Alpha Fold 2
By : Vishwas Narayan
Lot of new things
Proteomics,Genomics,Computer Architecture and other aspects of science
just started to emerge in 2015 as soon as tensorflow was open source thus its a
new journey from then to everybody.
Lot of new things
Proteomics,Genomics,Computer Architecture and other aspects of science just
started to emerge in 2015 as soon as tensorflow was open source thus its a new
journey from then to everybody, but it changed
now.
HOW??
Let's just focus on proteomics
What is a protein?
CASP Challenge
https://predictioncenter.org/
Isoforms of the Protein
There is a lot of Complexity in studying these
structures
● Money
● Time
● Efforts
● Infrastructure
https://predictioncenter.org/casp14/index.cgi?page=format#RR
They still love their world.
Potential of this project is
phenomenal
Reference
1. https://deepmind.com/blog/article/AlphaFold-Using-AI-for-scientific-discovery
2. https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology
3. https://github.com/deepmind/deepmind-research/tree/master/alphafold_casp13
4. https://github.com/dellacortelab/prospr
5. https://www.nature.com/articles/s41586-019-1923-7
6. https://www.nature.com/articles/s41586-019-1923-
7.epdf?author_access_token=Z_KaZKDqtKzbE7Wd5HtwI9RgN0jAjWel9jnR3ZoTv0MCcgAwHMgRx9mvLj
NQdB2TlQQaa7l420UCtGo8vYQ39gg8lFWR9mAZtvsN_1PrccXfIbc6e-
tGSgazNL_XdtQzn1PHfy21qdcxV7Pw-k3htw%3D%3D
7. https://onlinelibrary.wiley.com/doi/full/10.1002/prot.25834
8. https://deepmind.com/research/case-studies/alphafold

Alpha fold 2

Editor's Notes

  • #6 https://www.ebi.ac.uk/training/online/course/proteomics-introduction-ebi-resources/proteomics-resources-ebi
  • #14 http://rosalind.info/glossary/protein-isoform/
  • #16 https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance
  • #17 https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy
  • #18 https://en.wikipedia.org/wiki/X-ray_crystallography
  • #19 https://www.nobelprize.org/uploads/2018/06/anfinsen-lecture.pdf
  • #21 https://en.wikipedia.org/wiki/Protein_primary_structure https://web.archive.org/web/20110523080407/http://www-miller.ch.cam.ac.uk/levinthal/levinthal.html
  • #26 TWO EXAMPLES OF PROTEIN TARGETS IN THE FREE MODELLING CATEGORY. ALPHAFOLD PREDICTS HIGHLY ACCURATE STRUCTURES MEASURED AGAINST EXPERIMENTAL RESULT.
  • #30 https://predictioncenter.org/caspcommons/index.cgi
  • #31 https://github.com/deepmind/deepmind-research/tree/master/alphafold_casp13