglycemic and Limit test of Heavy metals and Arsenic.-1.pdf
This is one page summarise content as per your d.pharm course. This will help you in the examinations along with less effort of learning exposure.
Chapter 1 notes Part-2 (One Page Note) Error and limit test .pdf
This is short note for the quick revision of the chapter-1 of D.Pharm or any other pharmacy course syllabus.
It includes
-accuracy, precision and significant figures.
-Impurities (definition, sources and effects)
- Limit test (definition)
-Limit test for chlorides
-Limit test for sulphates.
Chapter 1 (One Page Note) Definition and errors of Pharmaceutical chemistry.pdf
This is for the D.pharm students who wants to quick revision and wants all content at one place
Precipitation_titration_mohr's_method_Chart.pptx
Mohr's method is a precipitation titration technique used to quantify chloride ions (Cl-) in samples. Silver nitrate (AgNO3) is used as the titrant, which reacts with chloride ions to form an insoluble white precipitate of silver chloride (AgCl). Potassium chromate (K2CrO4) is used as the indicator. At the endpoint of the titration, the silver nitrate also reacts with the indicator to form a red-brown precipitate of silver chromate (Ag2CrO4), signaling that all chloride ions have reacted. Mohr's method provides a simple and reliable way to determine the chloride content in various materials like water, food, and pharmaceuticals
Local Anaesthetic (General Overview).pptx
Local anaesthetics cause reversible loss of sensation in a specific part of the body. They block nerve conduction by decreasing sodium ion entry during depolarization, slowing nerve impulses. Local anaesthetics come in injectable and surface forms, with varying potencies and durations of action. They act by blocking sodium channels in resting, activated, and inactivated states. Important discoveries in local anaesthetics include cocaine in 1860 as the first agent, demonstration of anaesthetic properties in 1884, development of the first synthetic agent procaine in 1905, and discovery of lidocaine in 1948. Local anaesthetics must have low irritation, avoid permanent nerve damage, low systemic toxicity, rapid onset, and effectiveness with different routes of administration.
Gravimetric Analysis.pptx
This document discusses gravimetric analysis, which is an analytical chemistry technique that determines the amount of analyte in a sample by measuring the mass of a precipitate containing the analyte. There are two main types of gravimetric analysis: precipitation and volatilization. Gravimetric analysis is accurate, precise, and avoids some errors associated with volumetric analysis, though it is more time-consuming. The steps in a typical gravimetric analysis by precipitation include: (1) preparing a solution of the analyte, (2) adding a precipitating reagent to form a precipitate, (3) allowing the precipitate to form fully, (4) filtering out the precipitate, (5) washing to
High Performance Thin Layer Chromatography.pptx
This document provides an overview of High Performance Thin Layer Chromatography (HPTLC). HPTLC is an automated, sophisticated version of Thin Layer Chromatography that allows for both qualitative and quantitative analysis. It works on the principle of adsorption chromatography, separating components based on their varying affinities to the stationary phase. Key steps involve preparing samples, applying them to a silica gel plate, developing the plate in a solvent mobile phase, detecting and visualizing separated components, and scanning/documenting results. HPTLC is useful for applications like pharmaceutical analysis, forensics, and clinical/biomedical research.
(Kartik Tiwari) Inorganic Pharmaceutical Chemistry.pptx
This document provides information about the subject of pharmaceutical inorganic chemistry. It discusses the meaning and branches of pharmaceutical inorganic chemistry, as well as the importance and applications of inorganic compounds. It also outlines the topics that will be covered in 5 units, including pharmacopoeia, acids and bases, gastrointestinal agents, expectorants and emetics, and radiopharmaceuticals. The units will cover commonly used inorganic compounds for various therapeutic purposes and their properties.
(Kartik Tiwari) Pharmaceutical Chemistry D.Pharm syllabus orientation..pptx
D.Pharm 1st year syllabus of Pharmaceutical chemistry with brief ongoing to comprehend the whole year learning process.
Histaminic Agent.pptx
This document discusses various types of antihistamine agents. It describes 20 first generation antihistamines that work by blocking the H1 receptor to relieve allergic symptoms. It also discusses 5 second generation antihistamines that are less sedating. Additionally, it covers 3 H2 receptor antagonists that decrease stomach acid production and 4 proton pump inhibitors that irreversibly block the gastric acid pump. The document provides details on the mechanism of action and uses of each type of antihistamine and acid reducer.
continuous flow reactor M.Pharm .pptx
The document discusses continuous flow reactors for chemical synthesis. It introduces continuous flow chemistry as pumping reactants at controlled flow rates through reactors. This allows reactions to occur safely under extreme conditions with high product quality and reproducibility. The key components of flow reactors are described including pumps, mixing points, coils, and columns. Parameters like residence time, flow rates and stoichiometry are also discussed. Finally, examples of synthetic applications for continuous flow reactors producing pharmaceutical compounds are provided.
Gc-AAS (Gas chromatography - Atomic Absorption Spectroscopy).pptx
Gas chromatography-atomic absorption spectroscopy (GC-AAS) is an analytical technique used to separate and quantify elemental components in a sample. It combines gas chromatography, which separates compounds, with atomic absorption spectroscopy, which measures elemental concentrations. Key components of a GC-AAS system include a gas chromatograph unit with a carrier gas, injection port, column, and detector; an atomic absorption spectrometer with a light source, atomizer, monochromator, and detector; and an interface connecting the two instruments. GC-AAS is applied to quantify metals in various samples like industrial waste, alloys, foods, and more.
LC-FTIR PPT.pptx S.pptx
This document provides an overview of liquid chromatography-Fourier transform infrared spectroscopy (LC-FTIR). It begins by explaining the principles and instrumentation of LC/HPLC and FTIR individually. It then discusses how LC-FTIR works by coupling the two techniques, using interfaces to introduce LC eluent directly into the FTIR for online analysis. The document outlines some applications of LC-FTIR and concludes by noting it allows for characterization of separated components from LC in a non-invasive manner.
3D QSAR.pptx
This document provides an introduction to 3D quantitative structure-activity relationship (QSAR) modeling. It discusses the objectives and limitations of classical QSAR methods, and describes how 3D-QSAR approaches aim to address these limitations by incorporating spatial and structural information. The document outlines various assumptions of 3D-QSAR methods and provides classifications based on dimensionality and chemometric techniques. It introduces common 3D-QSAR methods like COMFA and COMSIA.
Kartik Tiwari microwave ppt.pptx
The document discusses microwave-assisted reactions including their merits such as faster reactions and better yields compared to conventional heating methods. It describes the mechanisms of microwave heating including dipolar polarization, ionic conduction, and interfacial polarization. Various types of microwave-assisted organic reactions are outlined including those using solvents, under solvent-free conditions, and on solid supports. Applications to name reactions and other areas like materials chemistry and polymer synthesis are also mentioned.
Affinity Chromatography MP MPAT Presentation.pptx
Affinity chromatography is a type of liquid chromatography that uses the reversible biological interaction or molecular recognition between a ligand and target molecule for their separation. It involves attaching a ligand with specific binding affinity to a solid support to act as the stationary phase. When a sample mixture is passed through the column, target molecules that bind to the ligand are separated from other substances. Bound molecules can then be eluted by altering conditions like pH or ionic strength to disrupt ligand-target binding.
(Kartik Tiwari) Denovo Drug Design.pptx
Hygia Institute of Pharmaceutical Education and Research provides information on drug design. There are two main types of drug design: ligand-based which relies on existing molecules that bind to the target, and structure-based which relies on the 3D structure of the target. De-novo drug design uses the 3D structure of the receptor to design new molecules and involves optimizing ligands to fit the receptor's active site properties. LUDI software aids de-novo design through identifying interaction sites in the receptor, fitting molecular fragments, and linking fragments together to form new drug candidates.
Presentation on Lead Discovery (1).ppt
This document discusses the process of drug discovery, focusing on finding a lead compound. It describes the key steps as: 1) Choosing a disease target, 2) Identifying a drug target within that disease, 3) Developing a bioassay to test compounds, and 4) Finding a lead compound with the desired activity against the target. It provides details on various methods for identifying lead compounds, including screening natural products, existing drugs, and synthetic compound libraries.
More from Kartik Tiwari (20)
Diuretic, Hypoglycemic and Limit test of Heavy metals and Arsenic.-1.pdf
Diuretic, Hypoglycemic and Limit test of Heavy metals and Arsenic.-1.pdf
Chapter 1 notes Part-2 (One Page Note) Error and limit test .pdf
Chapter 1 notes Part-2 (One Page Note) Error and limit test .pdf
Chapter 1 (One Page Note) Definition and errors of Pharmaceutical chemistry.pdf
Chapter 1 (One Page Note) Definition and errors of Pharmaceutical chemistry.pdf
(Kartik Tiwari) Inorganic Pharmaceutical Chemistry.pptx
(Kartik Tiwari) Inorganic Pharmaceutical Chemistry.pptx
(Kartik Tiwari) Pharmaceutical Chemistry D.Pharm syllabus orientation..pptx
(Kartik Tiwari) Pharmaceutical Chemistry D.Pharm syllabus orientation..pptx
Gc-AAS (Gas chromatography - Atomic Absorption Spectroscopy).pptx
Gc-AAS (Gas chromatography - Atomic Absorption Spectroscopy).pptx
Recently uploaded
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
The History of Stoke Newington Street Names
Presented at the Stoke Newington Literary Festival on 9th June 2024
www.StokeNewingtonHistory.com
How to Manage Your Lost Opportunities in Odoo 17 CRM
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...Nguyen Thanh Tu Collection
https://app.box.com/s/y977uz6bpd3af4qsebv7r9b7s21935vdANATOMY AND BIOMECHANICS OF HIP JOINT.pdf
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
What is Digital Literacy? A guest blog from Andy McLaughlin, University of Ab...
What is Digital Literacy? A guest blog from Andy McLaughlin, University of Aberdeen
Digital Artifact 1 - 10VCD Environments Unit
Digital Artifact 1 - 10VCD Environments Unit - NGV Pavilion Concept Design
RPMS TEMPLATE FOR SCHOOL YEAR 2023-2024 FOR TEACHER 1 TO TEACHER 3
RPMS Template 2023-2024 by: Irene S. Rueco
Community pharmacy- Social and preventive pharmacy UNIT 5
Covered community pharmacy topic of the subject Social and preventive pharmacy for Diploma and Bachelor of pharmacy
The simplified electron and muon model, Oscillating Spacetime: The Foundation...
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
South African Journal of Science: Writing with integrity workshop (2024)
South African Journal of Science: Writing with integrity workshop (2024)Academy of Science of South Africa
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.Chapter 4 - Islamic Financial Institutions in Malaysia.pptx
Chapter 4 - Islamic Financial Institutions in Malaysia.pptxMohd Adib Abd Muin, Senior Lecturer at Universiti Utara Malaysia
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
Walmart Business+ and Spark Good for Nonprofits.pdf
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
Main Java[All of the Base Concepts}.docx
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
Recently uploaded (20)
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
How to Manage Your Lost Opportunities in Odoo 17 CRM
How to Manage Your Lost Opportunities in Odoo 17 CRM
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
What is Digital Literacy? A guest blog from Andy McLaughlin, University of Ab...
What is Digital Literacy? A guest blog from Andy McLaughlin, University of Ab...
RPMS TEMPLATE FOR SCHOOL YEAR 2023-2024 FOR TEACHER 1 TO TEACHER 3
RPMS TEMPLATE FOR SCHOOL YEAR 2023-2024 FOR TEACHER 1 TO TEACHER 3
Film vocab for eal 3 students: Australia the movie
Film vocab for eal 3 students: Australia the movie
Community pharmacy- Social and preventive pharmacy UNIT 5
Community pharmacy- Social and preventive pharmacy UNIT 5
The simplified electron and muon model, Oscillating Spacetime: The Foundation...
The simplified electron and muon model, Oscillating Spacetime: The Foundation...
South African Journal of Science: Writing with integrity workshop (2024)
South African Journal of Science: Writing with integrity workshop (2024)
Chapter 4 - Islamic Financial Institutions in Malaysia.pptx
Chapter 4 - Islamic Financial Institutions in Malaysia.pptx
Walmart Business+ and Spark Good for Nonprofits.pdf
Walmart Business+ and Spark Good for Nonprofits.pdf
Chapter -13, Anti-neoplastic drugs (one page notes).pptx
- 1. Prepared By – Kartik Tiwari (Lecturer) Hygia College of Pharmacy, Lucknow (U.P) Content as Per D. Pharm Syllabus ANTI-NEOPLASTIC AGENTS Anti-neoplastic agents are the medications or drugs that are used in the treatment of the cancer disease. Cancer is the disease or state in which the abnormal proliferation of the body cells or uncontrolled growth of the body cells in the milieu of the normal cells. Classification of anti-neoplastic agents One Page Notes KARTIK TIWARI One Page Notes Cyclophosphamide Fluorine atom at 5th position. Cisplatin Storage – It should be stored in the air tight closed container/boxes and keep away from the light and moisture. Alkylating agents: Alkylating agents chemically bound to nucleic acid and bring about change in DNA and RNA of cells. This includes cross-linking between strands of DNA which results in breaking of the nucleic acid which will not replicated. Antimetabolite: Antimetabolite is a substance that replaces or inhibits a specific metabolite (Intermediate and product of metabolism) of a cell and interferes with the normal cellular metabolic function. 1. Folic Acid Analogues 2. Purine Analogues 3. Pyrimidine Analogues Uses – It is used in the treatment of cancer. Antibiotics: The anticancer antibiotics are the drugs that affect DNA synthesis and replication by incorporate into DNA or by donating electrons which results in the production of highly reactive superoxide that cause breakage of DNA strands. Plant products: Plant also contain important chemicals for the prevention and treatment of cancer with a fewer or no side effects. 1. Vinca alkaloids 2. Epipodophyllotoxins 3. Taxanes 4. Camptotecin derivatives CANCER: Carcinoma: This type of cancer derived from epithelial cells. It represents breast, lung, prostrate, colon and pancreas cancer. Sarcoma: This type of malignant tumor arises from transformed cells of of connective tissue. This tumor is made of cartilage, fat, vascular, cancellous bone and hematopoietic tissue. Leukemia and Lymphoma: These two malignant tumors derived from hematopoietic (blood forming cells ). Germ cell tumor: It is derived from germ cells. It may be malignant or benign. Germ normally found in the ovary and testis. Blastoma: It is common in children. It is a tumor that resembles an immature or embryonic tissue. (eg. Nephroblastoma, medulloblastoma etc).