The document discusses the anatomy of the axial skeleton, specifically the vertebral column and cervical vertebrae. It notes that the vertebral column is made up of 26 vertebrae and provides details on the typical parts of a vertebra including the body, vertebral arch, and processes. It also summarizes the key features and functions of the cervical vertebrae, intervertebral discs, and muscles that control neck movement.
features and characteristics of the typical and the A typical cervical vertebrae, typical and A typical cervical vertebrae, attachments of cervical vetebrae, atlas and axis features
features and characteristics of the typical and the A typical cervical vertebrae, typical and A typical cervical vertebrae, attachments of cervical vetebrae, atlas and axis features
this is a presentation on atlanto-axial and atlanto-occipital joints. after reading this, most of you will know about atlas and axis, joint type, anatomy of joint, movements allowed by joint and its clinical considerations.
this is a presentation on atlanto-axial and atlanto-occipital joints. after reading this, most of you will know about atlas and axis, joint type, anatomy of joint, movements allowed by joint and its clinical considerations.
MUSCLES OF THE VERTEBRAL COLUMN- The system of ligaments in the vertebral column, combined with the tendons and muscles, provides a natural brace to help protect the spine from injury. For More Online Medical Resource, Visit at http://gisurgery.info
Anattomy of back with Dr. Ameera A. Al-Humidi .pptxAmeera Al-Humidi
this lecture describes the anatomy of bach and details of anatomical variations of vertebrae with related disorders.
the vertebral column consists of seven cervical vertebrae, tweleve thoracic vertebrae, five lumbar vertebrae, sacral vertebrae, and five fused coccygeal vertebrae.
The larynx houses the vocal cords, and manipulates pitch and volume, which is essential for phonation. It is situated just below where the tract of the pharynx splits into the trachea and the esophagus.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. Hermizan Halihanafiah 2
Vertebra Column
• Spine @ backbone
• Composed of a series of
bones called vertebrae.
• Vertebral column,
sternum and ribs form the
skeleton of the trunk of
the body.
4. Hermizan Halihanafiah 4
Function of Vertebral Column
• Functions as a strong, flexible rod with elements
that can be move forward, backward and
sideways, and rotate.
• Enclosing and protecting the spinal cord
• Supports the head
• Serves as a point attachment for the ribs, pelvic
girdle and muscles of the back.
6. Hermizan Halihanafiah 6
Vertebral Column
• Early development is 33 bones.
• Grows up – several vertebrae in the sacral and
coccygeal regions fuse.
• Normal adults, typically contains 26 vertebrae.
• Consists: cervical , thoracic, lumbar, sacral and
coccyx vertebrae.
• cervical , thoracic, lumbar – movable
• sacral and coccyx vertebrae - immovable
7. Hermizan Halihanafiah 7
Vertebra Column
• Distributed as follows:
1. 7 cervical vertebrae – neck region
2. 12 thoracic vertebrae – posterior to the
thoracic cavity
3. 5 lumbar vertebrae – support the lower back.
4. 1 sacrum – consists of 5 fused sacral
vertebrae.
5. 1 coccyx – consists of 4 fused coccygeal
vertebrae.
9. Hermizan Halihanafiah 9
Parts of a Typical Vertebra
• Vertebrae in different regions of the spinal
column vary in size, shape, and details.
• Vertebrae typically consist:
1. Body
2. Vertebral arch
3. Processes
11. Hermizan Halihanafiah 11
Body
• Thick
• Disc shape anterior portion
• Weight bearing part of the vertebrae.
• Superior & inferior surface are roughened – attachment
of cartilaginous intervertebral disc.
• Anterior and lateral surface contain nutrien foramina,
opening for blood vessels deliver nutrient and O2 and
remove CO2 and wastes from bone tissues.
12. Hermizan Halihanafiah 12
Vertebral Arch
• 2 short, thick processes called the pedicles, project
posteriorly from the vertebrae body to unite with the
flat laminae, to form the vertebrae arch.
• Vertebral arch extend posteriorly from the body of
the vertebra, together with the body and vertebral
arch surround the spinal cord by forming the
vertebral foramen.
• Vertebral foramen contain spinal cord, adipose
tissue and areolar connective tissue and blood
vessels.
13. Hermizan Halihanafiah 13
Cont…
• Collectively, the vertebral foramina of all vertebrae
form the vertebral (spinal) cavity.
• The pedicles exhibit superior and inferior indentation
called vertebral notches.
• Superior and inferior vertebral notch are stacked on
top of ones another to form intervertebral foramen.
• Intervertebral foramen permits the passage of single
spinal nerve that passes to a spesific region of the
body.
15. Hermizan Halihanafiah 15
Processes
• 7 processes arise from the vertebral arch.
• At the point where lamina and pedicle join, a
transverse process extends laterally on each
side.
• A single spinous process projects posteriorly
from the junction of the laminae.
• These 3 processes serve as points of
attachments for muscles.
16. Hermizan Halihanafiah 16
Cont..
• The remaining 4 processes forms joints with other
vertebrae above and below.
• 2 superior articular processes articulate with the
2 inferior articular processes of vertebrae above
them.
• The articulating surfaces of articular processes
called facets.
• Articulation between the bodies and articular facets
of successive vertebrae are called intervertebral
joint.
17. Hermizan Halihanafiah 17
• Neural foramen
• Notches between adjacent
vertebrae.
• Allows for the passage of
the spinal nerve roots,
spinal artery, veins, nerve
plexus, and ligaments
Intervertebral Foramen
18. Hermizan Halihanafiah 18
Intervertebral Discs
• Intervertebral
fibrocartilage.
• Lie between adjacent
vertebrae in the spine.
• Each disc forms a
cartilaginous joint to allow
slight movement of the
vertebrae
• Acts as a ligaments to hold
the vertebrae together.
19. Hermizan Halihanafiah 19
Intervertebral Disc
• Absorb shock
• Discs consist of an outer annulus fibrosus, which surrounds
the inner nucleus pulposus.
• As people age, the nucleus pulposus begins to dehydrate,
which limits its ability to absorb shock. The annulus fibrosus
gets weaker with age and begins to tear.
20. Hermizan Halihanafiah 20
Cervical Vertebrae
• C1-C7
• C1, C2, C7 = Atypical , C2 – C6 = Typical
• The bodies are smaller than thoracic vertebrae.
• Vertebral arches are larger.
• Have one vertebral foramina, and two transverse
foramina.
• Vertebral foramina of cervical vertebrae are the largest in the
spinal column because they house the cervical enlargement
of the spinal cord.
21. Hermizan Halihanafiah 21
Cont…
• Each cervical transverse processes contain a
transverse foramen through which the vertebral
artery, vein and nerve pass.
• Spinous processes of C2-C6 are often bifid – split
into two parts.
• The first two cervical vertebra considerably from
others.
• First cervical vertebrae (C1) called atlas, and
second cervical vertebrae (C2) called axis.
23. Hermizan Halihanafiah 23
Cervical 1 (Atlas)
• The atlas is a ring of bone with anterior and posterior arches
and large lateral masses.
• Lacks a body and a spinous process.
• Large vertebral foramen (triangular)
• The superior surface of the lateral masses called superior
articular facets are concave.
• Superior articular facets articulate with occipital condyle of
occipital bone to form atlanto – occipital joint.
25. Hermizan Halihanafiah 25
Cont…
• These articulation permits the movement for “yes”.
• Inferior surface of the lateral masses called inferior articular
facets, articulate with axis vertebrae to form atlanto-axial joint.
• Transverse process and transverse foramina of the atlas are
quiet large.
• The large vertebral foramina divide into 2 foramina by the
transverse ligament; larger posterior foramina (spinal cord)
and smaller anterior foramina (dens)
28. Hermizan Halihanafiah 28
Cervical 2 (Axis)
• Atypical cervical vertebra
• Have a body
• Peglike process called dens or odontoid process projects
up through anterior portion of the vertebral foramen of the
atlas.
• The dens makes a pivot on which the atlas and head
rotate, as in moving the head to signify “ NO”.
31. Hermizan Halihanafiah 31
Cont…
• This arrangement allow side to side rotation of the head.
• The articulation formed between the anterior arch (facet) of
the atlas and dens of the axis, and between their
articulation facets (inferior and superior articular facets)
called the atlanto-axial joint.
33. Hermizan Halihanafiah 33
Cervical 7 (C7)
• Called the vertebra prominents.
• Has single large spinous process that can be felt at the
base of the neck.
• Spinous process is not bifid.
• Body is larger.
• Pedicles are directed more posteriorly than laterally.
• Inferior articular facets face more anteriorly than
downwards.
• Vertebral foramen, generally smaller than other cervical
vertebrae.
36. Hermizan Halihanafiah 36
MUSCLES OF THE NECK THAT
MOVE THE HEAD
Balance and movement of the head on the
vertebral column involves several neck muscles.
• Sternocleidomastoid
• Semispinalis capitis
• Splenius capitis
• Longissimus capitis
37. Hermizan Halihanafiah 37
Sternocleidomastoid
• Origin : sternal head from superior and anterior
surface of manubrium of sternum; clavicular
head from medial half of clavicle
• Insertion : mastoid process of temporal bone
• Action : bilaterally – flex cervical portion of
vertebral column, flex head and elevate ribs
during force inhalation
: unilaterally – laterally rotate and flex
head to side opposite contracting
muscles.
39. Hermizan Halihanafiah 39
Semispinalis Capitis
• Origin : transverse process of C7 and T1 – T7
vertebra.
• Insertion : occipital bone between superior and
inferior nuchal line.
• Action : bilaterally extend head , unilaterally
lateral rotate head to same side as contracting
muscle.
• Nerve innervations : cervical and thoracic
spinal nerves
41. Hermizan Halihanafiah 41
Splenius Capitis
• Origin : ligamentum nuchae and spinous
process of C7 and T1 – T4
• Insertion : occipital bones and mastoid process
of temporal bone.
• Action : Bilaterally extend head, unilaterally
lateral rotate head to same side as contracting
muscle.
• Nerve innervations : cervical spinal nerves
43. Hermizan Halihanafiah 43
Longissimus Capitis
• Origin : transverse process of T1 – T4 and
articular process of C4 – C7
• Insertion : posterior margin of mastoid process
of temporal bone.
• Action : Bilaterally extend head, unilaterally
lateral rotate head to same side as contracting
muscle.
• Nerve innervations : middle and inferior
cervical spinal nerves