Animal experiments are commonly used to develop new medicines and test product safety. In 2005 in Europe, over 12 million animals were used in testing. While animal experiments have led to treatments for diseases, they cause suffering and reduce animal quality of life. There is debate around the necessity, usefulness, costs, and morality of animal testing when alternatives may be available such as non-animal models, clinical research, and epidemiological studies. Reducing animal use, refining techniques to minimize suffering, and replacing animals when possible are advocated approaches known as the Three Rs.