This document provides information on various types of anti-cancer drugs, including their mechanisms of action, uses, and side effects. It discusses alkylating agents, antimetabolites, natural products/taxanes, antibiotics, platinum compounds, and drugs that alter the hormonal milieu. It also classifies anti-cancer drugs according to how they directly act on cells and their mechanism of action. Key drugs discussed include chlorambucil, cyclophosphamide, busulfan, methotrexate, fluorouracil, doxorubicin, paclitaxel, etoposide, and hydroxyurea.
This document provides a classification and overview of various anticancer drugs. It divides the drugs into categories such as alkylating agents, antimetabolites, plant alkaloids, antitumor antibiotics, hormonal drugs, and miscellaneous drugs. For each drug category and individual drugs, it describes the mechanism of action, common uses, side effects, and other relevant information. The document aims to comprehensively summarize the different types of chemotherapy agents used to treat cancer.
Chemotherapy classes
for more lectures please contact
Dr. Salah Mabrouk Khallaf
MD Medical Oncology & BMT
South Egypt Cancer Institute
Email: salahmab76@yahoo.com
1) Recent advances in cancer chemotherapy include the development of newer alkylating agents, platinum compounds, antimetabolites, mitotic spindle inhibitors, and topoisomerase inhibitors with improved efficacy and reduced toxicity profiles.
2) Many newer agents aim to overcome resistance to existing drugs by bypassing drug efflux pumps or having activity in cisplatin/taxane resistant settings.
3) Several new drugs have received FDA approval in the last decade for cancers like breast cancer, lung cancer, and leukemia, offering additional treatment options.
Alkylating agents are a class of chemotherapy drugs that work by alkylating DNA. Key points about alkylating agents from the document include:
1) Common alkylating agents discussed include cyclophosphamide, ifosfamide, melphalan, chlorambucil, thiotepa, busulfan, and nitrosoureas.
2) They work by adding alkyl groups to DNA, forming covalent bonds that lead to cross-linking of DNA strands and cell death.
3) Toxicities include myelosuppression, nausea/vomiting, alopecia, and secondary cancers, among others. Special precautions are often required due to toxicities.
Antiviral drugs are a class of medication used specifically for treating viral infections.Like antibiotics for bacteria, specific antivirals are used for specific viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development.
The document discusses several new anti-neoplastic agents approved by the FDA between 2008 and 2013, including alkylating agents like bendamustine and pralatrexate, natural products such as vinCRIStine liposomal injection, hormonal therapies including enzalutamide, degarelix, and abiraterone, and provides information on their indications, mechanisms of action, formulations and dosing regimens.
Cisplatin is a chemotherapy drug used to treat several types of cancer. It works by binding to DNA in cancer cells, interfering with transcription and replication and killing the cells. Common side effects include nausea, low blood cell counts, kidney problems and hearing loss. It is administered intravenously and eliminated primarily through urine within days of administration, though tissue levels can remain elevated for months.
Topoisomerases are enzymes that regulate DNA topology during replication and transcription by introducing temporary breaks in DNA strands. Topoisomerase inhibitors can be classified as topoisomerase I or II inhibitors. Camptothecins like irinotecan and topotecan are topoisomerase I inhibitors that stabilize the covalent complex between topoisomerase I and DNA, preventing rejoining of DNA strands. They are used to treat colorectal cancer and other cancers. Anthracyclines like doxorubicin are topoisomerase II inhibitors that stabilize cleavable complexes and cause DNA damage. They are commonly used to treat breast cancer, lymphomas, sarcomas and other cancers. Both classes
This document provides a classification and overview of various anticancer drugs. It divides the drugs into categories such as alkylating agents, antimetabolites, plant alkaloids, antitumor antibiotics, hormonal drugs, and miscellaneous drugs. For each drug category and individual drugs, it describes the mechanism of action, common uses, side effects, and other relevant information. The document aims to comprehensively summarize the different types of chemotherapy agents used to treat cancer.
Chemotherapy classes
for more lectures please contact
Dr. Salah Mabrouk Khallaf
MD Medical Oncology & BMT
South Egypt Cancer Institute
Email: salahmab76@yahoo.com
1) Recent advances in cancer chemotherapy include the development of newer alkylating agents, platinum compounds, antimetabolites, mitotic spindle inhibitors, and topoisomerase inhibitors with improved efficacy and reduced toxicity profiles.
2) Many newer agents aim to overcome resistance to existing drugs by bypassing drug efflux pumps or having activity in cisplatin/taxane resistant settings.
3) Several new drugs have received FDA approval in the last decade for cancers like breast cancer, lung cancer, and leukemia, offering additional treatment options.
Alkylating agents are a class of chemotherapy drugs that work by alkylating DNA. Key points about alkylating agents from the document include:
1) Common alkylating agents discussed include cyclophosphamide, ifosfamide, melphalan, chlorambucil, thiotepa, busulfan, and nitrosoureas.
2) They work by adding alkyl groups to DNA, forming covalent bonds that lead to cross-linking of DNA strands and cell death.
3) Toxicities include myelosuppression, nausea/vomiting, alopecia, and secondary cancers, among others. Special precautions are often required due to toxicities.
Antiviral drugs are a class of medication used specifically for treating viral infections.Like antibiotics for bacteria, specific antivirals are used for specific viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development.
The document discusses several new anti-neoplastic agents approved by the FDA between 2008 and 2013, including alkylating agents like bendamustine and pralatrexate, natural products such as vinCRIStine liposomal injection, hormonal therapies including enzalutamide, degarelix, and abiraterone, and provides information on their indications, mechanisms of action, formulations and dosing regimens.
Cisplatin is a chemotherapy drug used to treat several types of cancer. It works by binding to DNA in cancer cells, interfering with transcription and replication and killing the cells. Common side effects include nausea, low blood cell counts, kidney problems and hearing loss. It is administered intravenously and eliminated primarily through urine within days of administration, though tissue levels can remain elevated for months.
Topoisomerases are enzymes that regulate DNA topology during replication and transcription by introducing temporary breaks in DNA strands. Topoisomerase inhibitors can be classified as topoisomerase I or II inhibitors. Camptothecins like irinotecan and topotecan are topoisomerase I inhibitors that stabilize the covalent complex between topoisomerase I and DNA, preventing rejoining of DNA strands. They are used to treat colorectal cancer and other cancers. Anthracyclines like doxorubicin are topoisomerase II inhibitors that stabilize cleavable complexes and cause DNA damage. They are commonly used to treat breast cancer, lymphomas, sarcomas and other cancers. Both classes
This document summarizes several alkylating agents used in chemotherapy. Alkylating agents work by alkylating DNA and RNA, which can cause DNA breaks or abnormal sequences and damage cells' ability to replicate. Common side effects include myelosuppression, nausea/vomiting, and alopecia. Specific agents discussed include cyclophosphamide, ifosfamide, melphalan, busulfan, carmustine, lomustine, procarbazine, dacarbazine, streptozocin, bendamustine, altretamine, and chlorambucil. Each has unique indications and toxicity profiles involving bone marrow suppression, gastrointestinal upset, organ toxicity, secondary cancers, and more.
This document summarizes information about anthracyclines, a class of chemotherapy drugs that includes daunorubicin, doxorubicin, epirubicin, and idarubicin. It discusses their development, mechanisms of action including DNA intercalation and topoisomerase II inhibition, clinical uses, dosing, side effects with a focus on cardiotoxicity, and risk factors for cardiotoxicity. The document provides detailed information on the structures, properties, and clinical applications of various anthracycline drugs.
This document summarizes various alkylating agents and antimetabolites used in cancer chemotherapy. It discusses the history and mechanisms of alkylating agents such as nitrogen mustards, nitrosoureas, triazines, and platinum compounds. It provides details on specific alkylating agents including their mechanisms of action, uses, dosages, and adverse effects. The summary highlights the development of nitrogen mustard as the first alkylating agent to treat cancer and the discovery of platinum-based drugs like cisplatin through serendipity.
Alkylating agents and antimetabolites are two classes of chemotherapy drugs. Alkylating agents work by binding to DNA and RNA, causing crosslinking or breaks that prevent replication. The main types are nitrogen mustards, alkyl sulphonates, nitrosoureas, and thiazines. Antimetabolites mimic normal metabolites and inhibit DNA or RNA synthesis by becoming incorporated. Major types are folate antagonists like methotrexate, pyrimidine analogs like 5-fluorouracil, and purine analogs like mercaptopurine. Both classes cause bone marrow suppression and gastrointestinal toxicity, and resistance can develop through drug inactivation or changes to drug targets.
The document discusses the mechanism of action, resistance mechanisms, and adverse effects of alkylating agents and anti-metabolites. Alkylating agents work by transferring alkyl groups to biologically important molecules like DNA, RNA, and proteins. This impairs cell function and can cause cross-linking of DNA. Anti-metabolites inhibit key enzymes in folate and purine synthesis pathways, interfering with DNA, RNA, and protein production. Both classes of drugs can cause myelosuppression and gastrointestinal toxicity as main adverse effects. Resistance can develop through increased DNA repair, reduced drug uptake, or alterations in target enzymes.
This document discusses opioid receptors and their effects when activated, including opening potassium channels, closing calcium channels, and reducing neurotransmitter release. It then describes various opioid analgesics that are μ receptor agonists like morphine, methadone, fentanyl, and heroin. The document also discusses the organ system effects of full opioid agonists such as analgesia, euphoria, sedation, respiratory depression, and others. Codeine and buprenorphine are also described.
This document provides an overview of anticancer drugs, including their classification, mechanisms of action, and examples. It discusses 10 main classes of anticancer drugs: alkylating agents, platinum coordination complexes, antimetabolites, microtubule damaging agents, topoisomerase inhibitors, antibiotics, miscellaneous cytotoxic drugs, targeted drugs, and hormonal drugs. For each drug class and some examples, it describes indications, dosages, and mechanisms of inhibiting cancer cell growth and proliferation. The document concludes with nursing responsibilities in administering these drugs and educating patients.
The document discusses various types of anticancer drugs including alkylating agents like cisplatin and cyclophosphamide, antimetabolites like methotrexate and 5-fluorouracil, and targeted drugs. It describes their mechanisms of action, toxicities, and common uses in treating cancers like breast cancer, leukemia, lymphoma, and others. The goal of cancer chemotherapy is to cure cancer when possible or induce remission, but the drugs can also be used for palliation to reduce tumor size and prolong life when the cancer is not curable.
This document describes alkylating agents, a class of chemotherapy drugs that work by alkylating DNA and proteins. It discusses their mechanism of action, including how they crosslink DNA and cause DNA damage, leading to cell death. It also covers resistance mechanisms, adverse effects like bone marrow toxicity and nausea/vomiting, and important alkylating agents like cisplatin, carboplatin, oxaliplatin, cyclophosphamide, and carmustine. For each drug, it provides absorption, indications, dosage ranges, and special considerations.
This document summarizes a seminar presentation on antineoplastic agents. It defines antineoplastic agents as those used to prevent abnormal or uncontrolled cell growth, also known as anticancer agents. The document classifies antineoplastic agents into seven categories - alkylating agents, antimetabolites, plant products, antibiotics, hormones, immunotherapy agents, and miscellaneous agents. For each category, examples are provided and brief descriptions of mechanisms of action and uses. Syntheses of cyclophosphamide and chlorambucil are also outlined.
This document discusses various aspects of anticancer drugs and chemotherapy, including:
1. Types of chemotherapy drugs like alkylating agents, antimetabolites, antibiotics, and their mechanisms of action and cell cycle effects.
2. Goals and principles of cancer therapy like cure, remission, combination chemotherapy, and developing resistance.
3. Toxicities of chemotherapy drugs and methods to counter them, like growth factors and protective agents.
4. Targeted therapies like monoclonal antibodies and tyrosine kinase inhibitors used to treat specific cancers.
Antineoplastic agents can be classified as cytotoxic drugs, hormones, or miscellaneous agents. Cytotoxic drugs include alkylating agents, antimetabolites, plant derivatives, and antibiotics. They work by directly damaging DNA or interfering with cell division and metabolism. Combination therapy is more effective than single agents to increase response rates and decrease resistance development.
Recent advances in cancer treatment include new drug carrier systems and nanotechnology to more precisely target cancer cells. New drug carrier systems such as polymer drug conjugates, cyclodextrins, and self-emulsifying drug delivery formulations aim to enhance drug delivery to tumors while avoiding healthy tissues to reduce side effects. Nanotechnology uses carbon nanotubes and nanoparticles to transport drugs across biological barriers and directly into cancer cells. Additionally, newer cancer vaccines using antigens, dendritic cells, and DNA aim to stimulate the immune system to recognize and destroy cancerous cells.
Chapter 24.1 kinase inhibitors and monoclonal antibodiesNilesh Kucha
Tyrosine kinases are enzymes that help transfer phosphate groups and play a role in cell signaling. There are two types: receptor tyrosine kinases which are transmembrane proteins, and non-receptor tyrosine kinases which act as intracellular signal transducers. When tyrosine kinases are mutated or overexpressed, they can lead to uncontrolled cell growth and survival contributing to cancer. Tyrosine kinase inhibitors are small molecule drugs that target the intracellular tyrosine kinase domain to inhibit phosphorylation and downstream signaling, thereby inhibiting cancer cell growth and survival. Examples of tyrosine kinase inhibitors discussed in the document include imatinib, gefitinib, lapatinib, crizotinib, sorafenib, sunitin
The document discusses various classes of anticancer drugs including cytotoxic drugs derived from natural sources like plants and microbes. It focuses on the mechanisms of action and classification of antitumor antibiotic drugs derived from Streptomyces bacteria. Specifically, it describes the structures, mechanisms involving DNA intercalation and inhibition of topoisomerases, and clinical uses of important anthracycline antibiotics like doxorubicin, daunorubicin and actinomycin antibiotics like dactinomycin and mitomycin C.
This document summarizes key information about alkylating agents, a class of anticancer drugs. It describes their mechanisms of action involving alkylation of DNA, which interferes with its integrity and functions. Specific agents discussed include nitrogen mustards, nitrosoureas, triazines, and others. Toxicities involving bone marrow suppression and effects on other rapidly dividing tissues are also summarized. Pharmacological properties, indications, and dosing schedules are provided for several common alkylating agents including cyclophosphamide, ifosfamide, chlorambucil, melphalan, busulfan, dacarbazine, temozolamide, and procarbazine.
This document classifies and describes various anticancer drugs, including cytotoxic drugs like alkylating agents, platinum coordination drugs like cisplatin, antimetabolites, microtubule damaging agents like vincristine and vinblastine, topoisomerase inhibitors, antibiotics, targeted drugs, hormonal drugs, and miscellaneous drugs. It provides details on the mechanisms of action, uses, doses, and common side effects of representative drugs from each class, such as how cisplatin causes DNA cross-linking, how vinca alkaloids inhibit microtubule assembly, and how paclitaxel and docetaxel inhibit beta-tubulin.
This document discusses various types of anti-cancer drugs and their mechanisms of action. It describes six main categories: alkylating agents, antimetabolites, cytotoxic antibiotics, plant derivatives, hormones, and monoclonal antibodies. Alkylating agents form cross-links with DNA. Antimetabolites block metabolic pathways involved in DNA synthesis. Cytotoxic antibiotics directly damage DNA through intercalation or inhibiting topoisomerase enzymes. Plant derivatives like vinca alkaloids and taxanes inhibit microtubule formation. Hormones inhibit hormone-dependent tumor growth. Monoclonal antibodies target specific proteins on cancer cells to induce immune-mediated killing or inhibit growth factor receptors.
The document discusses various classes of antineoplastic agents (cancer drugs) including their mechanisms of action and clinical applications. It describes how alkylating agents like cyclophosphamide work by alkylating DNA, which can cause cross-linking and inhibit DNA synthesis and function. Antimetabolites like methotrexate inhibit key enzymes involved in DNA synthesis. The document provides examples of several alkylating agents and antimetabolites, and discusses their mechanisms of action, common uses in treating different cancer types, typical administration routes, and common side effects.
The document discusses various types of antineoplastic agents (anticancer drugs) that are used to treat cancer. It describes how the drugs work, their classifications, mechanisms of action, examples of drugs within each class, dosages and side effects. The classes discussed include alkylating agents, antimetabolites, vinka alkaloids, taxanes, epipodophyllotoxins, antibiotics, and miscellaneous cytotoxic drugs.
Brief review of renal failure with chemotherapeutic agentsKasarla Dr Ramesh
Chemotherapy drugs can damage the kidneys through various mechanisms. Cisplatin is one of the most nephrotoxic drugs that directly injures the proximal tubules. Symptoms of kidney damage include decreased urine output and blood in the urine. Kidney function is assessed through blood tests of creatinine and BUN. Prevention strategies for cisplatin nephrotoxicity include IV fluids, sodium thiosulfate, and dose modifications based on glomerular filtration rate. Methotrexate requires monitoring and urine alkalinization due to precipitation in acidic urine causing tubular injury. Gemcitabine can cause thrombotic microangiopathy requiring dose reductions with glomerular filtration rate below 30 mL/
This document summarizes several alkylating agents used in chemotherapy. Alkylating agents work by alkylating DNA and RNA, which can cause DNA breaks or abnormal sequences and damage cells' ability to replicate. Common side effects include myelosuppression, nausea/vomiting, and alopecia. Specific agents discussed include cyclophosphamide, ifosfamide, melphalan, busulfan, carmustine, lomustine, procarbazine, dacarbazine, streptozocin, bendamustine, altretamine, and chlorambucil. Each has unique indications and toxicity profiles involving bone marrow suppression, gastrointestinal upset, organ toxicity, secondary cancers, and more.
This document summarizes information about anthracyclines, a class of chemotherapy drugs that includes daunorubicin, doxorubicin, epirubicin, and idarubicin. It discusses their development, mechanisms of action including DNA intercalation and topoisomerase II inhibition, clinical uses, dosing, side effects with a focus on cardiotoxicity, and risk factors for cardiotoxicity. The document provides detailed information on the structures, properties, and clinical applications of various anthracycline drugs.
This document summarizes various alkylating agents and antimetabolites used in cancer chemotherapy. It discusses the history and mechanisms of alkylating agents such as nitrogen mustards, nitrosoureas, triazines, and platinum compounds. It provides details on specific alkylating agents including their mechanisms of action, uses, dosages, and adverse effects. The summary highlights the development of nitrogen mustard as the first alkylating agent to treat cancer and the discovery of platinum-based drugs like cisplatin through serendipity.
Alkylating agents and antimetabolites are two classes of chemotherapy drugs. Alkylating agents work by binding to DNA and RNA, causing crosslinking or breaks that prevent replication. The main types are nitrogen mustards, alkyl sulphonates, nitrosoureas, and thiazines. Antimetabolites mimic normal metabolites and inhibit DNA or RNA synthesis by becoming incorporated. Major types are folate antagonists like methotrexate, pyrimidine analogs like 5-fluorouracil, and purine analogs like mercaptopurine. Both classes cause bone marrow suppression and gastrointestinal toxicity, and resistance can develop through drug inactivation or changes to drug targets.
The document discusses the mechanism of action, resistance mechanisms, and adverse effects of alkylating agents and anti-metabolites. Alkylating agents work by transferring alkyl groups to biologically important molecules like DNA, RNA, and proteins. This impairs cell function and can cause cross-linking of DNA. Anti-metabolites inhibit key enzymes in folate and purine synthesis pathways, interfering with DNA, RNA, and protein production. Both classes of drugs can cause myelosuppression and gastrointestinal toxicity as main adverse effects. Resistance can develop through increased DNA repair, reduced drug uptake, or alterations in target enzymes.
This document discusses opioid receptors and their effects when activated, including opening potassium channels, closing calcium channels, and reducing neurotransmitter release. It then describes various opioid analgesics that are μ receptor agonists like morphine, methadone, fentanyl, and heroin. The document also discusses the organ system effects of full opioid agonists such as analgesia, euphoria, sedation, respiratory depression, and others. Codeine and buprenorphine are also described.
This document provides an overview of anticancer drugs, including their classification, mechanisms of action, and examples. It discusses 10 main classes of anticancer drugs: alkylating agents, platinum coordination complexes, antimetabolites, microtubule damaging agents, topoisomerase inhibitors, antibiotics, miscellaneous cytotoxic drugs, targeted drugs, and hormonal drugs. For each drug class and some examples, it describes indications, dosages, and mechanisms of inhibiting cancer cell growth and proliferation. The document concludes with nursing responsibilities in administering these drugs and educating patients.
The document discusses various types of anticancer drugs including alkylating agents like cisplatin and cyclophosphamide, antimetabolites like methotrexate and 5-fluorouracil, and targeted drugs. It describes their mechanisms of action, toxicities, and common uses in treating cancers like breast cancer, leukemia, lymphoma, and others. The goal of cancer chemotherapy is to cure cancer when possible or induce remission, but the drugs can also be used for palliation to reduce tumor size and prolong life when the cancer is not curable.
This document describes alkylating agents, a class of chemotherapy drugs that work by alkylating DNA and proteins. It discusses their mechanism of action, including how they crosslink DNA and cause DNA damage, leading to cell death. It also covers resistance mechanisms, adverse effects like bone marrow toxicity and nausea/vomiting, and important alkylating agents like cisplatin, carboplatin, oxaliplatin, cyclophosphamide, and carmustine. For each drug, it provides absorption, indications, dosage ranges, and special considerations.
This document summarizes a seminar presentation on antineoplastic agents. It defines antineoplastic agents as those used to prevent abnormal or uncontrolled cell growth, also known as anticancer agents. The document classifies antineoplastic agents into seven categories - alkylating agents, antimetabolites, plant products, antibiotics, hormones, immunotherapy agents, and miscellaneous agents. For each category, examples are provided and brief descriptions of mechanisms of action and uses. Syntheses of cyclophosphamide and chlorambucil are also outlined.
This document discusses various aspects of anticancer drugs and chemotherapy, including:
1. Types of chemotherapy drugs like alkylating agents, antimetabolites, antibiotics, and their mechanisms of action and cell cycle effects.
2. Goals and principles of cancer therapy like cure, remission, combination chemotherapy, and developing resistance.
3. Toxicities of chemotherapy drugs and methods to counter them, like growth factors and protective agents.
4. Targeted therapies like monoclonal antibodies and tyrosine kinase inhibitors used to treat specific cancers.
Antineoplastic agents can be classified as cytotoxic drugs, hormones, or miscellaneous agents. Cytotoxic drugs include alkylating agents, antimetabolites, plant derivatives, and antibiotics. They work by directly damaging DNA or interfering with cell division and metabolism. Combination therapy is more effective than single agents to increase response rates and decrease resistance development.
Recent advances in cancer treatment include new drug carrier systems and nanotechnology to more precisely target cancer cells. New drug carrier systems such as polymer drug conjugates, cyclodextrins, and self-emulsifying drug delivery formulations aim to enhance drug delivery to tumors while avoiding healthy tissues to reduce side effects. Nanotechnology uses carbon nanotubes and nanoparticles to transport drugs across biological barriers and directly into cancer cells. Additionally, newer cancer vaccines using antigens, dendritic cells, and DNA aim to stimulate the immune system to recognize and destroy cancerous cells.
Chapter 24.1 kinase inhibitors and monoclonal antibodiesNilesh Kucha
Tyrosine kinases are enzymes that help transfer phosphate groups and play a role in cell signaling. There are two types: receptor tyrosine kinases which are transmembrane proteins, and non-receptor tyrosine kinases which act as intracellular signal transducers. When tyrosine kinases are mutated or overexpressed, they can lead to uncontrolled cell growth and survival contributing to cancer. Tyrosine kinase inhibitors are small molecule drugs that target the intracellular tyrosine kinase domain to inhibit phosphorylation and downstream signaling, thereby inhibiting cancer cell growth and survival. Examples of tyrosine kinase inhibitors discussed in the document include imatinib, gefitinib, lapatinib, crizotinib, sorafenib, sunitin
The document discusses various classes of anticancer drugs including cytotoxic drugs derived from natural sources like plants and microbes. It focuses on the mechanisms of action and classification of antitumor antibiotic drugs derived from Streptomyces bacteria. Specifically, it describes the structures, mechanisms involving DNA intercalation and inhibition of topoisomerases, and clinical uses of important anthracycline antibiotics like doxorubicin, daunorubicin and actinomycin antibiotics like dactinomycin and mitomycin C.
This document summarizes key information about alkylating agents, a class of anticancer drugs. It describes their mechanisms of action involving alkylation of DNA, which interferes with its integrity and functions. Specific agents discussed include nitrogen mustards, nitrosoureas, triazines, and others. Toxicities involving bone marrow suppression and effects on other rapidly dividing tissues are also summarized. Pharmacological properties, indications, and dosing schedules are provided for several common alkylating agents including cyclophosphamide, ifosfamide, chlorambucil, melphalan, busulfan, dacarbazine, temozolamide, and procarbazine.
This document classifies and describes various anticancer drugs, including cytotoxic drugs like alkylating agents, platinum coordination drugs like cisplatin, antimetabolites, microtubule damaging agents like vincristine and vinblastine, topoisomerase inhibitors, antibiotics, targeted drugs, hormonal drugs, and miscellaneous drugs. It provides details on the mechanisms of action, uses, doses, and common side effects of representative drugs from each class, such as how cisplatin causes DNA cross-linking, how vinca alkaloids inhibit microtubule assembly, and how paclitaxel and docetaxel inhibit beta-tubulin.
This document discusses various types of anti-cancer drugs and their mechanisms of action. It describes six main categories: alkylating agents, antimetabolites, cytotoxic antibiotics, plant derivatives, hormones, and monoclonal antibodies. Alkylating agents form cross-links with DNA. Antimetabolites block metabolic pathways involved in DNA synthesis. Cytotoxic antibiotics directly damage DNA through intercalation or inhibiting topoisomerase enzymes. Plant derivatives like vinca alkaloids and taxanes inhibit microtubule formation. Hormones inhibit hormone-dependent tumor growth. Monoclonal antibodies target specific proteins on cancer cells to induce immune-mediated killing or inhibit growth factor receptors.
The document discusses various classes of antineoplastic agents (cancer drugs) including their mechanisms of action and clinical applications. It describes how alkylating agents like cyclophosphamide work by alkylating DNA, which can cause cross-linking and inhibit DNA synthesis and function. Antimetabolites like methotrexate inhibit key enzymes involved in DNA synthesis. The document provides examples of several alkylating agents and antimetabolites, and discusses their mechanisms of action, common uses in treating different cancer types, typical administration routes, and common side effects.
The document discusses various types of antineoplastic agents (anticancer drugs) that are used to treat cancer. It describes how the drugs work, their classifications, mechanisms of action, examples of drugs within each class, dosages and side effects. The classes discussed include alkylating agents, antimetabolites, vinka alkaloids, taxanes, epipodophyllotoxins, antibiotics, and miscellaneous cytotoxic drugs.
Brief review of renal failure with chemotherapeutic agentsKasarla Dr Ramesh
Chemotherapy drugs can damage the kidneys through various mechanisms. Cisplatin is one of the most nephrotoxic drugs that directly injures the proximal tubules. Symptoms of kidney damage include decreased urine output and blood in the urine. Kidney function is assessed through blood tests of creatinine and BUN. Prevention strategies for cisplatin nephrotoxicity include IV fluids, sodium thiosulfate, and dose modifications based on glomerular filtration rate. Methotrexate requires monitoring and urine alkalinization due to precipitation in acidic urine causing tubular injury. Gemcitabine can cause thrombotic microangiopathy requiring dose reductions with glomerular filtration rate below 30 mL/
Define cancer and Describe cell cycle.
Able to demonstrate the risk factor, character , diagnosis and treatment of cancer
Able to understand the warning signs of cancer.
List the anti cancer drug classification.
Able to demonstrate the mechanism of cancer drugs.
Describe the toxic effects of anti cancer drugs.
Cancer is the rapid creation of abnormal cells that grow beyond their usual boundaries, and which can then invade adjoining parts of the body and spread to other organs. This process is referred to as metastasis. Metastases are the major cause of death from cancer. (WHO)
Cancer known medically as a malignant neoplasm, is a broad group of diseases involving unregulated cell growth.
In cancer, cellsdivide and grow uncontrollably, forming malignant tumors, and invading nearby parts of the body.
The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream.
Not all tumors are cancerous; benign tumors do not invade neighboring tissues and do not spread throughout the body.
There are over 200 different known cancers that affect humans.
This document discusses various chemotherapeutic agents used in ENT. It describes the different phases of chemotherapeutic trials and principles of chemotherapy. It discusses single agent versus multidrug combination therapy and covers cell cycle concepts. It then details specific chemotherapeutic drugs like alkylating agents, antimetabolites, cytotoxic antibiotics, antimitotic plant products, and targeted therapies. It addresses limitations of cytotoxic agents in not being cancer-cell specific.
Cancer is caused by uncontrolled cell growth and can spread through the body. Risk factors include tobacco, sunlight, viruses, and family history. Diagnosis involves biopsy and imaging tests while treatment aims to cure, palliate, or induce remission through surgery, radiation, chemotherapy, and targeted therapy. Chemotherapy drugs work by various mechanisms including alkylating DNA, blocking DNA synthesis, and affecting microtubule function. Major classes include alkylating agents, antimetabolites, antitumor antibiotics, plant alkaloids, and miscellaneous cytotoxic drugs. Combination regimens and consideration of each drug's cell cycle specificity can improve outcomes.
This document discusses chemotherapy and neoplastic drugs. It begins by defining neoplasms and tumors, describing benign and malignant tumors. It then covers cancer characteristics and classifications such as carcinoma, sarcoma, lymphoma, and leukemia. The document discusses genetic and environmental causes of cancer. Methods of cancer diagnosis and various treatment approaches are outlined, including surgery, chemotherapy, radiation therapy, and palliative care. Common chemotherapeutic drug classes like alkylating agents, antimetabolites, plant alkaloids, and their mechanisms and uses are also summarized.
This document discusses anticancer drugs, also known as chemotherapy drugs. It describes the main classes of anticancer drugs, including alkylating agents, antimetabolites, cytotoxic antibiotics, hormones, and enzymes. Alkylating agents work by alkylating DNA and inhibiting its replication. Common alkylating agents include cyclophosphamide and cisplatin. Antimetabolites are structurally similar to essential metabolites and interfere with DNA synthesis, examples include methotrexate and fluorouracil. Cytotoxic antibiotics like doxorubicin act directly on DNA. The document also covers the mechanisms of action, clinical uses, and side effects of several important chemotherapy drugs.
The document discusses anti-cancer drugs and their classification. It begins by providing background on cancer and its treatment, including surgery, radiotherapy, and chemotherapy. It then discusses the classification of anti-cancer drugs according to their chemical structure, mechanism of action, and cell cycle specificity. Examples are given of commonly used anti-cancer drugs like alkylating agents, antimetabolites, antibiotics, and hormones. The steps of developing new anti-cancer drugs from non-clinical research to clinical trials are also summarized.
This document provides an overview of anticancer drugs and chemotherapy. It discusses the general approach to cancer therapy, including killing cancer cells and modifying their growth. The main modalities of cancer treatment are described as chemotherapy, surgery, and radiation. The goals of chemotherapy are cure, prolonged remission, or palliation. Common anticancer drug classes are also summarized, including their mechanisms of action, examples, and toxicities.
Malignant disease accounts for many deaths in industrialized countries. Cancer occurs when normal cells are transformed into abnormal cells through genetic alterations. Chemotherapy aims to palliate symptoms, induce remission, or cure cancer by destroying cancer cells. The document discusses the classification, mechanisms of action, indications, and side effects of various classes of anticancer drugs including alkylating agents, antimetabolites, and antibiotics. It also outlines the multi-phase process of clinical trials required to approve new anticancer drugs.
1) The patient is a 45-year-old woman who presented with a wound on her left breast that had been present for over 2 years. Physical examination found lymphadenopathy in her left axilla and groin.
2) Investigations including blood tests and biopsy revealed metastatic triple negative breast cancer that had spread to other organs.
3) Her treatment plan involved a total mastectomy in July 2022 followed by chemotherapy. She received her first chemotherapy of FEC in August 2022 but unfortunately passed away in November 2022.
Malignant diseases account for many deaths in developed countries. Cancer chemotherapy aims to palliate symptoms, induce remission, and possibly cure. There are several classes of anticancer drugs including alkylating agents, antimetabolites, and antibiotics. Alkylating agents like cyclophosphamide work by alkylating DNA and inhibiting cell replication. Antimetabolites like fluorouracil interfere with DNA synthesis by blocking thymidylate synthetase. New drugs undergo long testing including pre-clinical and four phases of clinical trials to evaluate safety, efficacy, and appropriate dosage before approval.
This document discusses anti-protozoal agents used to treat various protozoal infections. It begins by listing important protozoal infections and their causative organisms. It then describes the drugs used to treat each infection, including nitroimidazoles, amphotericin B, eflornithine, iodoquinol, melarsoprol, miltefosine, nifurtimox, benznidazole, and nitazoxanide. It provides details on the mechanisms of action, pharmacokinetics, therapeutic uses and dosages, toxicities, and side effects of these individual agents.
This document discusses the classification and mechanisms of action of various anti-cancer drugs. It categorizes drugs according to their cell cycle specificity, biochemical mechanism, and chemical structure. It provides examples of drugs that are cell cycle nonspecific and cell cycle specific. It also describes the mechanisms and examples of alkylating agents, antimetabolites, antimicrotubule agents, anticancer antibiotics, hormonal agents, and topoisomerase inhibitors. Common toxicities of different drug classes are mentioned.
This document discusses various classes of chemotherapy drugs used to treat cancer. It provides details on mechanisms of action, pharmacokinetics, clinical uses, and adverse effects for several alkylating agents, antimetabolites, plant alkaloids, antibiotics, hormones, targeted therapies, and other miscellaneous agents. The key classes covered are alkylating agents, antimetabolites, plant-derived products, and hormonal agents. Adverse effects including bone marrow suppression and nausea are common across many of the drug classes.
This document summarizes several clinical trials focusing on cancer drugs. It discusses MEDI4736 from AstraZeneca for non-small cell lung cancer, ABRAXANE from Celgene for squamous cell lung cancer, Pertuzumab from Roche for HER2-positive breast cancer, and Doxorubicin plus Olaratumab from Eli Lilly for soft tissue sarcoma. It provides details on the companies, drugs, mechanisms, studies and adverse events. The document also reviews combination therapies using these drugs and their targets including PD-L1, HER2, PDGFRα and mechanisms of action.
Overview and classification of chemotherapeutic agents and theorySaurabh Gupta
This document provides an overview of chemotherapy. It discusses key figures in the development of chemotherapy like Paul Ehrlich and Sidney Farber. It describes different classes of chemotherapeutic agents including alkylating agents, antimetabolites, antitubulins, topoisomerase inhibitors, antibiotics, and their mechanisms and uses for treating various cancers. Side effects of different drug classes are also outlined.
This document discusses anticancer drugs and their classification and mechanisms of action. It provides details on several common cytotoxic drugs including alkylating agents like cyclophosphamide and ifosfamide; antimetabolites like methotrexate; cytotoxic antibiotics like doxorubicin; and plant derivatives like vincristine. It describes the mechanisms of these drug classes and highlights specific drugs, their indications, dosages, and common toxicities. The document provides an overview of the general approach to cancer management and use of chemotherapy.
1. The document discusses chemotherapy agents commonly used in breast cancer, including their mechanisms of action, dosages, and side effects. Alkylating agents like cyclophosphamide and antimetabolites like methotrexate are covered. Anthracycline antibiotics doxorubicin and epirubicin are also summarized. The document provides details on each drug to inform safe and effective use in breast cancer treatment.
This document summarizes information about anticancer agents and their classification. It discusses various alkylating agents like nitrogen mustards, nitrosoureas, and alkyl sulfonates. It also covers antimetabolites such as fluorouracil, mercaptopurine, and methotrexate. The document provides information on the mechanisms of action, synthesis, adverse effects and uses of these anticancer drugs for treating different types of cancer.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Patient compliance with medical adviceRavish Yadav
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
This document defines osmosis and osmotic pressure, and describes how osmotic systems utilize these principles for controlled drug delivery. It discusses the basic components of osmotic systems, including drugs, osmotic agents, semi-permeable membranes, and plasticizers. It also describes various types of osmotic systems for both oral and implantable drug delivery, including elementary osmotic pumps, push-pull osmotic pumps, and implantable mini-osmotic pumps. The document provides equations to describe drug release from these systems driven by osmotic pressure.
The document discusses opioid analgesics and their mechanisms of action. It notes that the body has an endogenous analgesic system centered in the brainstem that is stimulated by opioids. Opioids work by binding to mu, delta, and kappa receptors in the brain and spinal cord, inhibiting pain signal transmission. Several opioid analgesics are described, including morphine, codeine, heroin, fentanyl, and methadone. Tolerance, side effects, metabolism, and antagonists are also discussed. The future of opioid analgesics is seen to involve further study of the kappa receptor and endogenous opioid peptides to develop safer drugs.
Infrared spectrum / infrared frequency and hydrocarbonsRavish Yadav
This document provides information about infrared (IR) spectroscopy and analyzing IR spectra of different functional groups. It discusses:
1. The conditions required for IR absorption and the division of the IR spectrum into the functional group and fingerprint regions.
2. The characteristic IR absorptions of common functional groups like alkanes, alkenes, alkynes, alcohols, phenols, ethers, aldehydes, ketones, carboxylic acids, esters, amides, amines, and aromatics. Specific examples and their spectra are provided.
3. Factors that affect IR frequencies, such as bond strength, mass of atoms, resonance, conjugation, and hydrogen bonding.
Neurotransmitters are endogenous chemicals that transmit signals between neurons. The major categories are small-molecule neurotransmitters like acetylcholine and amino acids, and large peptides. They act on ligand-gated ion channels or G protein-coupled receptors. After release, they are typically removed from the synapse by reuptake back into the presynaptic neuron or breakdown by enzymes. Examples include acetylcholine, which activates nicotinic and muscarinic receptors, and glutamate, the main excitatory neurotransmitter in the brain. GABA is the primary inhibitory neurotransmitter and binds GABAA/B/C receptors. Neuropeptides are longer amino acid chains that modulate synaptic transmission.
Narcotic drugs and psychotropic substances act, 1985Ravish Yadav
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Medicinal and toilet preparations (excise duties) act, 1995 and rules, 1956Ravish Yadav
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Lipids can be classified by their structure as simple lipids like fats and oils or complex lipids like phospholipids. They can also be classified based on whether they undergo hydrolysis in alkaline solutions. Lipids are made up of fatty acids and glycerol, forming triglycerides. Fats are usually saturated while oils contain some unsaturated fatty acids. Waxes differ from fats and oils in that they are esters of long-chain alcohols and fatty acids with higher melting points. Lipids serve important functions and have many applications, such as in soaps, foods, and cosmetics.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The document summarizes the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle or citric acid cycle. It discusses that the TCA cycle involves the oxidation of acetyl-CoA to carbon dioxide and water and is the final common pathway for carbohydrates, fats, and amino acids. The cycle occurs in the mitochondrial matrix and generates energy in the form of NADH and FADH2 that are used in the electron transport chain to produce ATP. Key enzymes and reactions in the cycle are described, including the generation of citrate, isocitrate, alpha-ketoglutarate, succinyl-CoA, fumarate, oxaloacetate
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Anti mycobacterial drugs (tuberculosis drugs)Ravish Yadav
This document discusses anti-mycobacterial drugs used to treat tuberculosis. It begins by describing tuberculosis and how it is caused by the bacterium Mycobacterium tuberculosis. First-line drugs to treat tuberculosis are listed as isoniazid, rifampin, pyrazinamide, ethambutol, and streptomycin. Each drug's mechanism of action and potential resistance issues are then explained individually. Second-line drugs discussed include ethionamide, capreomycin, cycloserine, aminosalicylic acid, and fluoroquinolones. Common adverse drug reactions are also outlined.
This document provides information on various anti-malarial agents. It discusses the life cycle of Plasmodium parasites and the four species that cause malaria in humans. It then describes various classes of anti-malarial drugs including those derived from natural sources like cinchona alkaloids and artemisinin, as well as synthetic agents like chloroquine, primaquine, mefloquine, and antifolate drugs. For each class, it provides details on examples, mechanisms of action, structure-activity relationships, resistance issues, and pharmacological properties. The document aims to comprehensively cover the major therapeutic options available to treat malaria.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
How to Fix the Import Error in the Odoo 17Celine George
An import error occurs when a program fails to import a module or library, disrupting its execution. In languages like Python, this issue arises when the specified module cannot be found or accessed, hindering the program's functionality. Resolving import errors is crucial for maintaining smooth software operation and uninterrupted development processes.
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
This presentation includes basic of PCOS their pathology and treatment and also Ayurveda correlation of PCOS and Ayurvedic line of treatment mentioned in classics.
The simplified electron and muon model, Oscillating Spacetime: The Foundation...RitikBhardwaj56
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
2. A=Anticancer drugs cause
N=Nausea and vomiting
T=Treatment regimen must be followed
I=Individualized dosage
N=New drugs appear on the market
E=Exposure time kept to a minimum
O=Only a physician can administer
P=Protect yourself
L=Look, listen, and learn
A=Assessment of laboratory tests
S=Safe dosage based on weight
T=Toxicities
I=Inform patients
C=Classification of agents
3. Neoplasm
It is an abnormal mass of tissue as a result of Neoplasia
(Neoplasia (new growth in Greek) is the abnormal proliferation of cells)
Classification of Neoplasm
Benign
Potentially malignant
Malignant
4. Warning Signs of Neoplasm
Changes in bowel or bladder habits
A sore (swelling/ inflammation) that will not
heal
Unusual bleeding, discharge
Thickening or lump in breast or elsewhere
Indigestion, difficulty swallowing
Obvious change in wart or mole
Nagging cough, hoarseness
5. Antineoplastic Agent
• Don’t kill tumor cells directly; interrupt development, growth, spread of
abnormal cells
•Normal Healthy cells
•Interfere with cell replication
•Antimetabolites interfere with DNA synthesis
7. According to Drug Acting Directly on Cells
Alkylating agent
•Nitrogen Mustard
e.g. : Mechlorethamine (Mustine HCL), Chlorambucil,
Cyclophosphamide, Ifosfamide, Melphalan
•Alkyl Sulphonate
e.g. : Busulfan,
•Nitrosourea
e.g. : Carmustine, Lomustine, streptozocine
•Triazine
e.g. : Dacarbazine, procarbazine
timozolomide
10. Drug Altering Hormonal milieu
•Glucocorticoids
e.g. : Prednisolone & Its Derivatives
•Estrogen
e.g.: Fosfestrol, Ethinylestradiol
•Antiestrogen
e.g.: Tomoxifen
•Antiandrogen
e.g.: Flutamide
•5 reductase inhibitor
e.g.: Finasteride
•GnRH analogues
e.g.: Naferelin, Goserelin
11. according to mechanism of action
• Drugs affecting biosynthesis of nucleic acid
• Drugs destroying DNA structure and function
• Drugs interfering with transcription (DNA is
copied into RNA) and blocking
RNA synthesis
• Drugs affecting protein synthesis
• Hormonal agents
12. Drug Affecting Nucleic Acid Synthesis
Hydroxyurea
Drug Destroying DNA Structure & its Function
Antitumor Antibiotics
Cisplatin & carboplantin
Alkylating Agent
Camptothecins
13. Drugs interfering with transcription
Dactinomycin
Doxorubicin
Daunorubicin
Drugs
affecting
protein
synthesis
L - Asparaginase
Podophyllotoxin : Teniposide &
Etoposide
Taxanes : Taxol & Taxotere
Vincristine & Vinblastin
14. Alkylating agents
HN
N N
N
R
O
H2N
Guanine in DNA
R-X HN
N N
N
R
O
H2N
R
HN
N N
N
R
O
H2N
R
HN
N N
N
R
O
H2N
R
Produce Highly reactive carbonium Ion
which transfer alkyl group to position 7
of guanine by the covalent bond.
16. •The estrogen analogue estramustine phosphate
used in prostate cancer and also as powerful
vesicant (irritant).
•It also helps to cure lymphoid malignancies
such as Hodgkin’s disease, lymphosarcoma (a
malignant tumor of connective or other non-
epithelial tissue.), chronic myelocytic leukemia,
polycythemia vera (disorders of the bone
marrow) and bronchogenic carcinoma.
USES
17. • IUPAC: N,N-Bis (2-chloroethyl) tetrahydro-2H-
1,1,2,2-oxazophosphorin-2-amine-2-oxide
•It is inactive & producing active metabolite.
It has prominent immunosuppressant
property.
•Dose: Oral - 2-3 mg/kg/day, i.v. – every 10-
15 mg/kg, i.m. – 7-10 mg/kg/day
•Branded Name: Endoxan, Cycloxan
CYCLOPHOSPHAMIDE
Structure:
18. USES
•In Chemotherapy to suppress immune
response
•lymphoma, multiple myeloma
•Leukemia, ovarian cancer
•Breast cancer
•Small cell lung cancer
•Neuroblastoma
•Sarcoma
22. Mechanism:
It interfere with DNA replication and damaging the DNA in a cell.
The DNA damage induces cell cycle arrest and cellular apoptosis
via the accumulation of cytosolic p53 and subsequent activation of
Bax, an apoptosis (cell death)promoter.
Chlorambucil alkylates and cross-links DNA during all phases of
the cell cycle, inducing DNA damage via three different methods of
covalent adduct generation with double-helical DNA.
Attachment of alkyl groups to DNA bases, resulting in the DNA
being fragmented by repair enzymes in their attempts to replace the
alkylated bases, preventing DNA synthesis and RNA transcription
from the affected DNA.
DNA damage via the formation of cross-links which prevents DNA
from being separated for synthesis or transcription.
Induction of mispairing of the nucleotides leading to mutations.
23. Side Effects
•Nausea and vomiting.
•Skin rash
•Increases in blood tests measuring liver function.
•Increased risk of developing a secondary malignancy
such as an acute leukemia, with long-term use of this
drug.
•Your fertility, meaning your ability to conceive or
father a child, may be affected by chlorambucil.
•Pulmonary toxicity (damage to the lungs) for long
term exposure
28. Pyrimidine antagonists
Fluorouracil (5-Fu)
Mechanism: convert to 5F-dUMP and inhibit thynidylate
synthase,block the synthesis of dTMP
Clinical uses: good effect on cancer of digestive tract, breast
cancer
Toxicity : myelosuppression and mucositis
Dose: 1 gm orally on alternative days.
Branded Name: Fluracil, five fluro250 mg cap, 5 ml for i.v. inj.
Cytarabine (Ara-C )
Ara-C →Ara-CMP →→Ara-CTP, competitively inhibit DNA
polymerase. The triphosphate of Cytarabine is an inhibitor of
DNA polymerase.
Clinical uses: acute granulocytic leukemia, mononuclearcyte
leukemia
Toxicity: severe myelosuppression , nausea etc
Dose: 1.5-3 mg/kg i.v. BD for 5-10 days
Branded Name: Cytarabine, cytosar & cytabin 100, 500, 1000 mg
inj.
29. Vinka Alkaloids
Mechanism of action
Bind specifically to the micro tubular protein
tubulin in dimeric form, terminate assembly of
microtubules and result in mitotic arrest at
metaphase, cause dissolution of the mitotic
spindle and finally interfere with chromosome
segregation
31. Taxanes
Paclitaxal
•Mechanism: Enhance tubulin polymerization and
promote microtubule assembly
•Clinical uses: First choice for ovarian and advanced
breast cancer
• Toxicity : Hypersensitivity, Peripheral neuropathy,
Neutropenia , thrombocytopenia
•Dose: 175 mg by i.v. infusion over 3 hr, repeated every
3 weeks.
•Branded Name: Intaxel, paxtal 30 mg in 5 ml cremophor
emulsion.
Docetaxel:
•More potent then Paclitaxel
•Use: breast & ovarian cancer. Also in gastric & head,
neck carcinoma.
•Dose: 100 mg i.v over 1 hr repeat at 3 weeks
•Branded Name: Daxotel 20 mg, 80 mg inj.
32. Epipodophyllotoxin
Etoposide:
Semi synthetic derivative of podophyllotoxin. It arrest the
cells in G2 phase & cause the DNA breaks by affecting the
DNA topoisomerase II function .
Use: testicular tumor, lung cancer, Hodgkin's disease.
Dose: 50-100 mg /day oral for 5 days.
Branded Name: Peltasol 100 mg in 5 ml inj.
33. Camptothecin Analogues
Topotecan & Irinotecan are two semi synthetic analogues of
Camptothecin. They act similar as Etoposide but interact with
different enzyme topoisomerase I .
Topotecan:
Use: In metastatic carcinoma of ovary & small cell lung
cancer.
AE: pain abdomen, vomiting & diarrhea
Dose: 1.5 mg i.v. over 30 min daily for 5 days.
Branded Name : Topotel 2.5 mg & 4.0 mg inj
Irinotecan:
It produces the cholinergic effects because it inhibit the
AChE.
Use : Colorectal carcinoma, cancer lung/cervix/ovary
AE: body ach, weakness.
Dose: 125 mg i.v. over 90 min weekly for 4 weeks
Branded Name: Irinotel 40 mg, 100 mg inj.
34. Antibiotics
Dactinomycin
• Mechanism: bind tightly to double-stranded DNA
through interaction between adjacent guanine-cytosine
base pair, and inhibit all forms of DNA-dependent
RNA synthesis
• Clinical uses: narrow-spectrum
In combination with surgery and Vincristine in the
adjuvant treatment of Wilm’s tumor
• Toxicity : evident myelosuppression
• Dose: 15 g/kg i.v. daily for 5 days.
• Branded Name: 0.5 mg/vial inj.
35. Doxorubicin & Daunorubicin:
• Mechanism : Bind with high affinity to DNA through
intercalation and then block the synthesis of DNA and
RNA
• Clinical uses
ADM: one of the most important anticancer drugs ,
treatment of carcinoma of the breast, endometrium,
ovary, testicle, thyroid, lung and many sarcoma,
acute leukemia, Hodgkin’s disease
Daunorubicin: acute leukemia
• Dose: Doxorubicin 60-75 mg slow i.v. inj. every 3 weeks.
• Daunorubicin: 30-60 mg daily for 3 days repeat weekly.
• Branded Name: Daunocin 20 mg/vial inj
• Adrimycin Doxorubicin Oncodria 10 mg, 50 mg per vial
inj.
Mitoxantrone :
• It is a analogue of doxorubicin
• Use : chronic myelogenous leukemia, non Hodgkin’s
lymphoma & carcinoma breast.
• Branded Name: 20 mg / 10 ml inj.
36. Bleomycin:
• It is mixture of glycopeptides antibiotics having anti tumor
activity.
• Dose: 30 mg twice weekly i.v./i.m.
• Branded Name: Bleocin, Oncobleo 15 mg inj.
Mitomycin:
• Use: In resistant cancer of stomach, cervix, colon, rectum,
bladder etc.
• Dose: 10 mg infused i.v. in one day.
• Branded name: Mytomycin C-2 10 mg inj.
37. Miscellaneous Cytotoxic Drugs
Hydroxyurea
Inhibit ribonucleotide reductase
Clinical uses: chronic granulocytic leukemia
Toxicity: bone marrow depression, nausea, vomiting
Dose: 20-30 mg/kg daily or 80 ml i.v. inj.
Branded Name: Cytodrox 500 mg cap.
Procarbazine:
Inhibit nucleic acid synthesis & cause chromosomal damage.
Use : Oat cell carcinoma of lung.
Dose: 100-300 mg oral daily, maintenance dose 1-2
mg/kg/day
L- Asparaginase
it inhibit the synthesis of L- Asparagines to L-aspartic acid
which cause the cell death.
AE: Liver damage, pancreatitis & CNS symptoms (due to
protein synthesis)
Dose: 50-200 KU/kg i.v. daily for 2-4 weeks
Branded Name: Leunase 10,000 KU per vial inj.
38. Cisplatin & Carboplatin
• Clinical uses:
• Genitourinary cancers, particular ovarian and bladder cancer
• Testicular cancer: in combination with Vinblastin and
Bleomycin
• Toxicity
• Acute toxicity: nausea, vomiting
• Renal toxicity: hydration with saline infusion & diuretics
• Myelosuppression
Dose: 50-100 mg every 3-4 weeks
Branded name: Cisplatin, cisplate, Plantinex 10 mg, 50 mg vial.
Dose: 400 mg i.v. infusion over 15-60 min.
Branded Name: Oncocarbin 150 mg inj, kemocrab 150, 450
mg/vial inj.
39. Hormones
Glucocorticoids
Primarily used in childhood acute
leukemia & lymphomas .
Secondary effect in Breast cancer
Anti Androgen
Palliative effect in advanced / metastatic
cases because it increase the androgen
level.
Antiestrogen
Effective in positive estrogen receptor as
well as negative breast cancer in
postmenopausal women.
Estrogens
Use in carcinoma of male breast.
120-240 mg orally.
5 reductase inhibitor
Inhibit the conversion of testosterone to
dihydrotestosterone
GnRH agonists
Indirectly inhibit the secretion of androgen
/estrogen by suppressing the FSH & LH
has effect on prostate/breast
Progestin
Use in temporary remission in some cases
of advanced & metastatic endometrial
carcinoma
40. Side Effects
•Toxic effects on normal cells
•Bone marrow suppression
•Bleeding
•Stomatitis
•Nausea, vomiting, diarrhea resulting in weight
loss, malnutrition
•Hair loss
•Fetal malformations