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GURU JAMBESHWAR UNIVERSITY OF
SCIENCE AND TECHNOLOGY HISAR
TOPIC- 3-D PRINTING OF
PHARMACEUTICALS
Submitted to – Dr. D.C. Bhatt
Submitted by – Sheetal
What is 3D Printing?
 It was first developed by Charls Haul in 1984.
 3D printing or additive manufacturing is a process of making three
dimensional solid objects from a digital file.
 The creation of a 3D printed object is achieved using additive processes.In an
additive process an object is created by laying down successive layers of
material until the entire object is created.
 It is also called as RAPID PROTOTYPING.
How it works?
 A virtual design of the object is created.
 CAD (Computer Aided Design) uses a 3D modeling program or 3D scanner for
virtual design.The software slices the final model into hundreds or thousands
of horizontal layers.
 The printer creates the object layer by layer, resulting in one three
dimensional object.
3D Printing versus traditional printing
Traditional manufacturing
1. Higher manufacturing cost
2. Less innovative design due to cost
constraints
3. More time to build final product
4. Create more waste
3-D Printing
1. Cost efficient as compared to
traditional manufacturing
techniques
2. Allows for easy yet inexpensive
innovation in design
3. Lesser time taken due to
compressed design cycle
4. Lighter and smaller amount of
waste
WORK FLOW
Software of 3-D printing
Methods & Technologies
 Several ways to realize 3D objects –
 Selective laser sintering (SLS): Uses a high power laser to fuse input
materials like plastic, metal, glass, etc. It scans the powdered material layer
by layer.
 Fused deposition modelling (FDM): Uses a plastic filament or metal wire as
input material to an extrusion nozzle. The nozzle is heated to melt the
material and can be moved in both horizontal and vertical directions by CAM.
The material hardens immediately after extrusion from the nozzle.→
 Stereo lithography (SLA): Photo polymerization is used to produce a solid
part from a liquid. This technology employs a vat of liquid ultraviolet curable
photopolymer resin and an ultraviolet laser to build. the object's layers one at
a time. UV Laser solidifying the pattern.
Advantages
 High production rates due to its fast opening systems.
 3D saves time and cost. Clean process, Reduction of material wastage which
can save in the cost of production.
 Customization: A major advantage in 3D printing. With just a raw material, a
blue print & a 3D printer, one can print any design no matter how complex it
might be.
 Constant prototyping & Increased productivity: It enables quick production
with high number of prototypes or small scale versions. Better communication
between the designer & user.
Disadvantages
 High machinery cost.
 Unsuitability to very large product.
 Difficult to remove or install manually.
 Mechanical issues.
 Component do not have enough strength.
 Limited raw materials.
 Production of dangerous items.
Medical Applications
 Medical application of 3-D printing are expanding rapidly and are expected to
revolutionize health care.
 Medical uses of 3-D printing both actual and potential can be organised in
several broad categories:
 Tissue and organ fabrication
 Creation of customized prosthetics.
 Implants and anatomical model
 Pharmaceutical research regarding drug dosage form, delivery and discovery.
Direct Applications of 3D Bioprinting
 ACL reconstruction
 3D printing of the scaffolds Bone regeneration
 The application to tissue engineering Many of mesenchymal stem cell's areas
of differentiation overlap with tissue types that are in high demand in
medicine
Challenges
 Cost: June 2011-The current cost for a personal printer is $1200. The
cheapest Commercial printer can be commissioned at $30,000
 Inability to easily print in multiple materials on the same machine:
Particularly plastic, metal and conductive materials. The colors are a touch
dull and matt finish only. A decent standard for model designs:
 The current standard STL files have some limitations. July 2011-A new
standard has-been proposed - the AMF file format, but at this stage it is not
well known or well used.
 Speed: Printing is slow. It takes a long time to build even the smallest piece.
Most videos you see are sped up or cut so you are not sitting there for an hour
while you build a tap washer. Aug 2011- The Ultimaker is able to print much
faster than Makerbot now.
THANK YOU

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3- d printing of pharmaceuticals.pptx

  • 1. GURU JAMBESHWAR UNIVERSITY OF SCIENCE AND TECHNOLOGY HISAR TOPIC- 3-D PRINTING OF PHARMACEUTICALS Submitted to – Dr. D.C. Bhatt Submitted by – Sheetal
  • 2. What is 3D Printing?  It was first developed by Charls Haul in 1984.  3D printing or additive manufacturing is a process of making three dimensional solid objects from a digital file.  The creation of a 3D printed object is achieved using additive processes.In an additive process an object is created by laying down successive layers of material until the entire object is created.  It is also called as RAPID PROTOTYPING.
  • 3. How it works?  A virtual design of the object is created.  CAD (Computer Aided Design) uses a 3D modeling program or 3D scanner for virtual design.The software slices the final model into hundreds or thousands of horizontal layers.  The printer creates the object layer by layer, resulting in one three dimensional object.
  • 4. 3D Printing versus traditional printing Traditional manufacturing 1. Higher manufacturing cost 2. Less innovative design due to cost constraints 3. More time to build final product 4. Create more waste 3-D Printing 1. Cost efficient as compared to traditional manufacturing techniques 2. Allows for easy yet inexpensive innovation in design 3. Lesser time taken due to compressed design cycle 4. Lighter and smaller amount of waste
  • 6. Software of 3-D printing
  • 7. Methods & Technologies  Several ways to realize 3D objects –  Selective laser sintering (SLS): Uses a high power laser to fuse input materials like plastic, metal, glass, etc. It scans the powdered material layer by layer.  Fused deposition modelling (FDM): Uses a plastic filament or metal wire as input material to an extrusion nozzle. The nozzle is heated to melt the material and can be moved in both horizontal and vertical directions by CAM. The material hardens immediately after extrusion from the nozzle.→  Stereo lithography (SLA): Photo polymerization is used to produce a solid part from a liquid. This technology employs a vat of liquid ultraviolet curable photopolymer resin and an ultraviolet laser to build. the object's layers one at a time. UV Laser solidifying the pattern.
  • 8. Advantages  High production rates due to its fast opening systems.  3D saves time and cost. Clean process, Reduction of material wastage which can save in the cost of production.  Customization: A major advantage in 3D printing. With just a raw material, a blue print & a 3D printer, one can print any design no matter how complex it might be.  Constant prototyping & Increased productivity: It enables quick production with high number of prototypes or small scale versions. Better communication between the designer & user.
  • 9. Disadvantages  High machinery cost.  Unsuitability to very large product.  Difficult to remove or install manually.  Mechanical issues.  Component do not have enough strength.  Limited raw materials.  Production of dangerous items.
  • 10. Medical Applications  Medical application of 3-D printing are expanding rapidly and are expected to revolutionize health care.  Medical uses of 3-D printing both actual and potential can be organised in several broad categories:  Tissue and organ fabrication  Creation of customized prosthetics.  Implants and anatomical model  Pharmaceutical research regarding drug dosage form, delivery and discovery.
  • 11. Direct Applications of 3D Bioprinting  ACL reconstruction  3D printing of the scaffolds Bone regeneration  The application to tissue engineering Many of mesenchymal stem cell's areas of differentiation overlap with tissue types that are in high demand in medicine
  • 12. Challenges  Cost: June 2011-The current cost for a personal printer is $1200. The cheapest Commercial printer can be commissioned at $30,000  Inability to easily print in multiple materials on the same machine: Particularly plastic, metal and conductive materials. The colors are a touch dull and matt finish only. A decent standard for model designs:  The current standard STL files have some limitations. July 2011-A new standard has-been proposed - the AMF file format, but at this stage it is not well known or well used.  Speed: Printing is slow. It takes a long time to build even the smallest piece. Most videos you see are sped up or cut so you are not sitting there for an hour while you build a tap washer. Aug 2011- The Ultimaker is able to print much faster than Makerbot now.