Transamination, deamination, and decarboxylation are the three main reactions in amino acid metabolism. Transamination involves transferring the amino group from an amino acid to α-ketoglutarate, catalyzed by a transaminase, forming a new amino acid (usually glutamate) and α-keto acid. Glutamate can then donate its amino group for biosynthesis or have its amino group removed by oxidative deamination via glutamate dehydrogenase into α-ketoglutarate and ammonium, providing α-ketoglutarate for further transamination reactions. This process funnels amino nitrogen into glutamate and ultimately results in its removal as ammonium, a form excreted from the body.