1. Charles V was elected Holy Roman Emperor in 1519. When he departed for Germany in 1520, he left Cardinal Adrian of Utrecht to rule Castile. This led to a revolt called the Revolt of the Comuneros by citizens in Castile against Charles V's rule.
2. Philip II inherited a vast empire from his father Charles I. He faced many problems during his reign including wars with France and confrontations with the Turks and English.
3. Spain began to lose its supremacy in the 17th century due to economic crisis, population decline, and an impoverished society. France rose to supremacy under the absolute rule of Louis XIV.