The document describes the main structures and functions of the human eye. It discusses the cornea, iris, pupil, lens, retina, optic nerve, and blind spot. It explains how the pupil controls the amount of light entering the eye and how the lens focuses light to allow vision both near and far. Common eye conditions like myopia, hyperopia, astigmatism, glaucoma and cataracts are also outlined.
This is a powerpoint targeted toward people looking to understand their eyes better, specifically kids who are getting glasses for the first time and really don't understand why.
This is a powerpoint targeted toward people looking to understand their eyes better, specifically kids who are getting glasses for the first time and really don't understand why.
The human color vision describes about The Cornea, The Sclera/ Sclerotic coat, The Pupil, The Retina, The Choroid Coat, The vitreous humor, The aqueous humor, The lens, Foveal Pit, Yellow Spot, Blind Spot, How the Human Eye Works, The Rods, The Cone Cells, Types of Cones, Spectral sensitivity, Defective color vision/ Color blindness, Symptoms of Color Blindness, Causes of Color Blindness, Trichromates, Dichromates, Monochromates, Anomalous Trichromates.
The anatomy of the eye consists of various essential components working in harmony to enable vision. These include the cornea, iris, pupil, lens, retina, optic nerve, sclera, and vitreous humor. Each of these structures plays a vital role in capturing, focusing, and transmitting visual information to the brain. Understanding the intricacies of the eye's anatomy is crucial for comprehending its function and any potential eye-related issues that may arise.
The eyeball is a spherical structure having 2.5 diameters. Structurally, the eyeball has three layers:- sclerotic layer (outer layer); choroid (middle layer) and retina (inner layer).
Outermost layer contains sclera and cornea
Middle layer contains choroid, ciliary body and iris.
Innermost layer consists of retina
The eyeball is a spherical structure having 2.5 diameters. Structurally, the eyeball has three layers:- sclerotic layer (outer layer); choroid (middle layer) and retina (inner layer).
Focuses an image by refracting, or bending the light rays using cornea and the lens. At the yellow spot of retina an inverted image is formed. Most of the refraction of light occurs in cornea due to its curved surface.
The human color vision describes about The Cornea, The Sclera/ Sclerotic coat, The Pupil, The Retina, The Choroid Coat, The vitreous humor, The aqueous humor, The lens, Foveal Pit, Yellow Spot, Blind Spot, How the Human Eye Works, The Rods, The Cone Cells, Types of Cones, Spectral sensitivity, Defective color vision/ Color blindness, Symptoms of Color Blindness, Causes of Color Blindness, Trichromates, Dichromates, Monochromates, Anomalous Trichromates.
The anatomy of the eye consists of various essential components working in harmony to enable vision. These include the cornea, iris, pupil, lens, retina, optic nerve, sclera, and vitreous humor. Each of these structures plays a vital role in capturing, focusing, and transmitting visual information to the brain. Understanding the intricacies of the eye's anatomy is crucial for comprehending its function and any potential eye-related issues that may arise.
The eyeball is a spherical structure having 2.5 diameters. Structurally, the eyeball has three layers:- sclerotic layer (outer layer); choroid (middle layer) and retina (inner layer).
Outermost layer contains sclera and cornea
Middle layer contains choroid, ciliary body and iris.
Innermost layer consists of retina
The eyeball is a spherical structure having 2.5 diameters. Structurally, the eyeball has three layers:- sclerotic layer (outer layer); choroid (middle layer) and retina (inner layer).
Focuses an image by refracting, or bending the light rays using cornea and the lens. At the yellow spot of retina an inverted image is formed. Most of the refraction of light occurs in cornea due to its curved surface.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
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A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
5. CORNEA
(clear lens in front
of eye)
transparent covering of
the front of the eye
Allows for the passage of
light into the eye and
functions as a fixed lens.
13. SCLERA – a tough white skin
(made of tissue) that covers all of
the eyeball except the cornea.
SCLERA
(white part)
whites of the eye
supports eyeball
provides
attachment for
muscles
21. • On retina where optic
nerve leads back into the
brain
• No rod or cone cells
• Other eye compensates
for this area
BLIND SPOT
22. • Try this test to prove you
have a blind spot…
Small spot on the
back of the retina
Other eye
compensates for
this area
23. • On retina where optic
nerve leads back into the
brain
• No rod or cone cells
• Other eye compensates
for this area
• Try this test to prove you
have a blind spot…
THE EYE: Blind Spot
24. Blind Spot (Optic Disk)
Close your right eye and look directly at the number
3. Can you see the yellow spot in your peripheral
vision? Now slowly move towards or away from the
screen. At some point, the yellow spot will disappear.
25.
26. Your 2 Lenses: Cornea and Lens
• There are two lenses in your eye, the cornea and the lens.
• The cornea, the front surface of the eye, does most of the focusing
in your eye
• The lens provides adjustable fine-tuning of the focus
27. How Your Lens Focuses
• Your lens has a small depth of field
– You can't see something close and far with both objects
in focus at the same time
• Hold out your thumb about a foot away from your eye
– Then, alternately focus on thumb and me (right above
your thumb)
• Note that you cannot see both me and your thumb sharply
(in focus) at the same time
– You focus on one or the other by changing the bulge of
your lens
28. less bulgy
teacher is in focus
thumb is out of focus
more bulgy
thumb is in focus
Teacher is out of focus
31. Focusing Problems
PRESBYOPIA
• Form of far-sightedness
• Harder for people to read
as they age
• Lens loses elasticity
• Corrected by glasses with
converging lenses
32. Focusing Problems
MYOPIA
• Near-sightedness
• Problem seeing objects
far away
• Distance between lens
and retina too large
• Light focused in front of
retina
• Correct with diverging
lenses
34. Diseases of the Eye
ASTIGMATISM
• Eye cannot focus an
object’s image on a single
point on retina
• Cornea is oval instead of
spherical
• Causes blurred vision
• Some types can be
corrected with lenses
35. Diseases of the Eye
GLAUCOMA
• Group of diseases
• Affects optic nerve -
pressure
• Loss of ganglion cells
• Gradual loss of sight and
eventual blindness
• Check eyes regularly
• Can be treated
36. Diseases of the Eye
CATARACTS
• Clouding forms in lens
due to denaturing of lens
protein
• Obstructs passage of light
• Caused by age, chronic
exposure to UV, or due to
trauma
• Removed by surgery
37. Vision Correction
CONTACT LENSES
• Artificial lens placed over
cornea
• Same as glasses
• Corrects for both near
and far-sightedness
• Also used for cosmetic
purposes (eye colour,
Hollywood)
38. Videos
“How Eyes Work: An Introduction” (10:48)
http://www.youtube.com/watch?v=SCn83DHC1Ug
Bill Nye The Science Guy on the Eyeball (2:12)
http://www.youtube.com/watch?v=cFVbLnXWn6A
“How the Human Eye Works”
http://www.youtube.com/watch?v=fn6v3SkH0LI
The Human Eye and How it Works (22:59)
http://www.youtube.com/watch?v=28NysX8JHDo
62. Reading
What is wrong with
with this sentence?
Aoccdrnig to rscheearch at Cmabrigde
Uinervtisy, it deosn't mttaer in waht oredr the
ltteers in a wrod are, the olny iprmoetnt tihng is
taht the frist and lsat ltteer be at the rghit pclae.
The rset can be a toatl mses and you can sitll
raed it wouthit a porbelm. Tihs is bcuseae the
huamn mnid deos not raed ervey lteter by istlef,
but the wrod as a wlohe.
65. Blind Spot
• On retina where optic
nerve leads back into the
brain
• No rod or cone cells
• Other eye compensates
for this area
• Try this test to prove you
have a blind spot…
66. Blind Spot (Optic Disk)
Close your right eye and look directly at the number
3. Can you see the yellow spot in your peripheral
vision? Now slowly move towards or away from the
screen. At some point, the yellow spot will disappear.
67. Now stare at the red dot with your right eye from 12 inches, covering
your left eye with your left hand. Notice that the gap in the blue bar fills
in (completes). Move your left hand to unblock your left eye and the
gap re-appears.
68. Close left eye and approach screen while
staring at the letters…watch the dot!
69. Optical Illusion Video Clips
10 Best Optical Illusions of 2014 (10:18)
http://www.youtube.com/watch?v=VxTFGVp2R-
8
Moving Illusions (10:47)
http://www.youtube.com/watch?v=Iw8idyw_N6
Q