Virsh allows you to manage virtual machines from the command line. You can define new VMs by specifying their XML configuration files, list both active and inactive VMs, start and shutdown VMs, and edit VM attributes like CPUs, memory, and network interfaces by exporting the XML configuration, making changes, and reimporting it. USB devices can be passed through to VMs after modifying AppArmor settings and specifying the device's vendor and product IDs in the VM's XML configuration.