Transport of O2 O2 & Hb dissociation curve and it’s factors Reaction of Hb & O2 Transport of CO2 Cyanosis

1. WELCOME TO OUR
PRESENTATION

2. Group members
1. Md. Shariar Islam
2. Anika baree mumu
3. Eshita nasrin vabna
4. Tahmid hossen fahim
5. Afshana mim
6. Mst. Suraya akter

3. Concepts
 Transport of O2
 O2 & Hb dissociation curve and it’s factors
 Reaction of Hb & O2
 Transport of CO2
 Cyanosis

4. Transport of O2
Transport of oxygen from alveolar air into tissue cell can
be considered in 4 steps:
1. Diffusion of O2 from alveolar air into pulmonary
capillary
2. Transport of O2 in blood
3. Diffusion of O2 from blood to tissue interstitial fluid
4. Diffusion of O2 from interstitial fluid into cells

5. Diffusion of O2 from alveolar air into
pulmonary capillary
• The partial pressure of O2 in alveolus is 104
mm of Hg.
• The partial pressure of O2 in pulmonary
capillary at arterial end is 40 mm of Hg
• The pressure difference is (104-40)=64 mm of
Hg
• For the balance of O2 partial pressure O2
diffuse into pulmonary blood from alveolar air

6. Transport of O2 in blood
1. In the form of oxy-haemoglobin- About 97%
2. As physical solution – remaining 3%

7. Diffusion of O2 from blood to tissue
interstitial fluid
• The partial pressure of O2 in blood is 95 mm of
Hg
• The partial pressure of O2 in interstitial fluid is
40 mm of Hg
• The pressure difference is (95-40)=55 mm of
Hg
• The difference causes diffusion of O2 into
interstitial fluid

8. Diffusion of O2 from interstitial fluid
into cells
• The partial pressure of O2 in interstitial fluid is
40 mm of Hg
• The partial pressure of O2 in cell is average 23
mm of Hg
• For the requirement of O2 pressure for
chemical process causes diffusion of O2 from
interstitial fluid into cells

10. Oxygen Haemoglobin dissociation
curve

11. Oxygen Haemoglobin dissociation curve is
graphical recording which shows a progressive
increase in the percentage saturation of the
haemoglobin that is bound with oxygen as the
P O2 increase

12. Factors affecting
• pH
• Blood temperature
• H+ ion

14. Reaction of Hb and O2
iron protein
Represent as Hb4 contain Fe2+
Reaction:
• Hb4+O2= Hb4O2
• Hb4O2+ O2= Hb4O4
• Hb4O4+ O2= Hb4O6
• Hb4O6+ O2= Hb4O8
Haem Globin

16. Transport of CO2
• CO2 produce by tissue cells and diffuse into
plasma.
• Over 90% CO2 diffuse into RBC and some
combine with Hb
• Most CO2 form H2CO3 and then dissociate into
H+ and HCO3
-
• Most ot the HCO3
- diffuse out of the RBC into
the plasma
• In the lungs Hb releases the H+ ion and it
combine with the HCO3
- to reform carbonic
acid

17. • Carbonic acid break up into H2O and CO2
• CO2 diffuses out of pulmonary capillary into
the alveoli and then the atmosphere

18. Chemical forms in which CO2 is carried
to the blood
Two different ways:
1. As bicarbonate ions: CO2 + H2O = H2CO3
H2CO3 = H+ + HCO3
-
2. As carbomino compound:
• Carbomino haemoglobin:CO2+HbNH2= HbNHCOOH
• Carbomino protein:PrNH2 + CO2 = PrNHCOOH

20. Cyanosis
Definition:
Reduced haemoglobin has a dark colour and a
dusky bluish discoloration of the tissues called
cyanosis.

21. Symptoms
• The skin on the finger tips, toes, palms or feet
is bluey green.
• The affected body part feels cold to the touch.
• The colour returns to normal after warming
up the body part.

23. Sites
1. Nail beds
2. Mucous membranes
3. Ear lobes
4. Fingers
5. Tip of the nose
6. Tip of the tongue

24. Causes
1. Narrow of blood vessels
2. Low blood pressure
3. Hypothermia
4. Vein or artery problems
5. Heart fail to pump blood
6. Problems with the lymph system

25. Treatment
1. Medicine for treat heart and lung condition
2. Life system change such as quitting smoking