3D printing has significant potential to impact healthcare by enabling the creation of customized medical devices, implants, and tissue scaffolds. It allows for new designs that cannot be created through traditional manufacturing. The technology is also being used to print microfluidic chips, customized food, and the first approved 3D printed drug. While standards are still being developed, 3D printing promises to transform healthcare through personalized solutions, on-demand manufacturing, and open collaboration between various stakeholders in the industry and research community.

1. 3D Health Products:
Shaping Healthcare through Innovation
presented by
Yeong Wai Yee
Assistant Professor
School of Mechanical and Aerospace Engineering
Nanyang Technological University, Singapore
Email: wyyeong@ntu.edu.sg
Oct 2016

2. What is 3D Printing?
• Construct physical models directly from Computer-Aided Design
(CAD) data.
• Other names: 3D printing, Additive Manufacturing, Rapid Prototyping,
layered manufacturing, solid freeform fabrication

3. A HOT TOPIC

4. 3D Printing machines
4

5. Different Technologies
ASTM F2792

6. What can you print: Materials
6
Plastic
Ceramics
Biomaterials
Glass
Metal
Wood
plastic and carbon composite
Solid filament, flakes Liquid resin Powder
Different Format of Materials:

7. In Biomedical and Healthcare
Scaffold for tissue
engineering
Bioprinting
Micro-tissue ,
mini-organ,
drug
Biomodel
Medical
Devices
Implant

8. 3D Printing as Advanced Manufacturing
Technology for Medical Devices
Intervertebral body fusion device(Credit: Joimax)
3D printed polymer, spinal load-bearing device
(Credit: OPM)
http://tissuesys.com/technology
TRS Scaffold Technology
Surgical guide
Porous load
bearing implant
Solid load bearing
implant
Porous
degradable
implantHearing aid shell

9. 3D printing of a tracheobronchial
splint (TBS)
3D Printing meets urgent medical needs

10. Umbilical cord clamps
• 3D printed for direct use in local clinics at Haiti
http://reliefweb.int/report/haiti/field-ready-project-haiti
3D Printing meets global medical needs,
overcoming logistic challenges

11. Home-based printed
assisted devices
http://enablingthefuture.org/
Open source design file available
3D Printing enables new co-creation,
open innovation platform in healthcare

12. Enables New Device Design :
Customized Lattice Metal Implants for Enhanced
Osteointegration
SL Sing, WY Yeong, FE Wiria. (2016). Selective laser melting of titanium
alloy with 50 wt% tantalum: Microstructure and mechanical properties.
Journal of Alloys and Compounds, 660, 461–470
SL Sing, WY Yeong, FE Wiria, BY Tay. (2015). Characterization of
Titanium Lattice Structures Fabricated by Selective Laser Melting using
an Adapted Compressive Test Method. Experimental Mechanics, ,
10.1007/s11340-015-0117-y
Sing, S. L., An, J., Yeong, W. Y. and Wiria, F. E. (2015). Laser and
electron-beam powder-bed additive manufacturing of metallic implants: A
review on processes, materials and designs. Journal of Orthopaedic
Research, Accepted, doi: 10.1002/jor.23075.

13. Creating New Materials :
Patent pending

14. New diagnostic and testing capability in pharma: 3D
Printed Microfluidics Chip
Jia Min LEE, Meng ZHANG, Wai Yee YEONG. (2016). Characterization and evaluation of 3D printed
microfluidic chip for cell processing. Microfluidics and Nanofluidics, 20(1), 1-15
• 3D printing provides design freedom in micro-to-macro
fluidics chip features and designs.
• Enable new capabilities in cells processing, drug testing
and biosensor diagnostic testing .

15. New combinational medical device:
3D Printed Biodegradable Scaffold for Tissue
Engineering
Yeong WY, et al: Porous polycaprolactone scaffold for cardiac tissue engineering fabricated by selective laser sintering.
Acta Biomater; 2010 Jun;6(6):2028-34

16. W.L Ng, S.Wang, W.Y.Yeong, M.W. Naing (2016) SKIN BIOPRINTING: IMPENDING REALITY
OR FANTASY, Trends in Biotechnology 2016 Sep;34(9):689-99
Emerging technologies: Bioprinting
Patterning and
printing of cells
inside/on
constructs
Cells as one of
the raw materials
to be printed

17. Complex regulatory future
http://www.rapidtoday.com/future.html
source: Google,
Organ Bioprinting = medical
device + drug + advanced
cell therapy

18. 3D Systems, TNO
Emerging technologies: 3D Printed Food

19. Provide personalized food for the increasing global population ( Shape,
colour, age, health requirements …)

20. 3D Printed Drug- Spritam
• FDA Approves Spritam (levetiracetam) as the First 3D Printed Drug
Product by Aprecia Pharmaceuticals
• to be available in the first quarter of 2016
• pill can be made more porous than typical pills, rapidly
disintegrate, Support dose loading up to 1,000 mg
https://www.aprecia.com/zipdose-platform/zipdose-technology.php

22. 22
Current AM
Standards
• ASTM International
Committee F42 on Additive
Manufacturing
Technologies, formed in
2009 and
• ISO Technical Committee
261 on Additive
Manufacturing, formed in
2011

23. Summary
•3D printing is a diverse technology with huge potential in
shaping the future of healthcare.
•Enables new business operation, new business model,
new technology creation and new solutions for patient
and healthcare practitioners.
•Close collaboration among industry partners, healthcare
practitioners and the researchers are necessary for
maximum impact in the near future.

24. Thank you
Images from google and articles.
For education purpose only.
https://scholar.google.com.sg/citations?user=CgowDcwAAAAJ&hl=en
Wai Yee Yeong - Google Scholar Citations