Pharmaceutical excipients are the substances other than active pharmaceutical ingredients in the formulation. Additives donot have any therapeutic activity. The following additives are commonly used Vehicles Preservative Antioxidant Organoleptic additives Colouring agent Flavouring agent Sweetening agent Surfactants Hydrocolloids Stabilizers VEHICLES: Vehicles are the solvents needed for dispensing the following preparations, Monophasic liquid dosage forms Biphasic liquid dosage forms Sterile dosage forms Ophthalmic products. PRESERVATIVE Many pharmaceutical preparations are liable to undergo deterioration on storage due to microbial growth. In order to avoid microbial growth, it is desirable to use a suitable preservative. Quality of an ideal preservative It should be effective in low concentration. It should be odourless and tasteless. It should be non-toxic and non-irritant. It should be stable and unaffected by pH. It should be economical. It should be soluble in suitable vehicle. Examples Benzoic acid Methyl p-hydroxybenzoate Propyl p-hydroxybenzoate Sodium metabisulphite Benzoic acid Benzyl alcohol Phenol ANTIOXIDANTS Antioxidants are compounds that inhibit oxidation. Both inorganic and organic compounds are used as antioxidants in food, drugs and cosmetics. Quality of an ideal preservative It should be effective in low concentration. It should be colourless, odourless and tasteless. It should be non-toxic and non-irritant. It should be stable and unaffected by pH. It should be economical. It should be soluble in suitable vehicle. Examples Tocopherol Ethyl gallate Propyl gallate Butylated hydroxy anisole (BHA) Butylated hydroxy toluene (BHT) Ascorbic acid Citric acid ORGANOLEPTIC ADDITIVES Organoleptic agents are one of the important members of pharmaceutical aids. Organoleptic additives promote appearance and palatability of pharmaceutical dosage forms. Colouring agent Flavouring agent Sweetening agent Colouring agent The pharmaceutical preparations are coloured due to following reasons, For identification of preparations To increase acceptability to patients To give warning Quality of an ideal preservative It should be readily soluble in water. It should have good colouring power. It should have no physiological activity. It should be economical Types of colouring agent 1. Mineral colours – Iron oxide, Carbon black, Titanium dioxide 2. Natural colours from plants and animals – Cochineal, Caramine 3. Coal tar colours – Amaranth, Erythrosine, Brilliant blue. Flavouring agent Flavours are used to make the preparation more palatable. Flavouring agents are used to mask the unpleasant taste and odour of the preparation. Examples Flavoured syrup – Cherry, Black current, Citrus fruits (Orange, Lemon) Aromatic oils – Volatile oils such as Anise, Careway, Chinnamon, Clove Synthetic flavours – Chloroform water, Benzaldehyde, Vanillin.