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Gene Expression & Wing Disc Regeneration in Drosophila
1.
GENE EXPRESSION FOLLOWING
INDUCTION OF REGENERATION IN DROSOPHILA WING IMAGINAL DISCS AND EXPRESSION PROFILE OF REGENERATING WING DISCS.
2.
3.
4.
5.
6.
7.
8.
METHODS AND MATERIALS
9.
10.
11.
12.
13.
14.
15.
Â
16.
Results and Discussion
17.
Whole genome expression
analysis of intact and regenerating wing discs
18.
19.
Total number of
up and downregulated genes in NC0->NC24, C0->C24 and C24->C72 microarrays. NC0 ->NC24 C0 ->C24 C24 ->C72 GENES (UP) 407 607 116 GENES (DOWN) 356 576 165 TOTAL 763 1183 281
20.
21.
22.
23.
24.
25.
26.
IDENTIFICATION OF GENES
WITH PUTATIVE ROLES IN REGENERATION
27.
28.
29.
30.
31.
Classification of differentially
expressed genes involved in wing imaginal disc regeneration .
32.
33.
34.
35.
36.
37.
38.
39.
40.
Transcriptional regulators acting
in early and late regeneration
41.
42.
JNK signalling pathway-
a necessary step in regeneration
43.
44.
45.
46.
47.
48.
49.
50.
Requirement of transcription
factors and chromatin remodelers in regeneration
51.
52.
Â
53.
54.
The transcription factor
Cbt as an example of Class III genes
55.
56.
57.
58.
CONCLUSIONS
59.
60.
61.
62.
Thank you
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