Vitamin C has roles as both an antioxidant and in collagen production. A study found that vitamin C deficiency in mice compromised collagen deposition in atherosclerotic plaques, reducing collagen content. However, vitamin C levels did not affect plaque size or foam cell formation. While vitamin C may stabilize plaques by increasing collagen, more research is needed to determine if excess vitamin C can reverse atherosclerosis or if local vitamin C treatment could increase plaque stability. The study demonstrates vitamin C's role in collagen production for plaque stability but did not determine its dominant role in atherosclerosis.