The document discusses body temperature measurement and fever in animals. It defines normal body temperatures for various animals and describes methods of measuring rectal temperature. It explains that mammals and birds are warm-blooded while others are cold-blooded. Fever is defined as an elevated core temperature above normal due to infection or inflammation. The stages of fever - increment, fastigium, and decrement - are outlined. Treatment focuses on addressing the underlying cause with antimicrobials while antipyretics may help reduce discomfort from high temperatures.
Mange is among the common illnesses that many dog owners are concerned about. People usually get tensed and do not know how to handle such situations. I present you this Presentation that speaks about Mange, a skin disease caused by tiny parasite mites on dogs. You can refer to this to know what Mange is all about, the types of Mange, the causes, the symptoms and a few easy ways to deal with it. Mange, if left untreated can be fatal. Therefore, timely knowledge and treatment about this disease is important. You can also add your views in the comments below.
For more information about Mange, you can refer to the following links:
http://www.vet-organics.com/types-of-mange-in-dogs/
http://pets.webmd.com/dogs/mange-dogs-canine-scabies
Mange is among the common illnesses that many dog owners are concerned about. People usually get tensed and do not know how to handle such situations. I present you this Presentation that speaks about Mange, a skin disease caused by tiny parasite mites on dogs. You can refer to this to know what Mange is all about, the types of Mange, the causes, the symptoms and a few easy ways to deal with it. Mange, if left untreated can be fatal. Therefore, timely knowledge and treatment about this disease is important. You can also add your views in the comments below.
For more information about Mange, you can refer to the following links:
http://www.vet-organics.com/types-of-mange-in-dogs/
http://pets.webmd.com/dogs/mange-dogs-canine-scabies
Ventilation is necessary in modern controlled poultry houses to provide fresh air into the house and to expel noxious gasses from the house to keep the environment fresh and birds healthy.
There are different types of ventilation depends on the weather like minimum ventilation in cold weather, transitional ventilation in optimum weather and tunnel ventilation in extreme weather.
In the tropical climate like India, the high ambient temperature along with high humidity is the major stressor (abiotic), thus resulting in the HEAT STRESS a major concern of poultry production.
55°F – 75°F Thermoneutral zone
65°F – 75°F Ideal temperature zone
75°F – 85°F A slight reduction in feed consumption
85°F – 90°F Feed consumption falls further, cooling should be started before this temp is reached.
90°F - 95°F Feed consumption continues to drop, danger of heat prostration among layers, cooling .
95°F-100°F Heat prostration, water consumption is high.
>100°F Emergency measures must be taken, survival is concern at these temperatures.
CONCEPTS AND STRATEGIES TO AMELIORATE THE HEAT STRESS
1. Environmental strategies
Intermittent Photoschedule(light).
2. Housing management
Sites election, design and construction, ventilation, internal and roof cooling, Density of birds.
3. Nutritional strategies
Increasing energy density
Dietary Protein level and Amino acid composition
Vitamins – A,C,E.
Minerals.
Non nutrient feed additives.
Water and electrolyte balance.
4. Feeding strategies
Early feeding
Intermittent feeding
Sex separate feeding
Fasting or feed with drawl.
5. Genetic strategies
Selection for heat tolerance.
Selection for disease resistance.
Use of major genes – Naked neck(Na), Frizzle(F), Dwarf(dw), Silky (h), Slow feathering (K).
ENVIRONMENT STRATEGIES:
A). Intermittent Photo schedule
An intermittent light regime can improve the feed efficiency and thus the broiler production efficiency, by decreasing the fat deposition associated with increased incidence of leg abnormalities, metabolic and cardiovascular diseases, ascites.
The favourable effect is related to the lower heat production during both light and dark period, although fluctuations in heat production are following closely the light-dark alternation.
This photo schedule contains more than one scotophase and one darkphase which recur at 24 hr intervals.
This regime increases the feed consumption during cooler part of the day.
Symmetric - when scotophase and dark phase are of equal length.
Asymmetric - when they are not in equal length.
3weeks age of broiler raised under 2L:4D intermittent light regime were significantly lighter than broilers raised in continuous light schedule but at 7 weeks it is reverse.(Proudfoot, 1975).
The initial reduction in body weight gain of birds under intermittent schedule is followed by compensatory growth, but the compensatory growth depends on genotype and sex.
Boschouwers and Nicaise (1992) observed that physical activity in broilers were lowest under 100Hz fluoroscent light and highest under incandescent.
HOUSING MANAGEMENT
Orientation : east west to reduce direct solar radiation
Shade of trees and green crops around the houses will prevent direct heating, .vegetation should be mowed frequently so that it doesnot obstruct air flow
Houses should be oriented perpendicular to wind direction for max
Body temperature by Pandian M, Tutor Dept of Physiology, DYPMCKOP, this PPT f...Pandian M
BODY TEMPERATURE
HEAT BALANCE
Mechanisms of heat gain
Mechanisms of heat loss
VARIATIONS OF BODY TEMPERATURE
REGULATION OF BODY TEMPERATURE
Thermoreceptors
Hypothalamus: the thermostat
Thermoregulatory effector mechanisms
ABNORMALITIES OF BODY TEMPERATURE
Ventilation is necessary in modern controlled poultry houses to provide fresh air into the house and to expel noxious gasses from the house to keep the environment fresh and birds healthy.
There are different types of ventilation depends on the weather like minimum ventilation in cold weather, transitional ventilation in optimum weather and tunnel ventilation in extreme weather.
In the tropical climate like India, the high ambient temperature along with high humidity is the major stressor (abiotic), thus resulting in the HEAT STRESS a major concern of poultry production.
55°F – 75°F Thermoneutral zone
65°F – 75°F Ideal temperature zone
75°F – 85°F A slight reduction in feed consumption
85°F – 90°F Feed consumption falls further, cooling should be started before this temp is reached.
90°F - 95°F Feed consumption continues to drop, danger of heat prostration among layers, cooling .
95°F-100°F Heat prostration, water consumption is high.
>100°F Emergency measures must be taken, survival is concern at these temperatures.
CONCEPTS AND STRATEGIES TO AMELIORATE THE HEAT STRESS
1. Environmental strategies
Intermittent Photoschedule(light).
2. Housing management
Sites election, design and construction, ventilation, internal and roof cooling, Density of birds.
3. Nutritional strategies
Increasing energy density
Dietary Protein level and Amino acid composition
Vitamins – A,C,E.
Minerals.
Non nutrient feed additives.
Water and electrolyte balance.
4. Feeding strategies
Early feeding
Intermittent feeding
Sex separate feeding
Fasting or feed with drawl.
5. Genetic strategies
Selection for heat tolerance.
Selection for disease resistance.
Use of major genes – Naked neck(Na), Frizzle(F), Dwarf(dw), Silky (h), Slow feathering (K).
ENVIRONMENT STRATEGIES:
A). Intermittent Photo schedule
An intermittent light regime can improve the feed efficiency and thus the broiler production efficiency, by decreasing the fat deposition associated with increased incidence of leg abnormalities, metabolic and cardiovascular diseases, ascites.
The favourable effect is related to the lower heat production during both light and dark period, although fluctuations in heat production are following closely the light-dark alternation.
This photo schedule contains more than one scotophase and one darkphase which recur at 24 hr intervals.
This regime increases the feed consumption during cooler part of the day.
Symmetric - when scotophase and dark phase are of equal length.
Asymmetric - when they are not in equal length.
3weeks age of broiler raised under 2L:4D intermittent light regime were significantly lighter than broilers raised in continuous light schedule but at 7 weeks it is reverse.(Proudfoot, 1975).
The initial reduction in body weight gain of birds under intermittent schedule is followed by compensatory growth, but the compensatory growth depends on genotype and sex.
Boschouwers and Nicaise (1992) observed that physical activity in broilers were lowest under 100Hz fluoroscent light and highest under incandescent.
HOUSING MANAGEMENT
Orientation : east west to reduce direct solar radiation
Shade of trees and green crops around the houses will prevent direct heating, .vegetation should be mowed frequently so that it doesnot obstruct air flow
Houses should be oriented perpendicular to wind direction for max
Body temperature by Pandian M, Tutor Dept of Physiology, DYPMCKOP, this PPT f...Pandian M
BODY TEMPERATURE
HEAT BALANCE
Mechanisms of heat gain
Mechanisms of heat loss
VARIATIONS OF BODY TEMPERATURE
REGULATION OF BODY TEMPERATURE
Thermoreceptors
Hypothalamus: the thermostat
Thermoregulatory effector mechanisms
ABNORMALITIES OF BODY TEMPERATURE
Temperature practical cum theory part by Pandian M, From DYPMCKOP. This PPT f...Pandian M
INTRODUCTION
HOMEOTHERMIC ANIMALS
POIKILOTHERMIC ANIMALS
BODY TEMPERATURE
Normal Body Temperatures
VARIATIONS OF BODY TEMPERATURE
Pathological Variations
HEAT GAIN OR HEAT PRODUCTIONIN THE BODY
HEAT LOSS FROM THE BODY
Regulation of Body Temperature
Hypothalamus has two centers which regulate the body temperature:
Applied
Fever is an elevation of body temperature that exceeds
normally daily variation and occurs in conjunction with an
increase in the hypothalamic set point for e.g. 37⁰C-
39⁰C.
vitals sign is the basic parameter used for all the patients to know the vital and general parameter for the patients and any changes in this parameter can cause the life threatening condition for the patients or clients life the proper technique and its alternatives assessment knowledge can help the nurses to improve academic performance and can be apply this knowledge in their clinical practices
The four main vital signs routinely monitored by medical professionals and health care providers include the following: Body temperature. Pulse rate. Respiration rate (rate of breathing) Blood pressure (Blood pressure is not considered a vital sign, but is often measured along with the vital signs.)
Learning Objectives
Identify normal vital sign ranges in the adults. Determine appropriate response to unstable or abnormal vital signs. Identify early trends in vital signs indicative of sepsis, hypoxia, and myocardial infarction. Explain the importance of accurate I&Os and daily weights in the patient's plan of care.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
2. The normal body temperature
• The body can only work properly at a certain temperature.
• The animal body maintains itself at a constant temperature,
within a small range, in order for the systems to work
properly.
• This normal body temperature is different in different types of
animals.
• There are a number of ways by which animals control the
temperature of the body:
Hair, wool, walking, running, shivering and the burning of
energy in feed keep the body warm.
Sweating, panting, wallowing in mud, and lying in the shade
cool the body.
3. •body temperature (internal temperature of a living
organism).
vMammals and birds are termed warm-blooded, or
homeothermic, i.e., they are able to maintain a
relatively constant inner body temperature.
4. • other animals are cold-blooded, or poikilothermic, i.e., their body
temperature varies according to the temperature of the environment
(Invertebrates, fish, amphibians, and reptiles are considered to be cold-
blooded).
5. •Farm animals maintain a relatively constant body core
temperature, homeothermy, This homeothermic state is
achieved by:
vphysiological mechanisms
v behavioural mechanisms
These mechanisms modify either :
1. The rates of heat loss from the body or
2. The rate at which heat is produced by :
Ømetabolism of feed or
Øbody energy reserves.
6. The hypothalamus is a small area in the ventral diencephalon of the forebrain, in the
floor of the third ventricle, and is a functional link between
the nervous and endocrine systems.
The hypothalamus controls most of the endocrine glands within the body, largely
through stimulation of the Pituitary Gland by secretion of neurohormones. It is a vital
regulator of homeostasis, including Thermoregulation.
8. • A thermometer is a device that measures
temperature or a temperature gradient.
• A thermometer has two important elements:
1. a temperature sensor (e.g. the bulb of a mercury-
in-glass thermometer or the pyrometric sensor in
an infrared thermometer) in which some change
occurs with a change in temperature.
2. some means of converting this change into a
numerical value (e.g. the visible scale that is
marked on a mercury-in-glass thermometer or the
digital readout on an infrared model).
• Thermometers are widely used in technology and
industry to monitor processes, in meteorology, in
medicine, and in scientific research.
9. An infrared thermometer is a
thermometer which infers temperature
from a portion of the thermal radiation
sometimes called black-body radiation
emitted by the object being measured.
They are sometimes called laser
thermometers as a laser is used to
help aim the thermometer, or non-
contact thermometers or temperature
guns, to describe the device's ability to
measure temperature from a distance.
By knowing the amount of infrared
energy emitted by the object and its
emissivity, the object's temperature can
often be determined within a certain
range of its actual temperature. Infrared
thermometers are a subset of devices
known as "thermal radiation
thermometers".
10. How to take the body temperature of animals
• Control the animal.
• Move the tail to the side.
• Put the thermometer gently into the anus, as far as possible.
• Hold the thermometer at an angle so that it touches the
wall of the rectum.
• Keep a firm grip on the thermometer, if the animal defecates
or coughs the thermometer could come out or go into the
rectum.
• Hold the thermometer in place for half a minute. If you do
not have a watch count slowly up to 30 (one, two,
three, ............ thirty).
• Remove the thermometer and wipe it if necessary and read
it. Do not touch the bulb as this could change the reading.
12. Normal body temperatures
Body temperatures may be 1°C above or below these temperatures.
*The camel's body temperature will vary with the time of day and water availability. When a camel is
watered daily its body temperature rises from 36.5°C in the morning to 39.5°C at noon, if the animal
has no water, the temperature range is 34.5°C to 41°C.
• If you suspect that the animal has a high temperature use your thermometer to check it.
• Remember that a high temperature is one sign of ill health. When an animal has a high
temperature, it has a fever.
Animal Normal Temperature °C Animal Normal Temperature °C
Cattle 38.5 Calf 39.5
Buffalo 38.2 Goat 39.5
Sheep 39.0 Camel* 34.5-41.0
Llama, alpaca 38.0 Horse 38.0
Donkey 38.2 Pig 39.0
Chicken 42.0 Piglet 39.8
13.
14. Fever (pyrexia )
§Definition :
Fever is a complicated pathological process characterized by an elevation of core
body temperature above that normally maintained by an animal and is
independent to the effects of ambient conditions on body temperature.
It is important to realize that fever is a combination of hyperthermia and
infection or inflammation that results from an elevated setpoint for temperature
regulation.
§Etiology
Fevers may be :
qseptic, the more common type, or
qaseptic, depending on whether or not infection is present.
15. 1. Pyrogenic activator
2. Endogenous pyrogen (EP)
3. Mechanisms of set point elevation caused
by EP
4. Pathogenesis of fever
mechanisms of fever ( pathogenesis of fever)
16. mechanisms of fever ( pathogenesis of fever)
1. Pyrogenic activator
2. Endogenous pyrogen (EP)
3. Mechanisms of setpoint elevation caused by EP
4. Pathogenesis of fever
Pyrogenic activator
Pyrogenic activator : A fever-inducing substances that can activate endogenous
pyrogen-generating cells to generate and release endogenous pyrogens.
18. • Interleukin-1 initiates fever by inducing an abrupt increase in the synthesis of
prostaglandins, particularly prostaglandin E2, in the anterior hypothalamus.
tissue Thermoregulatory center
of the hypothalamus so that the
thermostatic level of the body is raised
level of the body is raised.
EP
Affects
immediate
response
prevention of heat loss and the
increased
production of heat (increment,
or chill).
The
fastigiumthe
second period of
fever, or period
of constant
temperature
When the effect of the pyrogenic
substances is removed, the stage of
decrement, or fever defer vescence,
appears and the excess stored heat is
dissipated.
Vasodilatation, sweating
and muscle flaccidity are
marked and the body
temperature falls.
19. STAGES OF FEVER
1- increment stage
• Cutaneous vasoconstriction
• Absence of sweating
• Cold skin and extremities
• Reduced respiration
• Muscle shivering
• Reduced respiration
• Oliguria
• Rectal temperature is elevated
20. 2- Fastigium stage (state of constant
temperature)
• The period of heat increment raises
temperature to the new thermostatic level
• Cutaneous vasodilation to dissipate heat
• Severe sweating
• Diuresis (increased urine production)
• Decreased ruminal motility
• Increased metabolism and tissue wasting
21. 3- Decrement stage:
• Excess heat is dissipated via
• Vasodilatation
• Sweating
• Muscle falccidity
If toxaemia is present, the ability of
the tissues to respond to heat
production or conservation may be
lost and hypothermia may occur
before death
23. Clinical findings
The effects of fever are the combined effects of hyperthermia and infection or
inflammation. There is :
Øelevation of body temperature,
Øan increase in heart rate with a diminution of amplitude and strength of the
arterial pulse,
Ø hyperpnea,
Øwasting,
Øoliguria often with albuminuria,
Øincreased thirst,
Øanorexia,
Øscant feces,
Ødepression and muscle weakness.
The temperature elevation is always moderate and rarely goes above 42°C (107°F)
.
24. FORMS OF FEVER
• Transient : fever for short periods (hours)
• Continuous or sustained: without diurnal
variations
• Remittent: with diurnal variation
• Intermittent when fever peaks last for 2-3
days and interspersed with normal period
• Recurrent fever: peaks of fever for about
6 days interspersed with equal period of
normal temp.
• Atypical: when temperature variations are
irregular
31. Treatment
1. Antimicrobial agents; The most important aspects of the clinical management of
fever should be directed at its cause.
1. Antipyretics; Since fever ordinarily does little harm and usually benefits the
animal's defence mechanism, antipyretic agents are rarely essential and may
actually obscure the effect of a specific therapeutic agent or of the natural course
of the disease. If the fever is high enough to cause discomfort or in appetence, or is
so high that death due to hyperthermia is possible,
then nonsteroidal anti-inflammatory drugs
(NSAIDs) should be administered.
VOLTAREN Generic Name: diclofenac sodium