Introduction to chronology, chronotherapy, and chronopharmacology.
How chronopharmacology involved in asthma and helps to manage asthma?.
Biological rhythms in bronchial asthma.
Factors associated with nocturnal exacerbation of bronchial asthma.
Introduction to asthma and their symptoms.
Introduction to Antiasthmatic drugs like beta-blockers, leukotriene antagonists, steroids, etc.
Chronopharmacology division & their examples.
Advantages and disadvantages of chronopharmacology.
Marketed preparation and their images along with the price in India.
Introduction to chronology, chronotherapy, and chronopharmacology.
How chronopharmacology involved in asthma and helps to manage asthma?.
Biological rhythms in bronchial asthma.
Factors associated with nocturnal exacerbation of bronchial asthma.
Introduction to asthma and their symptoms.
Introduction to Antiasthmatic drugs like beta-blockers, leukotriene antagonists, steroids, etc.
Chronopharmacology division & their examples.
Advantages and disadvantages of chronopharmacology.
Marketed preparation and their images along with the price in India.
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
Protozoal infections and antiprotozoal drugs(therapy).Gagandeep Jaiswal
presentation comprising knowledge about various protozoal infections and therapy options available for the treatment of those infections. various different drugs used in the therapy with their proposed mechanism of action. Hope it will be useful for understanding the pharmacology of antiprotozoals.
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
Protozoal infections and antiprotozoal drugs(therapy).Gagandeep Jaiswal
presentation comprising knowledge about various protozoal infections and therapy options available for the treatment of those infections. various different drugs used in the therapy with their proposed mechanism of action. Hope it will be useful for understanding the pharmacology of antiprotozoals.
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Hypersensitivity reactions for Medical StudentsNCRIMS, Meerut
Hypersensitivity (animated) for MBBS Students
Hypersensitivity refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system.
Hypersensitivity reactions require a pre-sensitized state of the host.
Four types of hypersensitivity
Type I – anaphylactic
Type II – cytotoxic
Type III – immune complex mediated
Type IV – contact, tuberculin and granulomatous
Anaphylaxis is defined as a life-threatening allergic reaction set in action by a wide range of antigens and involving multiple organ systems.
The true incidence is difficult to estimate, but in 1973 the Boston Collaborative Drug Surveillance Program reported six anaphylactic reactions and 0.87 deaths from anaphylaxis per 10,000 patients.
Reactions to insect stings alone are responsible for at least 50 deaths in the United States each year.
These figures reveal the importance of continued research into the biology of anaphylaxis along with developing new (and improving existing) therapies.
Type 1 2 3 and 4 hypersensitivity reactions
Their mechanism of actions and advantages and disadvantages
Introduction
Categories
Causes
Diagnosis
Signs and symptoms
Neurotransmitters/General aspect and steps involved in neurotransmission.pptxSIRAJUDDIN MOLLA
Neurotransmission (Latin: transmission "passage, crossing" from transmitter "send, let through"), is the process by which signalling molecules called neurotransmitters are released by the axon terminal of a neuron and bind to and react with the receptors on the dendrites of another neuron
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
2. Index
Introduction
• Hypersensitivity reaction
• Allergy
Types of allergens
Type I hypersensitivity reaction
Type II hypersensitivity reaction
Type III hypersensitivity reaction
Type Iv hypersensitivity reaction
3. The immune system has vital functions for homeostasis and host defense.
But exaggerated or misdirect immune response result in tissue injury or
other pathological changes
This unwanted immune responses, termed as hypersensitivity reactions.
Require a pre-sensitized (immune) state of the host.
May be immediate or delayed
All this happens due to
– release of vasoactive substances
– phagocytosis or lysis of cell
– activation of inflammatory and cytolytic component of complement cell
– cytokines and other mediators
Hypersensitivity Reactions
Introduction
4. A disorder of the immune system often also referred to as
atopy.
Strictly, allergy is one of four forms of hypersensitivity and is
called type 1 (or immediate) hypersensitivity.
Allergic reactions occur to normally harmless
environmental substances known as allergens.
Reactions are acquired, predictable and rapid.
It includes eczema, hives, hay fever, asthma, food allergy
and reactions to drugs and the venom of stinging insect
such as wasp and bees
Allergy
5. Allergens are inciting agents of allergy i.e. The substances capable of
sensitizing the body in such away that an unusual response occurs in
hypersensitive person.
It may be of biologic, chemical, or of synthetic origin.
The substance such as pollens, dander's, dust etc. acts as natural
allergens.
Allergens are protein or glycoprotein .
ALLERGENS
7. Inhalant allergens are air borne substances as
chemicals, causing respiratory disease,
inflammation in nose and lungs.
Inhalant allergies caused by environmental factors
such as pollen, pets, house dust mites and
moulds.
Inflammation in nose & lungs may cause Hay fever
& Asthma.
SYMPTOMS
Sneezing
Lacrimation
Coughing and post nasal
drip
Itching eyes, nose and
throat.
Allergic shiner
1. INHALANT ALLERGENS
8. Allergens which are present in food stuff and swallowed are termed
ingestant (food allergy).
In food allergy, an immune system response to a food.
When foods are digested and the nutrients are absorbed, substances
in the food (ingestant allergens) stimulate allergic response. These
reactions cause a number of allergic symptoms.
Food allergens ordinarily cause GIT symptoms, but they may also
cause
• Skin rash
• Puffed lips and tongue
• Migraine
2. INGESTANT ALLERGENS
• Rhinitis
• Bronchial
asthma
10. 97% of food allergies
are due to only
8 foods
Which are……
Some most common
food allergens
11. Out of this 8 foods, 3 are most likely to cause anaphylaxis.
(a whole body, life-threatening response)
12. The injectants (injectable preparations and insects) cause
allergy in hypersensitive person.
The natural sources of injectable allergens are produced by
the sting of bees, hornets and wasps.
In addition to penicillin products, other injectable that may
cause allergies are liver extract, antitoxins and the glandular
products.
SYMPTOMS
Itching of the palms of hands and soles of feet
Erythema
Peeling of skin
3. INJECTANT ALLERGENS
13. "Any allergens they produce manifestation of hypersensitivity at the site
of skin or other mucous".
Aeroallergens, like various pollen grains containing oils, trichomes
various leaves, flowers
Small fragments of plants tissue carried by smoke originating from
fires, grass fires and burning leaves are also cause for contact
A Number of plants products used as additives in cosmetics and
perfumes are irritants and cause skin allergy.
Wool fat in cosmetics, soap and soap powders, plain detergents and
enzyme detergents, nail polishes, hair dye and hair spray are also
included among the major cause of contact dermatitis.
4. CONTACTANT ALLERGENS
14. Allergy caused by the metabolic product of living micro-organism in the
human body.
The continual presence of certain types of bacteria, protozoa's, molds,
helminths and other parasites in the body of human being are
for chronic infection.
In such patient bacterial metabolic waste are considered to be infectant
allergens.
5. INFECTANT ALLERGENS
6. Others
Sometimes temperature (cold temp.), radiation may also cause allergy
15. Hypersensitivity Types & Immune Reactants
Gell-Coombs classified the reactions into four types based on the
mechanisms involved and time taken for the reaction-
3 involve antibody
Types Name of Rxn Mediators Attack on Associated disease
Type I: immediate or
anaphylactic
hypersensitivity (allergy)
IgE Mast cell Atopy, Anaphylaxis,
Asthma
Type II: antibody-dependent
cytotoxic
hypersensitivity
IgG and IgM Attack host
antigen
Autoimmune disease
Erythroblast foetalis,
Goodpasture’s
disease
Type III: Immune complex-
mediated
hypersensitivity
Immune complex
(IgG &
complement)
Serum sickness,
Arthus reaction,
Lupus nephritis
One involves antigen specific cells-
Type IV: Cell-mediated or CD4 T-cell Tuberculosis,
16. Also called immediate or anaphylactic hypersensitivity (simply known as
‘allergy’)
It is sudden, widespread, potentially severe and life-threatening allergic
reactions(anaphylactic shock).
The effects may be localised to the nose (hay fever), eye, the bronchial
tree (the initial phase of asthma), the skin (urticaria) or the
tract atopic disorder
The reaction usually takes 15 - 30 minutes from the time of exposure to the
antigen
Begin with a feeling of uneasiness, followed by tingling sensations and
dizziness.
Type I Hypersensitivity
17. Mediated by
• antibody IgE
• biogenic amines- histamine, adenosine (enhance mast cell mediator
• enzymes- protease, acid hydrolases
The primary cellular component is the mast cell or basophil and eosinophils
The reaction is amplified and/or modified by platelets, neutrophils and
eosinophils.
Some important unwanted effects of drugs include anaphylactic
hypersensitivity responses.
It has two type of response: local and systemic anaphylaxis
Contd…
18. Atopy - genetically determined predisposition to develop localized
anaphylactic reactions to inhaled or ingested allergens.
Family history chr. 5q31
With higher serum IgE levels compared to general population
Local anaphylaxis has two phases:
1. Initial response Vasodilation, vascular leakage, smooth muscle spasm
or glandular secretions 5-30 min. after exposure subside in 60
minutes
2. Late-phase reaction 2-8 hrs. later without additional exposure to
antigen More intense infiltration of tissues with eosinophils,
neutrophils, basophils, monocytes & CD4+ T cells mucosal epithelial
A. Local Anaphylaxis:
19. Occur after administration of heterologous proteins (e.g. antisera),
hormones, enzymes, polysaccharides & drugs
Exposure itching, hives & skin erythema, contraction of resp.
bronchioles + resp. distress, laryngeal edema
B. Systemic anaphylaxis
20. In these individuals, substances that are not inherently noxious (such as
grass pollen, house dust mites, certain foodstuffs or drugs, animal fur
and so on) provoke the production of antibody, IgE
IgE has high affinity for its receptor on mast cells and basophils.
A subsequent exposure to the same allergen cross links the cell-bound
IgE and triggers the release of various pharmacologically active
substances like histamine, PAF, eicosanoids and cytokines.
Further produce IgE from B-cell
Cross-linking of IgE Fc-receptor to mast cells increases Calcium influx
in Mast cells and trigger degranulation of mast cells
Mechanism of type I Reaction
Fc (fragment crystallizable) region
22. On blood vessels
↑ blood flow & permeability
↑ fluid and cells protein in
tissues
↑ blood flow to lymph node
Effects
On airway
↓ diameter,
↑ Mucus congestion,
blockage
On GI
↑ fluid secretion,
↑ peristalsis
Expulsion-diarrhea
23. Skin (prick and intradermal) tests
Measurement of total IgE and specific IgE antibodies against the
suspected allergens.
Total IgE and specific IgE antibodies are measured by a enzyme
immunoassay (ELISA).
Increased IgE levels are indicative of an atopic condition.
Diagnostic tests for
immediate hypersensitivity
24. 1. Antihistamines which block histamine receptors - diphenhydramine,
hydroxyzine and
promethazine
2. Chromolyn sodium inhibits mast cell degranulation by inhibiting Ca2+
influx.
3. Leukotriene receptor blockers - montelukast, zafirlukast and zileuton
4. inhibitors of the cyclooxygenase pathway - aspirin
5. Bronchodilators (inhalants) for bronchoconstriction - salbutamol, salmeterol,
formoterol
6. Inhinbitors for cAMP-phosphodiesterase – dipyridamole, sildenafil,
theophylline
Treatments
25. Also called antibody-dependent cytotoxic hypersensitivity
Immune system (antibodies) targets tissue-specific antigens present on the
surface of host cell or other tissue components that are (or appear to be)
foreign
Host cells or proteins altered by drugs are sometimes mistaken by the
immune system for foreign organisms and evoke antibody formation.
Examples, some drugs alter neutrophils agranulocytosis of platelets
leading to thrombocytopenic purpura.
The antigens are normally endogenous, sometimes it may exogenous
Type II hypersensitivity
26. These type II reactions are also implicated in some types of
autoimmune disease (e.g. Hashimoto’s disease, haemolytic
anaemia, Rh disease of the new born.
The lesion contains antibody, complement and neutrophils
The reaction time is minutes to hours.
Primarily mediated by antibodies of the IgM or IgG classes and
complement
Antibody (IgG) mediates cell death
This reaction characterised by tissue damage.
Contd…
27. There are three type of mechanism involved in type II reaction
1. Antibody and Complement-mediated destruction
2. Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)
3. Antibody-mediated target cell dysfunction
Mechanism of type II reaction
28. Mechanism 1
Antibody-complement that mediate lysis
Antibody (IgM, IgG) + antigen on cell surface activation of
complement system formation of MAC (membrane attack
component) tissue damage
1. Antibody and Complement-mediated destruction
31. Occurs when target cell are too large and not possible to
phagocytised.
Cells exhibiting the foreign antigen are tagged with antibodies (1gG or
IgM).
Ab + Ag activation of NK cell bind to Fc fragment of IgG cell
lysis without phagocytosis kill these tagged cells
2. Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)
Mechanism II
39. Diagnostic tests include
• Detection of circulating antibody against the tissues involved
• The presence of antibody and complement in the lesion (biopsy)
by immunofluorescence.
Treatment
anti-inflammatory – aspirin, Ibuprofen, naproxen, diclofenac,
celecoxib
immunosuppressive agents – Cyclophosphamide (it is very efficient
in the therapy of systemic lupus erythematosus, autoimmune
Diagnostic tests and Treatment
40. It is a immune complex-mediated hypersensitivity, occurs when
antibodies react with soluble antigens which is not attached to the organ
involved.
The antigen-antibody complexes can activate complement and stimulate
the release of inflammatory mediators.
An experimental example of this is the Arthus reaction that occurs if a
foreign protein is injected subcutaneously into a rabbit or guinea pig
with high pre-existing circulating concentrations of antibody.
The reaction may take 3 - 10 hours after exposure to the antigen, the area
becomes red and swollen because the antigen–antibody complexes
precipitate in small blood vessels and activate complement.
Type III hypersensitivity reaction
41. Neutrophils are attracted and activated by C5a generate
toxic O2 species secrete enzymes.
Mast cells are also stimulated by C3a to release mediators.
Damage caused by this process is involved in serum sickness,
which occurs when antigen persists in the blood after
sensitization, causing a severe reaction, as in the response to
mouldy hay (known as farmer’s lung).
Also occurs in certain types of autoimmune kidney and
arterial disease, skin, blood vessels, joints (e.g., rheumatoid
arthritis)
mouldy hay
Contd…
Farmer's lung is a type of hypersensitivity pneumonitis that is
caused by precipitants such as moldy hay or straw.
42. Type III hypersensitivity is also implicated in lupus erythematosus (a
chronic, autoimmune inflammatory disease).
This reaction may be the pathogenic mechanism of diseases caused by
many microorganisms
Mediated by soluble immune complexes - mostly of the IgG and sometimes
IgM and complement (C3a, 4a and 5a).
Both exogenous (chronic bacterial, viral or parasitic infections) and
endogenous (non-organ specific autoimmunity) antigens can cause it.
The damage is caused by platelets and neutrophils
Contd…
44. Diagnosis involves
• Tissue biopsies for deposits of IgG or IgM and complement by
immunofluorescence.
• The presence of immune complexes in serum and depletion in the
level of complement
• Polyethylene glycol-mediated turbidity to detect immune complexes.
Treatment
• anti-inflammatory agents- aspirin, Ibuprofen, naproxen, diclofenac,
celecoxib
Diagnosis and Treatment
45. Its also known as cell-mediated or delayed type hypersensitivity
reaction.
The prototype of type IV hypersensitivity is the tuberculin reaction, a local
inflammatory response seen when proteins derived from cultures of the
tubercle bacillus are injected into the skin of a person who has been
sensitised by a previous infection or immunisation.
The reaction takes 2 to 3 days to develop.
An ‘inappropriate’ cell-mediated immune response is stimulated and
accompanied by infiltration of mononuclear cells and the release of
various cytokines.
Cell-mediated hypersensitivity is also the basis of the reaction seen in some
Type IV hypersensitivity
46. It is also important in the skin reactions to drugs or industrial chemicals.
chemical (termed a hapten) + proteins (in the skin) ‘foreign’
substance evokes the cell-mediated immune response.
In essence, inappropriately deployed T-cell activity underlies all types of
hypersensitivity, it only initiates types I, II and III, and being involved in
both the initiation and the effector phase in type IV.
These reactions are the basis of pathogenesis of many clinically important
group of autoimmune and infectious diseases.
• tuberculosis, leprosy, blastomycosis (fungal infection),toxoplasmosis
(a parasitic disease).
• granulomas due to infections and foreign antigens.
• contact dermatitis (poison ivy, chemicals, heavy metals, etc.)
Contd…
47. Can be classified into three categories depending on the time of onset and
clinical and histological presentation
Type Reaction
time
Clinical
appearance
histology Antigen and site
Contact 48-72 hr eczema lympocytes followed by
macrophage edema of
epidermis
Epidermal (organic
chemicals, poisons
ivy, heavy metals etc)
Tuberculin 48-72 hr Local
induration
lympocytes, monocytes,
macrophages
intradermal
(tuberculin lepromin,
etc
Granulom
a
21-28 days Hardening macrophages,
epitheoid and giant
cells, fibrosis
persistent antigen or
foreign body
(tuberculosis, leprosy,
etc.)
Contd…
48. TH1 release cytokines to activate vascular endothelium
Cytokines activate macrophages and cause release of more cytokines
and chemokines
Activated macrophages to produce chemotactic factor, interleukin-2,
interferon-gamma (IFN-y), Tumour necrosis factor (TNF), cytotoxin
etc.
Transform macrophages into giant multinucleated cell, which
eventually becomes necrotic
Mechanism of type IV reaction
50. Diagnostics
Diagnostic tests in vivo include delayed cutaneous reaction (e.g.
Montoux test) and patch test (for contact dermatitis).
In vitro tests for delayed hypersensitivity include mitogenic response,
lympho-cytotoxicity and IL-2 production.
Treatments
Corticosteroids and other immunosuppressive agents -
Cyclophosphamide
Immunosuppressive drugs and/or glucocorticoids are routinely employed
to treat such disorders.
Diagnostics and Treatments
Its cytotoxic effect is mainly due to cross-linking of strands of DNA
and RNA, and to inhibition of protein synthesis.
51.
52. RANG AND DALE'S PHARMACOLOGY, HP RANG, JM RITTER, RJ FLOWER
AND G. HENDERSON, 8TH EDITION, ELSEVIER LTD., 2016
https://karger.com/iaa/article-abstract/180/4/291/168203/Recent-
Advances-in-Clinical-Allergy-and-Immunology/2019
https://www.slideshare.net/harshi12345/natural-allergens-238855791
https://www.slideshare.net/rx_sonali/allergy-hypersensitivity
http://www.alcit.in/allergy-situation-in-india/
References