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Dr. Mustafa Kerem
Gazi U School of Medicine
Department of General Surgery
Case #1
 24 yo healthy M with one day hx of abdominal pain. Pain
was generalized at first, now worse in right lower abd &
radiates to his right groin. He has vomited twice today.
Denies any diarrhea, fevers, dysuria or other complaints.
No appetite today.
 Review of Systems (ROS) otherwise negative.
 Past Medical History (PMHx): negative
 Past Surgical History (PSurgHx): negative
 Meds: none
 No known drug allergies (NKDA)
 Social hx: no alcohol, tobacco or drug use
 Family hx: non-contributory
Abdominal pain
 What else do you want to know?
 What is on your differential diagnosis so far?
 (healthy male with RLQ abd pain….)
 How do you approach the complaint of abdominal
pain in general?
 Let’s review in this lecture:
 Types of pain
 History and physical examination
 Labs and imaging
 Abdominal pain in special populations (Elderly)
 Clinical pearls to help you in the ED
“Tell me more about your pain….”
 Location
 Quality
 Severity
 Onset
 Duration
 Modifying factors
 Change over time
What kind of pain is it?
 Visceral
 Involves hollow or solid organs; midline pain due to
bilateral innvervation
 Steady ache or vague discomfort to excruciating or
colicky pain
 Poorly localized
 Epigastric region: stomach, duodenum, biliary tract
 Periumbilical: small bowel, appendix, cecum
 Suprapubic: colon, sigmoid, GU tract
What kind of pain is it?
 Parietal
 Involves parietal peritoneum
 Localized pain
 Causes tenderness and guarding which progress
to rigidity and rebound as peritonitis develops
What kind of pain is it?
Referred
 Produces symptoms not signs
 Based on developmental embryology
 Ureteral obstruction → testicular pain
 Subdiaphragmatic irritation → ipsilateral
shoulder or supraclavicular pain
 Gynecologic pathology → back or proximal
lower extremity
 Biliary disease → right infrascapular pain
 MI → epigastric, neck, jaw or upper extremity
pain
Ask about relevant ROS
 GI symptoms
 Nausea, vomiting, hematemesis, anorexia, diarrhea,
constipation, bloody stools, melena stools
 GU symptoms
 Dysuria, frequency, urgency, hematuria, incontinence
 Gyn symptoms
 Vaginal discharge, vaginal bleeding
 General
 Fever, lightheadedness
And don’t forget the history
 GI
 Past abdominal surgeries, h/o GB disease, ulcers; FamHx IBD
 GU
 Past surgeries, h/o kidney stones, pyelonephritis, UTI
 Gyn
 Last menses, sexual activity, contraception, h/o PID or STDs, h/o ovarian
cysts, past gynecological surgeries, pregnancies
 Vascular
 h/o MI, heart disease, a-fib, anticoagulation, CHF, PVD, Fam Hx of AAA
 Other medical history
 DM, organ transplant, HIV/AIDS, cancer
 Social
 Tobacco, drugs – Especially cocaine, alcohol
 Medications
 NSAIDs, H2 blockers, PPIs, immunosuppression, coumadin
Moving on to the Physical Exam
 General
 Pallor, diaphoresis, level of distress or
discomfort, is the patient lying still or moving
around in the bed
 Vital Signs
 Orthostatic VS when volume depletion is
suspected
 Cardiac
 Arrhythmias
 Lungs
 Pneumonia
Moving on to the Physical Exam
 Abdomen
 Look for distention, scars, masses
 Auscultate – hyperactive or obstructive BS
increase likelihood of SBO fivefold – otherwise
not very helpful
 Palpate for tenderness, masses, aortic aneurysm,
organomegaly, rebound, guarding, rigidity
 Percuss for tympany
 Look for hernias!
 Rectal exam
Moving on to the Physical Exam
Back
 CVA tenderness
Pelvic exam
 Cervical motion tenderness (CMT)
 Vaginal discharge – Culture
 Adenexal mass or fullness
Abdominal Findings
Guarding
 Voluntary
 Contraction of abdominal musculature in
anticipation of palpation
 Diminish by having patient flex knees
 Involuntary
 Reflex spasm of abdominal muscles
 aka: rigidity
 Suggests peritoneal irritation
Abdominal Findings
 Rebound
 Present in 1 of 4 patients without peritonitis
 Pain referred to the point of maximum tenderness
when palpating an adjacent quadrant is suggestive
of peritonitis
 Rovsing’s sign in appendicitis
 Rectal exam
 Little evidence that tenderness adds any useful
information beyond abdominal examination
 Gross blood or melena indicates a GIB
Differential Diagnosis
It’s Huge!
 Use history and physical exam to narrow it down
 Rule out life-threatening pathology
 Half the time you will send the patient home with a
diagnosis of nonspecific abdominal pain (NSAP or
Abdominal Pain – NOS)
 90% will be better or asymptomatic at 2-3 weeks
Differential Diagnosis
 Gastritis, ileitis, colitis, esophagitis
 Ulcers: gastric, peptic, esophageal
 Biliary disease: cholelithiasis, cholecystitis
 Hepatitis, pancreatitis, Cholangitis
 Splenic infarct, Splenic rupture
 Pancreatic psuedocyst
 Hollow viscous perforation
 Bowel obstruction, volvulus
 Diverticulitis
 Appendicitis
 Ovarian cyst
 Ovarian torsion
 Hernias: incarcerated, strangulated
 Kidney stones
 Pyelonephritis
 Hydronephrosis
 Inflammatory bowel disease: crohns, UC
 Gastroenteritis, enterocolitis
 pseudomembranous colitis, ischemia colitis
 Tumors: carcinomas, lipomas
 Meckels diverticulum
 Testicular torsion
 Epididymitis, prostatitis, orchitis, cystitis
 Constipation
 Abdominal aortic aneurysm, ruptures aneurysm
 Aortic dissection
 Mesenteric ischemia
 Organomegaly
 Hemilith infestation
 Porphyrias
 ACS
 Pneumonia
 Abdominal wall syndromes: muscle strain, hematomas, trauma,
 Neuropathic causes: radicular pain
 Non-specific abdominal pain
 Group A beta-hemolytic streptococcal pharyngitis
 Rocky Mountain Spotted Fever
 Toxic Shock Syndrome
 Black widow envenomation
 Drugs: cocaine induced-ischemia, erythromycin, tetracyclines,
NSAIDs
 Mercury salts
 Acute inorganic lead poisoning
 Electrical injury
 Opioid withdrawal
 Mushroom toxicity
 AGA: DKA, AKA
 Adrenal crisis
 Thyroid storm
 Hypo- and hypercalcemia
 Sickle cell crisis
 Vasculitis
 Irritable bowel syndrome
 Ectopic pregnancy
 PID
 Urinary retention
 Ileus, Ogilvie syndrome
Most Common Causes in the ED
 Non-specific abd pain 34%
 Appendicitis 28%
 Biliary tract dz 10%
 SBO 4%
 Gyn disease 4%
 Pancreatitis 3%
 Renal colic 3%
 Perforated ulcer 3%
 Cancer 2%
 Diverticular dz 2%
 Other 6%
What kind of tests should you
order?
 Depends what you are looking for!
 Abdominal series
 3 views: upright chest, flat view of abdomen,
upright view of abdomen
 Limited utility: restrict use to patients with
suspected obstruction or free air
 Ultrasound
 Good for diagnosing AAA but not ruptured AAA
 Good for pelvic pathology
What kind of tests should you
order?
 CT abdomen/pelvis
 Noncontrast for free air, renal colic, ruptured AAA, (bowel obstruction)
 Contrast study for abscess, infection, inflammation, unknown cause
 MRI
 Most often used when unable to obtain CT due to contrast issue
 Labs
 CBC: “What’s the white count?”
 Chemistries
 Liver function tests, Lipase
 Coagulation studies
 Urinalysis, urine culture
 GC/Chlamydia swabs
 Lactate
Disposition
Depends on the source
Non-specific abdominal pain
 No source is identified
 Vital signs are normal
 Non specific abdominal exam, no evidence of
peritonitis or severe pain
 Patient improves during ED visit
 Patient able to take fluids
 Have patient return to ED in 12-24 hours for re-
examination if not better or if they develop new
symptoms
Back to Case #1….24 yo with RLQ pain
 Physical exam:
 T: 37.8, HR: 95, BP 118/76, R: 18, O2 sat: 100% room air
 Uncomfortable appearing, slightly pale
 Abdomen: soft, non-distended, tender to palpation in
RLQ with mild guarding; hypoactive bowel sounds
 Genital exam: normal
 What is your differential diagnosis and what do
you do next?
Appendicitis
 Classic presentation
 Periumbilical pain
 Anorexia, nausea, vomiting
 Pain localizes to RLQ
 Occurs only in ½ to 2/3 of
patients
 26% of appendices are
retrocecal and cause pain in
the flank; 4% are in the RUQ
 A pelvic appendix can cause
suprapubic pain, dysuria
 Males may have pain in the
testicles
 Findings
 Depends on duration of
symptoms
 Rebound, voluntary guarding,
rigidity, tenderness on rectal
exam
 Psoas sign
 Obturator sign
 Fever (a late finding)
 Urinalysis abnormal in 19-40%
 CBC is not sensitive or specific
 Abdominal xrays
 Appendiceal fecalith or gas,
localized ileus, blurred right
psoas muscle, free air
 CT scan
 Pericecal inflammation, abscess,
periappendiceal phlegmon,
fluid collection, localized fat
stranding
Appendicitis: Psoas Sign
Appendicitis: Psoas Sign
Appendicitis: Obturator Sign
Passively flex
right hip and knee
then internally
rotate the hip
Appendicitis: CT findings
Abscess, fat
stranding
Cecum
Appendicitis
 Diagnosis
 WBC
 Clinical appendicitis – call
your surgeon
 Maybe appendicitis - CT
scan
 Not likely appendicitis –
observe for 6-12 hours or re-
examination in 12 hours
 Treatment
 NPO
 IVFs
 Preoperative antibiotics –
decrease the incidence of
postoperative wound
infections
 Cover anaerobes, gram-
negative and enterococci
 Zosyn 3.375 grams IV or
Unasyn 3 grams IV
 Analgesia
Case #2
 68 yo F with 2 days of LLQ abd pain, diarrhea,
fevers/chills, nausea; vomited once at home.
 PMHx: HTN, diverticulosis
 PSurgHx: negative
 Meds: HCTZ
 NKDA
 Social hx: no alcohol, tobacco or drug use
 Family hx: non-contributory
Case #2 Exam
 T: 37.6, HR: 100, BP: 145/90, R: 19, O2sat: 99%
room air
 Gen: uncomfortable appearing, slightly pale
 CV/Pulmonary: normal heart and lung exam, no
LE edema, normal pulses
 Abd: soft, moderately TTP LLQ
 Rectal: normal tone, guiac neg brown stool
 What is your differential diagnosis & what
next?
Diverticulitis
 Risk factors
 Diverticula
 Increasing age
 Clinical features
 Steady, deep discomfort
in LLQ
 Change in bowel habits
 Urinary symptoms
 Tenesmus
 Paralytic ileus
 SBO
 Physical Exam
 Low-grade fever
 Localized tenderness
 Rebound and guarding
 Left-sided pain on rectal
exam
 Occult blood
 Peritoneal signs
 Suggest perforation or
abscess rupture
Diverticulitis
 Diagnosis
 CT scan (IV and oral
contrast)
 Pericolic fat stranding
 Diverticula
 Thickened bowel wall
 Peridiverticular abscess
 Leukocytosis present in
only 36% of patients
 Treatment
 Fluids
 Correct electrolyte
abnormalities
 NPO
 Abx: gentamicin AND
metronidazole OR
clindamycin OR
levaquin/flagyl
 For outpatients (non-toxic)
 liquid diet x 48 hours
 cipro and flagyl
Case #3
 46 yo M with hx of alcohol abuse with 3 days of
severe upper abd pain, vomiting, subjective fevers.
 Med Hx: negative
 Surg Hx: negative
 Meds: none; Allergies: No known drug allergies
(NKDA)
 Social hx: homeless, heavy alcohol use, smokes
2ppd, no drug use
Case #3 Exam
Vital signs: T: 37.4, HR: 115, BP: 98/65, R: 22, O2sat: 95%
room air
 General: ill-appearing, appears in pain
 CV: tachycardic, normal heart sounds, pulses normal
 Lungs: clear
 Abdomen: mildly distended, moderately tenderness to
palpation (TTP) epigastric, +voluntary guarding
 Rectal: heme neg stool
 What is your differential diagnosis & what next?
Pancreatitis
 Risk Factors
 Alcohol
 Gallstones
 Drugs
 Amiodarone, antivirals,
diuretics, NSAIDs, antibiotics,
more…..
 Severe hyperlipidemia
 Idiopathic
 Clinical Features
 Epigastric pain
 Constant, boring pain
 Radiates to back
 Severe
 N/V
 bloating
 Physical Findings
 Low-grade fevers
 Tachycardia, hypotension
 Respiratory symptoms
 Atelectasis
 Pleural effusion
 Peritonitis – a late finding
 Ileus
 Cullen sign*
 Bluish discoloration around the
umbilicus
 Grey Turner sign*
 Bluish discoloration of the
flanks
*Signs of hemorrhagic pancreatitis
Pancreatitis
 Diagnosis
 Lipase
 Elevated more than 2 times
normal
 Sensitivity and specificity
>90%
 Amylase
 Nonspecific
 Don’t bother…
 RUQ US if etiology unknown
 CT scan
 Insensitive in early or mild
disease
 NOT necessary to diagnose
pancreatitis
 Useful to evaluate for
complications
 Treatment
 NPO
 IV fluid resuscitation
 Maintain urine output of 100
mL/hr
 NGT if severe, persistent nausea
 No antibiotics unless severe
disease
 E coli, Klebsiella, enterococci,
staphylococci, pseudomonas
 Imipenem or cipro with
metronidazole
 Mild disease, tolerating oral
fluids
 Discharge on liquid diet
 Follow up in 24-48 hours
 All others, admit
Case #4
 72 yo M with hx of CAD on aspirin and Plavix with
several days of dull upper abd pain and now with
worsening pain “in entire abdomen” today. Some
relief with food until today, now worse after eating
lunch.
 Med Hx: CAD, HTN, CHF
 Surg Hx: appendectomy
 Meds: Aspirin, Plavix, Metoprolol, Lasix
 Social hx: smokes, denies alcohol or drug use, lives
alone
Case #4 Exam
 T: 99.1, HR: 70, BP: 90/45, R: 22, O2sat: 96% room
air
 General: elderly, thin male, ill-appearing
 CV: normal
 Lungs: clear
 Abd: mildly distended and diffusely tender to
palpation, +rebound and guarding
 Rectal: blood-streaked heme + brown stool
 What is your differential diagnosis & what
next?
Peptic Ulcer Disease
 Risk Factors
 H. pylori
 NSAIDs
 Smoking
 Hereditary
 Clinical Features
 Burning epigastric pain
 Sharp, dull, achy, or “empty” or
“hungry” feeling
 Relieved by milk, food, or antacids
 Awakens the patient at night
 Nausea, retrosternal pain and
belching are NOT related to PUD
 Atypical presentations in the elderly
 Physical Findings
 Epigastric tenderness
 Severe, generalized pain
may indicate perforation
with peritonitis
 Occult or gross blood per
rectum or NGT if bleeding
Peptic Ulcer Disease
 Diagnosis
 Rectal exam for occult blood
 CBC
 Anemia from chronic blood
loss
 LFTs
 Evaluate for GB, liver and
pancreatic disease
 Definitive diagnosis is by EGD
or upper GI barium study
 Treatment
 Empiric treatment
 Avoid tobacco, NSAIDs, aspirin
 PPI or H2 blocker
 Immediate referral to GI if:
 >45 years
 Weight loss
 Long h/o symptoms
 Anemia
 Persistent anorexia or vomiting
 Early satiety
 GIB
Here is your patient’s x-ray….
Perforated Peptic Ulcer
 Abrupt onset of severe epigastric pain followed by
peritonitis
 IV, oxygen, monitor
 CBC, T&C, Lipase
 Acute abdominal x-ray series
 Lack of free air does NOT rule out perforation
 Broad-spectrum antibiotics
 Surgical consultation
Case #5
 35 yo healthy F to ED c/o nausea and vomiting
since yesterday along with generalized abdominal
pain. No fevers/chills, +anorexia. Last stool 2 days
ago.
 Med Hx: negative
 Surg Hx: s/p hysterectomy (for fibroids)
 Meds: none, Allergies: NKDA
 Social Hx: denies alcohol, tobacco or drug use
 Family Hx: non-contributory
Case #5 Exam
 T: 36.9, HR: 100, BP: 130/85, R: 22, O2 sat: 97%
room air
 General: mildly obese female, vomiting
 CV: normal
 Lungs: clear
 Abd: moderately distended, mild TTP diffusely,
hypoactive bowel sounds, no rebound or guarding
 What is your differential and what next?
Upright abd x-ray
Bowel Obstruction
 Mechanical or nonmechanical
causes
 #1 - Adhesions from previous
surgery
 #2 - Groin hernia incarceration
 Clinical Features
 Crampy, intermittent pain
 Periumbilical or diffuse
 Inability to have BM or flatus
 N/V
 Abdominal bloating
 Sensation of fullness, anorexia
 Physical Findings
 Distention
 Tympany
 Absent, high pitched or
tinkling bowel sound or
“rushes”
 Abdominal tenderness:
diffuse, localized, or minimal
Bowel Obstruction
 Diagnosis
 CBC and electrolytes
 electrolyte abnormalities
 WBC >20,000 suggests bowel
necrosis, abscess or peritonitis
 Abdominal x-ray series
 Flat, upright, and chest x-ray
 Air-fluid levels, dilated loops of
bowel
 Lack of gas in distal bowel and
rectum
 CT scan
 Identify cause of obstruction
 Delineate partial from complete
obstruction
 Treatment
 Fluid resuscitation
 NGT
 Analgesia
 Surgical consult
 Hospital observation for ileus
 OR for complete obstruction
 Peri-operative antibiotics
 Zosyn or unasyn
Case #6
 48 yo obese F with one day hx of upper abd pain after
eating, does not radiate, is intermittent cramping pain,
+N/V, no diarrhea, subjective fevers. No prior similar
symptoms.
 Med hx: denies
 Surg hx: denies
 No meds or allergies
 Social hx: no alcohol, tobacco or drug use
Case #6 Exam
 T: 100.4, HR: 96, BP: 135/76, R: 18, O2 sat: 100%
room air
 General: moderately obese, no acute distress
 CV: normal
 Lungs: clear
 Abd: moderately TTP RUQ, +Murphy’s sign, non-
distended, normal bowel sounds
 What is your differential and what next?
Cholecystitis
 Clinical Features
 RUQ or epigastric pain
 Radiation to the back or
shoulders
 Dull and achy → sharp
and localized
 Pain lasting longer than
6 hours
 N/V/anorexia
 Fever, chills
 Physical Findings
 Epigastric or RUQ pain
 Murphy’s sign
 Patient appears ill
 Peritoneal signs suggest
perforation
Cholecystitis
 Diagnosis
 CBC, LFTs, Lipase
 Elevated alkaline phosphatase
 Elevated lipase suggests
gallstone pancreatitis
 RUQ US
 Thicken gallbladder wall
 Pericholecystic fluid
 Gallstones or sludge
 Sonographic murphy sign
 HIDA scan
 more sensitive & specific than
US
 H&P and laboratory findings
have a poor predictive value – if
you suspect it, get the US
 Treatment
 Surgical consult
 IV fluids
 Correct electrolyte
abnormalities
 Analgesia
 Antibiotics
 Ceftriaxone 1 gram IV
 If septic, broaden coverage to
zosyn, unasyn, imipenem or
add anaerobic coverage to
ceftriaxone
 NGT if intractable vomiting
Case #7
 34 yo healthy M with 4 hour hx of sudden onset
left flank pain, +nausea/vomiting; no prior hx of
similar symptoms; no fevers/chills. +difficulty
urinating, no hematuria. Feels like has to urinate
but cannot.
 PMHx: neg
 Surg Hx: neg
 Meds: none,
 Allergies: NKDA
 Social hx: occasional alcohol, denies tobacco or
drug use
 Family hx: non-contributory
Case #7 Exam
 T: 98.9, HR: 110, BP: 150/90, R: 20, O2 sat: 99% room air
 General: writhing around on stretcher in pain,
+diaphoretic
 CV: tachycardic, heart sounds normal
 Lungs: clear
 Abd: soft; non-tender
 Back: mild left CVA tenderness
 Genital exam: normal
 Neuro exam: normal
 What is your differential diagnosis and what next?
Renal Colic
 Clinical Features
 Acute onset of severe,
dull, achy visceral pain
 Flank pain
 Radiates to abdomen or
groin including testicles
 N/V and sometimes
diaphoresis
 Fever is unusual
 Waxing and waning
symptoms
 Physical Findings
 non tender or mild
tenderness to palpation
 Anxious, pacing,
writhing in bed – unable
to sit still
Renal Colic
 Diagnosis
 Urinalysis
 RBCs
 WBCs suggest infection or
other etiology for pain (ie
appendicitis)
 CBC
 If infection suspected
 BUN/Creatinine
 In older patients
 If patient has single kidney
 If severe obstruction is
suspected
 CT scan
 In older patients or patients
with comorbidities (DM,
SCD)
 Not necessary in young
patients or patients with h/o
stones that pass
spontaneously
 Treatment
 IV fluid boluses
 Analgesia
 Narcotics
 NSAIDS
 If no renal insufficiency
 Strain all urine
 Follow up with urology in 1-2
weeks
 If stone > 5mm, consider
admission and urology consult
 If toxic appearing or infection
found
 IV antibiotics
 Urologic consult
Just a few more to go….hang in
there
 Ovarian torsion
 Testicular torsion
 Abd pain in the Elderly
Ovarian Torsion
 Acute onset severe pelvic pain
 May wax and wane
 Possible hx of ovarian cysts
 Menstrual cycle: midcycle also
possibly in pregnancy
 Can have variable exam:
 acute, rigid abdomen,
peritonitis
 Fever
 Tachycardia
 Decreased bowel sounds
 May look just like Appendicitis
 Ultrasound
 Labs
 CBC, beta-hCG,
electrolytes, T&S
 IV fluids
 NPO
 Pain medications
 GYN consult
Testicular Torsion
 Sudden onset of severe testicular
pain
 If torsion is repaired within 6
hours of the initial insult,
salvage rates of 80-100% are
typical. These rates decline to
nearly 0% at 24 hours.
 Approximately 5-10% of torsed
testes spontaneously detorse,
but the risk of retorsion at a later
date remains high.
 Most occur in males less than
20yrs old but 10% of affected
patients are older than 30 years.
 Detorsion
 Emergent urology consult
 Ultrasound with Doppler
Abdominal Pain in the Elderly
 Mortality rate for abdominal
pain in the elderly is 11-14%
 Perception of pain is altered
 Altered reporting of pain:
stoicism, fear,
communication problems
 Most common causes:
 Cholecystitis
 Appendicitis
 Bowel obstruction
 Diverticulitis
 Perforated peptic ulcer
 Don’t miss these:
 AAA, ruptured AAA
 Mesenteric ischemia
 Myocardial ischemia
 Aortic dissection
Abdominal Pain in the Elderly
 Appendicitis – do not exclude it because of prolonged
symptoms. Only 20% will have fever, N/V, RLQ pain and
↑WBC
 Acute cholecystitis – most common surgical emergency in
the elderly.
 Perforated peptic ulcer – only 50% report a sudden onset of
pain. In one series, missed diagnosis of PPU was leading
cause of death.
 Mesenteric ischemia – we make the diagnosis only 25% of
the time. Early diagnosis improves chances of survival.
Overall survival is 30%.
 Increased frequency of abdominal aortic aneurysms
 AAA may look like renal colic in elderly patients
Mesenteric Ischemia
 Consider this diagnosis in all elderly patients with risk factors
 Atrial fibrillation, recent MI
 Atherosclerosis, CHF, digoxin therapy
 Hypercoagulability, prior DVT, liver disease
 Severe pain, often refractory to analgesics
 Relatively normal abdominal exam
 Nausea, vomiting and anorexia are common
 50% will have diarrhea
 Eventually stools will be guiaic-positive
 Metabolic acidosis and extreme leukocytosis when advanced
disease is present (bowel necrosis)
 Diagnosis requires mesenteric angiography or CT
angiography
Abdominal Aortic Aneurysm
 Risk increases with age, women >70, men >55
 Abdominal pain in 70-80% (not back pain!)
 Back pain in 50%
 Sudden onset of significant pain
 Atypical locations of pain: hips, inguinal area, external genitalia
 Syncope can occur
 Hypotension may be present
 Palpation of a tender, enlarged aorta on exam is an important finding
 May present with hematuria
 Suspect it in any older patient with back, flank or abdominal pain especially
with a renal colic presentation
 Ultrasound can reveal the presence of a AAA but is not helpful for rupture. CT
abd/pelvis without contrast for stable patients. High suspicion in an unstable
patient requires surgical consult and emergent surgery.
Abdominal Pain Clinical Pearls
 Significant abdominal tenderness should never be attributed to gastroenteritis
 Incidence of gastroenteritis in the elderly is very low
 Always perform genital examinations when lower abdominal pain is present –
in males and females, in young and old
 In older patients with renal colic symptoms, exclude AAA
 Severe pain should be taken as an indicator of serious disease
 Pain awakening the patient from sleep should always be considered signficant
 Sudden, severe pain suggests serious disease
 Pain almost always precedes vomiting in surgical causes; converse is true for
most gastroenteritis and NSAP
 Acute cholecystitis is the most common surgical emergency in the elderly
 A lack of free air on a chest xray does NOT rule out perforation
 Signs and symptoms of PUD, gastritis, reflux and nonspecific dyspepsia have
significant overlap
 If the pain of biliary colic lasts more than 6 hours, suspect early cholecystitis

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Acute abdomen1

  • 1. Dr. Mustafa Kerem Gazi U School of Medicine Department of General Surgery
  • 2. Case #1  24 yo healthy M with one day hx of abdominal pain. Pain was generalized at first, now worse in right lower abd & radiates to his right groin. He has vomited twice today. Denies any diarrhea, fevers, dysuria or other complaints. No appetite today.  Review of Systems (ROS) otherwise negative.  Past Medical History (PMHx): negative  Past Surgical History (PSurgHx): negative  Meds: none  No known drug allergies (NKDA)  Social hx: no alcohol, tobacco or drug use  Family hx: non-contributory
  • 3. Abdominal pain  What else do you want to know?  What is on your differential diagnosis so far?  (healthy male with RLQ abd pain….)  How do you approach the complaint of abdominal pain in general?  Let’s review in this lecture:  Types of pain  History and physical examination  Labs and imaging  Abdominal pain in special populations (Elderly)  Clinical pearls to help you in the ED
  • 4. “Tell me more about your pain….”  Location  Quality  Severity  Onset  Duration  Modifying factors  Change over time
  • 5. What kind of pain is it?  Visceral  Involves hollow or solid organs; midline pain due to bilateral innvervation  Steady ache or vague discomfort to excruciating or colicky pain  Poorly localized  Epigastric region: stomach, duodenum, biliary tract  Periumbilical: small bowel, appendix, cecum  Suprapubic: colon, sigmoid, GU tract
  • 6. What kind of pain is it?  Parietal  Involves parietal peritoneum  Localized pain  Causes tenderness and guarding which progress to rigidity and rebound as peritonitis develops
  • 7. What kind of pain is it? Referred  Produces symptoms not signs  Based on developmental embryology  Ureteral obstruction → testicular pain  Subdiaphragmatic irritation → ipsilateral shoulder or supraclavicular pain  Gynecologic pathology → back or proximal lower extremity  Biliary disease → right infrascapular pain  MI → epigastric, neck, jaw or upper extremity pain
  • 8. Ask about relevant ROS  GI symptoms  Nausea, vomiting, hematemesis, anorexia, diarrhea, constipation, bloody stools, melena stools  GU symptoms  Dysuria, frequency, urgency, hematuria, incontinence  Gyn symptoms  Vaginal discharge, vaginal bleeding  General  Fever, lightheadedness
  • 9. And don’t forget the history  GI  Past abdominal surgeries, h/o GB disease, ulcers; FamHx IBD  GU  Past surgeries, h/o kidney stones, pyelonephritis, UTI  Gyn  Last menses, sexual activity, contraception, h/o PID or STDs, h/o ovarian cysts, past gynecological surgeries, pregnancies  Vascular  h/o MI, heart disease, a-fib, anticoagulation, CHF, PVD, Fam Hx of AAA  Other medical history  DM, organ transplant, HIV/AIDS, cancer  Social  Tobacco, drugs – Especially cocaine, alcohol  Medications  NSAIDs, H2 blockers, PPIs, immunosuppression, coumadin
  • 10. Moving on to the Physical Exam  General  Pallor, diaphoresis, level of distress or discomfort, is the patient lying still or moving around in the bed  Vital Signs  Orthostatic VS when volume depletion is suspected  Cardiac  Arrhythmias  Lungs  Pneumonia
  • 11. Moving on to the Physical Exam  Abdomen  Look for distention, scars, masses  Auscultate – hyperactive or obstructive BS increase likelihood of SBO fivefold – otherwise not very helpful  Palpate for tenderness, masses, aortic aneurysm, organomegaly, rebound, guarding, rigidity  Percuss for tympany  Look for hernias!  Rectal exam
  • 12. Moving on to the Physical Exam Back  CVA tenderness Pelvic exam  Cervical motion tenderness (CMT)  Vaginal discharge – Culture  Adenexal mass or fullness
  • 13. Abdominal Findings Guarding  Voluntary  Contraction of abdominal musculature in anticipation of palpation  Diminish by having patient flex knees  Involuntary  Reflex spasm of abdominal muscles  aka: rigidity  Suggests peritoneal irritation
  • 14. Abdominal Findings  Rebound  Present in 1 of 4 patients without peritonitis  Pain referred to the point of maximum tenderness when palpating an adjacent quadrant is suggestive of peritonitis  Rovsing’s sign in appendicitis  Rectal exam  Little evidence that tenderness adds any useful information beyond abdominal examination  Gross blood or melena indicates a GIB
  • 15. Differential Diagnosis It’s Huge!  Use history and physical exam to narrow it down  Rule out life-threatening pathology  Half the time you will send the patient home with a diagnosis of nonspecific abdominal pain (NSAP or Abdominal Pain – NOS)  90% will be better or asymptomatic at 2-3 weeks
  • 16. Differential Diagnosis  Gastritis, ileitis, colitis, esophagitis  Ulcers: gastric, peptic, esophageal  Biliary disease: cholelithiasis, cholecystitis  Hepatitis, pancreatitis, Cholangitis  Splenic infarct, Splenic rupture  Pancreatic psuedocyst  Hollow viscous perforation  Bowel obstruction, volvulus  Diverticulitis  Appendicitis  Ovarian cyst  Ovarian torsion  Hernias: incarcerated, strangulated  Kidney stones  Pyelonephritis  Hydronephrosis  Inflammatory bowel disease: crohns, UC  Gastroenteritis, enterocolitis  pseudomembranous colitis, ischemia colitis  Tumors: carcinomas, lipomas  Meckels diverticulum  Testicular torsion  Epididymitis, prostatitis, orchitis, cystitis  Constipation  Abdominal aortic aneurysm, ruptures aneurysm  Aortic dissection  Mesenteric ischemia  Organomegaly  Hemilith infestation  Porphyrias  ACS  Pneumonia  Abdominal wall syndromes: muscle strain, hematomas, trauma,  Neuropathic causes: radicular pain  Non-specific abdominal pain  Group A beta-hemolytic streptococcal pharyngitis  Rocky Mountain Spotted Fever  Toxic Shock Syndrome  Black widow envenomation  Drugs: cocaine induced-ischemia, erythromycin, tetracyclines, NSAIDs  Mercury salts  Acute inorganic lead poisoning  Electrical injury  Opioid withdrawal  Mushroom toxicity  AGA: DKA, AKA  Adrenal crisis  Thyroid storm  Hypo- and hypercalcemia  Sickle cell crisis  Vasculitis  Irritable bowel syndrome  Ectopic pregnancy  PID  Urinary retention  Ileus, Ogilvie syndrome
  • 17. Most Common Causes in the ED  Non-specific abd pain 34%  Appendicitis 28%  Biliary tract dz 10%  SBO 4%  Gyn disease 4%  Pancreatitis 3%  Renal colic 3%  Perforated ulcer 3%  Cancer 2%  Diverticular dz 2%  Other 6%
  • 18. What kind of tests should you order?  Depends what you are looking for!  Abdominal series  3 views: upright chest, flat view of abdomen, upright view of abdomen  Limited utility: restrict use to patients with suspected obstruction or free air  Ultrasound  Good for diagnosing AAA but not ruptured AAA  Good for pelvic pathology
  • 19. What kind of tests should you order?  CT abdomen/pelvis  Noncontrast for free air, renal colic, ruptured AAA, (bowel obstruction)  Contrast study for abscess, infection, inflammation, unknown cause  MRI  Most often used when unable to obtain CT due to contrast issue  Labs  CBC: “What’s the white count?”  Chemistries  Liver function tests, Lipase  Coagulation studies  Urinalysis, urine culture  GC/Chlamydia swabs  Lactate
  • 20. Disposition Depends on the source Non-specific abdominal pain  No source is identified  Vital signs are normal  Non specific abdominal exam, no evidence of peritonitis or severe pain  Patient improves during ED visit  Patient able to take fluids  Have patient return to ED in 12-24 hours for re- examination if not better or if they develop new symptoms
  • 21. Back to Case #1….24 yo with RLQ pain  Physical exam:  T: 37.8, HR: 95, BP 118/76, R: 18, O2 sat: 100% room air  Uncomfortable appearing, slightly pale  Abdomen: soft, non-distended, tender to palpation in RLQ with mild guarding; hypoactive bowel sounds  Genital exam: normal  What is your differential diagnosis and what do you do next?
  • 22. Appendicitis  Classic presentation  Periumbilical pain  Anorexia, nausea, vomiting  Pain localizes to RLQ  Occurs only in ½ to 2/3 of patients  26% of appendices are retrocecal and cause pain in the flank; 4% are in the RUQ  A pelvic appendix can cause suprapubic pain, dysuria  Males may have pain in the testicles  Findings  Depends on duration of symptoms  Rebound, voluntary guarding, rigidity, tenderness on rectal exam  Psoas sign  Obturator sign  Fever (a late finding)  Urinalysis abnormal in 19-40%  CBC is not sensitive or specific  Abdominal xrays  Appendiceal fecalith or gas, localized ileus, blurred right psoas muscle, free air  CT scan  Pericecal inflammation, abscess, periappendiceal phlegmon, fluid collection, localized fat stranding
  • 25. Appendicitis: Obturator Sign Passively flex right hip and knee then internally rotate the hip
  • 26. Appendicitis: CT findings Abscess, fat stranding Cecum
  • 27. Appendicitis  Diagnosis  WBC  Clinical appendicitis – call your surgeon  Maybe appendicitis - CT scan  Not likely appendicitis – observe for 6-12 hours or re- examination in 12 hours  Treatment  NPO  IVFs  Preoperative antibiotics – decrease the incidence of postoperative wound infections  Cover anaerobes, gram- negative and enterococci  Zosyn 3.375 grams IV or Unasyn 3 grams IV  Analgesia
  • 28. Case #2  68 yo F with 2 days of LLQ abd pain, diarrhea, fevers/chills, nausea; vomited once at home.  PMHx: HTN, diverticulosis  PSurgHx: negative  Meds: HCTZ  NKDA  Social hx: no alcohol, tobacco or drug use  Family hx: non-contributory
  • 29. Case #2 Exam  T: 37.6, HR: 100, BP: 145/90, R: 19, O2sat: 99% room air  Gen: uncomfortable appearing, slightly pale  CV/Pulmonary: normal heart and lung exam, no LE edema, normal pulses  Abd: soft, moderately TTP LLQ  Rectal: normal tone, guiac neg brown stool  What is your differential diagnosis & what next?
  • 30. Diverticulitis  Risk factors  Diverticula  Increasing age  Clinical features  Steady, deep discomfort in LLQ  Change in bowel habits  Urinary symptoms  Tenesmus  Paralytic ileus  SBO  Physical Exam  Low-grade fever  Localized tenderness  Rebound and guarding  Left-sided pain on rectal exam  Occult blood  Peritoneal signs  Suggest perforation or abscess rupture
  • 31. Diverticulitis  Diagnosis  CT scan (IV and oral contrast)  Pericolic fat stranding  Diverticula  Thickened bowel wall  Peridiverticular abscess  Leukocytosis present in only 36% of patients  Treatment  Fluids  Correct electrolyte abnormalities  NPO  Abx: gentamicin AND metronidazole OR clindamycin OR levaquin/flagyl  For outpatients (non-toxic)  liquid diet x 48 hours  cipro and flagyl
  • 32. Case #3  46 yo M with hx of alcohol abuse with 3 days of severe upper abd pain, vomiting, subjective fevers.  Med Hx: negative  Surg Hx: negative  Meds: none; Allergies: No known drug allergies (NKDA)  Social hx: homeless, heavy alcohol use, smokes 2ppd, no drug use
  • 33. Case #3 Exam Vital signs: T: 37.4, HR: 115, BP: 98/65, R: 22, O2sat: 95% room air  General: ill-appearing, appears in pain  CV: tachycardic, normal heart sounds, pulses normal  Lungs: clear  Abdomen: mildly distended, moderately tenderness to palpation (TTP) epigastric, +voluntary guarding  Rectal: heme neg stool  What is your differential diagnosis & what next?
  • 34. Pancreatitis  Risk Factors  Alcohol  Gallstones  Drugs  Amiodarone, antivirals, diuretics, NSAIDs, antibiotics, more…..  Severe hyperlipidemia  Idiopathic  Clinical Features  Epigastric pain  Constant, boring pain  Radiates to back  Severe  N/V  bloating  Physical Findings  Low-grade fevers  Tachycardia, hypotension  Respiratory symptoms  Atelectasis  Pleural effusion  Peritonitis – a late finding  Ileus  Cullen sign*  Bluish discoloration around the umbilicus  Grey Turner sign*  Bluish discoloration of the flanks *Signs of hemorrhagic pancreatitis
  • 35. Pancreatitis  Diagnosis  Lipase  Elevated more than 2 times normal  Sensitivity and specificity >90%  Amylase  Nonspecific  Don’t bother…  RUQ US if etiology unknown  CT scan  Insensitive in early or mild disease  NOT necessary to diagnose pancreatitis  Useful to evaluate for complications  Treatment  NPO  IV fluid resuscitation  Maintain urine output of 100 mL/hr  NGT if severe, persistent nausea  No antibiotics unless severe disease  E coli, Klebsiella, enterococci, staphylococci, pseudomonas  Imipenem or cipro with metronidazole  Mild disease, tolerating oral fluids  Discharge on liquid diet  Follow up in 24-48 hours  All others, admit
  • 36. Case #4  72 yo M with hx of CAD on aspirin and Plavix with several days of dull upper abd pain and now with worsening pain “in entire abdomen” today. Some relief with food until today, now worse after eating lunch.  Med Hx: CAD, HTN, CHF  Surg Hx: appendectomy  Meds: Aspirin, Plavix, Metoprolol, Lasix  Social hx: smokes, denies alcohol or drug use, lives alone
  • 37. Case #4 Exam  T: 99.1, HR: 70, BP: 90/45, R: 22, O2sat: 96% room air  General: elderly, thin male, ill-appearing  CV: normal  Lungs: clear  Abd: mildly distended and diffusely tender to palpation, +rebound and guarding  Rectal: blood-streaked heme + brown stool  What is your differential diagnosis & what next?
  • 38. Peptic Ulcer Disease  Risk Factors  H. pylori  NSAIDs  Smoking  Hereditary  Clinical Features  Burning epigastric pain  Sharp, dull, achy, or “empty” or “hungry” feeling  Relieved by milk, food, or antacids  Awakens the patient at night  Nausea, retrosternal pain and belching are NOT related to PUD  Atypical presentations in the elderly  Physical Findings  Epigastric tenderness  Severe, generalized pain may indicate perforation with peritonitis  Occult or gross blood per rectum or NGT if bleeding
  • 39. Peptic Ulcer Disease  Diagnosis  Rectal exam for occult blood  CBC  Anemia from chronic blood loss  LFTs  Evaluate for GB, liver and pancreatic disease  Definitive diagnosis is by EGD or upper GI barium study  Treatment  Empiric treatment  Avoid tobacco, NSAIDs, aspirin  PPI or H2 blocker  Immediate referral to GI if:  >45 years  Weight loss  Long h/o symptoms  Anemia  Persistent anorexia or vomiting  Early satiety  GIB
  • 40. Here is your patient’s x-ray….
  • 41. Perforated Peptic Ulcer  Abrupt onset of severe epigastric pain followed by peritonitis  IV, oxygen, monitor  CBC, T&C, Lipase  Acute abdominal x-ray series  Lack of free air does NOT rule out perforation  Broad-spectrum antibiotics  Surgical consultation
  • 42. Case #5  35 yo healthy F to ED c/o nausea and vomiting since yesterday along with generalized abdominal pain. No fevers/chills, +anorexia. Last stool 2 days ago.  Med Hx: negative  Surg Hx: s/p hysterectomy (for fibroids)  Meds: none, Allergies: NKDA  Social Hx: denies alcohol, tobacco or drug use  Family Hx: non-contributory
  • 43. Case #5 Exam  T: 36.9, HR: 100, BP: 130/85, R: 22, O2 sat: 97% room air  General: mildly obese female, vomiting  CV: normal  Lungs: clear  Abd: moderately distended, mild TTP diffusely, hypoactive bowel sounds, no rebound or guarding  What is your differential and what next?
  • 45. Bowel Obstruction  Mechanical or nonmechanical causes  #1 - Adhesions from previous surgery  #2 - Groin hernia incarceration  Clinical Features  Crampy, intermittent pain  Periumbilical or diffuse  Inability to have BM or flatus  N/V  Abdominal bloating  Sensation of fullness, anorexia  Physical Findings  Distention  Tympany  Absent, high pitched or tinkling bowel sound or “rushes”  Abdominal tenderness: diffuse, localized, or minimal
  • 46. Bowel Obstruction  Diagnosis  CBC and electrolytes  electrolyte abnormalities  WBC >20,000 suggests bowel necrosis, abscess or peritonitis  Abdominal x-ray series  Flat, upright, and chest x-ray  Air-fluid levels, dilated loops of bowel  Lack of gas in distal bowel and rectum  CT scan  Identify cause of obstruction  Delineate partial from complete obstruction  Treatment  Fluid resuscitation  NGT  Analgesia  Surgical consult  Hospital observation for ileus  OR for complete obstruction  Peri-operative antibiotics  Zosyn or unasyn
  • 47. Case #6  48 yo obese F with one day hx of upper abd pain after eating, does not radiate, is intermittent cramping pain, +N/V, no diarrhea, subjective fevers. No prior similar symptoms.  Med hx: denies  Surg hx: denies  No meds or allergies  Social hx: no alcohol, tobacco or drug use
  • 48. Case #6 Exam  T: 100.4, HR: 96, BP: 135/76, R: 18, O2 sat: 100% room air  General: moderately obese, no acute distress  CV: normal  Lungs: clear  Abd: moderately TTP RUQ, +Murphy’s sign, non- distended, normal bowel sounds  What is your differential and what next?
  • 49. Cholecystitis  Clinical Features  RUQ or epigastric pain  Radiation to the back or shoulders  Dull and achy → sharp and localized  Pain lasting longer than 6 hours  N/V/anorexia  Fever, chills  Physical Findings  Epigastric or RUQ pain  Murphy’s sign  Patient appears ill  Peritoneal signs suggest perforation
  • 50. Cholecystitis  Diagnosis  CBC, LFTs, Lipase  Elevated alkaline phosphatase  Elevated lipase suggests gallstone pancreatitis  RUQ US  Thicken gallbladder wall  Pericholecystic fluid  Gallstones or sludge  Sonographic murphy sign  HIDA scan  more sensitive & specific than US  H&P and laboratory findings have a poor predictive value – if you suspect it, get the US  Treatment  Surgical consult  IV fluids  Correct electrolyte abnormalities  Analgesia  Antibiotics  Ceftriaxone 1 gram IV  If septic, broaden coverage to zosyn, unasyn, imipenem or add anaerobic coverage to ceftriaxone  NGT if intractable vomiting
  • 51. Case #7  34 yo healthy M with 4 hour hx of sudden onset left flank pain, +nausea/vomiting; no prior hx of similar symptoms; no fevers/chills. +difficulty urinating, no hematuria. Feels like has to urinate but cannot.  PMHx: neg  Surg Hx: neg  Meds: none,  Allergies: NKDA  Social hx: occasional alcohol, denies tobacco or drug use  Family hx: non-contributory
  • 52. Case #7 Exam  T: 98.9, HR: 110, BP: 150/90, R: 20, O2 sat: 99% room air  General: writhing around on stretcher in pain, +diaphoretic  CV: tachycardic, heart sounds normal  Lungs: clear  Abd: soft; non-tender  Back: mild left CVA tenderness  Genital exam: normal  Neuro exam: normal  What is your differential diagnosis and what next?
  • 53. Renal Colic  Clinical Features  Acute onset of severe, dull, achy visceral pain  Flank pain  Radiates to abdomen or groin including testicles  N/V and sometimes diaphoresis  Fever is unusual  Waxing and waning symptoms  Physical Findings  non tender or mild tenderness to palpation  Anxious, pacing, writhing in bed – unable to sit still
  • 54. Renal Colic  Diagnosis  Urinalysis  RBCs  WBCs suggest infection or other etiology for pain (ie appendicitis)  CBC  If infection suspected  BUN/Creatinine  In older patients  If patient has single kidney  If severe obstruction is suspected  CT scan  In older patients or patients with comorbidities (DM, SCD)  Not necessary in young patients or patients with h/o stones that pass spontaneously  Treatment  IV fluid boluses  Analgesia  Narcotics  NSAIDS  If no renal insufficiency  Strain all urine  Follow up with urology in 1-2 weeks  If stone > 5mm, consider admission and urology consult  If toxic appearing or infection found  IV antibiotics  Urologic consult
  • 55. Just a few more to go….hang in there  Ovarian torsion  Testicular torsion  Abd pain in the Elderly
  • 56. Ovarian Torsion  Acute onset severe pelvic pain  May wax and wane  Possible hx of ovarian cysts  Menstrual cycle: midcycle also possibly in pregnancy  Can have variable exam:  acute, rigid abdomen, peritonitis  Fever  Tachycardia  Decreased bowel sounds  May look just like Appendicitis  Ultrasound  Labs  CBC, beta-hCG, electrolytes, T&S  IV fluids  NPO  Pain medications  GYN consult
  • 57. Testicular Torsion  Sudden onset of severe testicular pain  If torsion is repaired within 6 hours of the initial insult, salvage rates of 80-100% are typical. These rates decline to nearly 0% at 24 hours.  Approximately 5-10% of torsed testes spontaneously detorse, but the risk of retorsion at a later date remains high.  Most occur in males less than 20yrs old but 10% of affected patients are older than 30 years.  Detorsion  Emergent urology consult  Ultrasound with Doppler
  • 58. Abdominal Pain in the Elderly  Mortality rate for abdominal pain in the elderly is 11-14%  Perception of pain is altered  Altered reporting of pain: stoicism, fear, communication problems  Most common causes:  Cholecystitis  Appendicitis  Bowel obstruction  Diverticulitis  Perforated peptic ulcer  Don’t miss these:  AAA, ruptured AAA  Mesenteric ischemia  Myocardial ischemia  Aortic dissection
  • 59. Abdominal Pain in the Elderly  Appendicitis – do not exclude it because of prolonged symptoms. Only 20% will have fever, N/V, RLQ pain and ↑WBC  Acute cholecystitis – most common surgical emergency in the elderly.  Perforated peptic ulcer – only 50% report a sudden onset of pain. In one series, missed diagnosis of PPU was leading cause of death.  Mesenteric ischemia – we make the diagnosis only 25% of the time. Early diagnosis improves chances of survival. Overall survival is 30%.  Increased frequency of abdominal aortic aneurysms  AAA may look like renal colic in elderly patients
  • 60. Mesenteric Ischemia  Consider this diagnosis in all elderly patients with risk factors  Atrial fibrillation, recent MI  Atherosclerosis, CHF, digoxin therapy  Hypercoagulability, prior DVT, liver disease  Severe pain, often refractory to analgesics  Relatively normal abdominal exam  Nausea, vomiting and anorexia are common  50% will have diarrhea  Eventually stools will be guiaic-positive  Metabolic acidosis and extreme leukocytosis when advanced disease is present (bowel necrosis)  Diagnosis requires mesenteric angiography or CT angiography
  • 61. Abdominal Aortic Aneurysm  Risk increases with age, women >70, men >55  Abdominal pain in 70-80% (not back pain!)  Back pain in 50%  Sudden onset of significant pain  Atypical locations of pain: hips, inguinal area, external genitalia  Syncope can occur  Hypotension may be present  Palpation of a tender, enlarged aorta on exam is an important finding  May present with hematuria  Suspect it in any older patient with back, flank or abdominal pain especially with a renal colic presentation  Ultrasound can reveal the presence of a AAA but is not helpful for rupture. CT abd/pelvis without contrast for stable patients. High suspicion in an unstable patient requires surgical consult and emergent surgery.
  • 62. Abdominal Pain Clinical Pearls  Significant abdominal tenderness should never be attributed to gastroenteritis  Incidence of gastroenteritis in the elderly is very low  Always perform genital examinations when lower abdominal pain is present – in males and females, in young and old  In older patients with renal colic symptoms, exclude AAA  Severe pain should be taken as an indicator of serious disease  Pain awakening the patient from sleep should always be considered signficant  Sudden, severe pain suggests serious disease  Pain almost always precedes vomiting in surgical causes; converse is true for most gastroenteritis and NSAP  Acute cholecystitis is the most common surgical emergency in the elderly  A lack of free air on a chest xray does NOT rule out perforation  Signs and symptoms of PUD, gastritis, reflux and nonspecific dyspepsia have significant overlap  If the pain of biliary colic lasts more than 6 hours, suspect early cholecystitis