NY Prostate Cancer Conference - M. Litwin - Session 6: Documenting outcomes with patient reported questionnaires
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This document discusses the importance of documenting outcomes using patient-reported questionnaires in prostate cancer treatment. It outlines how patient-centered outcomes like health-related quality of life are as important as objective clinical measures. It also describes several validated questionnaires that are used to measure quality of life domains affected by prostate cancer and its treatment, such as urinary, sexual, and bowel function as well as general physical and mental health. Principles for documenting outcomes include using validated instruments, relying on patient self-assessment, tracking outcomes longitudinally, and interpreting changes from a patient's own baseline.
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Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Studies have shown that exercise may help reduce the risk of recurrence in cancer patients. It can also help improve mood and sleep, reduce anxiety, boost energy, and so much more. Join Dr. Shannon Armbruster, gynecologic oncologist at Virginia Tech’s Carilion Clinic, as she talks about these benefits, exercise guidelines for cancer survivors, her research, and more. One form of exercise that has mind-body benefits for cancer survivors is yoga. Dr. Samantha Harden, an associate professor of Human Nutrition, Foods, and Exercise and 500 hour registered yoga teacher, will share some of the research findings related to yoga for cancer survivors and include a brief, accessible demonstration of the yoga kernels for public health (breathing, movement, moment-to-moment awareness). Learn about and reap the benefits of movement with us during this Gynecologic Cancer Awareness Month!
D045023028
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
My Research Projects
Rajeshwari Punekar is a researcher studying various health-related topics including work disability rates in cancer survivors compared to other chronic conditions, factors associated with community health centers providing enabling services, trends in employment-based health insurance, medical expenditures of cancer survivors, and mental health of cancer survivors and their spouses. Her roles include being a research assistant, co-investigator, and assistant data analyst. She uses large datasets and statistical methods like regression analysis to analyze topics and has worked on multiple research projects.
Research Trends in Exercise and Colorectal Cancer Webinar
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Fatores de risco iu pós prostatectomia
- 59% of men were incontinent 6 weeks after prostatectomy, with incontinence rates similar between obese and non-obese men.
- 22% of men were incontinent 58 weeks after prostatectomy. Incontinence rates were higher in obese men and physically inactive men.
- The highest rates of incontinence at 58 weeks (59% incontinent) were found in men who were both obese and physically inactive prior to surgery. Physical activity appeared to offset some of the negative effects of obesity on incontinence. The best outcomes were seen in non-obese, physically active men (16% incontinent).
The Challenges of Sarcopenia: Definition, Underlying Mechanisms, Intervention...
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A gradual decline in muscle mass and strength begins around 30 years of age with this condition, and annual losses get larger throughout life. The self-reporting of functional difficulties to health care providers may give an indication that sarcopenia is present, but a more precise definition is needed for research and clinical use.
Efforts made in Europe and the US have used grip strength, gait speed and lean mass to define sarcopenia, but these definitions lead to large differences in prevalence rate and discordance in who is labelled as “sarcopenic”. To assess this condition, lean mass as measured by dual x-ray absorptiometry (DXA) may not accurately reflect actual muscle mass, but a new technique using dilution of deuterium-labelled creatine may prove to be superior in clinically diagnosing sarcopenia. Currently, a consensus has not been reached on the clinical outcome assessments that can be used by regulatory agencies to judge the effectiveness of drugs for sarcopenia.
A number of potential interventions are being explored to treat sarcopenia in older people, but no drugs are currently approved for this condition. The antidiabetic drug metformin shows promise in preventing many age-associated conditions, but appears to blunt the benefits of exercise on muscle. Senolytic drugs, which clear senescent cells, may improve muscle repair following injury preferentially in older individuals.
MCC 2011 - Slide 15
Quality of life questionnaires commonly used to assess outcomes after rectal cancer surgery such as the SF-36 and EORTC QLQ-C30/QLQ-CR38 may not be fully adequate or sensitive enough to capture important changes in bowel function and symptoms. Preoperative chemoradiation can impair bowel function and sexual function long-term, though patients may adapt, and overall quality of life scores are often similar to those without chemoradiation. Sphincter-saving procedures like low anterior resection with a colonic J-pouch may provide better function than straight resection or colostomy.
nihms411798
This study examined the association between pre- and post-diagnostic recreational physical activity and BMI with colorectal cancer-specific and all-cause mortality in 1339 women from the Women's Health Initiative who were diagnosed with colorectal cancer. The study found that women who reported pre-diagnostic recreational physical activity of ≥18 MET-hours/week had significantly lower colorectal cancer-specific and all-cause mortality compared to women reporting no pre-diagnostic activity. Similar inverse associations were seen for post-diagnostic recreational physical activity. Neither pre- nor post-diagnostic BMI were associated with mortality after colorectal cancer diagnosis.
Psychosocial aspect of bariatric surgery
1) This study examined changes in employment impairment and productivity in 164 patients one year after bariatric surgery.
2) It found significant reductions in work impairment and improvements in work productivity, as well as improved quality of life and reduced depression and anxiety symptoms.
3) Pre-surgery depression, anxiety, and quality of life scores were significant predictors of changes in work outcomes after surgery, but a history of psychiatric illness was not a predictor. Patients with greater pre-surgery work impairment and psychopathology experienced the greatest employment improvements.
Prp intradiskal 2015
This study examined the effectiveness of platelet-rich plasma (PRP) injections for chronic lumbar diskogenic pain. 47 participants with chronic low back pain received either an intradiskal PRP injection or a control injection after provocative diskography. Participants who received PRP reported significantly greater improvements in pain, physical function, and satisfaction over the 8 week period compared to the control group. At the 1 year follow up, those receiving PRP maintained significant improvements in physical function. No serious adverse events were reported. The study provides preliminary evidence that PRP injections may effectively treat chronic low back pain caused by damaged disks. Larger and more standardized studies are still needed.
Similar to NY Prostate Cancer Conference - M. Litwin - Session 6: Documenting outcomes with patient reported questionnaires (20)
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The document summarizes key information about prostate cancer including incidence, mortality rates, clinical stages, risk groups for localized prostate cancer, treatment options for advanced disease including hormone therapy and chemotherapy, and results from clinical trials of chemotherapy agents like docetaxel and cabazitaxel.W. Hassen - Bladder cancer - Guidelines
Thank you for the overview. Let me know if you need any clarification or have additional questions.
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1 azim
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H. Azim - Lymphomas - State of the art
This document discusses treatment of diffuse large B-cell lymphoma (DLBCL). It notes that DLBCL is a heterogeneous disease with genetic subgroups that have different prognoses and responses to treatment. The addition of the antibody rituximab to chemotherapy like CHOP has improved outcomes for DLBCL compared to chemotherapy alone in the post-rituximab era. Strategies to further improve outcomes include targeting specific genetic subgroups like the activated B-cell subtype using drugs like bortezomib that inhibit pathways like NF-kB.
S. Khleif - Ovarian cancer - General lecture on vaccine
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A. Hassan - Ovarian cancer - Guidelines and clinical case presentation (2-3 c...
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- Ovarian cancer is the ninth most common cancer in women and the fifth leading cause of cancer death in women. Risk factors include age over 60, obesity, talcum powder use, fertility drugs, genetic predispositions like BRCA mutations.
- Surgical staging is essential for determining prognosis and appropriate treatment. For early stage disease adjuvant chemotherapy is recommended. Advanced stage disease is treated with cytoreductive surgery followed by platinum/taxane chemotherapy.
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A. Hassan - Cervical cancer - Guidelines and clinical case presentation (2-3 ...
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Nearly 500,000 new cases of cervical cancer occur worldwide each year, with the majority in developing countries. Infection with HPV is responsible for virtually all cervical cancer cases. Screening includes Pap smears and HPV testing, while vaccination may prevent up to 70% of cases but is not widely available due to cost. Diagnosis is through biopsy and histopathological examination, while staging uses the FIGO system based on tumor size and spread. Treatment depends on stage but commonly includes surgery such as hysterectomy with or without radiation or chemotherapy.V. Kesic - Cervical cancer - State of the art
- Cervical cancer is a major cause of cancer deaths worldwide, with over 500,000 new cases and 260,000 deaths estimated annually. Most deaths occur in developing countries where screening and prevention programs are lacking.
- Early detection through screening programs can make cervical cancer highly curable, but the majority of cases in developing nations are diagnosed at late stages when survival rates are low. Vaccination and screening can help prevent a large percentage of cervical cancer cases.
- Risk factors for cervical cancer include human papillomavirus infection and lack of access to healthcare. While HPV infection is necessary, most infections clear without causing cancer. Other factors like multiple pregnancies, smoking, and HIV infection can increase the risk.
T. Cufer - Breast cancer - State of the art for advanced breast cancer
The document summarizes the current state of metastatic breast cancer treatment. It discusses how survival rates have improved over time and metastatic breast cancer is now considered a chronic, treatable disease rather than an immediately terminal condition. Treatment involves systemic therapies like chemotherapy, endocrine therapy, targeted therapies, as well as radiation, surgery, and supportive care. Selection of optimal first-line systemic treatment depends on disease characteristics and patient factors. Ongoing research focuses on tailoring and sequencing treatments to overcome resistance and further extend patient survival and quality of life.
N. El Saghir - Breast cancer - State of the art for early breast cancer
1) Breast cancer is heterogeneous with different subtypes defined by receptor status and gene expression profiles. The subtypes have different biological behaviors and clinical outcomes.
2) Accurate diagnosis requires biopsy (FNA or core) followed by receptor testing before treatment decisions. Surgery options include breast conserving therapy or mastectomy with/without reconstruction.
3) For early breast cancer, sentinel lymph node biopsy guides the need for further axillary lymph node dissection. Omission of further dissection may be adequate for sentinel node positive patients.
S. Cascinu - Liver/Hepatobiliary - State of the art
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S. Cascinu - Colorectal cancer - Guidelines and clinical case presentation (2...
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1) A trial found that adding bevacizumab to chemotherapy for stage III colon cancer extended disease-free survival compared to chemotherapy alone, delaying cancer relapse but not preventing it completely.
2) There was no overall survival benefit observed from adding bevacizumab, suggesting it delays but does not alter the underlying biology of the disease.
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This document provides an overview of squamous cell carcinoma of the head and neck (SCCHN), including its anatomical sites, incidence and mortality rates, risk factors, staging guidelines, and treatment approaches. It discusses the roles of surgery, radiation therapy, chemotherapy, concurrent chemoradiation, and targeted therapies like cetuximab in managing localized and advanced SCCHN. Concurrent chemoradiation is now standard for improving local control and organ preservation compared to radiation alone. The addition of cetuximab to radiation was shown to improve locoregional control and overall survival.More from European School of Oncology (20)
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- 12. Doctor or patient perspective Physician vs Patient perception of QOL impairment Sonn, J Urol 2009 n = 1,366
- 13. Doctor or patient perspective Physician vs Patient perception of QOL impairment Sonn, J Urol 2009 n = 1,366
- 14. National longitudinal QOL Cohort Sanda, NEJM 2008 n = 1,201
- 15. UCLA longitudinal QOL cohort SF-36 Physical Composite Litwin, Cancer 2007 n = 580
- 16. UCLA longitudinal QOL cohort PCI Sexual Function % Return to baseline Litwin, Cancer 2007 n = 580
- 18. Websites for further information on patient-reported outcomes proqolid.org outcomes.cancer.gov sf-36.org
Editor's Notes
- Again, the SF-36 scales run from 0-100 with higher scores representing better outcomes. Physical function was similar between groups.
- Men undergoing brachytherapy had substantially worse AUASI scores that persisted, even a year after treatment.