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Eating Disorders
June 26, 2012
                  Carl Christensen, MD PhD
      Pain Recovery Solutions, Ann Arbor Mi
        Depts of OB Gyn & Psychiatry, WSU
                 cchriste@med.wayne.edu
“My War With Food Addiction”
   “Some people fight battles with guns and
    tanks, others use spoons and kitchen utensils.
    I remember the Battle of the Bulge. The
    Ponderosa Salad Bar suffered a six-plate
    defeat. I remember a war with a chocolate
    Easter bunny. In the middle of the night, I bit
    its head off. I admit it. I was a food addict.
    My life was controlled by food. Moderation
    was never my strong point.
                    EATING DISORDERS 06 22 10         2
“My War With Food Addiction”
   When it came to ice cream, one scoop was never
    enough. I once ate a two-and-a-half gallon tub of
    maple walnut ice cream. It almost froze my stomach.
    To make matters worse, it was my roommate’s ice
    cream! I felt so badly afterwards that I put a 12-foot
    chain through the handles of the refrigerator and
    cupboards and told my roommate, "here's the key to
    your food." He wasn't impressed.”
                  Tom McGregor, “Eating in Freedom”


                      EATING DISORDERS 06 22 10          3
Step Two: Overeater’s Anonymous
   “We have driven miles in the dead of night to
    satisfy a craving for food. We have eaten
    food that was frozen, burnt, stale, or even
    dangerously spoiled. We have eaten food off
    of other people’s plates, off the floor, off the
    ground. We have dug food out of the garbage
    and eaten it.”

                     EATING DISORDERS 06 22 10         4
Step Two: Overeater’s Anonymous
   “We have frequently lied about what we have
    eaten-lied to others because we didn’t want to
    face the truth ourselves. We have stolen food
    from our friends, ….we have also stolen
    money to buy food. We have eaten beyond
    the point of being full, beyond the point of
    being sick of eating. We have continued to
    overeat, knowing all the while we were
    disfiguring and maiming our bodies.”
                    EATING DISORDERS 06 22 10        5
Anorexia
   “I don’t see what they tell me they see in the
    mirror. My cheeks are too full, my hips and
    thighs are too wide and round, my arms carry
    too much fat and my stomach bulges.
    Looking in the mirror is a daily torture that I
    allow myself, because who can resist the
    temptation of that reflective sheet of glass?
    Of glimpsing who they think they are?
                    EATING DISORDERS 06 22 10         6
Anorexia
   I am afraid. Someone please tell me there is a
    better way, because I just don’t know where
    to turn or what to do. I am fifteen, and I will
    join the ranks of those who call themselves
    anorexic.”

-Anonymous

                    EATING DISORDERS 06 22 10     7
Tonight’s talk
   What is an eating disorder?
   Are eating disorders addictions?
   What is addiction?
   What parts of the brain are involved?
   What is obesity?
   What are the consequences of eating disorders?
   How are eating disorders treated? What about medication?
   Brain scans: the lights are bright, but nobody’s home……
   Where can I get help?


                        EATING DISORDERS 06 22 10              8
“…..he’s very depressing” (2007)



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“I left tonight entirely without
          hope” (2011)



            EATING DISORDERS 06 22 10   10
Eating Disorders ≠ weight disorder
   Anorexia Nervosa
   Bulimia
   Binge eating disorder




                   EATING DISORDERS 06 22 10   11
Anorexia Nervosa
   Refuses to maintain a “normal” weight or
    >15% below IBW
   Fear of weight gain
   Severe body image disturbance
   Absence of menstrual cycles (if post-
    menstrual female)
   2 types: restrictive and binging/purging*
                    EATING DISORDERS 06 22 10   12
Bulimia Nervosa
   Episodes of binge eating with a sense of loss of
    control
   followed by compensatory behavior of the purging
    type (self-induced vomiting, laxative abuse, diuretic
    abuse) or nonpurging type (excessive exercise,
    fasting, or strict diets).
   Binges and the resulting compensatory behavior
    must occur a minimum of two times per week for
    three months
   Dissatisfaction with body shape and weight
                       EATING DISORDERS 06 22 10            13
Binge Eating Disorder
   Eating much more rapidly than normal
   Eating until uncomfortably full
   Eating large amounts of food when not
    feeling physically hungry
   Eating alone because of embarrassment
   Feeling disgusted, depressed, or very guilty
    after overeating
                    EATING DISORDERS 06 22 10      14
Eating Disorders: are they Addictions?



              EATING DISORDERS 06 22 10   15
What is Addiction?
   Physiologic Dependence?
   Lack of willpower?
   An “amoral” condition?
   A brain disease?




                  EATING DISORDERS 06 22 10   16
Physiologic Dependence: Tolerance
and Withdrawal
   Tolerance: requiring increasing amounts of
    drug to get the same effect

   Withdrawal: the opposite effect of the drug
    when it is removed

   NEITHER of these imply chemical
    dependency (addiction)
                    EATING DISORDERS 06 22 10     17
Lack of Willpower?




            EATING DISORDERS 06 22 10   18
An “amoral” condition?




            EATING DISORDERS 06 22 10   19
RUSH!




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A Brain Disease?




    EATING DISORDERS 06 22 10   21
VTA: supplies DA to the N Acc
The NA: GO!!!
Frontal Cortex: STOP!!!!




                   EATING DISORDERS 06 22 10   22
EATING DISORDERS 06 22 10   23
“I feel like I don’t belong in my
own skin….”          anonymous alcoholic

   Decreased Dopamine receptors =decreased
    Dopamine =
 Decreased                             Hedonic
    Tone

                                                 Salsitz 2006

                  EATING DISORDERS 06 22 10                  24
Can you find the (alleged) future
alcoholic?




                EATING DISORDERS 06 22 10   25
Chemical Dependence: DSM IV
definition
   Tolerance                            Great deal of time
   Withdrawal                            spent in
   Take more/take longer                 obtaining/using
    than intended                         /recovering
   Can’t cut down or
                                         Important
    control use                           social/occ/recreation
                                          given up 2º to use
                                         Use despite
                                          physical/psych
                                          problem
                     EATING DISORDERS 06 22 10                    26
Addiction/chemical
dependence: working definition
   A chronic progressive disease characterized by the following physical and
    psychological symptoms (the four (five) C’s):

   Craving
   Compulsion
   Loss of Control
   Continued use despite consequences, and
   Chronic use

                             EATING DISORDERS 06 22 10                     27
RELAPSE: the problem with addiction
   Drug triggered: “I thought I could
    (eat/smoke/drink) just one….”

   Stress triggered: “I’m going through too much
    right now. Gimme that!”

   Cue triggered: “Wet faces and wet places”
                    EATING DISORDERS 06 22 10   28
Drug Triggered Relapse: Gardner
2006




             EATING DISORDERS 06 22 10   29
Stress Triggered Relapse: Gardner
2006




              EATING DISORDERS 06 22 10   30
Cue Triggered Relapse: Gardner 2006




             EATING DISORDERS 06 22 10   31
Other parts of the Brain
   Dorsal Striatum (Craving)
   Amygdala (Memory/Danger/emergency)
   Hippocampus (memory)
   Frontal cortex (? Inhibition)
   Hypothalamus (Appetite/satiety)



                 EATING DISORDERS 06 22 10   32
Other Neurochemicals in the Brain
   Norepinephrine (stimulates/satiates)
   Serotonin (calms)
   Endocannabinoids (super size that, please!)
   Endorphins (increased feeding)
   Leptin (antagonist of EC)
   Ghrelin (stimulates appetite)

                    EATING DISORDERS 06 22 10     33
FA/OA                                      AA/NA
   “We ask that during                   “Don’t let yourself
    your share you not                     become Hungry,
    mention specific food                  Angry, Lonely, or
    groups by name”                        Tired!”




                      EATING DISORDERS 06 22 10                  34
“Hi…I’m Joe. I’m cross addicted”




              EATING DISORDERS 06 22 10   35
Food Addiction????
   FA: “Hi, I’m Joe. I’m a food addict”.
   OA: “Hi, I’m Joe. I’m a compulsive
    overeater.”

   Both are describing the same thing: an
    abnormal relationship with food.


                   EATING DISORDERS 06 22 10   36
How many of these are
    addicitons?


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Are Eating Disorders Addictions?
Mark Gold, “Eating Disorders, Overeating, and Pathological Attachment to
                               Food”.

   “The 1960s were known as the decade of sex, drugs, and rock
    and roll. Food seems to be an afterthought and it may be that
    it is suppressed by drug-taking.
   …the heavier the patient, the less alcohol and illegal drugs
    they use. It is almost as if they are competing for the same
    reward sites in the brain.
   Treatment of addicts appears to result in weight gain….all
    supervised drug abstinence treatment causes weight gain.
   …loss of control over eating and obesity produces changes in
    the brain, which are similar to those produced by drugs of
    abuse.”

                           EATING DISORDERS 06 22 10                       44
Are Eating Disorders Addictions?
              Nora Volkow
   Many obesity researchers focus on how the
    body's fuel and fat levels control appetite.
    But as binge eaters know, habits and desire
    often override metabolic need, which share
    some of the characteristics of drug using
    behavior in drug-addicted subjects.



                    EATING DISORDERS 06 22 10      45
Why Healthy Fast Food May Not
Work…..




             EATING DISORDERS 06 22 10   46
Obesity: use despite consequences
   How do you define it?
   How has it changed in the U.S.?
   What are the known causes ASSOCIATIONS
    not causes)?




                 EATING DISORDERS 06 22 10   47
BMI Graph




            EATING DISORDERS 06 22 10   48
Obesity Trends* Among U.S. Adults
              BRFSS, 1990, 1995, 2005
           (*BMI ≥30, or about 30 lbs overweight for 5’4” person)

            1990                                                          1995




                                       2005




No Data   <10%     10%–14%   15%–19%        20%–24%      25%–29%   ≥30%
                             EATING DISORDERS 06 22 10                           49
Obesity Trends* Among U.S. Adults
BRFSS, 1985                   (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)




   No Data   <10%   10%–14%
                                 EATING DISORDERS 06 22 10                     50
Obesity Trends* Among U.S. Adults
BRFSS, 1990                   (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)




   No Data   <10%   10%–14%
                                 EATING DISORDERS 06 22 10                      51
Obesity Trends* Among U.S. Adults
BRFSS, 1995                   (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)




   No Data   <10%   10%–14%     15%–19%
                                 EATING DISORDERS 06 22 10                     52
Obesity Trends* Among U.S. Adults
BRFSS, 2000               (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)




   No Data   <10%   10%–14%    15%–19%        ≥20%
                               EATING DISORDERS 06 22 10                        53
Obesity Trends* Among U.S. Adults
BRFSS, 2005         (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)




 No Data   <10%   10%–14%   15%–19%        20%–24%      25%–29%   ≥30%
                            EATING DISORDERS 06 22 10                     54
Obesity: known Associations
   Prenatal: mom’s caloric intake; maternal DM
   Breastfeeding: protective
   FH: one or both parents
   Energy expenditure: more important than
    food intake?
   TV: every 2 hours incr obesity 23% and DM
    14%
                   EATING DISORDERS 06 22 10      55
Obesity: known Associations
   Sleep deprivation (Spiegel 2004): causes
    decrease in leptin and increase in ghrelin
   Eating!
       “Fast food”: incr weight and insulin resistance
        (Pereira 2005)
       EATING DISORDERS: nighttime eating; binge
        eating disorders


                       EATING DISORDERS 06 22 10          56
Supersize Me




  EATING DISORDERS 06 22 10   57
Eating Disorders: Physical Problems
   Effects of caloric restriction
   Effects of purging
   Effects of overeating




                     EATING DISORDERS 06 22 10   58
Effects of Caloric Restriction
                (Anorexia)
   Osteoporosis/osteopenia
   Cardiac disease/sudden death
   Cognitive problems
   GI dysfunction
   Endocrine changes
   Electrolyte abnormalities
   Infertility
                   EATING DISORDERS 06 22 10   59
Effects of Caloric Restriction
   Constipation (vs distorted body image)
   Refeeding syndrome: cardiac collapse when
    food intake resumes; death due to low
    phosphate concentration




                  EATING DISORDERS 06 22 10     60
Effects of Purging (Bulimia)
   Dental erosion
   Enlarged salivary glands
   “finger sign”
   Esophageal damage




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Effects of Overeating: Metabolic
Syndrome
   Elevated waist circumference:
    Men — Equal to or greater than 40 inches (102 cm)
    Women — Equal to or greater than 35 inches (88 cm)
   Elevated triglycerides:
    Equal to or greater than 150 mg/dL
   Reduced HDL (“good”) cholesterol:
    Men — Less than 40 mg/dL
    Women — Less than 50 mg/dL
   Elevated blood pressure:
    Equal to or greater than 130/85 mm Hg
   Elevated fasting glucose:
    Equal to or greater than 100 mg/dL

                        EATING DISORDERS 06 22 10        63
Causes of Eating Disorders?
   Sexual abuse? (environment)
   Family history (genetics)
       6-10X increase if 1st degree relative affected
       More common in identical than fraternal twins
       More common if relatives have alcoholism
   Associated with other psychiatric disorders
   Associated with other chemical dependency (B>AN)
   ADDICTION?

                         EATING DISORDERS 06 22 10       64
Eating Disorder & Chemical
Dependency
   A 19 year old was admitted to residential
    treatment for cocaine dependency.
   She has been treated in the past for “eating
    problems” but it “is over now”.




                    EATING DISORDERS 06 22 10      65
ED + CD
   During the interview, however, she requests
    permission for:
       “extra laxatives”
       Lettuce only for meals
       Permission to “jog” without supervision
       Extra vitamin allowance.
   Records review: previous admission to ICU
    for severe malnutrition.
                       EATING DISORDERS 06 22 10   66
Do You Have an Eating Disorder?
        20 Questions




           EATING DISORDERS 06 22 10   67
Are You a Food Addict? 20 Questions
             from FAIR
1.   Have you ever wanted to stop eating and found you
     just couldn’t?
2.   Do you think about food or your weight constantly?
3.   Do you find yourself attempting one diet or food
     plan after another, with no lasting success?
4.   Do you binge and then “get rid of the binge”?
5.   Do you eat differently in private than you do in
     front of other people?

                      EATING DISORDERS 06 22 10       68
Are You a Food Addict? 20 Questions
             from FAIR

2.   Has a doctor or family member every approached
     you with concerns about your eating/weight?
3.   Do you eat large quantities of food at one time
     (binge)?
4.   Is your weight problem due to your “nibbling” all
     day long?
5.   Do you eat to escape from your feelings?
6.   Do you eat when you’re not hungry?

                      EATING DISORDERS 06 22 10          69
Are You a Food Addict? 20 Questions
             from FAIR
1.   Have you ever discarded food, only to
     retrieve and eat it later?
2.   Do you eat in secret?
3.   Do you fast or severely restrict your food
     intake?
4.   Have you ever stolen other people’s food?
5.   Have you ever hidden food to make sure you
     have “enough”?
                   EATING DISORDERS 06 22 10   70
Are You a Food Addict? 20 Questions
             from FAIR
1.   Do you feel driven to exercise excessively to
     control your weight?
2.   Do you obsessively calculate the calories you’ve
     burned against the calories you’ve eaten?
3.   Do you frequently feel guilty or ashamed about
     what you’ve eaten?
4.   Are you waiting for your life to begin “when you
     lose the weight?”
5.   Do you feel hopeless about your relationship with
     food?
                      EATING DISORDERS 06 22 10          71
Treatment for ED/Obesity
   Caloric Restriction
   Psychotherapy
   Spiritual
   Medical
   Surgical



                    EATING DISORDERS 06 22 10   72
Treatment for ED/Obesity
   Caloric Restriction: if diets worked, the
    auditorium would be empty tonight.
   Psychotherapy
   Spiritual
   Medical
   Surgical


                    EATING DISORDERS 06 22 10   73
Treatment for ED/Obesity
   Psychotherapy: CBT, WW, EDEN
   Spiritual
   Medical
   Surgical




                 EATING DISORDERS 06 22 10   74
Treatment for ED/Obesity
   Psychotherapy
   Spiritual: FA, OA, FAA
   Medical
   Surgical




                  EATING DISORDERS 06 22 10   75
Treatment for ED/Obesity
   Psychotherapy
   Spiritual
   Medical: Stimulants, AD, AED, CB1I, DAI
   Surgical




                  EATING DISORDERS 06 22 10   76
Treatment for ED/Obesity
   Psychotherapy
   Spiritual
   Medical
   Surgical: bypass, banding




                   EATING DISORDERS 06 22 10   77
Spirituality ≠ Religion
   Belief in a power greater than yourself
   “Turn your will over”
   Accept direction
   Live according to principles




                EATING DISORDERS 06 22 10     78
Spirituality




               EATING DISORDERS 06 22 10   79
Spirituality ≠ Religion




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Twelve Step Programs
                          Food Addicts in
                           Recovery Anonymous



                          Overeater’s
                           Anonymous




      EATING DISORDERS 06 22 10                 81
Twelve Steps of FA/OA
                            http://foodaddicts.org; http://oa.org
1.   We admitted we were powerless over
     food — that our lives had become               7.     Humbly asked Him to remove our
     unmanageable.                                         shortcomings.
2.   Came to believe that a Power greater           8.     Made a list of all persons we had harmed and
     than ourselves could restore us to sanity.            became willing to make amends to them all.
                                                    9.     Made direct amends to such people wherever
3.   Made a decision to turn our will and our              possible, except when to do so would injure
     lives over to the care of God as we                   them or others.
     understood Him.                                10.    Continued to take personal inventory and
4.   Made a searching and fearless moral                   when we were wrong, promptly admitted it.
     inventory of ourselves.                        11.    Sought through prayer and meditation to
5.   Admitted to God, to ourselves and to                  improve our conscious contact with God as we
                                                           understood Him, praying only for knowledge
     another human being the exact nature of               of His will for us and the power to carry that
     our wrongs.                                           out.
6.   Were entirely ready to have God remove         12.    Having had a spiritual awakening as the result
     all these defects of character.                       of these Steps, we tried to carry this message
                                                           to compulsive overeaters and to practice these
                                                           principles in all our affairs.




                                      EATING DISORDERS 06 22 10                                        82
Do men get eating disorders?




             EATING DISORDERS 06 22 10   83
From “Food Addiction: Stories of Men
           in Recovery”
   Being a man, I learned I was not supposed to worry
    about my weight. When I stopped drinking
    alcohol…my weight began to rise, and no matter
    what I tried, I could not control it. Food had become
    my alternative to alcohol.
   In FA, I was able to recognize that certain foods are
    addictive substances for me. I learned how to weigh
    and measure my food, putting boundaries around my
    meals. I have been able to return to the athletic
    activities that had become too painful…In FA, I am
    learning how to face life without using food as a
    drug.”
                      EATING DISORDERS 06 22 10         84
Treatment of AN/BN
   Cognitive Behavioral Therapy (Lewandowski
    1997)
   Interpersonal therapy
   Medications:
       For AN: little data, ? Olanzapine
       BN: fluoxetine, ? Ondansetron
   Hospitalization
   OA (Malenbaum 1988)
                       EATING DISORDERS 06 22 10   85
Medications for Obesity: Stimulants
     Phentermine (Adipex)
     Diethylproprion (Tenuate)
     Sibutramine (Meridia) (also serotonin)
     Ephedra/ Ma Huang




                     EATING DISORDERS 06 22 10   86
Medications for Obesity:
Antidepressants
   Act on serotonin:
       Sertraline (Zoloft)
       Fluoxetine (Prozac)
   Act on norepi/dopamine:
       Buproprion




                       EATING DISORDERS 06 22 10   87
Medications for Obesity: Antiepileptics
   Topiramate (Topomax)
       Commonly used for
        migraine prophylaxis
       Produces “topomax
        brain”




                         EATING DISORDERS 06 22 10   88
Medications for Obesity: EC
antagonists (Rimonabant, Acomplia)
   CB1 receptor blocker
   Compared to placebo:
       5% BW loss: 51 vs 19%
       10% BW loss: 27 vs 7%
       DEPRESSION: did not get FDA approval




                     EATING DISORDERS 06 22 10   89
Medications for Obesity: mu
antagonists (naltrexone, Vivitrol)
   May block the “reward” of eating through the
          mu opioid receptor  DA release
   Used to block the reward of alcohol, tobacco?
   ? Blocks natural endorphins
   Blocks the ability of anyone in the ER to give
    you pain meds when you break your leg!


                    EATING DISORDERS 06 22 10    90
Bariatric Surgery
   Indications
   Contraindications
   Complications




                   EATING DISORDERS 06 22 10   91
Bariatric Surgery
   Indications:
       BMI > 40 or 35 with complications
       Have failed medical therapy
       Surgical candidates




                      EATING DISORDERS 06 22 10   92
Bariatric Surgery
   Contraindications
       Binge eating disorder
       Current drug and alcohol use
       Untreated MDD or psychosis




                      EATING DISORDERS 06 22 10   93
Bariatric Surgery

   Complications
       Mortality: 1 – 20? %
       Malabsorption
       Post-surgical complications
       ? Addictive disorders



                       EATING DISORDERS 06 22 10   94
Gastric Banding




            EATING DISORDERS 06 22 10   95
SOS Study: Swedish Obese Subjects
   Randomized to either bariatric surgery or
    “conventional” treatment
   “conventional” treatment gained 2% over 10
    years
   Surgery group lost 16 % over 10 years



                   EATING DISORDERS 06 22 10     96
BRAIN SCANS
  apologies to PETA




   EATING DISORDERS 06 22 10   97
Dopamine




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Obese subjects have decreased DA




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Dopamine: Normal vs. Overweight




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Dopamine Receptors: Normal vs.
           Obese




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Effect of Cocaine Cues on Dopamine
   A cocaine addict is
    shown a picture of
    Bambi in the forest.
   The large amount of
    “red” indicates that
    dopamine hasn’t been
    released.



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Effect of Cocaine Cues on Dopamine
   The picture on the right
    shows less “red” =
   Dopamine has been
    released.
   THE CUE OF SEEING
    COCAINE CAUSED
    DOPAMINE RELEASE
   = RISK OF RELAPSE



                         EATING DISORDERS 06 22 10   105
Volkow: Placebo Ritalin Food
   The sight of food
    caused a release of
    dopamine, just like
    cocaine!
   In this “addict”, the
    drug is FOOD




                        EATING DISORDERS 06 22 10   106
Abnormal response to Ritalin is due to
abnormal brain chemistry




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DAKOTA
1995-2007




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Contact info
   Carl Christensen MD PhD
   Pain Recovery Solutions, Ypsi MI (734 434
    6600)
   Voice/fax: 734 448 0226
   Email:
     ccmdphd@mac.com



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READY, SET… RECOVER
INSPIRATIONS FOR EATING DISORDER
RECOVERY
RESOURCES
 ABOUND
EATING DISORDERS PROFESSIONAL
LEAGUE OF MICHIGAN


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 the treatment of eating disorders or those in need
 of help can access this site for free information
 regarding local treatment and support
EDEN
EATING DISORDERS AND
EDUCATION NETWORK

•   WWW.Edenprocess.com




    If you personally ARE struggling with an eating disorder please
     contact one of our EDEN facilitators who can point you to treatment
     professionals in your area who specialize in eating disorders.
     edenadmin@charter.net
       EDEN also offers community based support groups that will help
     you learn the HEALTHY COPING SKILLS NEEDED TO ATTAIN AND
     MAINTAIN RECOVERY. If there is no support group in your area
     EDEN also offers telephone support.
       If you know someone who is struggling we are here to help GIVE THE
CENTER FOR EATING
DISORDERS ANN ARBOR

    www.center4ed.org
•   The first step is the hardest.
•   Let us help.
•   Founded in 1983, the Center for Eating Disorders
    (CED) marks 25 years of serving our community.
    CED offers outpatient treatment, education, support,
    and referral services to children, adolescents, and
    adults with eating, weight, and body image disorders
    including anorexia nervosa, bulimia nervosa,
    compulsive eating/binge eating disorder and related
    issues.
UNIVERSITY OF MICHIGAN
  UNIVERSITY HEALTH
  SERVICES
Recovery is possible! Eating disorder treatment is available and recovery is
possible!
It is possible to access eating disorder treatment while taking classes at UM. In
some cases, students choose to take fewer credits or temporarily withdraw to
allow more time and energy for treatment. In any case, we can offer support
and assistance!
Regardless of how long you've struggled with eating issues or the severity of
your eating disorder, the sooner you begin treatment, the better. The longer
disordered eating patterns continue and the more deeply ingrained they
become, the more difficult recovery may be. Seek help soon if you think you or
a friend might be struggling with eating problems.
If you'd like information about eating disorder treatment or if you are concerned
about a friend or family member, check out
Resources for Eating Disorders and Body Image.

                     http://www.uhs.umich.edu/eatingdisorders
ANOREXIA BULIMIA ANONYMOUS
HTTP://WWW.ANOREXICSANDBULIMICSANONYMO
USABA.COM




•   WHO ARE WE?
    Anorexics and Bulimics Anonymous (ABA) is a Fellowship
    of individuals whose primary purpose is to find and
    maintain “sobriety” in our eating practices, and to help
    others gain sobriety. The only requirement for membership
    is a desire to stop unhealthy eating practices. There are no
    dues or fees for ABA membership; we are
    self-supporting through our own contributions. ABA is not
    affiliated with any other organization or institution, nor
    are we allied with any religion.
OVEREATERS ANONYMOUS
WWW.OA.ORG

•   OA Program of Recovery
•   Overeaters Anonymous offers a program of recovery
    from compulsive eating using the Twelve Steps and
    Twelve Traditions of OA. Worldwide meetings and
    other tools provide a fellowship of experience,
    strength and hope where members respect one
    another’s anonymity. OA charges no dues or fees; it is
    self-supporting through member contributions.
•   OA is not just about weight loss, gain or maintenance;
    or obesity or diets. It addresses physical, emotional
    and spiritual well-being. It is not a religious
    organization and does not promote any particular
    diet. If you want to stop your compulsive overeating,
    welcome to Overeaters Anonymous.
NATIONAL EATING DISORDERS
ASSOCIATION
      http://www.nationaleatingdisorders.org




        Welcome to the National Eating Disorders
        Association. We're glad you found us.

        NEDA is dedicated to providing education, resources
        and support to those affected by eating disorders.
        Whether you are an individual living with an eating
        disorder, a family member or friend looking to offer
        support to a loved one, or a treatment professional
        looking to help others — we are here for you. If you
        are looking for treatment options or a support group,
        click here: GET HELP TODAY.
ANAD
    NATIONAL ASSOCIATION OF ANOREXIA NERVOSA
    AND OTHER ASSOCIATED EATING DISORDERS

                        www.ANAD.org

National Association of Anorexia Nervosa and Associated Disorders is the oldest non-profit in the
country dedicated to alleviating and preventing eating disorders.  
                                                     
Visit our Get Help section if you are looking for a therapist, support group or treatment program.
  
         our  Get  Involved  section  if  you   
Visit                                         would like to become a member, volunteer or professional
partner.  
                                                                            
Visit our Get Information section to get accurate information and resources to help yourself of
someone else suffering from an eating disorder.                                                                              
        
Of course, our helpline (630) 577-1330 is available for questions, direction or further resources.    
WWW.GURZE.COM




                
                    
TREATMENTS
   Research has not provided us empirically proven
    treatments for the long term relief from eating
    disorders.




               WHAT DOES THIS MEAN?
CELEBRATE
STRONGLY SUPPORTED
TREATMENTS
COGNITIVE BEHAVIORAL THERAPY FOR EATING
DISORDERS
Cognitive-behavioral therapy is an active type of counseling. Sessions
usually are held once a week for as long as you need to master new skills.
Individual sessions last 1 hour, and group sessions may be longer.
During cognitive-behavioral therapy for anorexia or bulimia you learn:
About your illness, its symptoms, and how to predict when symptoms will
most likely recur.
To keep a diary of eating episodes, binge eating, purging, and the events
that may have triggered these episodes.
To eat more regularly, with meals or snacks spaced no more than 3 or 4
hours apart.
How to change the way you think about your symptoms. This reduces the
power the symptoms have over you.
How to change self-defeating thought patterns into patterns that are more
helpful. This improves mood and your sense of mastery over your life. This
helps you avoid future episodes.
Ways to handle daily problems differently.
What To Expect After Treatment
You can use your cognitive-behavioral skills throughout your life. You may
find that additional "tune-up" sessions help you stay on track with your new
skills.            http://www.webmd.com/mental-health/cognitive-behavioral-therapy-for-eating-disorders
INTERPERSONAL
PSYCHOTHERAPY


   Interpersonal Psychotherapy (IPT) is a time-limited
    psychotherapy that focuses on the interpersonal context
    and on building interpersonal skills. IPT is based on the
    belief that interpersonal factors may contribute heavily to
    psychological problems. ...

   A brief and highly structured manual-based psychotherapy
    that addresses interpersonal issues, to the exclusion of all
    other areas of clinical attention.

   Short-term therapy for depression that looks for solutions
    and strategies to deal with interpersonal problems rather
    than spending time on interpretation and analysis.
               highered.mcgraw-hill.com/sites/007242298x/student_view0/glossary.html
EMERGING TREATMENTS
 12-STEP PROGRAMS
 DBT DIALECTICAL BEHAVIOR THERAPY

 ACCEPTANCE & COMMITMENT THERAPY

 ONLINE SUPPORT GROUPS

 SUPPORT GROUPS
DIALECTICAL BEHAVIOR THERAPY
                                   DBT
DBT Therapy Treatment
Treatment in DBT therapy has four parts, which are all important to effective
treatment:
Individual Therapy
Telephone Contact
Therapist Consultation
- good communication between group therapist and individual therapist is
essential to the successful outcome of DBT therapy.
Skills Training
- Conducted by a behavioral technician or another therapist usually in a group
context.
- Conducted in weekly sessions of 2.5 hours with a break half way through each
session.
- The focus is on learning and practicing adaptive skills, not personal or specific
complaints of the clients and thus, any specific or personal issues are redirected
to be discussed in individual therapy.
                                 http://bipolar.about.com/cs/menu_treat/a/aa031016.htm
STAGES OF CHANGE
STAGES OF CHANGE


 Pre-Contemplation
 Contemplation

 Preparation

 Action

 Maintaining
TREATMENT FROM AN ADDICTION
PERSPECTIVE


You Do Not Will Yourself Out Of An Eating
 Disorder….

You Get Well By Working A Program,
And Through The Help Of Others
BUILD YOUR PROGRAM
 Physician
 Therapist

 Support Network/Groups

 Nutritional Counseling

 Residential Treatment
TAKE A WHOLE PERSON APPROACH
SEEK DEVELOPMENT & BALANCE
 Emotional
 Social

 Physical

 Spiritual
THE TREATMENT CHALLANGES


   COMPASSION & ACCOUNTABILTY

   EMOTIONAL AWARENESS & HABIT
    BREAKING

   FAILURE & INSPIRATION

   WILLINGNESS & ACCEPTANCE
FOR THOSE SUPPORTING
You are not alone.
Seek support for yourself.
Learn healthy boundary setting.
FOR THOSE TRYING TO RECOVER
YOU DO NOT HAVE TO DO THIS ALONE
YOU CAN DO THIS
YOU CAN LIKE YOURSELF TODAY
THANK YOU

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Eating Disorders: Brain Science and Addiction

  • 1. Eating Disorders June 26, 2012 Carl Christensen, MD PhD Pain Recovery Solutions, Ann Arbor Mi Depts of OB Gyn & Psychiatry, WSU cchriste@med.wayne.edu
  • 2. “My War With Food Addiction”  “Some people fight battles with guns and tanks, others use spoons and kitchen utensils. I remember the Battle of the Bulge. The Ponderosa Salad Bar suffered a six-plate defeat. I remember a war with a chocolate Easter bunny. In the middle of the night, I bit its head off. I admit it. I was a food addict. My life was controlled by food. Moderation was never my strong point. EATING DISORDERS 06 22 10 2
  • 3. “My War With Food Addiction”  When it came to ice cream, one scoop was never enough. I once ate a two-and-a-half gallon tub of maple walnut ice cream. It almost froze my stomach. To make matters worse, it was my roommate’s ice cream! I felt so badly afterwards that I put a 12-foot chain through the handles of the refrigerator and cupboards and told my roommate, "here's the key to your food." He wasn't impressed.”  Tom McGregor, “Eating in Freedom” EATING DISORDERS 06 22 10 3
  • 4. Step Two: Overeater’s Anonymous  “We have driven miles in the dead of night to satisfy a craving for food. We have eaten food that was frozen, burnt, stale, or even dangerously spoiled. We have eaten food off of other people’s plates, off the floor, off the ground. We have dug food out of the garbage and eaten it.” EATING DISORDERS 06 22 10 4
  • 5. Step Two: Overeater’s Anonymous  “We have frequently lied about what we have eaten-lied to others because we didn’t want to face the truth ourselves. We have stolen food from our friends, ….we have also stolen money to buy food. We have eaten beyond the point of being full, beyond the point of being sick of eating. We have continued to overeat, knowing all the while we were disfiguring and maiming our bodies.” EATING DISORDERS 06 22 10 5
  • 6. Anorexia  “I don’t see what they tell me they see in the mirror. My cheeks are too full, my hips and thighs are too wide and round, my arms carry too much fat and my stomach bulges. Looking in the mirror is a daily torture that I allow myself, because who can resist the temptation of that reflective sheet of glass? Of glimpsing who they think they are? EATING DISORDERS 06 22 10 6
  • 7. Anorexia  I am afraid. Someone please tell me there is a better way, because I just don’t know where to turn or what to do. I am fifteen, and I will join the ranks of those who call themselves anorexic.” -Anonymous EATING DISORDERS 06 22 10 7
  • 8. Tonight’s talk  What is an eating disorder?  Are eating disorders addictions?  What is addiction?  What parts of the brain are involved?  What is obesity?  What are the consequences of eating disorders?  How are eating disorders treated? What about medication?  Brain scans: the lights are bright, but nobody’s home……  Where can I get help? EATING DISORDERS 06 22 10 8
  • 9. “…..he’s very depressing” (2007) EATING DISORDERS 06 22 10 9
  • 10. “I left tonight entirely without hope” (2011) EATING DISORDERS 06 22 10 10
  • 11. Eating Disorders ≠ weight disorder  Anorexia Nervosa  Bulimia  Binge eating disorder EATING DISORDERS 06 22 10 11
  • 12. Anorexia Nervosa  Refuses to maintain a “normal” weight or >15% below IBW  Fear of weight gain  Severe body image disturbance  Absence of menstrual cycles (if post- menstrual female)  2 types: restrictive and binging/purging* EATING DISORDERS 06 22 10 12
  • 13. Bulimia Nervosa  Episodes of binge eating with a sense of loss of control  followed by compensatory behavior of the purging type (self-induced vomiting, laxative abuse, diuretic abuse) or nonpurging type (excessive exercise, fasting, or strict diets).  Binges and the resulting compensatory behavior must occur a minimum of two times per week for three months  Dissatisfaction with body shape and weight EATING DISORDERS 06 22 10 13
  • 14. Binge Eating Disorder  Eating much more rapidly than normal  Eating until uncomfortably full  Eating large amounts of food when not feeling physically hungry  Eating alone because of embarrassment  Feeling disgusted, depressed, or very guilty after overeating EATING DISORDERS 06 22 10 14
  • 15. Eating Disorders: are they Addictions? EATING DISORDERS 06 22 10 15
  • 16. What is Addiction?  Physiologic Dependence?  Lack of willpower?  An “amoral” condition?  A brain disease? EATING DISORDERS 06 22 10 16
  • 17. Physiologic Dependence: Tolerance and Withdrawal  Tolerance: requiring increasing amounts of drug to get the same effect  Withdrawal: the opposite effect of the drug when it is removed  NEITHER of these imply chemical dependency (addiction) EATING DISORDERS 06 22 10 17
  • 18. Lack of Willpower? EATING DISORDERS 06 22 10 18
  • 19. An “amoral” condition? EATING DISORDERS 06 22 10 19
  • 21. A Brain Disease? EATING DISORDERS 06 22 10 21
  • 22. VTA: supplies DA to the N Acc The NA: GO!!! Frontal Cortex: STOP!!!! EATING DISORDERS 06 22 10 22
  • 24. “I feel like I don’t belong in my own skin….” anonymous alcoholic  Decreased Dopamine receptors =decreased Dopamine =  Decreased Hedonic Tone  Salsitz 2006 EATING DISORDERS 06 22 10 24
  • 25. Can you find the (alleged) future alcoholic? EATING DISORDERS 06 22 10 25
  • 26. Chemical Dependence: DSM IV definition  Tolerance  Great deal of time  Withdrawal spent in  Take more/take longer obtaining/using than intended /recovering  Can’t cut down or  Important control use social/occ/recreation given up 2º to use  Use despite physical/psych problem EATING DISORDERS 06 22 10 26
  • 27. Addiction/chemical dependence: working definition  A chronic progressive disease characterized by the following physical and psychological symptoms (the four (five) C’s):  Craving  Compulsion  Loss of Control  Continued use despite consequences, and  Chronic use EATING DISORDERS 06 22 10 27
  • 28. RELAPSE: the problem with addiction  Drug triggered: “I thought I could (eat/smoke/drink) just one….”  Stress triggered: “I’m going through too much right now. Gimme that!”  Cue triggered: “Wet faces and wet places” EATING DISORDERS 06 22 10 28
  • 29. Drug Triggered Relapse: Gardner 2006 EATING DISORDERS 06 22 10 29
  • 30. Stress Triggered Relapse: Gardner 2006 EATING DISORDERS 06 22 10 30
  • 31. Cue Triggered Relapse: Gardner 2006 EATING DISORDERS 06 22 10 31
  • 32. Other parts of the Brain  Dorsal Striatum (Craving)  Amygdala (Memory/Danger/emergency)  Hippocampus (memory)  Frontal cortex (? Inhibition)  Hypothalamus (Appetite/satiety) EATING DISORDERS 06 22 10 32
  • 33. Other Neurochemicals in the Brain  Norepinephrine (stimulates/satiates)  Serotonin (calms)  Endocannabinoids (super size that, please!)  Endorphins (increased feeding)  Leptin (antagonist of EC)  Ghrelin (stimulates appetite) EATING DISORDERS 06 22 10 33
  • 34. FA/OA AA/NA  “We ask that during  “Don’t let yourself your share you not become Hungry, mention specific food Angry, Lonely, or groups by name” Tired!” EATING DISORDERS 06 22 10 34
  • 35. “Hi…I’m Joe. I’m cross addicted” EATING DISORDERS 06 22 10 35
  • 36. Food Addiction????  FA: “Hi, I’m Joe. I’m a food addict”.  OA: “Hi, I’m Joe. I’m a compulsive overeater.”  Both are describing the same thing: an abnormal relationship with food. EATING DISORDERS 06 22 10 36
  • 37. How many of these are addicitons? EATING DISORDERS 06 22 10 37
  • 44. Are Eating Disorders Addictions? Mark Gold, “Eating Disorders, Overeating, and Pathological Attachment to Food”.  “The 1960s were known as the decade of sex, drugs, and rock and roll. Food seems to be an afterthought and it may be that it is suppressed by drug-taking.  …the heavier the patient, the less alcohol and illegal drugs they use. It is almost as if they are competing for the same reward sites in the brain.  Treatment of addicts appears to result in weight gain….all supervised drug abstinence treatment causes weight gain.  …loss of control over eating and obesity produces changes in the brain, which are similar to those produced by drugs of abuse.” EATING DISORDERS 06 22 10 44
  • 45. Are Eating Disorders Addictions? Nora Volkow  Many obesity researchers focus on how the body's fuel and fat levels control appetite. But as binge eaters know, habits and desire often override metabolic need, which share some of the characteristics of drug using behavior in drug-addicted subjects. EATING DISORDERS 06 22 10 45
  • 46. Why Healthy Fast Food May Not Work….. EATING DISORDERS 06 22 10 46
  • 47. Obesity: use despite consequences  How do you define it?  How has it changed in the U.S.?  What are the known causes ASSOCIATIONS not causes)? EATING DISORDERS 06 22 10 47
  • 48. BMI Graph EATING DISORDERS 06 22 10 48
  • 49. Obesity Trends* Among U.S. Adults BRFSS, 1990, 1995, 2005 (*BMI ≥30, or about 30 lbs overweight for 5’4” person) 1990 1995 2005 No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% EATING DISORDERS 06 22 10 49
  • 50. Obesity Trends* Among U.S. Adults BRFSS, 1985 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% EATING DISORDERS 06 22 10 50
  • 51. Obesity Trends* Among U.S. Adults BRFSS, 1990 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% EATING DISORDERS 06 22 10 51
  • 52. Obesity Trends* Among U.S. Adults BRFSS, 1995 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% EATING DISORDERS 06 22 10 52
  • 53. Obesity Trends* Among U.S. Adults BRFSS, 2000 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% ≥20% EATING DISORDERS 06 22 10 53
  • 54. Obesity Trends* Among U.S. Adults BRFSS, 2005 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% EATING DISORDERS 06 22 10 54
  • 55. Obesity: known Associations  Prenatal: mom’s caloric intake; maternal DM  Breastfeeding: protective  FH: one or both parents  Energy expenditure: more important than food intake?  TV: every 2 hours incr obesity 23% and DM 14% EATING DISORDERS 06 22 10 55
  • 56. Obesity: known Associations  Sleep deprivation (Spiegel 2004): causes decrease in leptin and increase in ghrelin  Eating!  “Fast food”: incr weight and insulin resistance (Pereira 2005)  EATING DISORDERS: nighttime eating; binge eating disorders EATING DISORDERS 06 22 10 56
  • 57. Supersize Me EATING DISORDERS 06 22 10 57
  • 58. Eating Disorders: Physical Problems  Effects of caloric restriction  Effects of purging  Effects of overeating EATING DISORDERS 06 22 10 58
  • 59. Effects of Caloric Restriction (Anorexia)  Osteoporosis/osteopenia  Cardiac disease/sudden death  Cognitive problems  GI dysfunction  Endocrine changes  Electrolyte abnormalities  Infertility EATING DISORDERS 06 22 10 59
  • 60. Effects of Caloric Restriction  Constipation (vs distorted body image)  Refeeding syndrome: cardiac collapse when food intake resumes; death due to low phosphate concentration EATING DISORDERS 06 22 10 60
  • 61. Effects of Purging (Bulimia)  Dental erosion  Enlarged salivary glands  “finger sign”  Esophageal damage EATING DISORDERS 06 22 10 61
  • 63. Effects of Overeating: Metabolic Syndrome  Elevated waist circumference: Men — Equal to or greater than 40 inches (102 cm) Women — Equal to or greater than 35 inches (88 cm)  Elevated triglycerides: Equal to or greater than 150 mg/dL  Reduced HDL (“good”) cholesterol: Men — Less than 40 mg/dL Women — Less than 50 mg/dL  Elevated blood pressure: Equal to or greater than 130/85 mm Hg  Elevated fasting glucose: Equal to or greater than 100 mg/dL EATING DISORDERS 06 22 10 63
  • 64. Causes of Eating Disorders?  Sexual abuse? (environment)  Family history (genetics)  6-10X increase if 1st degree relative affected  More common in identical than fraternal twins  More common if relatives have alcoholism  Associated with other psychiatric disorders  Associated with other chemical dependency (B>AN)  ADDICTION? EATING DISORDERS 06 22 10 64
  • 65. Eating Disorder & Chemical Dependency  A 19 year old was admitted to residential treatment for cocaine dependency.  She has been treated in the past for “eating problems” but it “is over now”. EATING DISORDERS 06 22 10 65
  • 66. ED + CD  During the interview, however, she requests permission for:  “extra laxatives”  Lettuce only for meals  Permission to “jog” without supervision  Extra vitamin allowance.  Records review: previous admission to ICU for severe malnutrition. EATING DISORDERS 06 22 10 66
  • 67. Do You Have an Eating Disorder? 20 Questions EATING DISORDERS 06 22 10 67
  • 68. Are You a Food Addict? 20 Questions from FAIR 1. Have you ever wanted to stop eating and found you just couldn’t? 2. Do you think about food or your weight constantly? 3. Do you find yourself attempting one diet or food plan after another, with no lasting success? 4. Do you binge and then “get rid of the binge”? 5. Do you eat differently in private than you do in front of other people? EATING DISORDERS 06 22 10 68
  • 69. Are You a Food Addict? 20 Questions from FAIR 2. Has a doctor or family member every approached you with concerns about your eating/weight? 3. Do you eat large quantities of food at one time (binge)? 4. Is your weight problem due to your “nibbling” all day long? 5. Do you eat to escape from your feelings? 6. Do you eat when you’re not hungry? EATING DISORDERS 06 22 10 69
  • 70. Are You a Food Addict? 20 Questions from FAIR 1. Have you ever discarded food, only to retrieve and eat it later? 2. Do you eat in secret? 3. Do you fast or severely restrict your food intake? 4. Have you ever stolen other people’s food? 5. Have you ever hidden food to make sure you have “enough”? EATING DISORDERS 06 22 10 70
  • 71. Are You a Food Addict? 20 Questions from FAIR 1. Do you feel driven to exercise excessively to control your weight? 2. Do you obsessively calculate the calories you’ve burned against the calories you’ve eaten? 3. Do you frequently feel guilty or ashamed about what you’ve eaten? 4. Are you waiting for your life to begin “when you lose the weight?” 5. Do you feel hopeless about your relationship with food? EATING DISORDERS 06 22 10 71
  • 72. Treatment for ED/Obesity  Caloric Restriction  Psychotherapy  Spiritual  Medical  Surgical EATING DISORDERS 06 22 10 72
  • 73. Treatment for ED/Obesity  Caloric Restriction: if diets worked, the auditorium would be empty tonight.  Psychotherapy  Spiritual  Medical  Surgical EATING DISORDERS 06 22 10 73
  • 74. Treatment for ED/Obesity  Psychotherapy: CBT, WW, EDEN  Spiritual  Medical  Surgical EATING DISORDERS 06 22 10 74
  • 75. Treatment for ED/Obesity  Psychotherapy  Spiritual: FA, OA, FAA  Medical  Surgical EATING DISORDERS 06 22 10 75
  • 76. Treatment for ED/Obesity  Psychotherapy  Spiritual  Medical: Stimulants, AD, AED, CB1I, DAI  Surgical EATING DISORDERS 06 22 10 76
  • 77. Treatment for ED/Obesity  Psychotherapy  Spiritual  Medical  Surgical: bypass, banding EATING DISORDERS 06 22 10 77
  • 78. Spirituality ≠ Religion  Belief in a power greater than yourself  “Turn your will over”  Accept direction  Live according to principles EATING DISORDERS 06 22 10 78
  • 79. Spirituality EATING DISORDERS 06 22 10 79
  • 80. Spirituality ≠ Religion EATING DISORDERS 06 22 10 80
  • 81. Twelve Step Programs  Food Addicts in Recovery Anonymous  Overeater’s Anonymous EATING DISORDERS 06 22 10 81
  • 82. Twelve Steps of FA/OA http://foodaddicts.org; http://oa.org 1. We admitted we were powerless over food — that our lives had become 7. Humbly asked Him to remove our unmanageable. shortcomings. 2. Came to believe that a Power greater 8. Made a list of all persons we had harmed and than ourselves could restore us to sanity. became willing to make amends to them all. 9. Made direct amends to such people wherever 3. Made a decision to turn our will and our possible, except when to do so would injure lives over to the care of God as we them or others. understood Him. 10. Continued to take personal inventory and 4. Made a searching and fearless moral when we were wrong, promptly admitted it. inventory of ourselves. 11. Sought through prayer and meditation to 5. Admitted to God, to ourselves and to improve our conscious contact with God as we understood Him, praying only for knowledge another human being the exact nature of of His will for us and the power to carry that our wrongs. out. 6. Were entirely ready to have God remove 12. Having had a spiritual awakening as the result all these defects of character. of these Steps, we tried to carry this message to compulsive overeaters and to practice these principles in all our affairs. EATING DISORDERS 06 22 10 82
  • 83. Do men get eating disorders? EATING DISORDERS 06 22 10 83
  • 84. From “Food Addiction: Stories of Men in Recovery”  Being a man, I learned I was not supposed to worry about my weight. When I stopped drinking alcohol…my weight began to rise, and no matter what I tried, I could not control it. Food had become my alternative to alcohol.  In FA, I was able to recognize that certain foods are addictive substances for me. I learned how to weigh and measure my food, putting boundaries around my meals. I have been able to return to the athletic activities that had become too painful…In FA, I am learning how to face life without using food as a drug.” EATING DISORDERS 06 22 10 84
  • 85. Treatment of AN/BN  Cognitive Behavioral Therapy (Lewandowski 1997)  Interpersonal therapy  Medications:  For AN: little data, ? Olanzapine  BN: fluoxetine, ? Ondansetron  Hospitalization  OA (Malenbaum 1988) EATING DISORDERS 06 22 10 85
  • 86. Medications for Obesity: Stimulants  Phentermine (Adipex)  Diethylproprion (Tenuate)  Sibutramine (Meridia) (also serotonin)  Ephedra/ Ma Huang EATING DISORDERS 06 22 10 86
  • 87. Medications for Obesity: Antidepressants  Act on serotonin:  Sertraline (Zoloft)  Fluoxetine (Prozac)  Act on norepi/dopamine:  Buproprion EATING DISORDERS 06 22 10 87
  • 88. Medications for Obesity: Antiepileptics  Topiramate (Topomax)  Commonly used for migraine prophylaxis  Produces “topomax brain” EATING DISORDERS 06 22 10 88
  • 89. Medications for Obesity: EC antagonists (Rimonabant, Acomplia)  CB1 receptor blocker  Compared to placebo:  5% BW loss: 51 vs 19%  10% BW loss: 27 vs 7%  DEPRESSION: did not get FDA approval EATING DISORDERS 06 22 10 89
  • 90. Medications for Obesity: mu antagonists (naltrexone, Vivitrol)  May block the “reward” of eating through the mu opioid receptor  DA release  Used to block the reward of alcohol, tobacco?  ? Blocks natural endorphins  Blocks the ability of anyone in the ER to give you pain meds when you break your leg! EATING DISORDERS 06 22 10 90
  • 91. Bariatric Surgery  Indications  Contraindications  Complications EATING DISORDERS 06 22 10 91
  • 92. Bariatric Surgery  Indications:  BMI > 40 or 35 with complications  Have failed medical therapy  Surgical candidates EATING DISORDERS 06 22 10 92
  • 93. Bariatric Surgery  Contraindications  Binge eating disorder  Current drug and alcohol use  Untreated MDD or psychosis EATING DISORDERS 06 22 10 93
  • 94. Bariatric Surgery  Complications  Mortality: 1 – 20? %  Malabsorption  Post-surgical complications  ? Addictive disorders EATING DISORDERS 06 22 10 94
  • 95. Gastric Banding EATING DISORDERS 06 22 10 95
  • 96. SOS Study: Swedish Obese Subjects  Randomized to either bariatric surgery or “conventional” treatment  “conventional” treatment gained 2% over 10 years  Surgery group lost 16 % over 10 years EATING DISORDERS 06 22 10 96
  • 97. BRAIN SCANS apologies to PETA EATING DISORDERS 06 22 10 97
  • 100. Obese subjects have decreased DA EATING DISORDERS 06 22 10 100
  • 101. Dopamine: Normal vs. Overweight EATING DISORDERS 06 22 10 101
  • 102. Dopamine Receptors: Normal vs. Obese EATING DISORDERS 06 22 10 102
  • 103. Effect of Cocaine Cues on Dopamine  A cocaine addict is shown a picture of Bambi in the forest.  The large amount of “red” indicates that dopamine hasn’t been released. EATING DISORDERS 06 22 10 103
  • 104. EATING DISORDERS 06 22 10 104
  • 105. Effect of Cocaine Cues on Dopamine  The picture on the right shows less “red” =  Dopamine has been released.  THE CUE OF SEEING COCAINE CAUSED DOPAMINE RELEASE  = RISK OF RELAPSE EATING DISORDERS 06 22 10 105
  • 106. Volkow: Placebo Ritalin Food  The sight of food caused a release of dopamine, just like cocaine!  In this “addict”, the drug is FOOD EATING DISORDERS 06 22 10 106
  • 107. Abnormal response to Ritalin is due to abnormal brain chemistry EATING DISORDERS 06 22 10 107
  • 108. EATING DISORDERS 06 22 10 108
  • 110. EATING DISORDERS 06 22 10 110
  • 111. Contact info  Carl Christensen MD PhD  Pain Recovery Solutions, Ypsi MI (734 434 6600)  Voice/fax: 734 448 0226  Email:  ccmdphd@mac.com EATING DISORDERS 06 22 10 111
  • 112. READY, SET… RECOVER INSPIRATIONS FOR EATING DISORDER RECOVERY
  • 114. EATING DISORDERS PROFESSIONAL LEAGUE OF MICHIGAN WWW.EDleague.com Mission Statement We are a multi-disciplinary group of health and mental health professionals collaborating to network and to provide professional peer support, education outreach and advocacy concerning the treatment and prevention of eating disorders. At this point in time we simply function as an online resource for the public and professional community. Those specializing in the treatment of eating disorders or those in need of help can access this site for free information regarding local treatment and support
  • 115. EDEN EATING DISORDERS AND EDUCATION NETWORK • WWW.Edenprocess.com If you personally ARE struggling with an eating disorder please contact one of our EDEN facilitators who can point you to treatment professionals in your area who specialize in eating disorders. edenadmin@charter.net  EDEN also offers community based support groups that will help you learn the HEALTHY COPING SKILLS NEEDED TO ATTAIN AND MAINTAIN RECOVERY. If there is no support group in your area EDEN also offers telephone support.  If you know someone who is struggling we are here to help GIVE THE
  • 116. CENTER FOR EATING DISORDERS ANN ARBOR www.center4ed.org • The first step is the hardest. • Let us help. • Founded in 1983, the Center for Eating Disorders (CED) marks 25 years of serving our community. CED offers outpatient treatment, education, support, and referral services to children, adolescents, and adults with eating, weight, and body image disorders including anorexia nervosa, bulimia nervosa, compulsive eating/binge eating disorder and related issues.
  • 117. UNIVERSITY OF MICHIGAN UNIVERSITY HEALTH SERVICES Recovery is possible! Eating disorder treatment is available and recovery is possible! It is possible to access eating disorder treatment while taking classes at UM. In some cases, students choose to take fewer credits or temporarily withdraw to allow more time and energy for treatment. In any case, we can offer support and assistance! Regardless of how long you've struggled with eating issues or the severity of your eating disorder, the sooner you begin treatment, the better. The longer disordered eating patterns continue and the more deeply ingrained they become, the more difficult recovery may be. Seek help soon if you think you or a friend might be struggling with eating problems. If you'd like information about eating disorder treatment or if you are concerned about a friend or family member, check out Resources for Eating Disorders and Body Image. http://www.uhs.umich.edu/eatingdisorders
  • 118. ANOREXIA BULIMIA ANONYMOUS HTTP://WWW.ANOREXICSANDBULIMICSANONYMO USABA.COM • WHO ARE WE? Anorexics and Bulimics Anonymous (ABA) is a Fellowship of individuals whose primary purpose is to find and maintain “sobriety” in our eating practices, and to help others gain sobriety. The only requirement for membership is a desire to stop unhealthy eating practices. There are no dues or fees for ABA membership; we are self-supporting through our own contributions. ABA is not affiliated with any other organization or institution, nor are we allied with any religion.
  • 119. OVEREATERS ANONYMOUS WWW.OA.ORG • OA Program of Recovery • Overeaters Anonymous offers a program of recovery from compulsive eating using the Twelve Steps and Twelve Traditions of OA. Worldwide meetings and other tools provide a fellowship of experience, strength and hope where members respect one another’s anonymity. OA charges no dues or fees; it is self-supporting through member contributions. • OA is not just about weight loss, gain or maintenance; or obesity or diets. It addresses physical, emotional and spiritual well-being. It is not a religious organization and does not promote any particular diet. If you want to stop your compulsive overeating, welcome to Overeaters Anonymous.
  • 120. NATIONAL EATING DISORDERS ASSOCIATION http://www.nationaleatingdisorders.org Welcome to the National Eating Disorders Association. We're glad you found us. NEDA is dedicated to providing education, resources and support to those affected by eating disorders. Whether you are an individual living with an eating disorder, a family member or friend looking to offer support to a loved one, or a treatment professional looking to help others — we are here for you. If you are looking for treatment options or a support group, click here: GET HELP TODAY.
  • 121. ANAD NATIONAL ASSOCIATION OF ANOREXIA NERVOSA AND OTHER ASSOCIATED EATING DISORDERS www.ANAD.org National Association of Anorexia Nervosa and Associated Disorders is the oldest non-profit in the country dedicated to alleviating and preventing eating disorders.                                                         Visit our Get Help section if you are looking for a therapist, support group or treatment program.             our  Get  Involved  section  if  you    Visit                                         would like to become a member, volunteer or professional partner.                                                                               Visit our Get Information section to get accurate information and resources to help yourself of someone else suffering from an eating disorder.                                                                                        Of course, our helpline (630) 577-1330 is available for questions, direction or further resources.    
  • 122. WWW.GURZE.COM             
  • 123. TREATMENTS  Research has not provided us empirically proven treatments for the long term relief from eating disorders. WHAT DOES THIS MEAN?
  • 126. COGNITIVE BEHAVIORAL THERAPY FOR EATING DISORDERS Cognitive-behavioral therapy is an active type of counseling. Sessions usually are held once a week for as long as you need to master new skills. Individual sessions last 1 hour, and group sessions may be longer. During cognitive-behavioral therapy for anorexia or bulimia you learn: About your illness, its symptoms, and how to predict when symptoms will most likely recur. To keep a diary of eating episodes, binge eating, purging, and the events that may have triggered these episodes. To eat more regularly, with meals or snacks spaced no more than 3 or 4 hours apart. How to change the way you think about your symptoms. This reduces the power the symptoms have over you. How to change self-defeating thought patterns into patterns that are more helpful. This improves mood and your sense of mastery over your life. This helps you avoid future episodes. Ways to handle daily problems differently. What To Expect After Treatment You can use your cognitive-behavioral skills throughout your life. You may find that additional "tune-up" sessions help you stay on track with your new skills. http://www.webmd.com/mental-health/cognitive-behavioral-therapy-for-eating-disorders
  • 127. INTERPERSONAL PSYCHOTHERAPY  Interpersonal Psychotherapy (IPT) is a time-limited psychotherapy that focuses on the interpersonal context and on building interpersonal skills. IPT is based on the belief that interpersonal factors may contribute heavily to psychological problems. ...  A brief and highly structured manual-based psychotherapy that addresses interpersonal issues, to the exclusion of all other areas of clinical attention.  Short-term therapy for depression that looks for solutions and strategies to deal with interpersonal problems rather than spending time on interpretation and analysis. highered.mcgraw-hill.com/sites/007242298x/student_view0/glossary.html
  • 128. EMERGING TREATMENTS  12-STEP PROGRAMS  DBT DIALECTICAL BEHAVIOR THERAPY  ACCEPTANCE & COMMITMENT THERAPY  ONLINE SUPPORT GROUPS  SUPPORT GROUPS
  • 129. DIALECTICAL BEHAVIOR THERAPY DBT DBT Therapy Treatment Treatment in DBT therapy has four parts, which are all important to effective treatment: Individual Therapy Telephone Contact Therapist Consultation - good communication between group therapist and individual therapist is essential to the successful outcome of DBT therapy. Skills Training - Conducted by a behavioral technician or another therapist usually in a group context. - Conducted in weekly sessions of 2.5 hours with a break half way through each session. - The focus is on learning and practicing adaptive skills, not personal or specific complaints of the clients and thus, any specific or personal issues are redirected to be discussed in individual therapy. http://bipolar.about.com/cs/menu_treat/a/aa031016.htm
  • 131. STAGES OF CHANGE  Pre-Contemplation  Contemplation  Preparation  Action  Maintaining
  • 132. TREATMENT FROM AN ADDICTION PERSPECTIVE You Do Not Will Yourself Out Of An Eating Disorder…. You Get Well By Working A Program, And Through The Help Of Others
  • 133. BUILD YOUR PROGRAM  Physician  Therapist  Support Network/Groups  Nutritional Counseling  Residential Treatment
  • 134. TAKE A WHOLE PERSON APPROACH SEEK DEVELOPMENT & BALANCE  Emotional  Social  Physical  Spiritual
  • 135. THE TREATMENT CHALLANGES  COMPASSION & ACCOUNTABILTY  EMOTIONAL AWARENESS & HABIT BREAKING  FAILURE & INSPIRATION  WILLINGNESS & ACCEPTANCE
  • 136. FOR THOSE SUPPORTING You are not alone. Seek support for yourself. Learn healthy boundary setting.
  • 137. FOR THOSE TRYING TO RECOVER YOU DO NOT HAVE TO DO THIS ALONE YOU CAN DO THIS YOU CAN LIKE YOURSELF TODAY

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  54. EATING DISORDERS 6 23 09 We have never had an epidemic like this that we have been able to track so thoroughly and see. As I told you, this is conservative. About 60 million adults, or 30 percent of the adult population, are now obese, which represents a doubling of the rate since 1980.
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