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ACUTE MYELOIDACUTE MYELOID
LEUKAEMIALEUKAEMIA
WHOWHO
CLASSIFICATIONCLASSIFICATION
AML with Recurrent GeneticAML with Recurrent Genetic
AbnormalitiesAbnormalities
๏ฎ AML with t(8;21) RUNX1-RUNX1T1AML with t(8;21) RUNX1-RUNX1T1
๏ฎ AML with inv (16) or t(16;16)AML with inv (16) or t(16;16)
๏ฎ Acute promyelocytic leukaemia withAcute promyelocytic leukaemia with
t(15;17), PML-RARAt(15;17), PML-RARA
๏ฎ AML with t(9;11), MLLT3-MLLAML with t(9;11), MLLT3-MLL
๏ฎ AML with t(6;9),DEK-NUP214AML with t(6;9),DEK-NUP214
๏ฎ AML with inv (3)AML with inv (3)
AML with Recurrent GeneticAML with Recurrent Genetic
AbnormalitiesAbnormalities
๏ฎ AML (megakaryoblastic) with t(1;22),AML (megakaryoblastic) with t(1;22),
RBM15-MKL1RBM15-MKL1
๏ฎ AML with mutated NPM1AML with mutated NPM1
๏ฎ AML with mutated CEBPAAML with mutated CEBPA
๏ฎ AML with myelodysplasia relatedAML with myelodysplasia related
changes.changes.
๏ฎ Therapy related myeloid neoplasms.Therapy related myeloid neoplasms.
๏ฎ Myeloid sarcoma.Myeloid sarcoma.
๏ฎ Blastic plasmacytoid dendritic cellBlastic plasmacytoid dendritic cell
neoplasm.neoplasm.
๏ฎ Acute myeloid leukaemia, NOSAcute myeloid leukaemia, NOS
๏ƒ˜ AML with minimal differentiationAML with minimal differentiation
๏ƒ˜ AML without maturationAML without maturation
๏ƒ˜ AML with maturationAML with maturation
๏ƒ˜ Acute myelomonocytic leukaemiaAcute myelomonocytic leukaemia
๏ƒ˜ Acute monoblastic and monocyticAcute monoblastic and monocytic
leukaemia.leukaemia.
๏ƒ˜ Acute erythroid leukaemiaAcute erythroid leukaemia
๏ƒ˜ Acute megakaryoblastic leukaemiaAcute megakaryoblastic leukaemia
๏ƒ˜ Acute basophilic leukaemiaAcute basophilic leukaemia
๏ƒ˜ Acute panmyelosis with myelofibrosis.Acute panmyelosis with myelofibrosis.
๏ฎ Myeloid proliferations related toMyeloid proliferations related to
Down syndromeDown syndrome
๏ƒ˜ Transient abnormal myelopoiesisTransient abnormal myelopoiesis
๏ƒ˜ Myeloid leukaemia associated with DownMyeloid leukaemia associated with Down
syndromesyndrome

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Acute myeloid leukaemia, who

  • 2. AML with Recurrent GeneticAML with Recurrent Genetic AbnormalitiesAbnormalities ๏ฎ AML with t(8;21) RUNX1-RUNX1T1AML with t(8;21) RUNX1-RUNX1T1 ๏ฎ AML with inv (16) or t(16;16)AML with inv (16) or t(16;16) ๏ฎ Acute promyelocytic leukaemia withAcute promyelocytic leukaemia with t(15;17), PML-RARAt(15;17), PML-RARA ๏ฎ AML with t(9;11), MLLT3-MLLAML with t(9;11), MLLT3-MLL ๏ฎ AML with t(6;9),DEK-NUP214AML with t(6;9),DEK-NUP214 ๏ฎ AML with inv (3)AML with inv (3)
  • 3. AML with Recurrent GeneticAML with Recurrent Genetic AbnormalitiesAbnormalities ๏ฎ AML (megakaryoblastic) with t(1;22),AML (megakaryoblastic) with t(1;22), RBM15-MKL1RBM15-MKL1 ๏ฎ AML with mutated NPM1AML with mutated NPM1 ๏ฎ AML with mutated CEBPAAML with mutated CEBPA
  • 4. ๏ฎ AML with myelodysplasia relatedAML with myelodysplasia related changes.changes. ๏ฎ Therapy related myeloid neoplasms.Therapy related myeloid neoplasms. ๏ฎ Myeloid sarcoma.Myeloid sarcoma. ๏ฎ Blastic plasmacytoid dendritic cellBlastic plasmacytoid dendritic cell neoplasm.neoplasm.
  • 5. ๏ฎ Acute myeloid leukaemia, NOSAcute myeloid leukaemia, NOS ๏ƒ˜ AML with minimal differentiationAML with minimal differentiation ๏ƒ˜ AML without maturationAML without maturation ๏ƒ˜ AML with maturationAML with maturation ๏ƒ˜ Acute myelomonocytic leukaemiaAcute myelomonocytic leukaemia ๏ƒ˜ Acute monoblastic and monocyticAcute monoblastic and monocytic leukaemia.leukaemia.
  • 6. ๏ƒ˜ Acute erythroid leukaemiaAcute erythroid leukaemia ๏ƒ˜ Acute megakaryoblastic leukaemiaAcute megakaryoblastic leukaemia ๏ƒ˜ Acute basophilic leukaemiaAcute basophilic leukaemia ๏ƒ˜ Acute panmyelosis with myelofibrosis.Acute panmyelosis with myelofibrosis.
  • 7. ๏ฎ Myeloid proliferations related toMyeloid proliferations related to Down syndromeDown syndrome ๏ƒ˜ Transient abnormal myelopoiesisTransient abnormal myelopoiesis ๏ƒ˜ Myeloid leukaemia associated with DownMyeloid leukaemia associated with Down syndromesyndrome