This document provides an overview of addiction, including its definition, models for understanding it, and comparisons to other health conditions. In 3 sentences:
Addiction is defined as a chronic disease characterized by impaired control over substance use and continued use despite consequences. It involves genetic, environmental, and psychosocial factors and can be understood as a "hijacking" of the brain's reward system. Effective treatment requires viewing addiction similarly to other chronic health conditions like diabetes and hypertension that also often involve relapse and ongoing management.
Addiction is an old enemy of mankind. Here in this presentation, it is discussed how substances having abuse potential causes temporary and permanent changes to neuronal circuits in our brain.
Addiction is an old enemy of mankind. Here in this presentation, it is discussed how substances having abuse potential causes temporary and permanent changes to neuronal circuits in our brain.
The Physiology of Addiction - February 2012Dawn Farm
"The Physiology of Addiction" was presented on Tuesday February 21, 2012, by Dr. Carl Christensen, MD, PhD, FACOG, CRMO, ABAM. This program explores the differences in neurochemistry between the addicted brain and the normal brain, the progression of physiological changes that occur in people with alcohol/other drug addiction, the mechanisms of physiologic tolerance and withdrawal, and the effects of treatment on the addicted brain. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
The Physiology of Addiction - February 2012Dawn Farm
"The Physiology of Addiction" was presented on Tuesday February 21, 2012, by Dr. Carl Christensen, MD, PhD, FACOG, CRMO, ABAM. This program explores the differences in neurochemistry between the addicted brain and the normal brain, the progression of physiological changes that occur in people with alcohol/other drug addiction, the mechanisms of physiologic tolerance and withdrawal, and the effects of treatment on the addicted brain. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Obsessive-compulsive disorder (OCD) is an type of anxiety disorder , represented by a diverse group of symptoms that include intrusive thoughts, rituals, preoccupations, and compulsions.
Holding Hands With The Hopeless Edps Project Finalcmadison
This was initially completed as a project in one of my courses. However, understanding substance abuse as a disease and not a moral issue or lack of willpower is vitaly important to continue to make advancements in treatments and reimbursement issues, which are a huge threat.
Understanding the Fundamentals of Brain Health and Chronic Diseases Safdar...S'eclairer
Safdar I. Chaudhary, MD
Medical Director S’eclairer; Clinical Assistant Professor, Chatham
University; Board Certified in Adult Psychiatry by American Board of
Psychiatry and Neurology
Suicide Prevention and Addiction - January 2014Dawn Farm
“Suicide Prevention and Addiction” was presented on Tuesday January 28, 2014; by Raymond Dalton, MA; Dawn Farm Outpatient Services Coordinator. There is an alarmingly high prevalence of suicide among people with addiction and people in early recovery. This program will raise awareness of the signs of suicidal thinking and describe ways to offer support and obtain help for people who may be contemplating suicide. Viewers will learn how to recognize suicidal thinking, reach out and offer support to others contemplating suicide, obtain help when suicidal thoughts are present, and access local and national suicide prevention and intervention resources. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Cultivating Mindfulness to Support RecoveryDawn Farm
“Cultivating Mindfulness to Support Recovery” was presented on Tuesday December 17, 2013; by Libby Robinson Ph.D., MSW. Mindfulness practices can help support an individual’s recovery from substance use disorders. This presentation will describe mindfulness, provide opportunities to experience and cultivate mindfulness, and review the evidence of its positive effect on recovery. Dr. Robinson has taught Mindfulness-Based Stress Reduction since 2003. She has practiced mindfulness meditation since 1979 and was trained to teach Mindfulness-Based Stress Reduction by Jon Kabat-Zinn and colleagues at the University of Massachusetts Center for Mindfulness, where he developed this program for cultivating mindfulness. She recently retired from the University of Michigan, where she was a U of M Research Assistant Professor, carrying out NIH-funded research on the role of spiritual and religious change in recovery. She also did an NIAAA post-doctoral fellowship at the U of M Addiction Research Center and was on the social work faculty at Case Western Reserve University and the University at Buffalo. Dr. Robinson has an MSW and MPH from the University of Michigan, as well as her Ph.D. in Psychology and Social Work. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Addiction and Suicide Prevention - December 2012 Dawn Farm
“Addiction and Suicide Prevention” was presented on Tuesday December 18, 2012; by Raymond Dalton, MA; Dawn Farm therapist. There is an alarmingly high prevalence of suicide among people with addiction and people in early recovery. This program will raise awareness of the signs of suicidal thinking and describe ways to offer support and obtain help for people who may be contemplating suicide. Viewers will learn how to recognize suicidal thinking, reach out and offer support to others contemplating suicide, obtain help when suicidal thoughts are present, and access local and national suicide prevention and intervention resources. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Collegiate Recovery Programs: Supporting Second Chances - October 2012Dawn Farm
The transition to a college environment can pose significant risk to a recovering student and to students at risk for alcohol/other drug problems. Many colleges and universities, including the University of Michigan, have developed programs to help recovering students maintain their recovery, excel academically and have a normative college experience apart from the culture of alcohol and other drug use. Research demonstrates exceptionally high rates of academic success and sustained recovery among students who participate in Collegiate Recovery Programs. This presentation will provide an overview of the national and local efforts to build recovery support programs on college campuses, and provide information about what parents and students should look for as they explore their options for pursuing a degree of higher education. The program is presented by Mary Jo Desprez, MA; Director of Health Promotion and Community Relations, for the University of Michigan. Mary Jo manages both the Alcohol and Other Drug Prevention Program and the Collegiate Recovery Program at the University of Michigan. She serves as the Co-Chair for both the Ann Arbor Campus and Community Coalition (A2C3), and the Michigan Campus Coalition (MC3). She is a Center Associate for the Higher Education Center for Alcohol and Other Drug Prevention (U.S Department of Education). Mary Jo has also been an adjunct instructor at Eastern Michigan University since 1997. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Grief and Loss in Addiction and Recovery - September 2012Dawn Farm
“Grief and Loss in Addiction and Recovery” was presented on September 25, 2012; by Janice Firn, LMSW, Clinical Social Worker, University of Michigan Hospital; Matthew Statman, LLMSW, CADC, Dawn Farm therapist and Education Series Coordinator; and Barb Smith, author of “Brent’s World” (http://compassionhearts.com.) The culture of addiction is rife with experiences of grief and loss for the person with addiction and for family and friends. The nature of these experiences combined with the stigma, shame and general lack of understanding of addiction can make grief and loss associated with addiction exceptionally lonely and difficult to heal from. This program will describe Worden's and Kubler-Ross' theories of grief and grief recovery, losses that the chemically dependent individual and his/her family experience throughout the addiction and recovery processes, and how recovery program tools can help individuals cope with grief and loss. It will include a personal account of addiction-related grief, loss and recovery from a mother who lost her son to addiction-related causes. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
"Eating Disorders" is presented by Dr. Carl Christensen, MD, Ph.D.; Addictionologist; and Lori Perpich, LLP, MS Clinical Behavioral Psychology; cognitive behavioral therapist and EDEN program facilitator. This program examines the evidence that eating disorders are true biopsychosocial diseases, similar to chemical dependency. It defines various eating disorders and their consequences, explores neurobiological theories of addiction, discusses screening tools used for eating disorders, and provides information on treatment options and resources for eating disorders. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
How To Support Recovery and Not Support Addiction - May 2012Dawn Farm
"How to Support Recovery and Not Support Addiction" was presented on Tuesday May 15, 2012, by Dr. Charles F. Gehrke, MD, FACP, FASAM. When all else has failed - what does work when confronted with a loved one’s addiction? What does not work? What can others do to help? What does not help? What role does an individual play in supporting another person’s recovery process? These and other questions will be addressed in order to assist participants to find effective methods to successfully support another person’s recovery, avoid enabling another person’s addiction, and maintain their own health and well-being. This program is part of the FREE, annual Dawn Farm Education Series. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please contact Matt Statman, LLMSW, CADC, Education Series Coordinator, at 734-485-8725 or info@dawnfarm.org, or see http://www.dawnfarm.org/programs/education-series.
The Intersection of Domestic Violence and Substance Abuse- April 2012Dawn Farm
"The Intersection of Domestic Violence and Substance Abuse" was presented on April 17, 2012, by Barbara Niess May, MPH, MSW; Executive Director, SafeHouse Center; and David J.H. Garvin, LMSW; Director, Alternatives to Domestic Aggression, Catholic Social Services of Washtenaw County. Domestic violence offender and survivor alcohol and other drug use/abuse is central to this discussion. The audience is provided with a primmer regarding batterer tactics, strategies, and core beliefs which hold the batterer accountable for his abusive behaviors while maintaining and promoting survivor safety. The program will help participants to recognize the critical importance of understanding domestic violence and alcohol/other drug use/abuse in order to safely and effectively intervene and/or interrupt the batterer's abusive behaviors and support the survivor. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Transformation of the Culture of Recovery in America by William L. White - Oc...Dawn Farm
"Transformation of the Culture of Recovery in America" was presented on Tuesday October 18, 2011; by William L. White, MA; Senior Research Consultant, Chestnut Health System. For almost three centuries, people recovering from severe alcohol and other drug problems have found ways to help each other initiate and sustain their recovery journeys. Today, recovering people, their families, and visionary professionals have responded to the stigma, criminalization, and lack of appropriate medical care associated with severe alcohol and other drug problems by creating an unprecedented growth in new structures of recovery support. This presentation will explore recent recovery community building activities and the influence they will exert on the future of addiction treatment and recovery in America. William White is one of the world’s best-know and most influential advocates, authors and public speakers on the subject of recovery from addiction. He has authored or coauthored more than 350 articles and monographs and fifteen books, including "Let's Go Make Some History: Chronicles of the New Addiction Recovery Advocacy Movement," "Pathways From The Culture of Addiction to the Culture of Recovery," and "Slaying the Dragon: The History of Addiction Treatment and Recovery in America" which received the McGovern Family Foundation Award for the best book on addiction recovery. This program is part of the FREE, annual Dawn Farm Education Series. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please contact Matt Statman, LLMSW, CADC, Education Series Coordinator, at 734-485-8725 or info@dawnfarm.org, or see http://www.dawnfarm.org/programs/education-series.
"Codependency" was presented on Tuesday March 22, 2011, by Ronald E. Harrison; Chemical Dependency Therapist. This program discusses the symptoms and progression of codependency and describes actions and resources that help codependent people to recover from codependency. This program is part of the FREE, annual Dawn Farm Education Series. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please contact Matt Statman, LLMSW, CADC, Education Series Coordinator, at 734-485-8725 or info@dawnfarm.org, or see http://www.dawnfarm.org/programs/education-series.
In The Doctors Office: Recovery Friend or Foe? - March 2012Dawn Farm
“In the Doctor’s Office: Recovery Friend or Foe?" was presented on Tuesday March 20, 2012; by Dr. Mark A. Weiner, MD; Internal Medicine and Addiction Medicine; and Matthew Statman, LLMSW, CADC; Dawn Farm therapist and Education Series Coordinator. It’s been said that the doctor’s office is a dangerous place for people in recovery from addiction. It’s also been said that recovering people are terrible patients. This program discusses whether these statements are fair and why doctors and other healthcare providers are essential allies for long term recovery. The program describes in detail how people in recovery from alcohol/other drug addiction can take responsibility for their physical health and recruit health care providers as allies. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Tobacco Cessation and Addiction Recovery - June 2011Dawn Farm
"Tobacco Cessation and Addiction Recovery" is presented by Anna Byberg, Dawn Farm Project Manager. This program describes the prevalence of tobacco addiction among alcoholics and drug addicts, the relationship between tobacco use and recovery, and basic information about how to quit using tobacco. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Relationships In and Out of Addiction and Recovery - May 2010Dawn Farm
"Relationships In and Out of Addiction and Recovery and Recovery" was presented by Ed Conlin, BSEd, CAC-R; addiction counselor, Detroit Capuchin Service System; and Janice Firn, LMSW; Clinical Social Worker, University of Michigan Hospital. This program describes the process of self-actualization; the formation of personal bonds; the dynamics of relationships in addiction; how patterns in thought, action and relationships are affected by addiction; and key attitudes and tools for healthy relationships. It is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
A History Of Alcoholics Anonymous - April 2011Dawn Farm
"A History of Alcoholics Anonymous" presents a fascinating overview of the history and development of the Alcoholics Anonymous (A.A.) program, including its founding and growth. The discussion also includes a brief overview of the Twelve Steps of A.A. The program is presented by James Balmer, President of Dawn Farm. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
The Doctors Opinion on Alcoholism – Revisited (November 2011)Dawn Farm
This program describes a physician's view of alcoholism, as presented in the literature of Alcoholics Anonymous and updated with the modern neurobiology of addictive illness. It includes a discussion of Dr. Silkworth’s explanation of alcoholism as a twofold disease, affecting mind and body, how Dr. Silkworth's opinion relates to the modern neurobiolgy of addictive illness, and identification of therapy for alcoholism as promoted by Alcoholics Anonymous and its relationship to Dr. Silkworth’s opinion. The program is presented by Dr. Herbert L. Malinoff, MD; addictionologist. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
“Adult Children of Alcoholics" was presented on May 19, 2009 by MaryGrace Fisher, LLMSW, CAAC; Dawn Farm Huron Street therapist. This program provides an overview of beliefs and behaviors that are common to adult children of alcoholics. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
"Relapse Prevention" was presented by Robin Edison, M.Ed., LPC, NCC, CAAC; Dawn Farm Downtown Program coordinator. This program discusses the dynamics of relapse, the warning signs that lead the chemically dependent person into a relapse, and strategies to prevent relapse and help handle high-risk situations. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
The Culture of Addiction and the Culture of RecoveryDawn Farm
"The Cultures of Addiction and Recovery" was presented by Robin Edison, M.Ed., LPC, NCC, CAAC, Coordinator of the Dawn Farm Huron Street program; and Quintin Williams, BS, CAC-M; Dawn Farm Huron Street therapist. This program discusses the cultural elements of addiction and recovery, explores the role of “cultures” in addiction and recovery, and describes how the symptoms and behaviors of culturally enmeshed alcoholics and addicts change as the individual moves from the culture of addiction to the culture of recovery. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Psychiatric Disorders in Chemically Dependent Individuals - October 2012Dawn Farm
This program provides an overview of co-occurring addiction and psychiatric illness, including standard diagnostic criteria, individual considerations for determining the appropriate course of treatment, available treatment interventions, and the perspectives of both the addict and the treatment provider on addiction and psychiatric illness. It is presented by Dr. Patrick Gibbons, LMSW, DO; Adjunct Clinical Instructor in Psychiatry at the University of Michigan; Medical Director of the WCHO Community Crisis Response Team; consultant with Pain Management Solutions in Ann Arbor; Medical Director of the Michigan Health Professionals Recovery Program, and Medical Director of Dawn Farm. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
Christian Spirituality and Recovery from Addiction - January 2014Dawn Farm
“Recovery From Addiction and Christian Spirituality” was presented on Tuesday January 21, 2014; by Brother Edward Conlin, BSEd, CADC; Addiction Counselor, Detroit Capuchin Service System. Spirituality often plays an important role in recovery initiation, recovery maintenance, and quality of life in recovery from chemical dependency. This program will describe a Christian perspective of how spirituality relates to recovery from chemical dependency, explore personal spiritual needs and life choices, and discuss the Twelve Steps as a spiritual program. This program is part of the Dawn Farm Education Series, a FREE, annual workshop series developed to provide accurate, helpful, hopeful, practical, current information about chemical dependency, recovery, family and related issues. The Education Series is organized by Dawn Farm, a non-profit community of programs providing a continuum of chemical dependency services. For information, please see http://www.dawnfarm.org/programs/education-series.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Definition of addiction
“Alcoholism is a primary, chronic
disease with genetic,
psychosocial and
environmental factors
influencing its development
and manifestations. The
disease is often progressive
and fatal.
It is characterized by continuous
or periodic impaired control
over drinking, preoccupation
with the drug alcohol, use of
alcohol despite adverse
consequences, and
distortions in thinking, most
notably denial.”
(National Council on Alcoholism and Drug Dependence, Inc. 2/3/90)
3. What is a disease?
The causal model:
1. cell, organ or system
2. defect or injury
3. measurable symptoms
4. A broken leg?
The causal model:
1. bone
2. defect?
3. symptoms?
4. treatment?
7. The causal model works
for easy diagnosis
• The model favors simple • In the absence of easy
organs. causality, what models
work?
– Addiction?
– Moral
– Brain disease? Liver
disease? – Personality
– Environment
8. Learning to drink
priming
early experimentation
being adult
designated driver
9. The mathematics of drinking
priming
early experimentation
building trust
reliable effect
learning how to use
signature experience
10. More is better
priming
early experimentation
building trust
reliable effect
learning how to use
signature experience
11. The rules of drinking
priming
early experimentation
building trust
reliable effect
learning how to use
signature experience
12. How alcoholism develops
priming
early experimentation
building trust
reliable effect
learning how to use
signature experience
44. Federal prison inmates whose most
serious conviction was a drug crime
rose from 4,749 in 1980 to 77,867 in
2004. (1540%)
Source: Maguire, Kathleen and Ann L.Pastore, eds. Sourcebook of Criminal Justice
Statistics [Online]. Available: http://www.albany.edu/sourcebook/ [7/3/05].
45. State prison inmates
whose most serious
conviction was a drug
crime rose from
19,000 in 1980 to
246,100 in 2001.
(1195%)
Source: Prisoners in 2002 & Prisoners in 1994, Bureau of Justice
Statistics [Online]. Available:
http://www.ojp.usdoj.gov/bjs/pubalp2.htm#Prisoners [7/3/05]
46. Jail inmates whose most
serious charge was a drug
crime rose from 20,420 in
1983 to 155,249 in 2002.
(660%)
Source: Maguire, Kathleen and Ann L.Pastore, eds. Sourcebook of Criminal
Justice Statistics [Online]. Available: http://www.albany.edu/sourcebook/
[7/3/05].
47. From 1986 to 1999 the average
term drug offenders entering prison
could expect to serve rose from an
average 30 months to 66 months.
(120%)
Source: Federal Drug Offenders, 1999 with Trends, 1984-99, Bureau of Justice Statistics [Online].
Available: http://www.ojp.usdoj.gov/bjs/abstract/fdo99.htm [7/3/05]
64. Is the addicted
person viewed
as…
Dr. Jekyll: Real Mr. Hyde: Real
person is the sober person revealed by
self; addiction is intoxication and
about goodness disinhibition;
corrupted by addiction is the
sickness revelation of badness
(White, 2004)
65. “If you want to treat an illness
that has no easy cure, first of all,
treat them with hope”
George Vaillant