Effects of physical exercise in cerebrovascular mechanisms of adaptation to a...Enrike G. Argandoña
Microvascular environment plays a fundamental role in the adaptive response to increases in activity, involving an increase in energy demand. To puntual increases in demand, the response is effected by changes in local flow, but if demand remains high, angiogenic process is triggered through the formation of new capillaries from preexisting vessels. The trigger factor of angiogenesis is local neuronal hypoxia as result of increased activity, mediated by angioglioneurins whose main exponent is VEGF. There are situations in which hypoxia is not from an increased activity, but a decrease in available oxygen, as occurs in the altitude exposure.
Our goal is to study the changes underlying microvascular acute adaptation to moderate altitude and the possible effects of physical exercise.
Wistar rats bred to 400 m (P47) and transported to a height of 2800m on a journey of 35 minutes. We used the following cohorts of 7 rats each: a group was housed indoors in standard laboratory conditions, another group had free access to
an exercise wheel. As controls, we used animals born at 400m. After 48 h, animals were sacrificed and after neuropathological examination by conventional histology, capillary density was quantified using computer assisted stereology on thick sections processed using Butyryl Cholinesterase Histochemistry (Argandoña, Brain Res, 1996).
Three cortical areas were quantified, motor, somatosensory and visual cortices.
Rats with free access to exercise wheel showed higher vascular density in response to hypoxia, while the rest showed similar values. Differences were significant in all three areas, being highest in the motor cortex.
The acute adaptation to moderate altitude is an increasingly relevant issue given the increase in displacements at moderate or high altitudes, with serious consequences such as Acute Mountain Sickness, which in its most severe degree leads to
Brain edema. Our results show that exercise can play a protective role through adaptive angiogenesis.
A empresa digital Airbnb está impedida, por decisão liminar obtida pelo Ministério Público de Santa Catarina (MPSC), de anunciar, reservar e intermediar a locação de espaços e acomodações entre terceiros durante o prazo de vigência da norma estadual que limita a atividade de hotelaria como medida de evitar a propagação do coronavírus. Reservas efetuadas antes da decisão judicial deverão ser canceladas, desde que o hóspede ainda não tenha ingressado no imóvel.
Effects of physical exercise in cerebrovascular mechanisms of adaptation to a...Enrike G. Argandoña
Microvascular environment plays a fundamental role in the adaptive response to increases in activity, involving an increase in energy demand. To puntual increases in demand, the response is effected by changes in local flow, but if demand remains high, angiogenic process is triggered through the formation of new capillaries from preexisting vessels. The trigger factor of angiogenesis is local neuronal hypoxia as result of increased activity, mediated by angioglioneurins whose main exponent is VEGF. There are situations in which hypoxia is not from an increased activity, but a decrease in available oxygen, as occurs in the altitude exposure.
Our goal is to study the changes underlying microvascular acute adaptation to moderate altitude and the possible effects of physical exercise.
Wistar rats bred to 400 m (P47) and transported to a height of 2800m on a journey of 35 minutes. We used the following cohorts of 7 rats each: a group was housed indoors in standard laboratory conditions, another group had free access to
an exercise wheel. As controls, we used animals born at 400m. After 48 h, animals were sacrificed and after neuropathological examination by conventional histology, capillary density was quantified using computer assisted stereology on thick sections processed using Butyryl Cholinesterase Histochemistry (Argandoña, Brain Res, 1996).
Three cortical areas were quantified, motor, somatosensory and visual cortices.
Rats with free access to exercise wheel showed higher vascular density in response to hypoxia, while the rest showed similar values. Differences were significant in all three areas, being highest in the motor cortex.
The acute adaptation to moderate altitude is an increasingly relevant issue given the increase in displacements at moderate or high altitudes, with serious consequences such as Acute Mountain Sickness, which in its most severe degree leads to
Brain edema. Our results show that exercise can play a protective role through adaptive angiogenesis.
A empresa digital Airbnb está impedida, por decisão liminar obtida pelo Ministério Público de Santa Catarina (MPSC), de anunciar, reservar e intermediar a locação de espaços e acomodações entre terceiros durante o prazo de vigência da norma estadual que limita a atividade de hotelaria como medida de evitar a propagação do coronavírus. Reservas efetuadas antes da decisão judicial deverão ser canceladas, desde que o hóspede ainda não tenha ingressado no imóvel.
Streamlining Eligibility and Enrollment: Models for Health Reform ImplementationNASHP HealthPolicy
What is Maximizing Enrollment? an initiative funded by Robert Wood Johnson Foundation with
Goals to “Move the Needle” and Document what works, increase enrollment of eligible uninsured
children in 8 grantee states
and improve enrollment systems to be ready for 2014 presented by Alice Weiss Co-Director, Maximizing Enrollment/NASHP
CCNxCon2012: Session 4: Disjoint Path Discovery in CCN NetworksPARC, a Xerox company
Disjoint Path Discovery in CCN Networks
Asanga Udugama, Xinyi Zhang, Yasir Zaki, Carmelita Goerg (University of Bremen), Andreas Timm-Giel (Hamburg University of Technology)
O Município de Urussanga, em ação civil pública movida pelo Ministério Público de Santa Catarina (MPSC), foi condenado a adequar a acessibilidade de todas as 10 unidades básicas de saúde municipais. A sentença, confirmada por acórdão do Tribunal de Justiça de Santa Catarina, fixou o prazo de 12 meses para a execução das obras de adaptação necessárias.
Katalog Maluch+ Opieka Żłobkowa 2019/2020 - Mała Motoryka. Nowa SzkołaNowa Szkoła
Przygotowana przez nas oferta spełnia warunki realizacji kolejnego etapu rządowego programu Maluch+ 2019 na dofinansowanie działań na rzecz rozwoju i utrzymania infrastruktury opieki nad dziećmi w wieku do lat 3, takich jak: żłobki, kluby dziecięce, miejsca u dziennych opiekunów. Prezentowany katalog produktów jest zgodny z rekomendacjami asortymentu w projekcie Maluch+ 2019.
Na stronach katalogu znajdziecie Państwo również propozycje wyposażenia dedykowanego najmłodszym dzieciom. Wśród nich znalazły się m.in. akcesoria do karmienia, łóżeczka, materace oraz pościel.
Życzymy udanych zakupów i zapraszamy do kontaktu.
Strona www: https://nowaszkola.com/
Sklep internetowy: https://sklep.nowaszkola.com/
زیرساخت کلید عمومی به بستر فراهم شده در کشورها جهت بهکارگیری گواهیهای الکترونیکی گفته میشود که شامل مجموعهای از قوانین، سیاستها و دستورالعملها، استانداردها، سختافزارها، نرمافزارها و فرایندهاست. مزایای استفاده از گواهی الکترونیکی در تعاملات الکترونیکی: «اطمینان از دستنخوردگی اسناد مبادله شده»، «اطمینان از هویت شخص ارسالکننده» و «اطمینان از انکارناپذیری تولید سند توسط تولیدکننده آن» است. بنابراین زیرساخت کلید عمومی (که بستر بهکارگیری و مدیریت گواهیهای الکترونیکی را در یک کشور فراهم میکند) پیشنیاز برقراری تعاملات تجاری/غیر تجاریِ الکترونیکی مطمئن در میان طرفین داخلی یا بینالمللی است.
Streamlining Eligibility and Enrollment: Models for Health Reform ImplementationNASHP HealthPolicy
What is Maximizing Enrollment? an initiative funded by Robert Wood Johnson Foundation with
Goals to “Move the Needle” and Document what works, increase enrollment of eligible uninsured
children in 8 grantee states
and improve enrollment systems to be ready for 2014 presented by Alice Weiss Co-Director, Maximizing Enrollment/NASHP
CCNxCon2012: Session 4: Disjoint Path Discovery in CCN NetworksPARC, a Xerox company
Disjoint Path Discovery in CCN Networks
Asanga Udugama, Xinyi Zhang, Yasir Zaki, Carmelita Goerg (University of Bremen), Andreas Timm-Giel (Hamburg University of Technology)
O Município de Urussanga, em ação civil pública movida pelo Ministério Público de Santa Catarina (MPSC), foi condenado a adequar a acessibilidade de todas as 10 unidades básicas de saúde municipais. A sentença, confirmada por acórdão do Tribunal de Justiça de Santa Catarina, fixou o prazo de 12 meses para a execução das obras de adaptação necessárias.
Katalog Maluch+ Opieka Żłobkowa 2019/2020 - Mała Motoryka. Nowa SzkołaNowa Szkoła
Przygotowana przez nas oferta spełnia warunki realizacji kolejnego etapu rządowego programu Maluch+ 2019 na dofinansowanie działań na rzecz rozwoju i utrzymania infrastruktury opieki nad dziećmi w wieku do lat 3, takich jak: żłobki, kluby dziecięce, miejsca u dziennych opiekunów. Prezentowany katalog produktów jest zgodny z rekomendacjami asortymentu w projekcie Maluch+ 2019.
Na stronach katalogu znajdziecie Państwo również propozycje wyposażenia dedykowanego najmłodszym dzieciom. Wśród nich znalazły się m.in. akcesoria do karmienia, łóżeczka, materace oraz pościel.
Życzymy udanych zakupów i zapraszamy do kontaktu.
Strona www: https://nowaszkola.com/
Sklep internetowy: https://sklep.nowaszkola.com/
زیرساخت کلید عمومی به بستر فراهم شده در کشورها جهت بهکارگیری گواهیهای الکترونیکی گفته میشود که شامل مجموعهای از قوانین، سیاستها و دستورالعملها، استانداردها، سختافزارها، نرمافزارها و فرایندهاست. مزایای استفاده از گواهی الکترونیکی در تعاملات الکترونیکی: «اطمینان از دستنخوردگی اسناد مبادله شده»، «اطمینان از هویت شخص ارسالکننده» و «اطمینان از انکارناپذیری تولید سند توسط تولیدکننده آن» است. بنابراین زیرساخت کلید عمومی (که بستر بهکارگیری و مدیریت گواهیهای الکترونیکی را در یک کشور فراهم میکند) پیشنیاز برقراری تعاملات تجاری/غیر تجاریِ الکترونیکی مطمئن در میان طرفین داخلی یا بینالمللی است.
Louie Cheng, Founder PureLiving, has lived in China since 2005. Before launching PureLiving, Louie was the Asia Pacific strategy director for Thomson Scientific, a managing consultant with IBM, and a chemical engineer in the US Army. He is a member of the Indoor Air Quality Association and has trained with the American Council for Accredited Certification and the US Centers for Disease Control. He holds a BA from Harvard and an MBA from Dartmouth Business School.
Pure Living is teaming with Cannon Design to design cutting edge heat transfer technology with plant walls to create a biosystem with pure air and energy savings, while teaching students about ecology. Schools are at the forefront of the drive to provide clean, healthy indoor learning environments but the usual method of installing hundreds of purifiers is expensive, uses filters that add to landfills, and consumes high energy resulting in even more coal consumption and more pollution.
Ask the Pros: How to Manage Social Media at Your NonprofitBig Duck
Facebook? Twitter? Pinterest? Instagram? With so many channels, it can be hard to know where to start, how to make time for it, or if you're doing it well. Social media has fundamentally shifted the way we communicate and connect with our supporters. Farra Trompeter, Vice President of Big Duck, will moderated a panel of nonprofiteers who manage communities and social media for their organizations. Together they will shared how they use social media to engage their communities.
HCI Korea 2012 Keynote Talk on Model-Driven Research in Social ComputingEd Chi
Model-Driven Research in Social Computing
Research in Augmented Social Cognition is aimed at enhancing the ability of a group of people to remember, think, and reason. Our approach to creating this augmentation or enhancement is primarily model-driven. Our system developments are informed by models such as information scent, sensemaking, information theory, probabilistic models, and more recently, evolutionary dynamic models. These models have been used to understand a wide variety of user behaviors, from individuals interacting with social bookmark search in Delicious and MrTaggy.com to groups of people working on articles in Wikipedia. These models range in complexity from a simple set of assumptions to complex equations describing human and group behaviors.
By studying online social systems such as Google Plus, Twitter, Delicious, and Wikipedia, we further our understanding of how knowledge is constructed in a social context. In this talk, I will illustrate how a model-driven approach could help illuminate the path forward for research in social computing and community knowledge building.
Lab manual for Air Pollution Sampling and Analysis.
This laboratory manual is useful to environmental engineers, scientists, undergraduate and graduate students, chemists and environmental field engineers. The manual has been prepared as per the US EPA and IS standards
Similar to ACTEP2014: The routine to research R2R concept your way out of a research dead end (20)
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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27. 7
The two Death Valleys of the clinical
translational continuum
Capacity to translate research results to the next stage, affecting, first, our
ability to commercialize research results (Valley 1), and, second, our
effectiveness at moving results into clinical practice (Valley 2)
www.cihr-irsc.gc.ca/e/41232.html
30. *- -7,1
,12 (PCI)
Value:
*? American College of Cardiology Foundation
(ACC) ', American Heart Association Guideline (AHA) (#O
P secondary prevention
Aspirin/Clopidogrel
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39. Literature Review
Standardized work (Checklist)
12
Benefit of Post PCI Medical Checklist to
Improve Adhering with Best Practice
Guidelines in the Patients with Coronary
artery disease undergoing Percutaneous
Coronary Intervention (PCI)
101. Combined 2.5%
Phenylephrine and
0.75%Tropicamide
Double-blind Randomized controlled trial
Patients
# of Pupil size 7
mm
# of Pupil size 7
mm
40 min and 120 min
Primary Outcome: Number of patients whose pupil
reached 7 mm. within 40 minutes
102. Results
Outcomes
Sequential
drug
(n=18)
Combined
drug (n=22)
p -
value
Number of patients whose pupil
reached 7 mm. within 40 minutes 38.9% 77.3% 0.02
Pupil size: mean ± SD (mm.)
At 40 minutes
At 2 hours
6.0 ± 0.9
6.7 ± 0.8
6.6 ± 0.8
6.8 ± 0.9
0.03
0.44
For the combined drug, Time to pupil size 7 mm = 32 min (mean)
Blood pressure and pulse rate were stable and similar in both
groups.
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107. Medical Institute of the Kingdom
toward International Excellence
Human Capital
Excellence
Routine work
Clinical
Excellence
Knowledge
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Innovation
Publication
Knowledge
Translation
Support
(Back office)
Quality Criteria e.g. HA, JCIA TQA
41
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109. -Workflow (input process output)
• Care team: care process
• Laboratory: Specimen collection, preparation, obtain, handling, storage,
process, report
• Lean: Value Stream Mapping
• Siriraj Clinical Tracer + (SiCT+)
2. 1%* + -Complaint incidence
• What have happened
• What/How factors associated with the incidence
• What should be the solution / What is the best way to solve the problem
• 4 #+
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• Target, Timing
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42