This document profiles 10 blind or deaf people who changed the world through their accomplishments and innovations. It describes Galileo Galilei's astronomical discoveries despite losing his sight later in life. It also discusses Thomas Edison's inventions like the phonograph despite becoming deaf from illnesses as a child. Additionally, it mentions Laurent Clerc co-founding the first school for the deaf in America and Franklin D. Roosevelt being one of the most popular US presidents despite vision impairments.