it contains all the physiology of lung volume and capacity.
in this we study:-
introduction
lung volume
lung capacities
measurements of lung volume and capacities.
measurement of FRC and RV.
vital capacity.
FEV
RMV
MBC
PEFR
restrictive and obstructive respiratory disease.
it contains all the physiology of lung volume and capacity.
in this we study:-
introduction
lung volume
lung capacities
measurements of lung volume and capacities.
measurement of FRC and RV.
vital capacity.
FEV
RMV
MBC
PEFR
restrictive and obstructive respiratory disease.
The apparatus used to measure
Volume of air exchanged during breathing
Respiratory rate
The record is called a spirogram
Upward deflection inhalation
Downward deflection exhalation
This presentation describes the indications, contraindications, methods of performing spirometry. It explains the interpretation of spirometry with examples.
Surfactant & compliance, LAW OF LAPLACE, Work of Breathing (the guyton and ha...Maryam Fida
It is a lipoprotein mixture present in thin layer of fluid lining the alveoli at the air fluid interface.
COMPOSITION
It is composed of
Apoprotein
Calcium ions
Phospholipids i.e. dipalmitoyl lecithin
Surfactant is secreted by
1. Mainly type II alveolar cells in the lungs.
2. Clara cells, which are situated in the bronchioles.
It lowers the surface tension of fluid lining the alveoli.
Surface tension is inversely proportional to surfactant concentration.
During inspiration surfactant molecules move apart as lungs are expanded and during expiration surfactant molecules become concentrated as lungs shorten.
When there is no surfactant, Surface Tension is 50 dynes/cm. when surfactant is present it is 5-30 dynes/cm depending upon the concentration
Prevents collapse of lungs
Stabilize size of alveoli
Surfactant helps to keep lungs expanded. If there is deficiency of surfactant then the pressure of -20 to -30 mm of Hg will be required to keep the lungs expanded
Surfactant also helps to keep the alveoli dry and prevent development of pulmonary edema.
Surfactant is also helpful in lung expansion at birth. If there is deficiency then there is Respiratory Distress Syndrome.
LAW OF LAPLACE:
pressure required to keep a hollow viscous distended = 2 T/R
Where T is tension and R is radius.
During expiration, size of alveoli decreases so R is decreased and if T does not decrease, much higher pressure will be required to keep the alveoli distended.
When adequate amount of surfactant is there T also decreases so increased pressure is not required. This prevents the collapse of lungs and also stabilizes the equal size of alveoli
Definition:
“Compliance is the measure of expansibility or distensibility of the lungs. It indicates with how much ease lungs can be expanded”.
Work of Breathing
In certain diseases there is increased work of breathing and depending upon the nature of breath there will be specific increase in work of breathing.
In asthma there is increase in work of breathing to overcome airway resistance
In restrictive lung diseases there is increase work of breathing in both tissue resistance and elastic recoil.
Demo Cum Lecture on the topic of Spirometry by Pandian M, Tutor, Dept. of Phy...Pandian M
PY 6.8 Demonstrate the correct technique to perform & interpret Spirometry.
SLOs: After attending lecture & studying the assigned materials, the student will:
1. State the principles of recording of Spirometry.
2. Define & draw different lung volumes & capacities.
3. Explain FEV (TVC) correctly with its clinical significance.
4. Describe the helium dilution method to record the FRC.
5. Demonstrate the correct procedure of recording the spirogram.
6. Interpret the spirogram correctly
The apparatus used to measure
Volume of air exchanged during breathing
Respiratory rate
The record is called a spirogram
Upward deflection inhalation
Downward deflection exhalation
This presentation describes the indications, contraindications, methods of performing spirometry. It explains the interpretation of spirometry with examples.
Surfactant & compliance, LAW OF LAPLACE, Work of Breathing (the guyton and ha...Maryam Fida
It is a lipoprotein mixture present in thin layer of fluid lining the alveoli at the air fluid interface.
COMPOSITION
It is composed of
Apoprotein
Calcium ions
Phospholipids i.e. dipalmitoyl lecithin
Surfactant is secreted by
1. Mainly type II alveolar cells in the lungs.
2. Clara cells, which are situated in the bronchioles.
It lowers the surface tension of fluid lining the alveoli.
Surface tension is inversely proportional to surfactant concentration.
During inspiration surfactant molecules move apart as lungs are expanded and during expiration surfactant molecules become concentrated as lungs shorten.
When there is no surfactant, Surface Tension is 50 dynes/cm. when surfactant is present it is 5-30 dynes/cm depending upon the concentration
Prevents collapse of lungs
Stabilize size of alveoli
Surfactant helps to keep lungs expanded. If there is deficiency of surfactant then the pressure of -20 to -30 mm of Hg will be required to keep the lungs expanded
Surfactant also helps to keep the alveoli dry and prevent development of pulmonary edema.
Surfactant is also helpful in lung expansion at birth. If there is deficiency then there is Respiratory Distress Syndrome.
LAW OF LAPLACE:
pressure required to keep a hollow viscous distended = 2 T/R
Where T is tension and R is radius.
During expiration, size of alveoli decreases so R is decreased and if T does not decrease, much higher pressure will be required to keep the alveoli distended.
When adequate amount of surfactant is there T also decreases so increased pressure is not required. This prevents the collapse of lungs and also stabilizes the equal size of alveoli
Definition:
“Compliance is the measure of expansibility or distensibility of the lungs. It indicates with how much ease lungs can be expanded”.
Work of Breathing
In certain diseases there is increased work of breathing and depending upon the nature of breath there will be specific increase in work of breathing.
In asthma there is increase in work of breathing to overcome airway resistance
In restrictive lung diseases there is increase work of breathing in both tissue resistance and elastic recoil.
Demo Cum Lecture on the topic of Spirometry by Pandian M, Tutor, Dept. of Phy...Pandian M
PY 6.8 Demonstrate the correct technique to perform & interpret Spirometry.
SLOs: After attending lecture & studying the assigned materials, the student will:
1. State the principles of recording of Spirometry.
2. Define & draw different lung volumes & capacities.
3. Explain FEV (TVC) correctly with its clinical significance.
4. Describe the helium dilution method to record the FRC.
5. Demonstrate the correct procedure of recording the spirogram.
6. Interpret the spirogram correctly
Lung Volumes and Capacities are referred to the volume of air in the lungs at different phases of the respiratory cycle. Important part of the assessment of Pulmonary Tests
Common medication used for anesthesia, there action; dosage; adverse effect; duration of action.
They Include {inhalation + Induction + Muscle relaxant + Anticholinergic + Analgesic + Resuscitation}
in this presentation lecture we gone take a hypo and hyper thyrodism that affect the human cell because both situation may increase or decrease the basal metabolic rate.
When the pituitary Gland it' s function is increased whether the cause are?
Both anterior and Posterior gland secretions are increased the most causes are ADENOMAS
in this presentation you will be learn the different drug form that all medical health workers prescribing the medication.
the medical student should have a good knowledge and keep in mind these drug forms based on medical administration the drugs are classified into invasive (injection and transdermal implantation) and non invasive (oral, inhalers, suppository)
Medical equipment and tools are crucial to saving a person's life or performing any procedure.
i presented here the most and commonly equipment used by medical student to improve their skills
This note paper is short notes of general physiology for medical students who which to understand the concept of the physiology, physiology is the mother of medicine.
A summary of skeletal muscle contraction and relaxationAyub Abdi
it consist for 4 pages and cover all the steps that occur during muscle contraction and relaxation, I does not take a time just 5 minute is enough to read. I hope it's interesting.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. • Useful in assessing the functional status of the
respiratory system both in physiological and
pathological conditions.
• Lung function tests are based on the 1)
measurement of volume of air breathed in and
out in quiet breathing and 2) forced breathing.
3. 1- TIDAL VOLUME:
• is the volume of air breathed in and
out of lungs in a single normal quiet
respiration.
• Tidal volume signifies the normal depth
of breathing.
• This is about 500 ml in adults.
• The 500ml of tidal volume will divide
into:
• 150 ml containing in (dead space).
• 350 ml containing in (alveolar
ventilation).
4. 2- INSPIRATORY RESERVE
VOLUME:
• is an additional volume of air that can be
inspired forcefully after the end of normal
inspiration.
• The normal IRV is 3.3 liters in men and 1.9
liters in women.
• a maximal inspiratory effort.
5. 3- EXPIRATORY RESERVE
VOLUME:
• is the additional volume of air that can be
expired out forcefully, after normal
expiration.
• The normal ERV is 1.2 liter in men and 0.7
liter in women.
• a maximum expiratory effort.
6. 4- RESIDUAL VOLUME:
• is the volume of air remaining in lungs even
after forced expiration.
• Normally, lungs cannot be emptied completely
even by forceful expiration.
• Some quantity of air always remains in the
lungs even after the forced expiration.
• The normal value of RV in men is 1.2 liter and
in women is 1.1 liter.
8. Spirometry.
• is a common office test used to assess how well your lungs
work by measuring how much air you inhale, how much
you exhale and how quickly you exhale.
• Pulmonary ventilation can be studied by recording the
volume movement of air into and out of the lungs.
• Spirometry is used to diagnose asthma, chronic
obstructive pulmonary disease (COPD) and other
conditions that affect breathing.
• Spirometry may also be used periodically to monitor your
lung condition and check whether a treatment for a
chronic lung condition is helping you breathe better.
• Spirometry is generally a safe test. You may feel short of
breath or dizzy for a moment after you perform the test.
9.
10.
11.
12. lung capacities:
• lung capacities are the combination of two or
more lung volumes.
IC = TV + IRV
FRC = ERV + RV
VC = IRV + TV + ERV
TLC = IRV + TV + ERV + RV
15. VITAL CAPACITY:
is the maximum volume of air that can be expelled
out of lungs forcefully after a maximal or deep
inspiration.
16. RESPIRATORY MINUTE VOLUME:
• Also called; Pulmonary ventilation or minute
ventilation.
• is the volume of air breathed in and out of
lungs every minute.
• It is the product of tidal volume (TV) and
respiratory rate (RR).
OR
17. • When the Respiratory rate increases 40/min for
example, the tidal volume will equal to that of
vital capacity = 4600ml.
So the RMV = tidal volume X RR
RMV = 4600ml X 40/min.
RMV = 184000ml or 184 L.
• When the respiratory rate decreases 4/min for
ex, the tidal volume will not changed to it’s
normal =500ml.
So the RMV = tidal volume X RR
RMV = 500ml X 4/min.
RMV = 2000ml or 2 L.
18. ALVEOLAR VENTILATION:
• is the amount of air utilized for gaseous
exchange every minute.
• Alveolar ventilation is different from pulmonary
ventilation.
• Is the areas that include the alveoli, alveolar
sacs, alveolar ducts, and respiratory bronchioles.
• The rate at which new air reaches these areas
called alveolar ventilation and can be calculated
as this:
19. DEAD SPACE:
• Some of the air a person breathes never reaches the gas
exchange areas but simply fills respiratory passages
where gas exchange does not occur, such as the nose,
pharynx, and trachea.
• This air is called dead space air because it is not useful
for gas exchange.
• Volume of normal dead space is 150 mL
20.
21. TYPES OF DEAD SPACE :
1- Anatomical Dead Space:
• Anatomical dead space extends from nose up to terminal
bronchiole.
• It includes nose, pharynx, trachea, bronchi and branches of
bronchi up to terminal bronchioles.
• These structures serve only as the passage for air movement.
• Gaseous exchange does not take place in these structures.
2- Physiological Dead Space:
• Air in the alveoli, which are non-functioning.
• In some respiratory diseases, alveoli do not function because
of dysfunction or destruction of alveolar membrane.
• Air in the alveoli, which do not receive adequate
blood flow.