This document provides an overview of Lean Six Sigma and its application in healthcare. It discusses Lean Six Sigma concepts like eliminating waste, enhancing value-added operations, and reducing process variation. Examples of Lean Six Sigma projects at St. Elizabeth Regional Health are presented, focusing on improving patient outcomes, safety, and throughput while controlling costs. Common Lean and Six Sigma tools are outlined, such as process mapping and statistical process control. The benefits of Six Sigma level performance for reducing errors and defects are also reviewed.