sulfonamides are the antimicrobial agents.It's act by folic acid synthesis inhibitors.It is PABA analogue competitive antagonist. first synthesised drug is prontosil.
In this slide contents history, mechanism of action, SAR, classification of drugs, some structure of important drugs, choice of drugs in different purpose, side effect, adverse effect.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
sulfonamides are the antimicrobial agents.It's act by folic acid synthesis inhibitors.It is PABA analogue competitive antagonist. first synthesised drug is prontosil.
In this slide contents history, mechanism of action, SAR, classification of drugs, some structure of important drugs, choice of drugs in different purpose, side effect, adverse effect.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Quinolones are synthetic antimicrobials having a quinolone
structure.
Active against gram-ve bacteria, newer fluorinated compounds also inhibit gram +ve bacteria.
First member was nalidixic acid introduced in 1960’s
Their usefulness is limited to urinary and GI tract infections because of
Low potency
Modest blood and tissue levels
Limited spectrum
High frequency of bacterial resistance
In gram negative bacteria –
Inhibition of DNA gyrase enzyme (Inhibit negative super coiling)
In gram positive bacteria –
Inhibition of Topoisomerase IV – Inhibition of nicking and separation of daughter DNA strands after DNA replication
The malformed DNA is digested by Exoneucleases
Sulphonamides Pharmacology For Pharmacy studentsMalay Pandya
This is the PowerPoint presentation of the Antimicrobial drug - SULPHOANMIDE.
Sulphonamide is the first antimicrobial agent
It Can be employed for suppressive therapy of chronic urinary tract infection, streptococcal pharyngitis and gum infection.
Combined with trimethoprim (cotrimoxazole) sulfamethoxazole is used for many bacterial infections.
This will be useful to all Pharmacy Student ...
Quinolones are synthetic antimicrobials having a quinolone
structure.
Active against gram-ve bacteria, newer fluorinated compounds also inhibit gram +ve bacteria.
First member was nalidixic acid introduced in 1960’s
Their usefulness is limited to urinary and GI tract infections because of
Low potency
Modest blood and tissue levels
Limited spectrum
High frequency of bacterial resistance
In gram negative bacteria –
Inhibition of DNA gyrase enzyme (Inhibit negative super coiling)
In gram positive bacteria –
Inhibition of Topoisomerase IV – Inhibition of nicking and separation of daughter DNA strands after DNA replication
The malformed DNA is digested by Exoneucleases
Sulphonamides Pharmacology For Pharmacy studentsMalay Pandya
This is the PowerPoint presentation of the Antimicrobial drug - SULPHOANMIDE.
Sulphonamide is the first antimicrobial agent
It Can be employed for suppressive therapy of chronic urinary tract infection, streptococcal pharyngitis and gum infection.
Combined with trimethoprim (cotrimoxazole) sulfamethoxazole is used for many bacterial infections.
This will be useful to all Pharmacy Student ...
Amoebiasis is an infection with Entamoeba histolytica produced by the ingestion of cysts of this organism. Amoebiasis can be asymptomatic or can lead to severe, life-threatening dysentery. The organism exists in two forms, the motile trophozoite form or the dormant cyst form.
In the intestine, the cysts develop into trophozoites that adhere to colonic epithelial cells by means of lectin on the parasitic membrane, which has similarity to the host adherence proteins.
The trophozoite then lyses the host cell (hence histolytica) and invades the submucosa, where it may secrete a factor that inhibits IFNY- activated macrophages, which would otherwise kill it. These processes may result in dysentery
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
1. Ms. Mandakini Sampat Holkar
(Assistant Professor)
Dept. of Pharmaceutics
Shri Vithal Education and Research Institute’s
College of Pharmacy, Pandharpur
2. Overview
Introduction
Life cycle of Entamoeba histolytica
Classification
Detail study of following drugs-
Metronidazole*, Tinidazole, Ornidazole,
Diloxanide, Iodoquinol, Pentamidine Isethionate,
Atovaquone,
3. Introduction
Antiprotozoals are used to treat protozoal infections, which include
amebiasis, giardiasis, cryptosporidiosis, microsporidiosis, malaria,
babesiosis, trypanosomiasis, leishmaniasis, and toxoplasmosis
Amoebiasis, also known amoebic dysentery, is an infection caused
by any of the amoebae of the Entamoeba group. Symptoms are most
common during infection by Entamoeba histolytica.
Symptoms may include abdominal pain, diarrhea, or bloody diarrhea.
Complications can include inflammation and ulceration of the colon
with tissue death or perforation, which may result in peritonitis .People
affected may develop anemia due to loss of blood.
4. Life cycle of
Entamoeba histolytica
Entamoeba histolytica exists in two forms:
1.Cysts form (That can survive out side the body)
2.Trophozoites form (That are labile and don’t Persist outside the body)
5. 1.Ingestion of cysts
Cysts are ingested through faeces, contaminated food or water
2.Formation of trophozoites
Cysts are passed in to the lumen of intestine, where the trophozoites
are librated.
3.Penetration and multiplication of trophozoites
Trophozoites are penetrated in intestinal wall and multiply within
colon wall. They either invade and ulcerate the mucosa of large
intestine or simply feed on intestinal bacteria.
Life cycle consist of following steps:
6. 4.Systemic invasion
Large numbers of trophozoites within the colon wall can also
lead to systemic invasion and caused liver abscess.
5.Cysts discarded
The trophozoites within the intestine are slowly carried toward
the rectum , where they return to cyst form and are excreted in
faeces
7.
8. Classification
A. Tissue amoebicides-
1. For both intestinal and extra intestinal amoebiasis
Nitroimdazoles-Metronidazole,Tinidazole,Ornidazole
Alkaloids –Emetine
2. For extra intestinal amoebiasis only-Chloroquine
B.Luminal amoebiasis-
a. Amide-diloxanide furate
b. 8-hydroxyquinolones-Idoquinol
c. Antibiotics-Tetracycline
9. Metronidazole
Metronidazole, marketed under the brand name Flagyl , is an antibiotic
and antiprotozoal medication.
Metronidazole is primarily used to treat: bacterial vaginosis, pelvic
inflammatory disease , pseudomembranous colitis, aspiration pneumonia,
rosacea (topical), fungating wounds (topical), intra-abdominal infections,
lung abscess, periodontitis, amoebiasis, oral infections, giardiasis,
trichomoniasis
10. Mechanism of action of Metronidazole
Metronidazole
enter in to cell by
diffusion
Highly reactive
nitro radical
Nitro group is
reduced by
Which exerts
cytotoxicity
Energy
metabolism of
anaerobes is
disrupted
redox
protein
operative
only in
anaerobic
11. Tinidazole
Tinidazole is a drug used against protozoan infections. It is widely known
throughout Europe and the developing world as a treatment for a variety of
amoebic and parasitic infections. It was developed in 1972 and is a
prominent member of the nitroimidazole antibiotic class
use of tinidazole for infections from amoebae, giardia, and trichomonas, just
like metronidazole
12. Ornidazole
Ornidazole is an antibiotic used to treat protozoan infections. A
synthetic nitroimidazole, it is commercially obtained from an acid-
catalyzed reaction between 2-methyl-5-nitroimidazole and
epichlorohydrin. Antimicrobial spectrum is similar to that of
metronidazole .
13. Diloxanide
Diloxanide furoate works only in the digestive tract and is a
lumenal amebicide.It is considered second line treatment for
infection with amoebas when no symptoms are present but the
person is passing cysts, in places where infections are not
common.
Paromomycin is considered the first line treatment for these
cases. For people who are symptomatic, it is used after
treatment with ambecides that can penetrate tissue, like
metronidazole or tinidazole
14. Iodoquinol is an amebocide used against Entamoeba
histolytica, and it is active against both cyst and trophozoites
that are localized in the lumen of the intestine. It is considered
the drug of choice for treating asymptomatic or moderate
forms of amebiasis
Iodoquinol
15. Pentamidine
Pentamidine is an antimicrobial medication used to treat African
trypanosomiasis, leishmaniasis, babesiosis, and to prevent and treat
pneumocystis pneumonia
16. Atovaquone
Atovaquone (alternative spelling: atavaquone) is a chemical
compound that belongs to the class of naphthoquinones
Uses-
pneumocystis pneumonia (PCP)
toxoplasmosis
malaria
babesia