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Rencontres Interventionnelles - Transradial Approach
                             Prague, Czech Republic,
                   Thursday 29th & Friday 30th September 2011




       Special Mediterrannean session

Distal LM, MVD, TRA, elderly patient
	
                 Dr	
  Faouzi	
  Addad	
  
	
  
	
             Professor	
  of	
  cardiology	
  
	
  
	
  
         Department	
  of	
  cardiology-­‐	
  University	
  
	
         hospital	
  A.	
  Mami-­‐Ariana-­‐Tunisia	
  
	
  
	
  
	
  
                                                                      1	
  
PaEent	
  	
  
       Male, 82 years old
       Risk factors
       • Hypertension
       • dyslipidemia
       Clinical past History
       • None
       Life style
       • Active lifestyle


vendredi,	
  octobre	
  7,	
  2011	
                      2	
  
Clinical Presentation
   	
  
   	
  
Sudden onset of chest
   	
  
   	
  
pain with a severe
   	
  
pulmonary oedema
   	
  
   	
  
 BP:90/60 mmHg
   	
  
invasive ventilation during
   	
  
   	
  
24 hours
ECG: anterior ST
segment depression


 vendredi,	
  octobre	
  7,	
  2011	
                             3	
  
Baseline	
  Angiography	
  by	
  right	
  TRA	
  
    leG	
  coronary	
  angiography	
  
Baseline	
  Angiography	
  
leG	
  coronary	
  angiography	
  
Baseline	
  Angiography    	
  
Right	
  coronary	
  angiography	
  
                                   	
  
LeG	
  Main:	
  Anatomic	
  characterisEcs	
  	
  
       	
  

Distal	
  locaEon	
  >70%	
  
                                                           Calcified>50%	
  cases	
  
            cases	
  

                                    MulEvessel	
  
                                Disease>70%	
  cases	
  
Risk	
  Evalua8on   	
  
               Euroscore   	
  




Euroscore=26,79%            Very high risk for surgery
high	
  risk	
  of	
  MACCE	
  at	
  one	
  and	
  three	
  year	
  	
  
SYNTAX Score=30   	
  
Bleeding	
  risk	
  evaluaEon	
  
Crusade	
  bleeding	
  risk	
  score	
  and	
  	
  
                          the	
  major	
  bleeding	
  rate	
  
          29,3%	
                                                                                                        13,3%	
  
30	
  
                                                                     14	
  
                      23,9%	
  
25	
                                                    22%	
        12	
  

                                                                     10	
  
20	
  
                                                                       8	
  
15	
                              12,7%	
   12,2%	
                                                  3,8%	
     4%	
  
                                                                       6	
  

10	
                                                                   4	
  

                                                                       2	
     0%	
       0%	
  
  5	
  
                                                                       0	
  
  0	
  




             34,2% are at high or                                                        Incidence of major
               very High risk of                                                         bleeding at hospital
                   bleeding                                                             according to Crusade
                                                                                                score
                                                        ROC curve: r=0.889

                                                                                                   SCA Ariana Registry
Key	
  points
                                         	
  
•    SymptomaEc	
  82	
  male	
  
•    Non	
  diabeEc	
  
•    Distal	
  leG	
  main	
  disease	
  (superficial	
  calcificaEon)	
  
•    Lesion	
  in	
  osEal	
  and	
  proximal	
  Cx	
  
•    Lesion	
  in	
  proximal	
  LAD	
  
•    Type	
  A	
  lesion	
  of	
  proximal	
  RCA	
  
•    Very	
  High	
  surgical	
  risk	
  	
  	
  	
  
•    Intermediate	
  Syntax	
  Score	
  
•    High	
  risk	
  of	
  bleeding	
  
•    High	
  risk	
  of	
  CIN	
  	
  	
  
Key	
  issues/strategy?	
  
•  PCI	
  vs	
  CABG?	
  

•  Which	
  strategy	
  for	
  LM	
  PCI	
  and	
  MVD?	
  
Key	
  issues/strategy?	
  
•  PCI	
  vs	
  CABG?	
  

•  Which	
  strategy	
  for	
  LM	
  PCI	
  and	
  MVD?	
  
PCI	
  dilemmas
                                               	
  
A/	
  Type	
  of	
  stent?	
  
•  Bare	
  metal	
  Stent?	
  Vs	
  Drug	
  eluEng	
  stent?	
  

B/	
  Size	
  of	
  sheat?	
  
•  6	
  or	
  7	
  F	
  

C/	
  Access	
  route	
  for	
  PCI	
  
•  Femoral	
  approach?	
  

•  Radial	
  approach?	
  

D/	
  Could	
  i	
  treat	
  this	
  pa8ent	
  without	
  IVUS-­‐guided?	
  
We choose a BMS for clinical reasons: Bleeding risk and problem
of compliance for DAPT (during one year) and for economic reasons:
only 2 stents/patient are reimbursed
What	
  is	
  the	
  best	
  strategy	
  for	
  PCI?	
  
•  RCA	
  PCI	
  first?	
  



•  LMD	
  disease	
  First?	
  



•  In	
  one	
  	
  and	
  two	
  Emes?	
  	
  
RCA	
  PCI	
  first	
  two	
  days	
  aGer	
  the	
  
  first	
  angiogram	
  (Right	
  TRA)         	
  




Right TRA: Direct stenting: Stent BMS: integrity 3.5 X 15 mm at 16 atm
PCI	
  for	
  LMD	
  and	
  mild	
  LAD	
  
•  Programmed	
  aGer	
  10	
  days	
  by	
  Right	
  TRA	
  

•  1	
  stent	
  or	
  two	
  stents?	
  

•  If	
  two	
  stents:	
  T	
  stenEng,	
  crush	
  stent,	
  mini	
  
   crush	
  stent,	
  culode	
  stenEng,	
  V	
  stenEng,	
  Y	
  
   stenEng?	
  
Single	
  vs	
  two	
  stents?	
  
The lesion of Circ is one of the key elements for the strategy
                       of Left Main PCI.
Proximal	
  LAD	
  PCI
                                 	
  

                                        Direct stenting
                                        Integrity 3.5 X 15 mm at 16 atm

                                        2 BMW wires




Plavix 300 mg + aspirine 100 mg + UFH 60 UI/Kg
Minicrush	
  stenEng	
  


                                                    Compliant balloon
                                                    2.0 X 15 mm at 10
                                                    atm




there is no consensus on the best option for elective stenting with 2 stents
Stent	
  deployment	
  in	
  the	
  osEum	
  of	
  
                 Cx 	
  


                                Stent Driver

                                2.75 X15 mm at 12 atm
StenEng	
  of	
  LM	
  


                          Driver
                          4.0 X 12 mm
Deployment	
  at	
  16	
  atm	
  
Result	
  aGer	
  the	
  stent	
  deployment
                                           	
  
Two-step Kissing Balloon post-dilation
Non	
  compliant	
  ballon	
  at	
  20	
  atm	
  
Final	
  result	
  aGer	
  the	
  Kissing	
  
              Balloon      	
  
Final	
  result	
  aGer	
  the	
  Kissing	
  
              Balloon      	
  
Conclusions

       	
  
       	
  
       	
  
       	
  
       	
  
       	
  
       	
  
       	
  
       	
  




vendredi,	
  octobre	
  7,	
  2011	
                   43	
  
vendredi,	
  octobre	
  7,	
  2011	
     44	
  

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Addad F

  • 1. Rencontres Interventionnelles - Transradial Approach Prague, Czech Republic, Thursday 29th & Friday 30th September 2011 Special Mediterrannean session Distal LM, MVD, TRA, elderly patient   Dr  Faouzi  Addad       Professor  of  cardiology       Department  of  cardiology-­‐  University     hospital  A.  Mami-­‐Ariana-­‐Tunisia         1  
  • 2. PaEent     Male, 82 years old Risk factors • Hypertension • dyslipidemia Clinical past History • None Life style • Active lifestyle vendredi,  octobre  7,  2011   2  
  • 3. Clinical Presentation     Sudden onset of chest     pain with a severe   pulmonary oedema     BP:90/60 mmHg   invasive ventilation during     24 hours ECG: anterior ST segment depression vendredi,  octobre  7,  2011   3  
  • 4. Baseline  Angiography  by  right  TRA   leG  coronary  angiography  
  • 5. Baseline  Angiography   leG  coronary  angiography  
  • 6. Baseline  Angiography   Right  coronary  angiography    
  • 7. LeG  Main:  Anatomic  characterisEcs       Distal  locaEon  >70%   Calcified>50%  cases   cases   MulEvessel   Disease>70%  cases  
  • 8. Risk  Evalua8on   Euroscore   Euroscore=26,79% Very high risk for surgery
  • 9. high  risk  of  MACCE  at  one  and  three  year     SYNTAX Score=30  
  • 11. Crusade  bleeding  risk  score  and     the  major  bleeding  rate   29,3%   13,3%   30   14   23,9%   25   22%   12   10   20   8   15   12,7%   12,2%   3,8%   4%   6   10   4   2   0%   0%   5   0   0   34,2% are at high or Incidence of major very High risk of bleeding at hospital bleeding according to Crusade score ROC curve: r=0.889 SCA Ariana Registry
  • 12. Key  points   •  SymptomaEc  82  male   •  Non  diabeEc   •  Distal  leG  main  disease  (superficial  calcificaEon)   •  Lesion  in  osEal  and  proximal  Cx   •  Lesion  in  proximal  LAD   •  Type  A  lesion  of  proximal  RCA   •  Very  High  surgical  risk         •  Intermediate  Syntax  Score   •  High  risk  of  bleeding   •  High  risk  of  CIN      
  • 13. Key  issues/strategy?   •  PCI  vs  CABG?   •  Which  strategy  for  LM  PCI  and  MVD?  
  • 14.
  • 15.
  • 16. Key  issues/strategy?   •  PCI  vs  CABG?   •  Which  strategy  for  LM  PCI  and  MVD?  
  • 17. PCI  dilemmas   A/  Type  of  stent?   •  Bare  metal  Stent?  Vs  Drug  eluEng  stent?   B/  Size  of  sheat?   •  6  or  7  F   C/  Access  route  for  PCI   •  Femoral  approach?   •  Radial  approach?   D/  Could  i  treat  this  pa8ent  without  IVUS-­‐guided?  
  • 18. We choose a BMS for clinical reasons: Bleeding risk and problem of compliance for DAPT (during one year) and for economic reasons: only 2 stents/patient are reimbursed
  • 19. What  is  the  best  strategy  for  PCI?   •  RCA  PCI  first?   •  LMD  disease  First?   •  In  one    and  two  Emes?    
  • 20.
  • 21. RCA  PCI  first  two  days  aGer  the   first  angiogram  (Right  TRA)   Right TRA: Direct stenting: Stent BMS: integrity 3.5 X 15 mm at 16 atm
  • 22. PCI  for  LMD  and  mild  LAD   •  Programmed  aGer  10  days  by  Right  TRA   •  1  stent  or  two  stents?   •  If  two  stents:  T  stenEng,  crush  stent,  mini   crush  stent,  culode  stenEng,  V  stenEng,  Y   stenEng?  
  • 23. Single  vs  two  stents?  
  • 24.
  • 25. The lesion of Circ is one of the key elements for the strategy of Left Main PCI.
  • 26. Proximal  LAD  PCI   Direct stenting Integrity 3.5 X 15 mm at 16 atm 2 BMW wires Plavix 300 mg + aspirine 100 mg + UFH 60 UI/Kg
  • 27.
  • 28. Minicrush  stenEng   Compliant balloon 2.0 X 15 mm at 10 atm there is no consensus on the best option for elective stenting with 2 stents
  • 29.
  • 30. Stent  deployment  in  the  osEum  of   Cx   Stent Driver 2.75 X15 mm at 12 atm
  • 31.
  • 32. StenEng  of  LM   Driver 4.0 X 12 mm
  • 34. Result  aGer  the  stent  deployment  
  • 35.
  • 36. Two-step Kissing Balloon post-dilation
  • 37. Non  compliant  ballon  at  20  atm  
  • 38.
  • 39. Final  result  aGer  the  Kissing   Balloon  
  • 40. Final  result  aGer  the  Kissing   Balloon  
  • 41.
  • 42.
  • 43. Conclusions                   vendredi,  octobre  7,  2011   43  
  • 44. vendredi,  octobre  7,  2011   44