Acne, rosacea and hidradenitis suppurativa
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The document discusses several inflammatory skin conditions including acne, rosacea, and hidradenitis suppurativa. It provides epidemiological data on acne, noting it commonly affects teenagers and has a genetic component. Treatment options for acne include topical retinoids, antibiotics, and isotretinoin. Rosacea is described as a chronic inflammatory condition of the face that may be influenced by environmental factors. Demodex mites are discussed as a possible cause. Treatment involves metronidazole, tetracycline, and laser therapy. Hidradenitis suppurativa is defined as a chronic suppurative and scarring condition of inverse skin areas. It is associated with obesity, smoking and
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26 skin
This document provides definitions and descriptions of terms related to normal skin anatomy and pathology. It begins with labeling diagrams of normal skin structures from the macroscopic to microscopic level. It then covers various skin conditions including pigmentation disorders, benign and malignant epidermal and dermal tumors, dermatoses, bullae, appendage disorders, panniculitis, and infections/infestations. For each condition, it lists key characteristics and histologic findings to aid in identification and diagnosis.
Introduction To Dermatopathology
Subspecialty of dermatology and pathology focused on performing and interpreting tests on human tissue samples to provide scientific data and consultative opinions to referring clinicians
Introduction to dermatopathology
This document provides an introduction to dermatopathology. It defines dermatopathology as a specialty focused on performing and interpreting skin biopsies to provide diagnostic information to clinicians. It discusses the dermatopathology thought process and considerations for planning and performing skin biopsies, including when a biopsy is most useful, appropriate biopsy techniques for different lesions, and proper specimen handling. The goal is to obtain a sample that can help distinguish between clinical hypotheses and provide accurate diagnostic information.
Psoriasis
This document discusses psoriasis, a chronic skin condition characterized by red patches covered with silvery scales. It defines psoriasis and outlines its various types including plaque, guttate, flexural, and pustular psoriasis. The causes of psoriasis including genetics and immune system dysfunction are described. Characteristics, incidence rates, clinical features, and treatment approaches for different psoriasis types are summarized.
Irritant contact dermatitis
Irritant contact dermatitis (ICD) is caused by direct cytotoxic effects of physical or chemical irritants on the skin. Acute ICD presents with erythema, edema, vesiculation and erosion while chronic ICD shows lichenification, hyperkeratosis and fissures. ICD is commonly caused by occupational exposure to chemicals like acids, alkalis, metals, solvents, detergents and cleansers. Clinical features depend on properties of the irritant, host factors, and environment. Management involves avoiding irritants, using protective measures, and restoring the skin barrier with emollients and moisturizers.
Dermatomyositis Dr. Saad Raheem Abed
Dermatomyositis is a rare inflammatory myopathy with characteristic skin manifestations and muscular weakness.
Polymyositis is a similar disease without skin lesions.
Amyopathic dermatomyositis: typical cutaneous manifestation of DM without clinical and/or laboratory findings of muscle involvement for at least 6 months after the onset of skin rash.
Skin manifestation of systemic disease
The document discusses various skin manifestations that can indicate underlying systemic diseases, including several paraneoplastic syndromes, endocrine diseases like diabetes and thyroid disorders, and rheumatological conditions. Specific conditions mentioned include acquired ichthyosis, acrokeratosis paraneoplastica, alopecia neoplastica associated with various cancers, pretibial myxedema in Graves' disease, necrobiosis lipoidica and scleredema diabeticorum in diabetes, and dermatomyositis which can indicate ovarian cancer. Treatment options are provided for some conditions.
ANCANTHOSIS NIGRICANS
Acanthosis nigricans causes dark, thickened skin patches and is often associated with obesity, darker skin, and diabetes or prediabetes. It occurs when skin cells reproduce too quickly due to high insulin levels, most commonly from insulin resistance associated with obesity. Treatment focuses on addressing the underlying metabolic condition through lifestyle changes like weight loss and medication management of blood sugar levels. Treating the root cause allows the skin patches to fade over time.
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26 skin
This document provides definitions and descriptions of terms related to normal skin anatomy and pathology. It begins with labeling diagrams of normal skin structures from the macroscopic to microscopic level. It then covers various skin conditions including pigmentation disorders, benign and malignant epidermal and dermal tumors, dermatoses, bullae, appendage disorders, panniculitis, and infections/infestations. For each condition, it lists key characteristics and histologic findings to aid in identification and diagnosis.
Introduction To Dermatopathology
Subspecialty of dermatology and pathology focused on performing and interpreting tests on human tissue samples to provide scientific data and consultative opinions to referring clinicians
Introduction to dermatopathology
This document provides an introduction to dermatopathology. It defines dermatopathology as a specialty focused on performing and interpreting skin biopsies to provide diagnostic information to clinicians. It discusses the dermatopathology thought process and considerations for planning and performing skin biopsies, including when a biopsy is most useful, appropriate biopsy techniques for different lesions, and proper specimen handling. The goal is to obtain a sample that can help distinguish between clinical hypotheses and provide accurate diagnostic information.
Psoriasis
This document discusses psoriasis, a chronic skin condition characterized by red patches covered with silvery scales. It defines psoriasis and outlines its various types including plaque, guttate, flexural, and pustular psoriasis. The causes of psoriasis including genetics and immune system dysfunction are described. Characteristics, incidence rates, clinical features, and treatment approaches for different psoriasis types are summarized.
Irritant contact dermatitis
Irritant contact dermatitis (ICD) is caused by direct cytotoxic effects of physical or chemical irritants on the skin. Acute ICD presents with erythema, edema, vesiculation and erosion while chronic ICD shows lichenification, hyperkeratosis and fissures. ICD is commonly caused by occupational exposure to chemicals like acids, alkalis, metals, solvents, detergents and cleansers. Clinical features depend on properties of the irritant, host factors, and environment. Management involves avoiding irritants, using protective measures, and restoring the skin barrier with emollients and moisturizers.
Dermatomyositis Dr. Saad Raheem Abed
Dermatomyositis is a rare inflammatory myopathy with characteristic skin manifestations and muscular weakness.
Polymyositis is a similar disease without skin lesions.
Amyopathic dermatomyositis: typical cutaneous manifestation of DM without clinical and/or laboratory findings of muscle involvement for at least 6 months after the onset of skin rash.
Skin manifestation of systemic disease
The document discusses various skin manifestations that can indicate underlying systemic diseases, including several paraneoplastic syndromes, endocrine diseases like diabetes and thyroid disorders, and rheumatological conditions. Specific conditions mentioned include acquired ichthyosis, acrokeratosis paraneoplastica, alopecia neoplastica associated with various cancers, pretibial myxedema in Graves' disease, necrobiosis lipoidica and scleredema diabeticorum in diabetes, and dermatomyositis which can indicate ovarian cancer. Treatment options are provided for some conditions.
ANCANTHOSIS NIGRICANS
Acanthosis nigricans causes dark, thickened skin patches and is often associated with obesity, darker skin, and diabetes or prediabetes. It occurs when skin cells reproduce too quickly due to high insulin levels, most commonly from insulin resistance associated with obesity. Treatment focuses on addressing the underlying metabolic condition through lifestyle changes like weight loss and medication management of blood sugar levels. Treating the root cause allows the skin patches to fade over time.
Skin involvement in rheumatic diseases/ DOI 10.13140/RG.2.2.10743.32169
Skin disorders are observed in a variety of rheumatologic conditions and constitute the primary features in lupus erythematosus, dermatomyositis and systemic sclerosis. Skin involvement is also observed in systemic vasculitides, rheumatoid arthritis, Sjögren syndrome, psoriatic arthritis, systemic-onset juvenile rheumatoid arthritis, and relapsing polychondritis. It is important for the clinician to recognize and discern the most common cutaneal lesions and patterns encountered in patients with rheumatic diseases (like makule, papule, nodul, plaque, purpura, petechia, pustul, squam, erosion, erythema, onychodystrophy, onycholysis, urticaria, butterfly rash, Gottron papules and sign etc) because they provide clues regarding the systemic involvement of the pathology, diagnosis, therapeutic approach and prognosis. Skin biopsies are usually useful in determining the precise nature of the skin disorder. Below are presented briefly the major skin manifestations observed in lupus erythematosus, dermatomiositis, scleroderma and rheumatoid arthritis
Genital Skin Lesions
This document discusses the approach to diagnosing and treating genital skin lesions. It covers common infections, neoplasms, and inflammatory conditions that can present as genital skin lesions. These include sexually transmitted infections (STIs) like herpes, molluscum contagiosum, and warts. Taking an appropriate sexual history is important for establishing a diagnosis. STIs are common and guidelines should be followed for systematic evaluation and treatment, including history, exam, investigations, and contact tracing. The document provides examples of clinical presentations and microscopic images to illustrate common STIs like gonorrhea and syphilis. Prevention through safe sexual practices is emphasized.
Acne with systemic syndromes
The document discusses several acne related syndromes:
1) SAPHO syndrome presents with sudden onset haemorrhagic acne on the face and chest along with palmoplantar pustulosis and pain over the chest wall. Its etiology is unknown but may involve an autoimmune reaction.
2) PAPA syndrome involves pyogenic artheritis, pyoderma gangrenosum, and acne conglobata. It is an autoinflammatory disorder caused by a gene mutation leading to increased interleukin-1beta.
3) Endocrine acne is associated with conditions like PCOS, Cushing's disease, and congenital adrenal hyperplasia which alter hormone levels.
Bullous pemphigoid
This document describes a biopsy of an 80-year-old female with a clinical diagnosis of bullous pemphigoid. Microscopic examination showed a subepidermal bulla filled with plasma, neutrophils, and eosinophils. The dermis beneath showed a dense perivascular infiltrate of lymphocytes, eosinophils, and plasma cells. These features are consistent with bullous pemphigoid. Bullous pemphigoid is an autoimmune blistering disease that typically affects the elderly and presents as large, tense bullae on the trunk and extremities. Histologically, it shows a subepidermal blister often containing eosinophils and a superficial perivascular mixed inflammatory infiltrate
Bullous diseases(group a)
This document discusses several types of blistering diseases:
1. Pemphigus is an autoimmune blistering disease caused by antibodies against desmoglein proteins, resulting in loss of cell adhesion between keratinocytes. Pemphigus vulgaris primarily affects the mucosa and has a mortality rate of 5-15%.
2. Dermatitis herpetiformis is associated with celiac disease and gluten sensitivity. It is characterized by grouped blisters and erosions on the elbows and knees. Treatment involves a gluten-free diet and dapsone.
3. Staphylococcal scalded skin syndrome and toxic epidermal necrolysis are severe blistering
Ichthyoses
They are a heterogenous group of inherited disorders of epidermal differentiation featuring excessive scaling, Ichthyosis vulgaris,
X-linked recessive ichthyosis,
Lamellar ichthyosis,
Non-bullous ichthyosiform erythroderma,
Bullous ichthyosiform erythroderma,
Ichthyosis bullosa of Siemens,
Harlequin ichthyosis
Erythroderma
This document provides an overview of erythroderma, also known as generalized exfoliative dermatitis. It defines erythroderma as an inflammatory dermatosis involving 90% or more of the skin surface. The clinical presentation includes patchy erythema becoming universal over 24-48 hours accompanied by malaise, shivering and pyrexia, followed by scaling after 2-6 days. Erythroderma can be caused by conditions like eczema, psoriasis, malignancy, and drug reactions. Complications can include edema, lymphadenopathy, cardiac failure, metabolic disturbance, hypothermia, and cutaneous or respiratory infection. Management involves close inpatient monitoring and initially topical st
Genital ulcer
This document summarizes an approach to diagnosing and treating cases of genital ulcers. It begins with definitions of genital ulcers and their etiologies, which can be sexually transmitted or non-sexually transmitted infections. It then describes three approaches: traditional clinical, laboratory-assisted, and syndromic management. The syndromic management approach diagnoses based on symptoms and signs and treats for the most common causes. Advantages include being fast, effective, inexpensive and allowing single-dose treatment. Limitations include potential over-treatment. Guidelines for taking history, examination, investigations, and treating common causes like herpes, syphilis, chancroid, and donovanosis are provided.
Dermatology 5th year, 3rd lecture (Dr. Faraedon Kaftan)
The skin can provide clues to underlying systemic diseases. Some examples include:
1. Seborrheic dermatitis may be associated with Parkinson's disease or HIV infection. Vitiligo is often associated with autoimmune thyroid disease or diabetes.
2. Blistering diseases like pemphigus vulgaris and bullous pemphigoid are associated with malignancy in elderly patients. Epidermolysis bullosa acquisita may be associated with inflammatory bowel disease.
3. Cutaneous metastases, Paget's disease, acanthosis nigricans, and amyloidosis can indicate underlying internal cancers.
Contact dermatitis
Contact dermatitis is a common inflammatory skin disease caused by direct or indirect contact with harmful substances. It can be irritant contact dermatitis from irritants like soaps or allergic contact dermatitis from allergens that cause a delayed hypersensitivity reaction. Symptoms include erythema, vesicles, papules and scaling with itch. Diagnosis involves identifying the causative agent through patient history and patch testing. Treatment focuses on eliminating contact with the irritant or allergen and using topical corticosteroids.
Epidermal nevus
This document discusses epidermal naevi, which are congenital developmental defects or birthmarks of the skin and mucosa. It describes different types of epidermal naevi classified based on the level of defect (epidermal, dermal, subcutaneous) and component cell (vascular, connective tissue, melanocytic). Verrucous epidermal naevi, also known as verrucous nevus or nevus verrucosus, are discussed in detail. They are keratinocyte hamartomas that can be either epidermolytic or non-epidermolytic types, with the latter having greater malignant potential and possible associations with extracutaneous abnormalities. Clinical features
Cutaneous tuberculosis
Cutaneous tuberculosis is a rare form of tuberculosis that involves the skin. It can be caused by Mycobacterium tuberculosis or Mycobacterium bovis. Diagnosis is usually done via skin biopsy showing caseating granulomas containing acid-fast bacilli. Additional tests may include the tuberculin skin test, Quantiferon blood test, sputum culture, chest X-ray, and interferon gamma release assays. Treatment follows the DOTS strategy of a two month intensive phase of four drugs including isoniazid, rifampin, and pyrazinamide, followed by a four month continuation phase of rifampin and isoniazid.
Bullous diseases
This document summarizes several bullous diseases:
1. It describes the locations and characteristics of vesicles and bullae. Vesicles can form within or under the epidermis or between the dermis and epidermis.
2. It then focuses on three main immunobullous diseases - pemphigus, pemphigoid, and linear IgA bullous disease. Pemphigus is caused by antibodies against desmoglein proteins and features flaccid blisters. Pemphigoid features tense blisters caused by antibodies against basement membrane proteins. Linear IgA bullous disease clinically resembles pemphigoid.
3. Dermatitis herpetiformis is described
Approach to chronic urticaria
Chronic urticaria lasts longer than 6 weeks and presents as recurrent hives and angioedema occurring more than 3 days a week. It can be classified as inducible or spontaneous. Inducible types are triggered by specific physical stimuli like pressure, cold, heat, or vibration. Chronic urticaria is considered after ruling out look-alike conditions such as urticarial vasculitis and other autoinflammatory syndromes. Its evaluation involves considering potential systemic triggers or underlying causes.
Seborrhoeic Dermatitis
This document discusses seborrheic dermatitis, a chronic papulosquamous skin condition characterized by yellowish, waxy, branny scaling along areas with sebaceous glands like the scalp, face, and trunk. It commonly affects infants under 3 months of age and adults between 40-70 years old. While the exact cause is unknown, factors like sebum production, microbial effects of Malassezia fungi, and genetic and environmental factors may play a role. The document describes the various clinical presentations in infants and adults and treatments involving topical antifungals, corticosteroids, keratolytics, and systemic antifungals.
Cutaneous mucinoses
This document provides an overview of cutaneous mucinoses, which are skin conditions characterized by increased deposition of mucin in the dermis. It describes the different types of mucin, staining patterns, classifications of primary and secondary mucinoses, and details several specific mucinosis conditions including pretibial myxoedema, lichen myxoedematosus, scleromyxoedema, scleredema of Buschke, follicular mucinosis, and cutaneous focal mucinosis. Histopathological features and treatment approaches are discussed for each condition. The document serves as a comprehensive reference for the clinical presentation, pathology, and management of cutaneous mucinosis disorders.
Physical urticaria
This document provides an overview of physical urticarias. It defines physical urticarias as urticarias induced by physical stimuli like pressure, vibration, heat, cold, etc. It describes several types of physical urticarias in detail, including dermographism (pressure urticaria), delayed pressure urticaria, and vibratory angioedema. For each type, it covers epidemiology, clinical features, pathogenesis, diagnostic testing, and treatment approaches. The document is a comprehensive review and classification of physical urticaria subtypes.
Basic Pathological Reactions of the Skin - Dr Zainab Almossalli
This document summarizes the basic pathological reactions of the skin. It describes the different tissue compartments that make up the skin, including the epidermis, dermal-epidermal junction, papillary dermis, deep dermis, and subcutaneous tissue. It then discusses various pathological processes that can disturb the structure and function of these compartments, such as disturbances in epidermal cell kinetics, differentiation, and cohesion. Specific diseases are provided as clinical correlations for each pathological reaction described. The summary focuses on providing a high-level overview of the key tissue compartments involved and some examples of related pathological processes and diseases.
Genodermatosis
Genodermatosis refers to inherited skin conditions caused by genetic mutations. This document summarizes information on three types: neurofibromatosis type 1 (NF1), tuberous sclerosis, and xeroderma pigmentosum. NF1 is caused by mutations in the NF1 gene and is characterized by café au lait spots, freckling, neurofibromas, and Lisch nodules. Tuberous sclerosis results from mutations in TSC1 or TSC2 and presents with ash leaf macules, angiofibromas, and connective tissue nevi. Xeroderma pigmentosum involves defective DNA repair causing photosensitivity and early development of skin cancers upon
Vitiligo presentation
Vitiligo is a skin condition characterized by loss of pigment cells called melanocytes, resulting in white patches of skin. It affects around 1% of the world's population and can appear at any age, though most commonly between 20-30 years old. The cause is unknown but may involve an autoimmune response or oxidative stress damaging melanocytes. Vitiligo is classified based on distribution of the white patches and can be localized, generalized, or total body coverage. While there is no cure, treatments can help repigmentation and protection from sun damage is important to prevent complications.
Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules and abscesses in apocrine gland-bearing areas. It typically presents in the axillae and groin and is diagnosed clinically. While its exact cause is unknown, it is associated with follicular occlusion and may have an immunological component. Treatment involves antibiotics, hormones, immunosuppressants, procedures like laser ablation, and wide excision surgery for severe cases.
Hidradenitis supurativa
Este documento proporciona información sobre la hidradenitis supurativa (HS), una enfermedad inflamatoria crónica que afecta las glándulas apocrinas. La HS comienza típicamente como nódulos dolorosos en las axilas, ingles e inframamarias y puede progresar a abscesos, fístulas y fibrosis. Su etiología es multifacotrial e incluye factores genéticos, infecciosos, endocrinos e inmunológicos. El tratamiento incluye antibióticos tó
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Skin involvement in rheumatic diseases/ DOI 10.13140/RG.2.2.10743.32169
Skin disorders are observed in a variety of rheumatologic conditions and constitute the primary features in lupus erythematosus, dermatomyositis and systemic sclerosis. Skin involvement is also observed in systemic vasculitides, rheumatoid arthritis, Sjögren syndrome, psoriatic arthritis, systemic-onset juvenile rheumatoid arthritis, and relapsing polychondritis. It is important for the clinician to recognize and discern the most common cutaneal lesions and patterns encountered in patients with rheumatic diseases (like makule, papule, nodul, plaque, purpura, petechia, pustul, squam, erosion, erythema, onychodystrophy, onycholysis, urticaria, butterfly rash, Gottron papules and sign etc) because they provide clues regarding the systemic involvement of the pathology, diagnosis, therapeutic approach and prognosis. Skin biopsies are usually useful in determining the precise nature of the skin disorder. Below are presented briefly the major skin manifestations observed in lupus erythematosus, dermatomiositis, scleroderma and rheumatoid arthritis
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This document discusses the approach to diagnosing and treating genital skin lesions. It covers common infections, neoplasms, and inflammatory conditions that can present as genital skin lesions. These include sexually transmitted infections (STIs) like herpes, molluscum contagiosum, and warts. Taking an appropriate sexual history is important for establishing a diagnosis. STIs are common and guidelines should be followed for systematic evaluation and treatment, including history, exam, investigations, and contact tracing. The document provides examples of clinical presentations and microscopic images to illustrate common STIs like gonorrhea and syphilis. Prevention through safe sexual practices is emphasized.
Acne with systemic syndromes
The document discusses several acne related syndromes:
1) SAPHO syndrome presents with sudden onset haemorrhagic acne on the face and chest along with palmoplantar pustulosis and pain over the chest wall. Its etiology is unknown but may involve an autoimmune reaction.
2) PAPA syndrome involves pyogenic artheritis, pyoderma gangrenosum, and acne conglobata. It is an autoinflammatory disorder caused by a gene mutation leading to increased interleukin-1beta.
3) Endocrine acne is associated with conditions like PCOS, Cushing's disease, and congenital adrenal hyperplasia which alter hormone levels.
Bullous pemphigoid
This document describes a biopsy of an 80-year-old female with a clinical diagnosis of bullous pemphigoid. Microscopic examination showed a subepidermal bulla filled with plasma, neutrophils, and eosinophils. The dermis beneath showed a dense perivascular infiltrate of lymphocytes, eosinophils, and plasma cells. These features are consistent with bullous pemphigoid. Bullous pemphigoid is an autoimmune blistering disease that typically affects the elderly and presents as large, tense bullae on the trunk and extremities. Histologically, it shows a subepidermal blister often containing eosinophils and a superficial perivascular mixed inflammatory infiltrate
Bullous diseases(group a)
This document discusses several types of blistering diseases:
1. Pemphigus is an autoimmune blistering disease caused by antibodies against desmoglein proteins, resulting in loss of cell adhesion between keratinocytes. Pemphigus vulgaris primarily affects the mucosa and has a mortality rate of 5-15%.
2. Dermatitis herpetiformis is associated with celiac disease and gluten sensitivity. It is characterized by grouped blisters and erosions on the elbows and knees. Treatment involves a gluten-free diet and dapsone.
3. Staphylococcal scalded skin syndrome and toxic epidermal necrolysis are severe blistering
Ichthyoses
They are a heterogenous group of inherited disorders of epidermal differentiation featuring excessive scaling, Ichthyosis vulgaris,
X-linked recessive ichthyosis,
Lamellar ichthyosis,
Non-bullous ichthyosiform erythroderma,
Bullous ichthyosiform erythroderma,
Ichthyosis bullosa of Siemens,
Harlequin ichthyosis
Erythroderma
This document provides an overview of erythroderma, also known as generalized exfoliative dermatitis. It defines erythroderma as an inflammatory dermatosis involving 90% or more of the skin surface. The clinical presentation includes patchy erythema becoming universal over 24-48 hours accompanied by malaise, shivering and pyrexia, followed by scaling after 2-6 days. Erythroderma can be caused by conditions like eczema, psoriasis, malignancy, and drug reactions. Complications can include edema, lymphadenopathy, cardiac failure, metabolic disturbance, hypothermia, and cutaneous or respiratory infection. Management involves close inpatient monitoring and initially topical st
Genital ulcer
This document summarizes an approach to diagnosing and treating cases of genital ulcers. It begins with definitions of genital ulcers and their etiologies, which can be sexually transmitted or non-sexually transmitted infections. It then describes three approaches: traditional clinical, laboratory-assisted, and syndromic management. The syndromic management approach diagnoses based on symptoms and signs and treats for the most common causes. Advantages include being fast, effective, inexpensive and allowing single-dose treatment. Limitations include potential over-treatment. Guidelines for taking history, examination, investigations, and treating common causes like herpes, syphilis, chancroid, and donovanosis are provided.
Dermatology 5th year, 3rd lecture (Dr. Faraedon Kaftan)
The skin can provide clues to underlying systemic diseases. Some examples include:
1. Seborrheic dermatitis may be associated with Parkinson's disease or HIV infection. Vitiligo is often associated with autoimmune thyroid disease or diabetes.
2. Blistering diseases like pemphigus vulgaris and bullous pemphigoid are associated with malignancy in elderly patients. Epidermolysis bullosa acquisita may be associated with inflammatory bowel disease.
3. Cutaneous metastases, Paget's disease, acanthosis nigricans, and amyloidosis can indicate underlying internal cancers.
Contact dermatitis
Contact dermatitis is a common inflammatory skin disease caused by direct or indirect contact with harmful substances. It can be irritant contact dermatitis from irritants like soaps or allergic contact dermatitis from allergens that cause a delayed hypersensitivity reaction. Symptoms include erythema, vesicles, papules and scaling with itch. Diagnosis involves identifying the causative agent through patient history and patch testing. Treatment focuses on eliminating contact with the irritant or allergen and using topical corticosteroids.
Epidermal nevus
This document discusses epidermal naevi, which are congenital developmental defects or birthmarks of the skin and mucosa. It describes different types of epidermal naevi classified based on the level of defect (epidermal, dermal, subcutaneous) and component cell (vascular, connective tissue, melanocytic). Verrucous epidermal naevi, also known as verrucous nevus or nevus verrucosus, are discussed in detail. They are keratinocyte hamartomas that can be either epidermolytic or non-epidermolytic types, with the latter having greater malignant potential and possible associations with extracutaneous abnormalities. Clinical features
Cutaneous tuberculosis
Cutaneous tuberculosis is a rare form of tuberculosis that involves the skin. It can be caused by Mycobacterium tuberculosis or Mycobacterium bovis. Diagnosis is usually done via skin biopsy showing caseating granulomas containing acid-fast bacilli. Additional tests may include the tuberculin skin test, Quantiferon blood test, sputum culture, chest X-ray, and interferon gamma release assays. Treatment follows the DOTS strategy of a two month intensive phase of four drugs including isoniazid, rifampin, and pyrazinamide, followed by a four month continuation phase of rifampin and isoniazid.
Bullous diseases
This document summarizes several bullous diseases:
1. It describes the locations and characteristics of vesicles and bullae. Vesicles can form within or under the epidermis or between the dermis and epidermis.
2. It then focuses on three main immunobullous diseases - pemphigus, pemphigoid, and linear IgA bullous disease. Pemphigus is caused by antibodies against desmoglein proteins and features flaccid blisters. Pemphigoid features tense blisters caused by antibodies against basement membrane proteins. Linear IgA bullous disease clinically resembles pemphigoid.
3. Dermatitis herpetiformis is described
Approach to chronic urticaria
Chronic urticaria lasts longer than 6 weeks and presents as recurrent hives and angioedema occurring more than 3 days a week. It can be classified as inducible or spontaneous. Inducible types are triggered by specific physical stimuli like pressure, cold, heat, or vibration. Chronic urticaria is considered after ruling out look-alike conditions such as urticarial vasculitis and other autoinflammatory syndromes. Its evaluation involves considering potential systemic triggers or underlying causes.
Seborrhoeic Dermatitis
This document discusses seborrheic dermatitis, a chronic papulosquamous skin condition characterized by yellowish, waxy, branny scaling along areas with sebaceous glands like the scalp, face, and trunk. It commonly affects infants under 3 months of age and adults between 40-70 years old. While the exact cause is unknown, factors like sebum production, microbial effects of Malassezia fungi, and genetic and environmental factors may play a role. The document describes the various clinical presentations in infants and adults and treatments involving topical antifungals, corticosteroids, keratolytics, and systemic antifungals.
Cutaneous mucinoses
This document provides an overview of cutaneous mucinoses, which are skin conditions characterized by increased deposition of mucin in the dermis. It describes the different types of mucin, staining patterns, classifications of primary and secondary mucinoses, and details several specific mucinosis conditions including pretibial myxoedema, lichen myxoedematosus, scleromyxoedema, scleredema of Buschke, follicular mucinosis, and cutaneous focal mucinosis. Histopathological features and treatment approaches are discussed for each condition. The document serves as a comprehensive reference for the clinical presentation, pathology, and management of cutaneous mucinosis disorders.
Physical urticaria
This document provides an overview of physical urticarias. It defines physical urticarias as urticarias induced by physical stimuli like pressure, vibration, heat, cold, etc. It describes several types of physical urticarias in detail, including dermographism (pressure urticaria), delayed pressure urticaria, and vibratory angioedema. For each type, it covers epidemiology, clinical features, pathogenesis, diagnostic testing, and treatment approaches. The document is a comprehensive review and classification of physical urticaria subtypes.
Basic Pathological Reactions of the Skin - Dr Zainab Almossalli
This document summarizes the basic pathological reactions of the skin. It describes the different tissue compartments that make up the skin, including the epidermis, dermal-epidermal junction, papillary dermis, deep dermis, and subcutaneous tissue. It then discusses various pathological processes that can disturb the structure and function of these compartments, such as disturbances in epidermal cell kinetics, differentiation, and cohesion. Specific diseases are provided as clinical correlations for each pathological reaction described. The summary focuses on providing a high-level overview of the key tissue compartments involved and some examples of related pathological processes and diseases.
Genodermatosis
Genodermatosis refers to inherited skin conditions caused by genetic mutations. This document summarizes information on three types: neurofibromatosis type 1 (NF1), tuberous sclerosis, and xeroderma pigmentosum. NF1 is caused by mutations in the NF1 gene and is characterized by café au lait spots, freckling, neurofibromas, and Lisch nodules. Tuberous sclerosis results from mutations in TSC1 or TSC2 and presents with ash leaf macules, angiofibromas, and connective tissue nevi. Xeroderma pigmentosum involves defective DNA repair causing photosensitivity and early development of skin cancers upon
Vitiligo presentation
Vitiligo is a skin condition characterized by loss of pigment cells called melanocytes, resulting in white patches of skin. It affects around 1% of the world's population and can appear at any age, though most commonly between 20-30 years old. The cause is unknown but may involve an autoimmune response or oxidative stress damaging melanocytes. Vitiligo is classified based on distribution of the white patches and can be localized, generalized, or total body coverage. While there is no cure, treatments can help repigmentation and protection from sun damage is important to prevent complications.
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This document provides information about rosacea, a chronic skin disorder that causes redness, pimples, and visible blood vessels on the face. It defines the four subtypes of rosacea (erythematotelangiectatic, papulopustular, phymatous, and ocular) and explains their characteristic symptoms and clinical features. Triggers that can worsen rosacea symptoms are also outlined. The pathogenesis is unknown but may involve factors like demodex mites, sun exposure, stress, and diet. Treatment involves topical medications to reduce redness and inflammation.
Hidradenitis suppurativa
A 47-year-old male ex-serviceman presented with multiple red, raised, purulent lesions discharging from his groin and buttocks for 2 years. He was initially diagnosed with folliculitis and treated with antibiotics without success. Examination found lesions consistent with hidradenitis suppurativa, a chronic inflammatory skin condition of apocrine gland-bearing skin characterized by recurrent abscesses, sinus tract formation, and scarring. Investigations ruled out other potential causes, and the patient was diagnosed with hidradenitis suppurativa and started on isotretinoin treatment.
Carbuncle&hydradenitis supurativa
Carbuncle & Hidradenitis Suppurativa is a chronic skin disease characterized by clusters of abscesses or subcutaneous boil-like infections, commonly affecting apocrine sweat gland areas like the armpits, under breasts, inner thighs, groin and buttocks. The infections are usually caused by bacteria like Staphylococcus aureus and Streptococcus pyogenes, resulting in an abscess larger than a boil that drains pus through one or more openings in the infected, fluid and dead tissue-filled mass. The main treatment is surgery to fully excise all abscess areas and membranes.
Tech Observer
Tech Observer is a global clinical research organization that has been operating since 2005. It has offices in 5 countries and provides medical affairs and clinical research services to support pharmaceutical and biotech clients through all phases of drug development. Some of its key services include medical writing, data management, biostatistics, and medical communication support. The presentation provides an overview of Tech Observer's capabilities and experience in various therapeutic areas.
Rashes in infants and children
This document provides information on common rashes seen in infants and children. It describes the appearance and characteristics of different types of rashes including macules, papules, vesicles, and plaques. It discusses the general approach to evaluating rashes and lists potential infectious causes such as viruses, fungi, bacteria, and infestations. Specific conditions covered include hand foot and mouth disease, herpangina, measles, rubella, erythema infectiosum, herpes, varicella, roseola infantum, tinea infections, impetigo, bullous impetigo, staphylococcal scalded skin syndrome, scarlet fever, erythema, scabies, head lice,
Central aortic pressure in management hypertension 2
This document discusses the importance of measuring central aortic pressure and arterial stiffness in managing hypertension. It notes that arterial stiffness increases with age and can be detected earlier than other types of target organ damage to help prevent cardiovascular disease. Measuring pulse wave velocity is identified as the gold standard for assessing arterial stiffness. The document presents several case studies showing how evaluating arterial stiffness in addition to brachial blood pressure can modify treatment approaches and help achieve better cardiovascular outcomes for patients with hypertension.
Psoriasis and subacute cutaneous lupus erythmatosis overlap deciding role o...
This document describes a case report of a 65-year-old female presenting with erythroderma and joint pain who was diagnosed with an overlap of psoriasis and subacute cutaneous lupus erythematosus (SCLE). Biopsy and immunological markers confirmed the diagnosis. The association between psoriasis and lupus erythematosus is rare, accounting for around 1.1% of lupus cases. Histopathology and immunological markers are important for diagnosis when the two diseases overlap.
Acne Rosacea- The Disease, Its Complications And Homeopathic Treatment
Acne rosacea is one of the major skin ailments affecting the face of millions around the world. It is more common in females than males. In extreme cases, the nose may appear very red and bulbous. If you are a teenager or young adult, you have high risk of developing it. There are 80+ highly effective homeopathic remedies for this ailment. Homeopathy enhances the level of internal health of the patient so that the face appears naturally healthy. You can find more of such informative Power Point Presentations as well as other useful health information at www.welcomecure.com, the definitive online homeopathic treatment portal.
Hidradenitis Supurativa
1) La hidradenitis supurativa es una enfermedad inflamatoria crónica que afecta los folículos pilosos, causando abscesos, nódulos y cicatrices. 2) Tiene un tratamiento complejo que depende de la gravedad y puede incluir antibióticos, cirugía y terapias biológicas como adalimumab. 3) El uso off-label de adalimumab mostró mejoría clínica importante en pacientes con hidradenitis supurativa refractaria a otros tratamientos.
Acne presentation
This document provides an overview of acne at different stages of life. It discusses neonatal acne, infantile acne, acne in childhood, adolescence, adulthood, pregnancy, and in ethnic skin. Treatment options are presented for each group, including topical retinoids, oral antibiotics, and isotretinoin. Updates are provided on the use of isotretinoin, including its efficacy, safety profile, and the new iPLEDGE registry system required for its prescription in the US.
chronic urticaria
This document discusses updates in the management of chronic urticaria. It begins with definitions of acute and chronic urticaria, noting that chronic urticaria is defined as symptoms lasting more than 6 weeks. It then discusses the classification of urticaria as either spontaneous or inducible. Mast cell activation and degranulation are identified as the key pathological mechanisms involved in urticaria symptoms. Autoimmune processes involving immunoglobulins such as IgG and IgE autoantibodies are also discussed as potential pathological factors in chronic urticaria. Guidelines for the treatment of urticaria have been updated.
Hidradenitis supurativa
La hidradenitis supurativa es una enfermedad crónica e inflamatoria de las glándulas apocrinas que causa la formación de protuberancias dolorosas, granos y úlceras en áreas como las axilas e ingles. Se produce por la obstrucción de las glándulas sudoríparas y folículos pilosos, lo que lleva a infecciones bacterianas bajo la piel. No tiene cura pero puede tratarse con antibióticos, corticoides, cirugía y cambios en el estilo de vida para prevenir exacerbaciones.
Rosacea and lymphocytic infiltration disorders
This document provides information on rosacea, including its definition, diagnostic criteria, pathogenesis, classification, clinical presentation, histopathology, and differential diagnosis. Rosacea is a chronic inflammatory skin condition of the central face characterized by flushing, permanent erythema, papules and pustules, telangiectasias, and occasionally nodules and plaques. It primarily affects fair-skinned individuals. The pathogenesis involves various factors such as solar irradiation, neurogenic mechanisms, oxidative stress, antimicrobial peptides, vasoactive mediators, and Demodex mites. It is classified into subtypes based on clinical features and has varying presentations ranging from mild flushing to severe inflammatory lesions.
Tratamiento Facial en Rosacea.
El documento describe los pasos de un tratamiento facial completo para una paciente. Comienza con una entrevista y luego aplica varios productos como una leche de limpieza, loción, desmaquillante para los ojos, alta frecuencia, brumización con loción, hidratación para los ojos y la piel, máscara de barro, y protector solar. El objetivo es limpiar, suavizar, hidratar y proteger la piel de la paciente.
UPDATE ON CONTACT DERMATITIS
This document summarizes contact dermatitis, including:
1) It classifies contact dermatitis into allergic contact dermatitis (ACD), caused by T lymphocytes, and irritant contact dermatitis (ICD), caused by irritants without prior sensitization.
2) ACD and ICD have different pathophysiologies - ACD is a type IV hypersensitivity reaction while ICD is a direct tissue reaction.
3) Common allergens that cause ACD include poison ivy, nickel, fragrances, hair dyes, and topical corticosteroids. Irritants that cause ICD include detergents, solvents, and excessive moisture.
Case presentation in Dermatology erythrodermic psoriasis
- Ahmad, a 50-year-old male, presented with generalized redness and scaling of his skin that began 3 days prior. He had a history of plaque psoriasis 5 years earlier.
- On examination, he had widespread erythema and thick scaling affecting over 90% of his skin surface, thick scaling of his scalp, and nail dystrophy.
- He was diagnosed with erythrodermic psoriasis based on his history of psoriasis, presentation of widespread redness and scaling, and physical examination findings. Erythrodermic psoriasis is a potentially life-threatening exacerbation of psoriasis involving over 90% of the skin surface.
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Central aortic pressure in management hypertension 2
Central aortic pressure in management hypertension 2
Psoriasis and subacute cutaneous lupus erythmatosis overlap deciding role o...
Psoriasis and subacute cutaneous lupus erythmatosis overlap deciding role o...
Acne Rosacea- The Disease, Its Complications And Homeopathic Treatment
Acne Rosacea- The Disease, Its Complications And Homeopathic Treatment
Case presentation in Dermatology erythrodermic psoriasis
Case presentation in Dermatology erythrodermic psoriasis
Similar to Acne, rosacea and hidradenitis suppurativa
Allergic skin diseases in tropical areas
GRF 2nd One Health Summit 2013: Presentation by Peter Schmid-Grendelmeier, Allergy Unit Dept. Of Dermatology University Hospital Zuerich Switzerland
Vitiligo in association with Erythema dyschromicum perstans
Twenty seven years old female patient two years ago after delivery has noticed appearance of irregular hypo- and achromic macules on her trunk, extremities and face. Two months ago she has seen on her trunk and extremities oval gray-blue hyperpigmented macules which are accompanied from a slight pruritus.
She has common complains of weight reduction of 5-6 kg, palpitation, sleep disturbance, fatigue and some joint pain.
Clinically our patient is IV phototype. She has two different type of exanthema. First type - vitiligo is presented from symmetrical distributed over the trunk, extremities and face hypopigmented and achromic macules from 0,5 cm to 20 cm in diameter. The second type exanthema has symmetrical distribution and involves abdomen, back and proximal part of extremities. The lesions are gray-blue macules with oval shape and size from 0,5 cm to 2 cm in diameter. There is no change in mucous membrane.
Deviations of the investigations include slight elevated ECR, reduced HGB, HCT, MCV, MCH, MCHC, monocytosis, reticulocytosis, low serum Fe, increase TIBC, decrease LDH, positive serological test for H. pylori, increased Tg-Ab and TSH-RAb, very low TSH, elevated FT4, nasal smear – S. aureus, vaginal smear – S. agalactiae. Ultrasound of thyroid gland shows normal topic, size, structure and enhanced blood flow.
Conducted by the clinical laboratory research fund and consultative examinations are specified comorbidities Grave’s disease, iron deficiency anemia, bacterial colpitis, and chronic gastritis.
Histopathological examination of the edge or the hyperchrome lesion show minor hydropic degeneration of basal layer, sparce, superficial, perivascular lymphocyte infiltrat, and macrophages containing melanin (incontinentia pigmenti).
Differentially were discussed lichen planus, postinflammatory hyperpigmentation, contact dermatitis, fixed drug reaction.
Based on the anamnesis, clinical picture, laboratory results and conducted histological examination answer the question what is this second type exanthema is Erythema dyschromicum perstans.
Conducted treatment for accompanying diseases is with Ciprofloxacin, Ferrous sulfate, Vitamins, Thiamazol, eradication therapy for H. pylori and local application of Mupirocin nasal ointment. We have made 7 procedures UVB 311 nm narrow band with slight improvement.
There are only few previously described cases of Erythema dyschromicum perstans & vitiligo in the same patient. These cases include patients with darker skin. In both diseases there is HLA-DR4 association in the pathogenesis. There are some common features between two diseases which include predominance of cytotoxic T-cell and almost the same ratio of CD4/CD8, Ia antigen positivity in the dendritic cells in epidermis and dermis and increased number of epidermal Langerhans cells.
- Disclaimer- This PPT is loaded as student material "as is", from the VRF Vitiligo Master Class Barcelona November 2011; VRF does not endorse or otherwise approve it.
Psoriasis and scabies by manaswi
This document discusses psoriasis and scabies. Psoriasis is a chronic inflammatory skin disorder characterized by thickened, scaly plaques that affects 1.5-3% of the population worldwide. Scabies is a contagious skin infection caused by the mite Sarcoptes scabiei that causes intense itching. Treatment for psoriasis includes topical therapies like corticosteroids and vitamin D analogues, phototherapy, and systemic immunosuppressants. Scabies is transmitted through direct skin contact and presents as a pimple-like rash and sores from scratching.
Psoriasis
Psoriasis is a chronic, inflammatory skin condition characterized by red, scaly patches that are sometimes itchy and painful. It occurs when skin cells multiply up to 10 times faster than normal. The most common type is plaque psoriasis, which causes raised, red patches covered with silvery scales. Psoriasis has no cure but can be managed with treatments targeting the immune system. It affects about 2-3% of the population worldwide and has genetic and environmental triggers.
Staphylococcal Scalded Skin Syndrome.pdf
This study reviewed 84 cases of pediatric staphylococcal scalded skin syndrome (SSSS) at a single hospital over 22 years. It found that suspected culprit pathogens were more often obtained from periorificial swabs though these were not tested for exfoliative toxin. Surgical debridement of skin lesions was associated with longer hospital stays. Adding the antibiotic clindamycin, which has anti-toxin effects, did not impact clinical course or length of hospitalization. Most cases were treated effectively with supportive care and antibiotics targeting Staphylococcus aureus such as cloxacillin.
Skin disorders-physiotherapy
The document discusses several skin conditions and the role of physiotherapy in treating them. It describes conditions like acne, alopecia, psoriasis, vitiligo, and hyperhidrosis. For each condition, it discusses symptoms, types, potential causes, and treatment options including medications, phototherapy, and physiotherapy techniques. Physiotherapy can include ultraviolet radiation therapy, exercises to improve joint mobility and circulation, maintaining skin integrity and hygiene, and reducing friction. Ultraviolet radiation is used to treat several dermatological conditions like psoriasis and increase vitamin D production.
TEN.pptx
Toxic epidermal necrolysis (TEN) is a severe skin reaction involving the epidermis and mucous membranes. It is characterized by fever, painful skin lesions, blistering, and at least 30% of the body surface area involved. The condition is caused by a cytotoxic reaction and hypersensitivity to certain medications, infections, or other agents. Treatment involves immediate discontinuation of any offending agents, supportive care including wound care and monitoring for complications, and consideration of treatments like IVIG. Prognosis depends on factors like age, extent of skin detachment, and presence of other organ involvement.
Psoriasis and Management in Primary Care
1. Psoriasis is a chronic, immune-mediated skin disorder characterized by patches of abnormal skin that are typically red, itchy, and scaly. It occurs worldwide and has various clinical subtypes defined by the appearance of the rashes.
2. The pathogenesis of psoriasis involves an interplay between immune system dysfunction, epidermal keratinocyte hyperproliferation, and vascular changes. Genetic and environmental factors contribute to its development.
3. Psoriasis is associated with increased risks of comorbidities like psoriatic arthritis, cardiovascular disease, and metabolic syndrome. Treatment involves topical agents for mild cases and progresses to phototherapy, systemic drugs, and bi
Atopic dermatitis(Eczema)
Dr Muhammad Raza's presentation provides information about atopic dermatitis (eczema), including its signs and symptoms, causes, diagnosis, and management. The key points are that it is a chronic skin condition causing red, itchy, cracked skin that is common in children; has genetic and immunological factors; and is typically diagnosed clinically and managed through moisturizers, topical steroids, and other topical or systemic treatments depending on severity. The goal is for participants to understand the basic concepts, diagnosis, management, and appropriate referrals for atopic dermatitis.
Scleroderma in children and young people
This document summarizes information about scleroderma in children and young people. It discusses the different subtypes of juvenile scleroderma, including localized scleroderma (morphea) and systemic sclerosis. Localized scleroderma is more common than systemic sclerosis. The document reviews epidemiological data on incidence rates and clinical manifestations. It also discusses disease assessment, treatments such as methotrexate for localized scleroderma, and outcomes. Prognosis is generally better for juvenile scleroderma compared to adult-onset disease, but internal organ involvement can still lead to mortality in severe cases. The document advocates for more collaborative research to improve understanding and treatment of scleroderma in children
Tinea incognito
1) Tinea incognito is a dermatophytic infection that presents with an atypical clinical appearance due to previous treatment with topical or systemic corticosteroids or immunomodulators like pimecrolimus and tacrolimus.
2) Tinea incognito often mimics conditions like neurodermatitis, atopic dermatitis, rosacea, and seborrheic dermatitis, making diagnosis difficult.
3) The use of topical corticosteroids is a common cause of tinea incognito by suppressing the immune response to dermatophytes and altering the clinical presentation of the infection.
Tinea incognito
Tinea incognito is a dermatophytic fungal infection that presents with atypical clinical features due to previous treatment with corticosteroids or immunomodulators like pimecrolimus and tacrolimus. This modifies the infection's appearance, making diagnosis difficult. Tinea incognito lesions may resemble various inflammatory skin conditions and often affect the face and arms. Definitive diagnosis requires microscopic identification of fungal elements in skin scrapings or cultures. Treatment involves oral antifungals for 2-4 weeks to clear the infection.
Drug-induced hypersensitivity syndrome (DIHS)/Drug reaction with eosinophilia...
Drug-induced hypersensitivity syndrome (DIHS)/Drug reaction with eosinophilia...Chulalongkorn Allergy and Clinical Immunology Research Group
Drug-induced hypersensitivity syndrome (DIHS)/Drug reaction with eosinophilia and systemic symptoms (DRESS)
Presented by Pongsawat Rodsaward, MD.
December 17, 2021
scleroderma
Systemic sclerosis, or scleroderma, is a rare autoimmune disease characterized by fibrosis of the skin and internal organs. It can be classified as either limited or diffuse cutaneous systemic sclerosis based on the extent of skin involvement. Common clinical features include Raynaud's phenomenon, skin thickening, gastrointestinal issues, lung fibrosis or pulmonary arterial hypertension, renal crisis, and calcinosis. The cause is unknown but likely involves environmental triggers in genetically susceptible individuals leading to endothelial cell dysfunction, inflammation, and excessive collagen deposition in affected tissues.
Common Skin Diseases - Dr.Noor Zalmy Azizan.pdf
COMMON SKIN DISEASES.
ECZEMA
SKIN INFECTION9963
URTICARIA
ACNE
PSORIASIS
PIGMENTARY DISORDERS
HAIR DISORDERS
DRUG REACTIONS
SKIN TUMOURS
PITYRIASIS ROSEA
2. jurnal reading DA.pptx
1) Atopic dermatitis (AD) is a common chronic inflammatory skin disease that typically presents in childhood but can also affect adults. The clinical presentation of AD can vary in adults and can be a diagnostic challenge.
2) Common forms of clinical presentation in adults include inflammatory eczema with areas of thickening (lichenified/exudative eczematous pattern) often affecting flexural areas as well as the face and hands. Isolated involvement of the head and neck region is also common.
3) Other clinical patterns seen in adults include hand eczema, generalized eczema, nummular eczema, and erythroderma. Atopic dermatitis should be considered
Presentation 3.pptx by yvette gham
This presentation discusses various terms related to the skin, nails, and skin conditions. It defines terms using Greek and Latin combining forms including: dermatitis (inflammation of the skin), dermatosis (abnormal skin condition), dermatologist (skin specialist), dermatology (study of skin), melanoma (black tumor), melanocyte (black cell), ichthyoderma (scaly skin), leukoderma (white skin), erythroderma (red skin), onychomalacia (softening of the nail), paronychia (nail infection), and onychectomy (nail removal). It then provides more detail on melanoma, including causes like genetics and UV radiation. Diagnosis
Dermatologic emergencies
This document provides guidance on evaluating and categorizing rashes in the emergency department. It emphasizes using a systematic approach focused on morphology, distribution, and pattern to determine toxicity and categorize the rash. Key considerations include differentiating toxic vs. non-toxic rashes, recognizing "red flags" based on history and vital signs, and knowing when urgent consultation or management is needed. Common toxic rashes like staphylococcal scalded skin syndrome and toxic shock syndrome are discussed. The goal is to improve recognition of potentially life-threatening dermatological conditions.
Psoriasis
Psoriasis is a chronic, autoimmune disease that causes scaly patches on the skin called plaques when immune system signals speed up skin cell growth. It can affect the nails and has different classifications including plaque, pustular, guttate, and forms linked to arthritis. Psoriasis reduces quality of life similarly to other chronic conditions. Genetics and immune system issues contribute to its cause. Diagnosis is usually based on visual inspection, though biopsies can confirm. Management includes topical treatments, phototherapy, systemic drugs, and alternative therapies. Psoriasis has no cure but available treatments can control symptoms.
scleroderma-191009073259 (1).pdf
Scleroderma is a multisystem collagen vascular disease characterized by fibrosis of the skin and internal organs. It results from endothelial cell injury, fibroblast activation, and immune system involvement. The disease manifests as skin thickening, Raynaud's phenomenon, and organ fibrosis affecting the lungs, heart, kidneys, and gastrointestinal tract. Treatment focuses on preventing further organ damage by treating specific organ system complications like pulmonary hypertension or renal crisis. Prognosis depends on the specific subtype and organ systems involved.
Similar to Acne, rosacea and hidradenitis suppurativa (20)
Vitiligo in association with Erythema dyschromicum perstans
Vitiligo in association with Erythema dyschromicum perstans
Drug-induced hypersensitivity syndrome (DIHS)/Drug reaction with eosinophilia...
Drug-induced hypersensitivity syndrome (DIHS)/Drug reaction with eosinophilia...
Acne, rosacea and hidradenitis suppurativa
- 1. Acne, Rosacea and Hidradenitis suppurativa Gregor Jemec Dermatologisk Afdeling, Roskilde Sygehus
- 3. The Skin
- 5. pseudomonas
- 6. Acne = folliculitis ? Roman confusion of the Greek ’acme’ Spotty eruption in the face
- 7. How do we view other people ?
- 20. Global map of acne for 11 - 22 years olds
- 25. Zouboulis et al., Exp Dermatol 2005; 14: 143
- 30. Treatment Sebum Endocrine faktors Bakteria
- 34. Systemic therapy
- 35. Another detour……
- 38. Rosacea
- 45. Demodex
- 46. Demodex
- 53. HS severity
- 56. Etiology Obesity Follicular plugging Tobacco Irritants Immunity, e.g. TLR Mechanical shear Bacteria Hidradenitis suppurativa
- 57. Patogenesis Inflammation and scarring Ruptured follicle Anatomical predisposition