HIV (human immunodeficiency virus) causes AIDS (acquired immunodeficiency syndrome) by attacking and weakening the immune system, making individuals susceptible to opportunistic infections. The virus is transmitted through blood, sexual contact, and from mother to child, with initial infection linked to simian immunodeficiency virus in primates. While there is no cure, antiretroviral therapy can manage HIV and prolong life, and strict precautions in dentistry are necessary to prevent transmission.