This document discusses issues surrounding the diagnosis and treatment of illnesses as idiopathic or of unknown origin. It argues that many conditions labeled as idiopathic may actually be iatrogenic, or caused by medical treatment. It notes that a high percentage of medical interventions and clinical practice guidelines are not evidence-based, and many medications' safety and efficacy have not been adequately tested, especially for women and children. As a result, so-called idiopathic conditions may in fact be adverse effects that were never studied or recognized. The document critiques overreliance on medication and lack of research into environmental or lifestyle causes of disease. It calls for more rigorous testing of treatments, especially for vulnerable groups.
Violence against women by their husband and postpartum depression finalChetkant Bhusal
The study aimed to determine the prevalence of violence against women by their husbands, postpartum depression, and the relationship between violence and depression in Nepal. The study found the incidence of postpartum depression was 19.4-22.2% and violence was 13.9-20.8%. No significant relationship was found between violence and depression, possibly due to small sample size. The study highlighted the need for further large-scale research on this topic in Nepal.
This document provides an overview of a project being undertaken by Lucine Health Sciences to better understand the real-world risks of hormonal contraceptives. The project team includes experts in various relevant fields who will take a holistic approach to assessing risk, accounting for factors like genetics, lifestyle, and the interactions between various risk factors. Their goal is to develop a risk calculator tool that provides personalized risk estimates for women, based on their individual health profiles, to facilitate more informed decisions about contraceptive options. The project is intended to further the discussion around contraceptive side effects and risks through a more comprehensive analysis than has typically been done.
Infertility is a common problem that affects millions of couples. It can be caused by factors in the male or female partner and sometimes both. While the main symptom is not being able to get pregnant, infertility can have wide-ranging emotional, psychological, physical, financial, social, and spiritual impacts on individuals and their relationships. Effective support and treatment requires addressing both the medical factors impacting fertility as well as the psychosocial needs of couples.
1. The document reviews the implications of rheumatoid arthritis (RA) on fertility and infertility. It finds that RA women tend to have smaller families and longer times to conception compared to healthy women.
2. Several factors may contribute to decreased fertility in RA women, including inflammatory processes, suppressed sexual function due to pain/fatigue, effects of drug treatments like NSAIDs on ovulation, and advanced maternal age. However, the mechanisms involved are still unclear.
3. The review examines the impact of RA on ovarian function, pregnancy loss, and risks like preeclampsia. It also discusses how inflammation may interact with the reproductive system, though more research is still needed to understand these relationships fully.
A discussion of hormones that affect women and how to stay balanced and optimize women's health through the stages of menopause. Treatment options including nutrition, lifestyle modification, hormone replacement therapy, herbal and botanical options, and bioidentical hormones discussed.
Treatment Programs HARPS Program (Helping At-Risk Pregnant Women Succeed) - C...ErikaAGoyer
NATIONAL PERINATAL ASSOCIATION CONFERENCE 2014 - Treatment Programs HARPS Program (Helping At-Risk Pregnant Women Succeed)
- Chris Cooper, MSN, NNP-CB, APRN and Dawn Forbes, MD
Violence against women by their husband and postpartum depression finalChetkant Bhusal
The study aimed to determine the prevalence of violence against women by their husbands, postpartum depression, and the relationship between violence and depression in Nepal. The study found the incidence of postpartum depression was 19.4-22.2% and violence was 13.9-20.8%. No significant relationship was found between violence and depression, possibly due to small sample size. The study highlighted the need for further large-scale research on this topic in Nepal.
This document provides an overview of a project being undertaken by Lucine Health Sciences to better understand the real-world risks of hormonal contraceptives. The project team includes experts in various relevant fields who will take a holistic approach to assessing risk, accounting for factors like genetics, lifestyle, and the interactions between various risk factors. Their goal is to develop a risk calculator tool that provides personalized risk estimates for women, based on their individual health profiles, to facilitate more informed decisions about contraceptive options. The project is intended to further the discussion around contraceptive side effects and risks through a more comprehensive analysis than has typically been done.
Infertility is a common problem that affects millions of couples. It can be caused by factors in the male or female partner and sometimes both. While the main symptom is not being able to get pregnant, infertility can have wide-ranging emotional, psychological, physical, financial, social, and spiritual impacts on individuals and their relationships. Effective support and treatment requires addressing both the medical factors impacting fertility as well as the psychosocial needs of couples.
1. The document reviews the implications of rheumatoid arthritis (RA) on fertility and infertility. It finds that RA women tend to have smaller families and longer times to conception compared to healthy women.
2. Several factors may contribute to decreased fertility in RA women, including inflammatory processes, suppressed sexual function due to pain/fatigue, effects of drug treatments like NSAIDs on ovulation, and advanced maternal age. However, the mechanisms involved are still unclear.
3. The review examines the impact of RA on ovarian function, pregnancy loss, and risks like preeclampsia. It also discusses how inflammation may interact with the reproductive system, though more research is still needed to understand these relationships fully.
A discussion of hormones that affect women and how to stay balanced and optimize women's health through the stages of menopause. Treatment options including nutrition, lifestyle modification, hormone replacement therapy, herbal and botanical options, and bioidentical hormones discussed.
Treatment Programs HARPS Program (Helping At-Risk Pregnant Women Succeed) - C...ErikaAGoyer
NATIONAL PERINATAL ASSOCIATION CONFERENCE 2014 - Treatment Programs HARPS Program (Helping At-Risk Pregnant Women Succeed)
- Chris Cooper, MSN, NNP-CB, APRN and Dawn Forbes, MD
Maternal Mental Health: CA Department of Public Health Nov 6, 2014Joy Burkhard
Maternal Mental Health is an underground health crisis impacting women, infants and families. This presentation was provided Nov. 6 2014 to the California Department of Public Health and discusses symptoms, risk factors and prevalence; impact on child development, why providers don't routinely screen/diagnose and treat, and what we can do to collectively change this course.
1) Eating disorders like anorexia and bulimia affect millions of Americans each year, especially women ages 15-25, and can have serious medical consequences including death.
2) While insurance companies do not typically view eating disorders as biological disorders requiring coverage, new scientific evidence demonstrates that eating disorders have genetic and neurological factors.
3) Research shows that eating disorders meet the definition of serious mental illnesses, negatively impacting people's quality of life and daily functioning. People struggling with eating disorders deserve access to treatment through insurance coverage.
This document discusses the work of Lucine Health Sciences, Inc. and its founder Dr. Chandler Marrs. It notes that current medical practices often lack accurate, individualized data. Lucine aims to gather real-world data on medication risks and side effects, especially those that may differ for women. Through its Hormones Matter website, Lucine collects patient stories and conducts online surveys to gain insights into conditions, identify patterns, and inspire further research. The goal is to develop more comprehensive and personalized approaches to assessing health risks.
Genetic counseling is a process that provides information about inherited disorders to allow informed choices about reproduction and management. It follows the characteristics of counseling by communicating between counselors and families confronting genetic disorders. The steps of genetic counseling involve taking an accurate history, constructing a pedigree chart, estimating risk, transmitting information, and discussing management options. Genetic counselors work with prenatal, pediatric, adult, and cancer populations to assess risk and discuss testing and management of genetic conditions. Nurses play a role in guiding patients, assisting with decisions, coordinating care, and providing support.
Prenatal alcohol exposure and offspring mental health: A systematic reviewBARRY STANLEY 2 fasd
A B S T R A C T
Background: High levels of alcohol use in pregnancy have been shown to be associated with negative physical health consequences in offspring. However, the literature is less clear on the association of alcohol use in pregnancy and offspring mental health, specifically for low levels of prenatal alcohol exposure. We conducted a systematic review to evaluate studies examining this association.
Methods: Studies were identified by searching PsycINFO, PubMed and Web of Science, and were included if they examined alcohol use during pregnancy as an exposure and offspring mental health at age 3 or older as an outcome. We excluded non-English language publications and studies of fetal alcohol syndrome.
Results: Thirty-three studies were included and were categorized by mental health outcomes: anxiety/depression, emotional problems, total internalizing problems, total problem score, and conduct disorder. Over half of the analyses reported a positive association of prenatal alcohol exposure and offspring mental health problems.
Conclusions: Our review suggests that maternal alcohol use during pregnancy is associated with offspring mental health problems, even at low to moderate levels of alcohol use. Future investigation using methods that allow stronger causal inference is needed to further investigate if these associations shown are causal.
Genetic testing ethical -legal psycho-socio aspects and genetic counselling Arifa T N
Genetic testing is used to analyze DNA, chromosomes, proteins, or certain metabolites to detect heritable disease-related genotypes, mutations, or karyotypes. There are several types and purposes of genetic testing, including diagnostic testing to confirm diagnoses, carrier testing to identify genetic disorders that may be passed on, preimplantation testing of embryos, newborn screening for treatable conditions, and prenatal screening and diagnosis. Genetic testing methods include analysis of blood, tissue, or other body fluids; ultrasounds; amniocentesis; chorionic villus sampling; and tests of multiple serum markers. The results of genetic testing can help with medical management and reproductive decision making.
This paper discusses the over-diagnosis of behavioral and conduct disorders like ADHD. Diagnostic criteria for these disorders are outlined in the DSM-V. There has been concern that ADHD is over-diagnosed, driven by increased prescription of stimulant medications for children. However, rates of diagnosis and medication use vary significantly between regions. Over-diagnosis can lead to potential short-term side effects from medications as well as long-term risks if symptoms are not properly assessed and treated. Comprehensive evaluations are needed to provide effective care and address concerns about over-diagnosis.
This document provides references for a paper on textual flow and other important matters related to academic writing for genetic counselors. It includes sections on using references, general to specific textual flow, less successful textual flow, and common errors to avoid in academic writing.
In the first study, researchers found that women who experienced early onset and frequent hot flashes had higher risks of cardiovascular disease. Specifically, these women showed poorer vascular health on certain indices compared to women with fewer or later hot flashes. A second study replicated these findings, further refining the understanding of how menopausal hot flashes may increase cardiovascular risks for some women. The studies suggest that experiencing hot flashes earlier and more frequently in midlife is linked to poorer vascular health and increased cardiovascular disease risk.
The document discusses various options for pregnancy planning for individuals living with HIV, including timed intercourse, home or clinical insemination with partner's sperm, use of donor sperm, and assisted reproductive technologies like sperm washing and IVF. It provides guidelines from organizations like ACOG and ASRM on eligibility and treatment for fertility services. The options aim to balance reproductive desires with minimizing risks of HIV transmission to partners or children.
This study analyzed data from a 30-year longitudinal study of over 500 women in New Zealand to examine the association between pregnancy outcomes and later mental health issues. The study found that after adjusting for potential confounding factors, women who had an abortion had rates of mental health disorders that were about 30% higher than those who did not have an abortion. No consistent associations were found between other pregnancy outcomes like miscarriage or live birth and increased risk of mental health problems. The authors concluded that the evidence suggests abortion may be associated with a small increase in risk of mental disorders.
The document discusses ethical dilemmas in clinical genetics. It begins with an introduction to ethical dilemmas and frameworks for ethical decision making. It then addresses various issues in genetic engineering, genetic testing, and genetic counseling. Some key issues discussed include risks of experimental animals and creating new diseases, predictive testing and determining who should access results, prenatal testing and potential pressure not to have children with disabilities. The document stresses the importance of informed consent, counseling, and respecting individual values in navigating these complex ethical issues.
The document discusses 10 scenarios involving genetic engineering and ethics. For each scenario, it presents options for actions and asks the reader to choose one. The scenarios cover issues like prenatal genetic testing, genetically modifying foods, cloning pets, designing "perfect" children, inheriting genetic disorders, predictive genetic testing, cloning for organ transplants, mandatory genetic databases, gene therapies, and mandatory genetic testing for health insurance.
This document summarizes a study that explored whether early sexual intercourse could impact women's reproductive health in middle adulthood. The study followed 522 females from age 14 to 43, asking about the timing of their first sexual experience and later reproductive health. It found that women who had early intercourse were more likely to have lower education, leave home earlier, have more abortions and miscarriages, and report more menstrual symptoms than those who had later first intercourse. The results suggest early sexual activity can predict certain reproductive health issues later in life.
This document discusses several ethical issues related to genetics and pre-implantation genetic diagnosis (PGD). It addresses questions around confidentiality and disclosure of genetic information, predictive genetic testing of children, criteria for offering prenatal genetic testing, revealing unexpected paternity results, implications for medical insurance, comparisons of PGD and prenatal diagnosis, and debates around the status of embryos and selecting for disability or non-medical traits. The document examines these issues in clinical genetics through common ethical themes of non-directiveness, informed consent, confidentiality, and avoiding psychological harm.
Intrauterine alcohol exposure and offspring mental health: A systematic reviewBARRY STANLEY 2 fasd
2
Abstract
Background: High levels of alcohol use in pregnancy have been shown to be associated with negative physical health consequences in offspring. However, the literature is less clear
on the association of alcohol use in pregnancy and offspring mental health disorders. We conducted a systematic review to evaluate studies examining this association.
Methods: Studies were identified by searching PsycINFO, PubMed and Web of Science, and were included if they examined alcohol use during pregnancy as an exposure and
offspring mental health at age 3 or older as an outcome. We excluded non-English language publications, and studies of foetal alcohol syndrome.
Results: Thirty-three studies were included and were categorised by mental health outcomes: anxiety/depression, emotional problems, total internalising problems, total
problem score, and conduct disorder. Over half of the analyses reported a positive association of intrauterine alcohol exposure and negative offspring mental health outcomes.
Conclusions: Our review suggests that maternal alcohol use during pregnancy is associated with negative offspring mental health outcomes, even at low to moderate levels of alcohol use. Future investigation using methods that allow stronger causal inference are needed to further investigate if these associations shown are causal.
Genetic counseling: Introduction, definition, purposes of genetic counseling, indications of genetic counseling, beneficiaries of genetic counseling, phases of genetic counseling, role of nurse in genetic counseling, application of genetic counseling.
This document discusses the interconnected factors contributing to declining health, including environmental toxins, nutrient deficiencies, and mitochondrial dysfunction. It argues that endocrine disrupting chemicals and epigenetic changes are important but secondary influences on health, and that mitochondrial energetics may be the primary driver of metabolism and cellular stress. The document advocates finding the root causes of health issues in order to properly address them.
This document provides an overview of a nutrition class presented by Chandler Marrs. Some key points:
- The class discusses navigating maternal health in the 21st century and covers topics like environmental toxicants, endocrine disruptors, nutrient-stripped food, over-medication, and transgenerational effects.
- People are exposed to thousands of environmental chemicals through food, air and consumer products, which are found in nearly all pregnant women and their babies.
- Processed foods and genetically modified produce are often nutrient-stripped while high in sugars, fats and chemicals.
- Rates of medication use, especially during pregnancy, have increased dramatically in recent decades despite harmful histories like DES and thalidom
A study found that exposing women to plus-size models in advertisements reduced their preference for extremely thin bodies, whereas exposing them to slim models increased their preference for thinness. The researchers argue that showing a more diverse range of body types in media could help promote healthier body attitudes among women. Increased exposure to larger-sized models may counteract the obsession with thinness perpetuated by the predominance of underweight celebrities and models currently featured. Addressing the narrow representation of female bodies could potentially help reduce eating disorder risk.
1. Amenorrhea, or the absence of menstrual periods, can be either primary or secondary. Primary amenorrhea refers to the lack of menses by age 15, while secondary amenorrhea is the absence of periods for 3 months after menarche.
2. A thorough history and physical exam is important to evaluate the potential causes of amenorrhea, which can include pregnancy, eating disorders, medical conditions, or anatomical abnormalities.
3. Laboratory tests and imaging may be needed to diagnose endocrine disorders, such as hypothalamic, pituitary, ovarian, or thyroid issues, which can cause amenorrhea. Genetic testing may be considered if Turner syndrome is suspected.
Maternal Mental Health: CA Department of Public Health Nov 6, 2014Joy Burkhard
Maternal Mental Health is an underground health crisis impacting women, infants and families. This presentation was provided Nov. 6 2014 to the California Department of Public Health and discusses symptoms, risk factors and prevalence; impact on child development, why providers don't routinely screen/diagnose and treat, and what we can do to collectively change this course.
1) Eating disorders like anorexia and bulimia affect millions of Americans each year, especially women ages 15-25, and can have serious medical consequences including death.
2) While insurance companies do not typically view eating disorders as biological disorders requiring coverage, new scientific evidence demonstrates that eating disorders have genetic and neurological factors.
3) Research shows that eating disorders meet the definition of serious mental illnesses, negatively impacting people's quality of life and daily functioning. People struggling with eating disorders deserve access to treatment through insurance coverage.
This document discusses the work of Lucine Health Sciences, Inc. and its founder Dr. Chandler Marrs. It notes that current medical practices often lack accurate, individualized data. Lucine aims to gather real-world data on medication risks and side effects, especially those that may differ for women. Through its Hormones Matter website, Lucine collects patient stories and conducts online surveys to gain insights into conditions, identify patterns, and inspire further research. The goal is to develop more comprehensive and personalized approaches to assessing health risks.
Genetic counseling is a process that provides information about inherited disorders to allow informed choices about reproduction and management. It follows the characteristics of counseling by communicating between counselors and families confronting genetic disorders. The steps of genetic counseling involve taking an accurate history, constructing a pedigree chart, estimating risk, transmitting information, and discussing management options. Genetic counselors work with prenatal, pediatric, adult, and cancer populations to assess risk and discuss testing and management of genetic conditions. Nurses play a role in guiding patients, assisting with decisions, coordinating care, and providing support.
Prenatal alcohol exposure and offspring mental health: A systematic reviewBARRY STANLEY 2 fasd
A B S T R A C T
Background: High levels of alcohol use in pregnancy have been shown to be associated with negative physical health consequences in offspring. However, the literature is less clear on the association of alcohol use in pregnancy and offspring mental health, specifically for low levels of prenatal alcohol exposure. We conducted a systematic review to evaluate studies examining this association.
Methods: Studies were identified by searching PsycINFO, PubMed and Web of Science, and were included if they examined alcohol use during pregnancy as an exposure and offspring mental health at age 3 or older as an outcome. We excluded non-English language publications and studies of fetal alcohol syndrome.
Results: Thirty-three studies were included and were categorized by mental health outcomes: anxiety/depression, emotional problems, total internalizing problems, total problem score, and conduct disorder. Over half of the analyses reported a positive association of prenatal alcohol exposure and offspring mental health problems.
Conclusions: Our review suggests that maternal alcohol use during pregnancy is associated with offspring mental health problems, even at low to moderate levels of alcohol use. Future investigation using methods that allow stronger causal inference is needed to further investigate if these associations shown are causal.
Genetic testing ethical -legal psycho-socio aspects and genetic counselling Arifa T N
Genetic testing is used to analyze DNA, chromosomes, proteins, or certain metabolites to detect heritable disease-related genotypes, mutations, or karyotypes. There are several types and purposes of genetic testing, including diagnostic testing to confirm diagnoses, carrier testing to identify genetic disorders that may be passed on, preimplantation testing of embryos, newborn screening for treatable conditions, and prenatal screening and diagnosis. Genetic testing methods include analysis of blood, tissue, or other body fluids; ultrasounds; amniocentesis; chorionic villus sampling; and tests of multiple serum markers. The results of genetic testing can help with medical management and reproductive decision making.
This paper discusses the over-diagnosis of behavioral and conduct disorders like ADHD. Diagnostic criteria for these disorders are outlined in the DSM-V. There has been concern that ADHD is over-diagnosed, driven by increased prescription of stimulant medications for children. However, rates of diagnosis and medication use vary significantly between regions. Over-diagnosis can lead to potential short-term side effects from medications as well as long-term risks if symptoms are not properly assessed and treated. Comprehensive evaluations are needed to provide effective care and address concerns about over-diagnosis.
This document provides references for a paper on textual flow and other important matters related to academic writing for genetic counselors. It includes sections on using references, general to specific textual flow, less successful textual flow, and common errors to avoid in academic writing.
In the first study, researchers found that women who experienced early onset and frequent hot flashes had higher risks of cardiovascular disease. Specifically, these women showed poorer vascular health on certain indices compared to women with fewer or later hot flashes. A second study replicated these findings, further refining the understanding of how menopausal hot flashes may increase cardiovascular risks for some women. The studies suggest that experiencing hot flashes earlier and more frequently in midlife is linked to poorer vascular health and increased cardiovascular disease risk.
The document discusses various options for pregnancy planning for individuals living with HIV, including timed intercourse, home or clinical insemination with partner's sperm, use of donor sperm, and assisted reproductive technologies like sperm washing and IVF. It provides guidelines from organizations like ACOG and ASRM on eligibility and treatment for fertility services. The options aim to balance reproductive desires with minimizing risks of HIV transmission to partners or children.
This study analyzed data from a 30-year longitudinal study of over 500 women in New Zealand to examine the association between pregnancy outcomes and later mental health issues. The study found that after adjusting for potential confounding factors, women who had an abortion had rates of mental health disorders that were about 30% higher than those who did not have an abortion. No consistent associations were found between other pregnancy outcomes like miscarriage or live birth and increased risk of mental health problems. The authors concluded that the evidence suggests abortion may be associated with a small increase in risk of mental disorders.
The document discusses ethical dilemmas in clinical genetics. It begins with an introduction to ethical dilemmas and frameworks for ethical decision making. It then addresses various issues in genetic engineering, genetic testing, and genetic counseling. Some key issues discussed include risks of experimental animals and creating new diseases, predictive testing and determining who should access results, prenatal testing and potential pressure not to have children with disabilities. The document stresses the importance of informed consent, counseling, and respecting individual values in navigating these complex ethical issues.
The document discusses 10 scenarios involving genetic engineering and ethics. For each scenario, it presents options for actions and asks the reader to choose one. The scenarios cover issues like prenatal genetic testing, genetically modifying foods, cloning pets, designing "perfect" children, inheriting genetic disorders, predictive genetic testing, cloning for organ transplants, mandatory genetic databases, gene therapies, and mandatory genetic testing for health insurance.
This document summarizes a study that explored whether early sexual intercourse could impact women's reproductive health in middle adulthood. The study followed 522 females from age 14 to 43, asking about the timing of their first sexual experience and later reproductive health. It found that women who had early intercourse were more likely to have lower education, leave home earlier, have more abortions and miscarriages, and report more menstrual symptoms than those who had later first intercourse. The results suggest early sexual activity can predict certain reproductive health issues later in life.
This document discusses several ethical issues related to genetics and pre-implantation genetic diagnosis (PGD). It addresses questions around confidentiality and disclosure of genetic information, predictive genetic testing of children, criteria for offering prenatal genetic testing, revealing unexpected paternity results, implications for medical insurance, comparisons of PGD and prenatal diagnosis, and debates around the status of embryos and selecting for disability or non-medical traits. The document examines these issues in clinical genetics through common ethical themes of non-directiveness, informed consent, confidentiality, and avoiding psychological harm.
Intrauterine alcohol exposure and offspring mental health: A systematic reviewBARRY STANLEY 2 fasd
2
Abstract
Background: High levels of alcohol use in pregnancy have been shown to be associated with negative physical health consequences in offspring. However, the literature is less clear
on the association of alcohol use in pregnancy and offspring mental health disorders. We conducted a systematic review to evaluate studies examining this association.
Methods: Studies were identified by searching PsycINFO, PubMed and Web of Science, and were included if they examined alcohol use during pregnancy as an exposure and
offspring mental health at age 3 or older as an outcome. We excluded non-English language publications, and studies of foetal alcohol syndrome.
Results: Thirty-three studies were included and were categorised by mental health outcomes: anxiety/depression, emotional problems, total internalising problems, total
problem score, and conduct disorder. Over half of the analyses reported a positive association of intrauterine alcohol exposure and negative offspring mental health outcomes.
Conclusions: Our review suggests that maternal alcohol use during pregnancy is associated with negative offspring mental health outcomes, even at low to moderate levels of alcohol use. Future investigation using methods that allow stronger causal inference are needed to further investigate if these associations shown are causal.
Genetic counseling: Introduction, definition, purposes of genetic counseling, indications of genetic counseling, beneficiaries of genetic counseling, phases of genetic counseling, role of nurse in genetic counseling, application of genetic counseling.
This document discusses the interconnected factors contributing to declining health, including environmental toxins, nutrient deficiencies, and mitochondrial dysfunction. It argues that endocrine disrupting chemicals and epigenetic changes are important but secondary influences on health, and that mitochondrial energetics may be the primary driver of metabolism and cellular stress. The document advocates finding the root causes of health issues in order to properly address them.
This document provides an overview of a nutrition class presented by Chandler Marrs. Some key points:
- The class discusses navigating maternal health in the 21st century and covers topics like environmental toxicants, endocrine disruptors, nutrient-stripped food, over-medication, and transgenerational effects.
- People are exposed to thousands of environmental chemicals through food, air and consumer products, which are found in nearly all pregnant women and their babies.
- Processed foods and genetically modified produce are often nutrient-stripped while high in sugars, fats and chemicals.
- Rates of medication use, especially during pregnancy, have increased dramatically in recent decades despite harmful histories like DES and thalidom
A study found that exposing women to plus-size models in advertisements reduced their preference for extremely thin bodies, whereas exposing them to slim models increased their preference for thinness. The researchers argue that showing a more diverse range of body types in media could help promote healthier body attitudes among women. Increased exposure to larger-sized models may counteract the obsession with thinness perpetuated by the predominance of underweight celebrities and models currently featured. Addressing the narrow representation of female bodies could potentially help reduce eating disorder risk.
1. Amenorrhea, or the absence of menstrual periods, can be either primary or secondary. Primary amenorrhea refers to the lack of menses by age 15, while secondary amenorrhea is the absence of periods for 3 months after menarche.
2. A thorough history and physical exam is important to evaluate the potential causes of amenorrhea, which can include pregnancy, eating disorders, medical conditions, or anatomical abnormalities.
3. Laboratory tests and imaging may be needed to diagnose endocrine disorders, such as hypothalamic, pituitary, ovarian, or thyroid issues, which can cause amenorrhea. Genetic testing may be considered if Turner syndrome is suspected.
The document summarizes research from "A Clinician’s Guide to Medical & Surgical Abortion" on potential negative reactions some women may experience after abortion, including depression, guilt, shame, regret, and grief. It notes researchers agree some women are more at risk, such as those who were coerced, committed to the pregnancy, or adolescents. Several studies cited found increased risks of substance abuse, depression, and suicide for women after abortion. Qualitative research found women still expressed shame about their abortions years later at menopause.
Experts appeal to cdc monitor eating disordersDiane_Ortiz
A coalition led by Harvard’s Strategic Training Initiative for the Prevention of Eating Disorders (STRIPED) is asking the Centers for Disease Control and Prevention (CDC) to monitor eating disorders as part of its national disease surveillance efforts. Bryn Austin, a professor at the Department of Social and Behavioral Sciences and director of STRIPED, explains why this is critical for the treatment and prevention of eating disorders.
Health Services Utilization Carly's Study DesignCarly Thompson
This document outlines a study examining barriers to eating disorder treatment among women. The study will use Anderson's Behavioral Model framework to identify predisposing, enabling, and need factors that influence barriers. The dependent variable is barriers to inpatient and intensive outpatient treatment. Independent variables include demographic, clinical, social, and system-related factors. The study aims to compare barriers across eating disorder subtypes to address disparities in access and utilization of treatment. Key hypotheses predict financial barriers will impact bulimia and OSFED most while shame will impact anorexia most.
MedicalResearch.com: Medical Research Interviews June 2014Marie Benz MD FAAD
This document summarizes key findings from several medical research studies and interviews. The main findings are:
1) Adults with late-diagnosed Asperger's Syndrome have a significantly higher risk of suicidal thoughts than the general population. Having both Asperger's and depression further increases risk.
2) Surgery requiring general anesthesia increases the risk of death or neurodevelopmental impairment in very low birth weight infants. However, minor surgeries under other types of anesthesia did not carry increased risk.
3) Women with polycystic ovary syndrome have a three to five times higher risk of developing diabetes, even after accounting for obesity. Regular diabetes screening is recommended for these women.
Birth Control, Big Money and Bad Medicine: A Deadly Trifecta in Women’s HealthHormones Matter
This document discusses the complex interactions of hormones in the body and argues that the oversimplified view of contraceptive hormones only impacting reproduction is flawed. It notes that hormones are synthesized throughout the body, act on multiple receptor types, and influence many physiological systems beyond just the reproductive system, including the brain, mitochondria, immune function and metabolism. The use of synthetic exogenous hormones in contraceptives is presented as an overly simplistic approach that fails to consider the full effects of hormones since they are similar but not identical to endogenous hormones and can impact health in unintended ways.
This document discusses the complex interactions of hormones in the body and argues that the oversimplified view of contraceptive hormones only impacting reproduction is flawed. It notes that hormones are synthesized throughout the body, act on multiple receptor types, and influence many physiological systems beyond just the reproductive system, including the brain, mitochondria, immune function and metabolism. The use of synthetic exogenous hormones in contraceptives is presented as an overly simplistic approach that fails to consider the full effects of hormones since they are similar but not identical to endogenous hormones and can impact health in unintended ways.
Women live over half of their life after menopause, but what was a transition viewed with dread can now be managed, and women are leading vibrant and rewarding lives, through and after menopause. This presentation helps women learn how to feel like themselves through the midlife transition and beyond.
1
Organ donation
Student’s name
Institution
Course number
Instructor
Due date
From the podcast , fewer human organs are required by the people. There is a shortage of organs like kidneys, liver, and heart. Even the surgery and the transplant itself can be risky procedures, and the patient or the donor can lose their life too. The donor and the recipient should have a march of their organs before the transplant is done (Abbasi et al.2018). This procedure involves a lot of tests and procedures before the transplant is done. The donor has to consent by signing accepting that they are donating their kidneys.
As per the debate in this video, trading the human organza should be legalized. From the debate, someone brought up the idea that if the family members are not a match or they have underlying conditions that they cannot donate any of their organs to the patient, then the next option that will be readily available in the buying of the kidney or the organ of interest. Legalizing trading will be a lifesaver for most individuals who need an urgent transplant. If the organs are available in the hospitals, they are visiting, and they can easily get the match of their kidneys rather than having the tests being done on their family members, which takes a long time.
References
Abbasi, M., Kiani, M., Ahmadi, M., & Salehi, B. (2018). Knowledge and ethical issues in organ transplantation and organ donation: Perspectives from Iranian health personnel. Annals of transplantation, 23, 292. ncbi.nlm.nih.gov/pmc/articles/PMC6248176/
Family Medicine 32: 33-year-old with painful cycles
User: Ralph Marrero
Email: [email protected]
Date: March 30, 2022 10:44 PM
Learning Objectives
The student should be able to:
Find and apply diagnostic criteria, risk factors and surveillance strategies for dysmenorrhea.
Elicit a focused history that includes information about menstrual history, obstetric history, sexuality and gender identification.
Describe appropriate components of a complete physical examination depending on symptoms or risk factors for gynecological
problems.
Summarize the key features of a patient presenting with dysmenorrhea, capturing the information essential for differentiating
between the common and “don’t miss” etiologies.
Describe the initial management of common diagnoses that present with dysmenorrhea.
Summarize the key features of a patient presenting with menorrhagia, capturing the information essential for differentiating
between the common and “don’t miss” etiologies.
Develop a health promotion plan for a patient of any age or gender that addresses preconception counseling.
Develop a health promotion plan for a patient of any age or gender that addresses family planning.
Describe the initial management of common and dangerous diagnoses that present with premenstrual syndrome.
Recognize “don’t miss” conditions that may present with PMS.
Demonstrate active listening skills a ...
This document discusses medical errors and misdiagnosis. It notes that one in five medical errors are potentially serious or fatal, and that the most common reasons for medical malpractice claims are surgery errors and diagnostic errors. Diagnostic errors account for many preventable deaths annually in the US. Some of the leading causes of misdiagnosis discussed include lack of healthcare professionals, poor teamwork and follow up, human cognitive factors, and too much focus on one exam finding. The document also provides strategies to reduce errors such as thorough history taking, physical exams, using diagnostic aids, and always following up on concerning symptoms.
Similar to Deconstructing Modern Illness: Idiopathic or Iatrogenic? (17)
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
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Deconstructing Modern Illness: Idiopathic or Iatrogenic?
1. Lucine Health Sciences, Inc. | Hormones Matter
Deconstructing Modern
Illness
Idiopathic or Iatrogenic?
2. Lucine Health Sciences, Inc. | Hormones Matter
You did then what you
knew how to do,
And when you knew better,
You did better.
Maya Angelou
3. Lucine Health Sciences, Inc. | Hormones Matter
Core Principles
o Pregnancy is an opportunity to break cycles of bad health
o Reproduction should be viewed from a much broader and longer
perspective.
o Dad’s health matters
o At least one year pre-conception – postpartum year
o Transgenerational – can’t undue sins of our parents and grandparents, but
we can protect our children and grandchildren
oEverything is connected – a more holistic and systems approach
to health
o Health is complicated, disease is individual, we have a lot to learn
o If the symptoms don’t fit Dx categories, trust your gut and figure
out what is wrong
5. Lucine Health Sciences, Inc. | Hormones Matter
Who am I?
oMom, wife, jock, researcher, writer, women’s health advocate
oBackground in maternal health and hormones
oMore recently, medication adverse reactions, nutrition and
mitochondrial damage
7. Lucine Health Sciences, Inc. | Hormones Matter
What I Really Do
o150,000+ monthly
views
o1200+ articles and
growing
o150 guest
contributors/writers
• 18 PhDs, 5 MDs, 2
DPTs
oThousands of
comments
Cause trouble.
11. Lucine Health Sciences, Inc. | Hormones Matter
What I Have Learned
oEnvironment matters
• More than genetics
oHealth and disease are both sudden and slow
• Thresholds and tipping points
oAll about the mitochondria
• Mitochondria determine everything
Everything we think we know is wrong.
12. Lucine Health Sciences, Inc. | Hormones Matter
Let the Deconstruction Begin.
Do we know what we think we know?
13. Lucine Health Sciences, Inc. | Hormones Matter
“There is often something sinister about familiar concepts.
The more familiar or ‘natural’ they appear, the less we
wonder what they mean; but because they are widespread
and well-known, we tend to act as if we know what we
mean when we use them.”
Devisch, I. & Murray, S., 2009. doi:10.1111/j.1365-2753.2009.01232.x
Just because it is familiar
Doesn’t make it right or true.
15. Lucine Health Sciences, Inc. | Hormones Matter
Implications of idiopathy
oEverything we don’t understand is idiopathic
• Illness of unknown origin is random – we cannot
know the causes
oWe have no responsibility for randomness
• Choices/behaviors don’t matter
• No need to study
• Can only treat but never cure or prevent
16. Lucine Health Sciences, Inc. | Hormones Matter
Cancer is random?
“These results suggest that only a third of the variation in
cancer risk among tissues is attributable to environmental
factors or inherited predispositions. The majority is due to
‘bad luck,’ that is, random mutations arising during DNA
replication in normal, noncancerous stem cells.”
Tomasetti & Vogelstein 2015. Science, Vol. 347, Issue 6217, pp. 78-81
DOI: 10.1126/science.1260825
18. Lucine Health Sciences, Inc. | Hormones Matter
Randomness means we can
ignore things like this
19. Lucine Health Sciences, Inc. | Hormones Matter
And this…
o Pharmaceutical and
environmental chemicals
rearrange MLL Gene via
topoisomerase inhibition
• Glyphosate (and other
herbicides/pesticides),
fluoroquinolone antibiotics,
hormonal contraceptives,
HRT and other drugs
o Topoisomerases manage
nDNA, mtDNA replication
and repair.
MLL- related leukemias are not heritable, not
found in germlines, but a result of exposure
in utero (infant leukemia) or during later child
development (pediatric leukemia).
20. Lucine Health Sciences, Inc. | Hormones Matter
25-75% of the symptoms reported in
outpatient settings are considered
medically unexplained.
How much of medicine is
idiopathic?
Source: Smith, R.C. and Dwamena, F.C., 2007. Classification and diagnosis of patients with medically unexplained symptoms. Journal of general internal medicine, 22(5),
pp.685-691.
21. Lucine Health Sciences, Inc. | Hormones Matter
Idiopathy exists, not because this stuff is
unknowable, but rather, because we
choose not to look.
Source: Smith, R.C. and Dwamena, F.C., 2007. Classification and diagnosis of patients with medically unexplained symptoms. Journal of general internal medicine, 22(5),
pp.685-691.
22. Lucine Health Sciences, Inc. | Hormones Matter
70% OF OB/GYN CLINCAL
PRACTICE GUIDELINES
NOT BASED ON EVIDENCE
For women…
Idiopathy runs rampant.
23. Lucine Health Sciences, Inc. | Hormones Matter
50%
OF MEDICAL
INTERVENTIONS
UNPROVEN
ONLY 35% KNOWN TO BE BENEFICIAL
Source: BMJ Clinical Evidence, http://clinicalevidence.bmj.com/x/set/static/cms/efficacy-categorisations.html
For medicine in general
We really don’t know what we think we know.
24. Lucine Health Sciences, Inc. | Hormones Matter
Source: BMJ Clinical Evidence, http://clinicalevidence.bmj.com/x/set/static/cms/efficacy-categorisations.html
25. Lucine Health Sciences, Inc. | Hormones Matter
Medication nation
Mayo Clinic Reports
o70% adults take
prescription medications
chronically
o50% take 2 or more meds
o20% take 5 or more meds
“Before the SSRIs, drugs were poisons that came with risks. Now they are fertilizers to be
used as widely as possible, being given in ever larger amounts to children and the elderly -
the only risks the authorities can see it would seem stem from not using enough of them.”
David Healy
26. Lucine Health Sciences, Inc. | Hormones Matter
If only 50% of medications have sufficient
evidence of efficacy, what happens when we
combine multiple medications?
Efficacy?
Safety?
27. Lucine Health Sciences, Inc. | Hormones Matter
Can we really know what illnesses chronic
polypharmacy use might spur if we’ve never
bothered to ask the question?
28. Lucine Health Sciences, Inc. | Hormones Matter
If 25-75% of symptoms can be considered
medically unexplained, how certain are we of
our current diagnostics?
30. Lucine Health Sciences, Inc. | Hormones Matter
The problem of iatrogenesis
o3rd leading cause of death in hospitalized patients
• Estimated at 200,000-400,000 patients annually
• 6.8% of cases were attributable to an adverse drug
reaction 1964-1995
oFDA/ADR data (2011)
• 2.1 to 2.7 million Americans suffer from an serious
adverse drug reaction annually
• 128,000 result in death
James, J.T., 2013. A new, evidence-based estimate of patient harms associated with hospital care. Journal of patient safety, 9(3), pp.122-128; Null, G., Dean, C.,
Feldman, M. and Rasio, D., 2005. Death by medicine. Journal of Orthomolecular Medicine, 20(1), pp.21-34; Makary, M.A. and Daniel, M., 2016. Medical error—the
third leading cause of death in the US. Bmj, 353, p.i2139; Stokowski, L.A., 2016. Who believes that medical error is the third leading cause of hospital deaths.
Medscape, May, 26Light, D.W., Lexchin, J. and Darrow, J.J., 2013. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs; Light, D.W.,
Lexchin, J. and Darrow, J.J., 2013. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs..
Even as currently defined.
31. Lucine Health Sciences, Inc. | Hormones Matter
Implications of iatrogenesis
oPresumes we know the scope of effects for a given
treatment
• If 50% of treatments unproven, do we really know the
scope of effects?
• Even when tested, often only tested in isolation, in men,
with little application to real world uses
oAnything we don’t know is random or idiopathic
oWe have no responsibility for randomness
oNo need to study
33. Lucine Health Sciences, Inc. | Hormones Matter
Deconstructing Women’s
Health
Where idiopathy, iatrogenesis and willful ignorance
intersect.
34. Lucine Health Sciences, Inc. | Hormones Matter
Women use more medications
than men
A review of insurance records for a 1 year period in 2010
showed:
• Women = 5 prescriptions
• Men = 3.7 prescriptions
• 68% of women versus 59% of men had one prescription for at
least one medication for a chronic or acute condition during the
study period.
Women’s Health 2012: The 20th Annual Congress; https://www.washingtonpost.com/blogs/the-checkup/post/women-prescribed-more-drugs-than-men-but-dont-
always-take-them-research-shows/2010/12/20/gIQAJm5hNS_blog.html?utm_term=.f913aa9f54a6
35. Lucine Health Sciences, Inc. | Hormones Matter
During Pregnancy
o80% of women take at least
one medication during
pregnancy
o~30% take 4 or more
medications during
pregnancy
• 60% increase in
medication use during
pregnancy in 30 years
36. Lucine Health Sciences, Inc. | Hormones Matter
Most of these drugs were never
safety tested with women
oNo testing on drugs approved before 1993
oGuidelines not enacted until 1998
37. Lucine Health Sciences, Inc. | Hormones Matter
Even after the regulations
oPer the GAO (2000)
• 52% of clinical trial participants women,
mostly later phases
• Only 22% of early phase trials, where safety
and dosing determined
oPer the IOM OWH (2010)
• Much the same
38. Lucine Health Sciences, Inc. | Hormones Matter
Here’s the thing
Even though women are now allowed in clinical trials, there is
no requirement for researchers/drug companies to determine
whether women react differently than men to a medication
before it is approved.
So they don’t.
39. Lucine Health Sciences, Inc. | Hormones Matter
As a result
oWomen suffer significantly more frequent and
more severe adverse drug events
oFew notice because none of these reactions were
documented in the first place
Cardiovascular disease is the most common cause of death in
American women and in recently recalled medications for heart
disease there were disproportionately higher fatalities and
serious adverse events in women than in men.
– Cochrane Reports
Idiopathic or iatrogenic?
40. Lucine Health Sciences, Inc. | Hormones Matter
Ethical conundrum
oTesting on women might impair reproductive
capacity
oMedication use during pregnancy might
harm the fetus
oBUT women use medications across the
lifespan and during pregnancy
• If we’re not going to test, should we really be
recommending these medications to women?
41. Lucine Health Sciences, Inc. | Hormones Matter
Possible solutions
oAnimal testing
oUse meds only sparingly
in pregnant women
oIntense post market
surveillance
Might temper some of the risks
43. Lucine Health Sciences, Inc. | Hormones Matter
What do human females and
male rodents have in common?
Apparently, they are equivalent.
44. Lucine Health Sciences, Inc. | Hormones Matter
Source: Beery, A., & Zucker, I. (2011). Sex Bias in Neuroscience and Biomedical Research. Neuroscience and Biobehavioral Reviews, 35 (3), 565-572.;
https://genderedinnovations.stanford.edu/case-studies/animals.html
45. Lucine Health Sciences, Inc. | Hormones Matter
No one considered
Until 2014!
that males and females
might be different
46. Lucine Health Sciences, Inc. | Hormones Matter
Perhaps it’s not about ethics at all, but rather,
expediency.
47. Lucine Health Sciences, Inc. | Hormones Matter
Long, inglorious history
• Used from 1957-1961
as anti-emetic,
hyperemesis mostly in
Europe
• 2000-100,000 children
born with severely
malformed limbs
• FDA denied approval
Thalidomide -prescribed for
morning sickness Of medicating women.
48. Lucine Health Sciences, Inc. | Hormones Matter
Diethylstilbestrol (DES) – to prevent miscarriage
At least 3 generations affected: sons, daughters
and grandchildren
Without research
• 5-10 million women from
1940-1970s
• FDA approved, no research
• Late 50s-60s first research:
increased risk of miscarriage
• Multi-generational damage
(cancer, organ malformation,
more)
• Used in farm animals
• Caused cancer in farm hands,
miscarriage and illness in
animals
• Banned in 1958 in animals
• Still used in women for
another 20+ years
51. Lucine Health Sciences, Inc. | Hormones Matter
And for social reasons
1959-1970s physicians and
researchers from the Royal Children’s
Hospital and the University of
Melbourne gave adolescent girls of
tall stature DES to stunt growth.
The rationale behind treating tall girls
was so they could do ballet, buy
clothes more easily, and find
boyfriends and husbands.
Source: Lee & Howell, Tall girls: the social shaping of a medical therapy. Arch Pediatr Adolesc Med. 2006 Oct;160(10):1035-9.
When Being a Tall Girl was a Medical
Condition: DES and the Tall Girls
52. Lucine Health Sciences, Inc. | Hormones Matter
And then covering it up
Used as a pregnancy test 1960s-70s
Equivalent to 13 morning after pills or 157
oral contraceptive pills
January 1975, Dr William Inman,
principal medical officer for the British
Government, had found that women
who took a hormone pregnancy test
“had a five-to-one risk of giving birth to
a child with malformations”.
Dr Inman wrote to Primodos’s German
manufacturer, Schering, so the firm could
“take measures to avoid medico-legal
problems”, rather than recall the drug.
A later document explains that Dr Inman
destroyed the materials on which his
findings were based, “to prevent
individual claims being based on his
material”.
Source: http://www.telegraph.co.uk/news/2017/03/18/new-evidence-claims-against-pregnancy-test-drugs-linked-
birth/
53. Lucine Health Sciences, Inc. | Hormones Matter
It’s worse for pregnant women
• There are no data for [insert vaccine]
administered to pregnant women to inform
vaccine-associated Package insert
• Available data on [insert vaccine] administered
to pregnant women are insufficient to inform
vaccine-associated risks in pregnancy.
• There were no developmental toxicity studies
of [insert vaccine] performed in animals.
• It is not known whether [insert vaccine] is
excreted in human milk.
• Data are not available to assess the effects of
on the breastfed infant or on milk
production/excretion.
Despite all marketing
to the contrary, most
medications and
vaccines were never
tested for use during
pregnancy.
Source: Package inserts
54. Lucine Health Sciences, Inc. | Hormones Matter
We never learned
With little evidence of safety and
efficacy
We continue to drug women
55. Lucine Health Sciences, Inc. | Hormones Matter
And for children
o Only 10-20% of
medications for
pediatric use have been
tested in children
o Pharmacokinetic and
pharmacodynamic
research developed in
adult males
o Rampant off-label for
kids, particularly kids in
foster care
Sources: Conroy, S., McIntyre, J., Choonara, I., & Stephenson, T. (2000). Drug trials in children: problems and the way forward. British Journal of Clinical Pharmacology, 49(2),
93–97. http://doi.org/10.1046/j.1365-2125.2000.00125.x ; FDA, https://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm143565.htm;
http://pharmaceuticalcommerce.com/brand-marketing-communications/pediatric-drug-market-finds-its-own-pathway/
“In the absence of rigorous pediatric clinical
trial data, physicians are forced to act as if
children are just ‘small adults’ with a smaller
weight, and then interpret the adult data to
adjust the dose. But statistically, we know that
approach only works in 6% of the cases.”
57. Lucine Health Sciences, Inc. | Hormones Matter
We’re addicted
Psychotropics prescribed in
the US
o 274,000 infants (0-1 year olds)
o 370,000 toddlers (1-3 year olds)
“Prescriptions of powerful
antipsychotics such as Risperdal for
infants and very young children have
also sharply risen. Office visits for
childhood bipolar disorder have risen
40-fold over the past decade in the
U.S.” To solving problems with pills
and looking away when
problems arise.
58. Lucine Health Sciences, Inc. | Hormones Matter
If drugs are not tested in women or children and thus, their
effects in women are unknown, they can easily be disregarded
and labeled as idiopathic.
If they are idiopathic, rather than iatrogenic, there is no need
to investigate or even acknowledge side effects as real.
For all intents and purposes, they simply do not exist.
59. Lucine Health Sciences, Inc. | Hormones Matter
For example
oLupron – GnRHa
• Chemically castrates
oDeveloped for male prostate cancer
• Tested on 6 healthy men
• One low dose for a drug to be used repeatedly and chronically at
higher doses
oApproved for
• Women with endometriosis, fibroids, heavy bleeding
• IVF
• Children with precocious puberty, gender dysphoria
60. Lucine Health Sciences, Inc. | Hormones Matter
Considered perfectly safe by
many practitioners
• No recognition chemical
castration might cause problems
• Depletes gonadal hormones
• Hormones have receptors
everywhere and are involved with
a myriad of functions beyond
reproduction
• With very little research pre – or
post-market, symptoms are
considered idiopathic or
hysteric.
61. Lucine Health Sciences, Inc. | Hormones Matter
It’s not safe
Lupron damages the mitochondria, perhaps irrevocably.
66. Lucine Health Sciences, Inc. | Hormones Matter
Environmental toxic soup
“Unlike the current system in Europe,
the 60,000-plus chemicals in
production when the US’s TSCA took
effect 39 years ago continued to be
used without any safety reviews. Most
are still in use today, although some
have since filed toxicity data.
The US allows the use of many
chemicals that are banned elsewhere,
and its primary chemicals law has
failed to keep up with thousands of
chemicals currently in use, including
the approximately 2,000 new chemicals
introduced each year.”
Source: https://www.theguardian.com/lifeandstyle/2015/feb/13/us-senate-toxic-chemicals-law-health-safety
Friday 13 February 2015 13.41 EST
67. Lucine Health Sciences, Inc. | Hormones Matter
That remain in our bodies
Certain polychlorinated biphenyls, organochlorine pesticides, PFCs,
phenols, PBDEs, phthalates, polycyclic aromatic hydrocarbons, and
perchlorate were detected in 99–100% of pregnant women. The median
number of detected chemicals by chemical class ranged from 4 of 12 PFCs
to 9 of 13 phthalates. Across chemical classes, median number ranged
from 8 of 17 chemical analytes to 50 of 71 chemical analytes.
BPA and tOP were detected in 92.6% and 57.4% of the persons, respectively...Females
had statistically higher BPA LSGM concentrations than males (p = 0.043). Children had
higher concentrations than adolescents (p < 0.001), who in turn had higher
concentrations than adults (p = 0.003).
69. Lucine Health Sciences, Inc. | Hormones Matter
What would normally filter the
damage
Medicines
Toxins
Bad diet
Nutrients
Exercise
Has been compromised.
70. Lucine Health Sciences, Inc. | Hormones Matter
Maternal nutrient deficiency is
rampant
Oxidative stress caused by free radicals has been implicated in many studies of the etiology
of preeclampsia (38). Because ascorbic acid and vitamin E inhibit free radical formation, a
double-blind randomized trial was conducted in 283 women who had either a previous
history of pregnancy complications or an abnormal ultrasound (39). The supplement
provided 1000 mg ascorbic acid and 400 IU vitamin E daily from week 16–22 of
pregnancy, and resulted in a 76% reduction in preeclampsia, and a 21% reduction in
indicators of endothelial activation and placental dysfunction.
Evidence from experimental animals supports the concept that in addition to primary deficiencies,
secondary embryonic and fetal nutritional deficiencies can be caused by diverse factors including
genetics, maternal disease, toxicant insults and physiological stressors that can trigger a maternal
acute phase response. These secondary responses may be significant contributors to the occurrence
of birth defects. An implication of the above is that the frequency and severity of pregnancy
complications may be reduced through an improvement in the micronutrient status of the mother.
Micronutrient status in fetal and early life may alter metabolism,
vasculature, and organ growth and function, leading to increased risk
of cardiometabolic disorders, adiposity, altered kidney function, and,
ultimately, to type 2 diabetes and cardiovascular diseases.
71. Lucine Health Sciences, Inc. | Hormones Matter
The food we eat
Isn’t really food
High calorie malnutrition
73. Lucine Health Sciences, Inc. | Hormones Matter
We’re told it’s real food
“Everything nature can do, man can do
so much better and more profitably.”
o ‘Natural’ cheese that matures in 72
hours.
o Preservatives prevent produce
browning
And if we can’t, then re-define
o ‘Clean labeling’ removes the most
glaring industrial ingredients and
replaces them with substitutes that
sound natural and benign.
“For the salesman, this preparation was
a technical triumph, a boon to caterers
who would otherwise waste unsold
food. There was a further benefit:
NatureSeal is classed as a processing
aid, not an ingredient, so there’s no
need to declare it on the label, no
obligation to tell consumers that their
“fresh” fruit salad is weeks old.”
But it isn’t.
74. Lucine Health Sciences, Inc. | Hormones Matter
Industrial food production
o Highly processed food-like products
o Sugar, carbs, fats and chemicals
o Genetically culled produce
o 70% reduced nutrient content
o With no genetic variation ( 96%)
o Glyphosate, toxic adjuvants and more
o Chemically laden meats
o Heavy antibiotics, antibiotic resistant bacteria,
growth and other hormones
Has stripped our food of critical nutrients
75. Lucine Health Sciences, Inc. | Hormones Matter
It’s an industrial descaling agent
oUsed to remove minerals from pipes
oDoes the same in our bodies
• Blocks critical enzymes and amino acids
• Disrupts vitamin A metabolism
• Weakens the blood brain barrier
oCarcinogenic, mutagenic, teratogenic
and an endocrine disruptor
• Topoisomerase inhibitor
• Glycine analog
• Mineral chelator
oWould kill all the plants if not
genetically altered to withstand the
toxinAnd a powerful antibiotic.
76. Lucine Health Sciences, Inc. | Hormones Matter
A perfect storm
Of pharmaceutical and environmental toxicants.
77. Lucine Health Sciences, Inc. | Hormones Matter
But, cancer is random?
And most women’s symptoms are psychosomatic – until they aren’t’.
84. Lucine Health Sciences, Inc. | Hormones Matter
Increase in childhood illness
o1-68 children develop
autism
o Neurodevelopmental and behavioral
problems on the rise
o1 in 13 children food
allergies
o1 in 1000 – 10,000 children
with autoimmune disorder
(celiac, JA, TD1)
JAMA Pediatr. 2013;167(2):141-148; Psychiatry (Edgmont). Aug 2005; 2(8): 14–19; Arch Gen Psychiatry. 2012;69(12):1247-1256; BMC
Pediatrics 2013, 13:40 3; JAMA. 2014;311(17):1778-1786.
Idiopathic or random?
85. Lucine Health Sciences, Inc. | Hormones Matter
Something is not working
• Spend more healthcare
• Highly vaccinated
• Taking lots of meds
• That were never tested
on over half the
population
• Of those, only 50%
considered effective
• Embrace
environmental/industrial
chemistry
• Living sicker
• With increasingly
complicated but
‘random’ diseases
• Dying younger
87. Lucine Health Sciences, Inc. | Hormones Matter
How can we reasonably assert
Which health issues are idiopathic and which are caused by us?
88. Lucine Health Sciences, Inc. | Hormones Matter
Except in rare cases
oMost modern illness is iatrogenic – caused by us
• Our choices individually and collectively
• Diet, lifestyle, pharmaceutical and environmental decisions
“I believe the collective denial of lifestyle disease is the reason cardiology is in
an innovation rut. This denial is not active or overt. It is indolent and
apathetic… This is how I see modern cardiology. Our tricks can no longer
overcome eating too much and moving too little. We approach health but
never get there. If you waddle, snore at night, and cannot see your toes while
standing, how much will a statin or ACE inhibitor or even LCZ696 help?”
Mandrola, J., 2015. Heart Disease and Lifestyle: Why Are Doctors in Denial? Medscape. http://www.medscape.com/viewarticle/837975
A hard truth that none of us wants to admit
89. Lucine Health Sciences, Inc. | Hormones Matter
Now what?
Who cares whether we call it idiopathic or iatrogenic,
how do we fix this mess?
90. Lucine Health Sciences, Inc. | Hormones Matter
Easy answer
oStop
• eating food-like products
• looking for medical
solutions to what are
lifestyle issues
oGo back to basics
• What does your body
need and is it getting it?
91. Lucine Health Sciences, Inc. | Hormones Matter
More complicated answer
oFind the root causes of illness and
fix them
• Stop treating symptoms
• Learn the chemistry
oBecome an expert in your/your
family’s health
• Own your health
oShare what you learn with others
• Build the knowledge base
• Publish/post online if you can
Entire model has to change.
92. Lucine Health Sciences, Inc. | Hormones Matter
What I have learned
It’s all about the
mitochondria.
Feed them well and life will be good.
93. Lucine Health Sciences, Inc. | Hormones Matter
Mitochondria
o1000-2000 per cell
oFuel source for cells
• Convert food to ATP
oSit at center of cell survival
• Sense and respond to all threats
oMasters at adapting to toxic environments – until
they aren’t
• Seemingly endless repertoire of survival cascades
• Threshold and tipping points
94. Lucine Health Sciences, Inc. | Hormones Matter
But that’s not all they do
o Mitochondria control just about everything
o Energy
o Steroidogenesis
o Inflammatory and immune
activation/deactivation
o Ca2+ homeostasis (cell excitotoxicity)
o Apoptosis/necrosis
Damage at your own risk.
95. Lucine Health Sciences, Inc. | Hormones Matter
All they ask of us is to feed them
well
oTo get from food to
ATP
• O2 (mitochondria
need to breathe)
• Lots of nutrients
• >24 vitamins and
minerals
And not hurl too many poisons at them.
Source: https://www.invitehealth.com/ARTICLE-nutrition-and-fibromyalgia.html
96. Lucine Health Sciences, Inc. | Hormones Matter
Western diet = high calorie
malnutrition.
We don’t.
Nutrient deficiency alone will damage mitochondria,
evoke chronic and complicated illness and can lead to
death.
97. Lucine Health Sciences, Inc. | Hormones Matter
All pharmaceutical, environmental, and
industrial chemicals damage the
mitochondria and deplete nutrients.
But wait, there’s more…
98. Lucine Health Sciences, Inc. | Hormones Matter
Mitochondria are targets
Sensors of cell danger
99. Lucine Health Sciences, Inc. | Hormones Matter
Poor nutrition, high toxic load
Foundation from
which most parents-
to-be approach
reproduction
With the cascade of ill-
health already in progress.
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Net result
“These are partial defects.
Mitochondrial dysfunction doesn’t
really cause anything, what it does is
predisposes towards seemingly
everything. It’s one of many risk factors
in multifactorial disease. It can
predispose towards epilepsy, chronic
fatigue, and even autism, but it doesn’t
do it alone. It does it in combination
with other factors, which is why in a
family with a single mutation going
through the family, everyone in the
family is affected in a different way.
Because it predisposes for disease
throughout the entire system.”
Dr. Richard Boles, Geneticist
Complicated disease processes that affect
everything and don’t fit our neat little
diagnostic categories.
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How prevalent is mitochondrial
disease or dysfunction?
“Disorders of the mitochondrial respiratory chain affect at least 1 in 8000 of the population,
making them among the most common genetically determined diseases.”
Patrick Chinnery, Medical School, Newcastle upon Tyne.
Prevalence is likely underestimated because
functional mitochondrial damage is often
overlooked and most mitochondrial
deficits, especially those emerging later in
life, remain undiagnosed.
Not widely recognized
1 in 500
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Energy is key
• Insufficient mitochondrial ATP
• Cells adapt alternative, less efficient
energy pathways
o Cancer pathways or they die
• Mitochondria activate danger
protocols and deactivate extraneous
tasks
• Cells die, tissues die, organs die,
and we die (sometimes slowly and
painfully, sometimes quickly)
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How important are nutrients
oCells cannot ‘breathe’ without certain
vitamins and minerals
• Thiamine and magnesium
oNutrient deficiency causes cellular hypoxia
• No obstruction necessary
oBrain and heart most adversely effected
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Not just about mom
o mDNA passed from mom-child,
o But mitochondria rely on
nuclear DNA to function (~90%)
o If Dad is unhealthy and
nutrient deficient,
dysfunctional mitochondria
are possible in the offspring,
even if mom is healthy
Dad’s health matters too!
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Long before conception
o The lifetime of unhealthy habits affect your
mitochondria
o Mitochondria have memories
o Cleaning up a few months before conception is
good but not good enough
o Should consider health of both parents at least a
year before conception
Health has to be considered
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Nutrients minimize damage
Medicines
Toxins
Diet
Nutrients
Exercise
Nutrient deficiency maximizes damage.
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Avoid the toxins
Clean up the diet
Feed the deficiencies
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Idiopathy versus iatrogenesis
oWhen presented with complicated case, a disease
process that doesn’t seem to fit into any one category
• Remove the notion of randomness/idiopathy
• Return the notion of responsibility
• Figure it out (together)
• Think mitochondria
oAsk
• What the patient needs to be healthy
• Are they getting it
oFix it
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Websites
o LucineHealthSciences.com I Business
o HormonesMatter.com I online journal, medication adverse events
surveys
Social Media
o Facebook pages: Hormones Matter, Lucine Women Community
o Twitter: @chanatlucine, @hormonesmatter
o Email: chandler@lucinehealthsciences.com or
chandler@hormonesmatter.com
How to find me
Editor's Notes
Leukemia in infants less than one year old is a rare, 41 cases per one million births annually in the US; but it is often deadly. Only 42% of infant leukemia patients survive beyond five years of age making it one of the more devastating forms of cancer. A large percentage (75%) of the babies with infant leukemia carry a specific mutation on the MLL gene at chromosome 11q23. The MLL gene is responsible for hematopoiesis or blood cell development. An error in blood cell development is at the root of this disease process, and unfortunately, it appears to be environmentally induced by specific, and increasingly common, in utero chemical exposures.