The document discusses cattle production and bovine respiratory disease (BRD) in the US feedlot system. It notes that over 32 million beef cows and 5.6 million replacement heifers are raised on over 766,000 operations. Once weaned, calves are transported to feedlots in groups of around 100 head. There are around 1,800 large feedlots with over 1,000 head capacity that market over 90% of cattle. BRD is a major risk in feedlots, and treatment involves either mass metaphylactic treatment of high-risk calves upon arrival or selective treatment of sick calves identified by pen riders.