this presentation is about the causal organism, symptoms, infection, prevention and treatment of the disease caused by bacillus anthracis. this presentation is for medical microbiology student to help in their understanding about the subject.
History of immunology grew out of the observation that individuals who have recovered from certain infectious diseases were thereafter protected from the disease.
The following presentation will give you an in-depth look at the early development of biotechnology and will get you thinking about the role of biotechnology in your daily life.
History of immunology grew out of the observation that individuals who have recovered from certain infectious diseases were thereafter protected from the disease.
The following presentation will give you an in-depth look at the early development of biotechnology and will get you thinking about the role of biotechnology in your daily life.
Rotavirus is a contagious virus that can cause gastroenteritis (inflammation of the stomach and intestines). Symptoms include severe watery diarrhea, often with vomiting, fever, and abdominal pain. Infants and young children are most likely to get rotavirus disease.
Brief discription about the Golden age of Microbiology and two important scientists Louis Pasteur and Joseph lister ,and their contributions to the field of microbiology .
In Sciences, my 7th graders were asked to present a PPt on "My Scientist". Each chose a different scientist and then their teacher of English took it one step further and asked them to do the same in English! Here is the result :) Robert Kock, by João
Rotavirus is a contagious virus that can cause gastroenteritis (inflammation of the stomach and intestines). Symptoms include severe watery diarrhea, often with vomiting, fever, and abdominal pain. Infants and young children are most likely to get rotavirus disease.
Brief discription about the Golden age of Microbiology and two important scientists Louis Pasteur and Joseph lister ,and their contributions to the field of microbiology .
In Sciences, my 7th graders were asked to present a PPt on "My Scientist". Each chose a different scientist and then their teacher of English took it one step further and asked them to do the same in English! Here is the result :) Robert Kock, by João
Microbiology is the study of organisms that are usually too small to be seen by the unaided eye; it employs techniques—such as sterilization and the use of culture media—that are required to isolate and grow these microorganisms.
This presentation is about STREPTOCOCCI, GRAM POSITIVE STTREPTOCOCCI, BROWN’S CLASSIFICATION, ALPHA HEMOLYTIC STREP.,BETA HEMOLYTIC STREPTOCOCCI, LANCIFIED CLASSIFICATION, GROUP A ( S. PYOGENS) , GROUP – B ( S. AGLACTIA ), GROUP - D, DISEASES, PEPTOSTREPTOCOCCI
TRANSMISSION, PATHOGENESIS,STREPTOCOCCUS PNEUMONIAE, IMPORTANT PROPERTIES, C - SUBSTANCE, TRANSMISSION, CONSOLIDATION OF LUNGS, FACTORS THAT PREDISPOSE PERSON TO PNEOMCOCCAL INFECTIONS, CLINICAL FINDINGS, LABORATORY DIAGNOSIS, TREATMENT
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
In this book, we use conservation of energy techniques on a fluid element to derive the Modified Bernoulli equation of flow with viscous or friction effects. We derive the general equation of flow/ velocity and then from this we derive the Pouiselle flow equation, the transition flow equation and the turbulent flow equation. In the situations where there are no viscous effects , the equation reduces to the Bernoulli equation. From experimental results, we are able to include other terms in the Bernoulli equation. We also look at cases where pressure gradients exist. We use the Modified Bernoulli equation to derive equations of flow rate for pipes of different cross sectional areas connected together. We also extend our techniques of energy conservation to a sphere falling in a viscous medium under the effect of gravity. We demonstrate Stokes equation of terminal velocity and turbulent flow equation. We look at a way of calculating the time taken for a body to fall in a viscous medium. We also look at the general equation of terminal velocity.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Salas, V. (2024) "John of St. Thomas (Poinsot) on the Science of Sacred Theol...Studia Poinsotiana
I Introduction
II Subalternation and Theology
III Theology and Dogmatic Declarations
IV The Mixed Principles of Theology
V Virtual Revelation: The Unity of Theology
VI Theology as a Natural Science
VII Theology’s Certitude
VIII Conclusion
Notes
Bibliography
All the contents are fully attributable to the author, Doctor Victor Salas. Should you wish to get this text republished, get in touch with the author or the editorial committee of the Studia Poinsotiana. Insofar as possible, we will be happy to broker your contact.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Toxic effects of heavy metals : Lead and Arsenicsanjana502982
Heavy metals are naturally occuring metallic chemical elements that have relatively high density, and are toxic at even low concentrations. All toxic metals are termed as heavy metals irrespective of their atomic mass and density, eg. arsenic, lead, mercury, cadmium, thallium, chromium, etc.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
2. HISTORY
• 700 B.C. – thought to be originated from Egypt and
Mesopotamia
• 1887 – ROBERT KOCH proved anthrax bacterium was cause of
disease that affected farm animals
• 1881 – LOUIS PATEUR created 1st vaccine and tested on farm
animals
• 1950’s – first anthrax vaccine for human was developed
• 2001 – bioterror attack on U.S. using bacterium spores
• 2016 – 2000 reindeers died and 13 people became sick in
Siberia, Russia
3. CAUSAL ORGANISM
• BACILLUS ANTHRACIS
• Bacteria(domain); Firmicules(phylum); bacilli(class);
bacillales(order); bacillaceae(family); bacillus(genus);
anthracis(species)
• Gram +ve, rod shaped bacterium, non motile, aerobic or
facultative anaerobe
• Genome is circular with 5,227,293 bp DNA molecule
• Cell wall contain peptidoglycan layer, lipoteichoic acids
and crystalline cell surface protein
• CAPSULE is made of poly-D-glutamic acid unlike other
bacteria which have polysaccharide capsules
4. TYPES OF ANTHRAX
Cutaneous
anthrax
• More common
• Mortality rate is low (approx. 20%)
Pulmonary
anthrax
• Very rare
• Mortality rate is very high (around 100%)
• Also known as wool sorter’s disease
Gastrointestinal
anthrax
• Incubation period is 1-7 days
• With treatment, 60% patients survive
5. PULMONARY ANTHRAXINFECTION
• These bacterial spores
can be dormant and
perennate for many years.
• Spore present in air or on
animals when inhaled
causes pulmonary
infection in our lungs
SYMPTOMS
• Sore throat, headache,
shortness of breath
• Pain in chest, coughing up
blood, necrosis
• Progressive haemorrhage
lymphadenitis
• shock, coma
6. CUTANEOUS ANTHRAXINFECTION
• Using bacterial spores
present in soil, air and on
animal fur
• Spores when come in
contact with skin or
wound, germinate to
infect.
SYMPTOMS
• Painless, dark, swelled
pustules
• Septicemia
• Muscle pain, headache,
fever, nausea and vomiting
• Swollen glands and lymph
nodes
7. GASTROINTESTINAL ANTHRAX
INFECTION
• By eating undercooked
contaminated meat
• Bacteria invade through
bowel walls and spreads
through bloodstream
SYMPTOMS
• Nausea
• loss of appetite
• Fever
• Abdominal pain
• Bloody diarrhea
8. PATHOGENESIS
• Helps to elude host’s immune system
• Made of poly-D-glutamic acid
• Acts as anti-phagocytic layers
BACTERIAL CAPSULE
• Helps in destruction of host cell
• Three types- edema factor(EF), lethal
factor(LF), protective antigen(PA)EXOTOXINS
9. EDEMA FACTOR
• Calmodulin dependent adenylate cyclase
• Utilizes ATP
• Causes elevation of intracellular cAMP
• Leads to production of massive amount of fluid causing inflammation
LETHAL FACTOR
• Decrease level of mitogen activated protein kinases
• Causes tissue necrosis and hypoxia
PROTECTIVE ANTIGEN
• Secreted in inactive form; activated by furin
• Facilitates the entry of edema factor and lethal factor inside cell
10.
11. DIAGNOSIS
1. Bacillus anthracis can be cultured in BLOOD AGAR medium
2. Bacteria may be found in
Cultures or smears in case of cutaneous anthrax
Throat swabs or sputum in case of pulmonary anthrax
3. Chest X-rays may shows changes in lymph nodes of lungs
4. Bacteria can be seen in blood using microscope once
anthrax is disseminated
5. History like occupation of person is important
12. PREVENTIONS
• Public health measures to prevent contact with infected animals
• Vaccine available for people at high risks
• Avoid contaminated meat consumptions
• Agencies working hard to prevent bioterrorist attack
14. VACCINATION
• Vaccine for anthrax in animals are available
• It is produced using protective antigen which is a type
of exotoxin
• Vaccine for humans are not yet available for general
public
• All current vaccine show local and general
reactogenicity(erythema, fever, soreness)
• New third generation vaccines are under research
including recombinant live vaccine