1) The document discusses a project to clone genes related to Parkinson's disease including LRRK2 and C9orf72 using APEX2 to study protein-protein interactions. 2) Repeats of GGGGCC in C9orf72 were found to cause neurotoxicity when expressed in Drosophila, linking it to ALS/FTD in humans. Expressing poly-GA, poly-GR and poly-PR in Drosophila eyes also caused pathogenic effects and shorter lifespans. 3) The speaker encountered problems cloning genes with repeat regions and constructing large plasmids, but aims to redesign primers and try new cloning methods like ligation or mutagenesis to complete the project.