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Pelvic fracture and
Pelvic Fracture Urethral Injury
Sukhdev
CMC Vellore
Outline
• Anatomy of pelvis and associated urinary tract
• Pelvic fracture classifications
• Pelvic fracture urethral injury classifications
• Imaging in PFUI
• Management
Pelvic anatomy
Urethral arterial blood supply
External iliac artery Internal iliac artery
↓ ↓
Femoral artery Anterior division
↓ ↓
Superficial External pudendal artery Internal pudendal artery
↓ ↓
Dorsolateral and ventrolateral axial arteries Bulbourethral, cavernosal and dorsal artery of penis
↓ ↓
Supply skin and subcutaneous tissue Bulbourethral – supplies urethra and corpus spongiosum
Cavernosal – supplies corpora cavernosa
Dorsal artery of penis – supplies tunica and tissue beneath Buck
fascia
• 1-sacroiliac ligament
• 2-sacrospinous ligament
• 3-sacrotuberous ligament
• *- iliolumbar ligament
RTA in India
• 16 citizens get killed and 53 injured every hour in India due to road
traffic accidents
Public health crisis of road traffic accidents in India, J Family Med Prime Care, 2019
Pelvic fracture classifications
Young and Burgess classification(1986)
Lateral compression fractures
Lateral compression type 1
Lateral compression type 2
Lateral compression type 3
Anteroposterior compression fractures
Anteroposterior compression fractures
AP compression type 1
AP compression type 2
AP compression type 3
Vertical shear fracture
Pelvic fracture and Urinary tract
Biomechanics of pelvic fracture
urethral injury
Andrich et al, BJUI, 2007
Andrich et al, BJUI, 2007
Andrich et al, BJUI, 2007
Urological injuries associated with pelvic trauma, J Urol, 1979
Clinical features
• Hemodynamically stable vs unstable
• Polytrauma
• Blood at meatus (sensitivity of 37-93%) – does not correlate with
severity of injury
• Palpable bladder and inability to void
• Perineal bruising
• DRE – elevated or displaced prostate in 34% of cases or even an
impalpable prostate due to pelvic hematoma
• Blood on examining finger – rectal injury
Lim PHC, Chung HC. Initial management of acute urethral injuries. Br J Urol 1989
Kotkin L, Koch MO. Impotence and incontinence after immediate realignment of posterior
urethral trauma: result of injury or management? J Urol1996
Imaging in PFUI
• Supine
• Pelvis elevated 300-450 in horizontal plane
• Thigh closest to table is flexed to 900 and upper thigh is straight
• Scout film to ensure proper positioning
Techniques of contrast injection
1. 60 cc syringe directly into the meatus – exposure to radiographer’s
hand more
2. 14F Foley with 2 cc balloon inflation in fossa navicularis
• Do not inject lubricant as the catheter
may slip out
• 30 ml of iodinated contrast agent
• Injected slowly under flouro
• Injection should continue till contrast
gets past the sphincter into the bladder
when image acquisition should be started
• Spasm of external sphincter can prevent
bladder filling – gentle positive pressure
will help
Urethrography in trauma setting
• Foam cushions underneath the left side of patient for a 300-450 tilt
• If movement is impossible or a spinal injury is suspected, the II should
be rotated to left anterior oblique angulation
Normal urethrogram
MRI in PFUI
Limitations of contrast based studies
• Poor retrograde filling
• Failure of bladder opening
• Prostate 3D location in relation to urethra
• Secondary passages may be overlooked
• Organic causes of post traumatic impotence missed
Oh et al. Magnetic resonance urethrography to assess obliterative posterior urethral
stricture: comparison to conventional retrograde urethrography with voiding
cystourethrography. J Urol. 2010
PFUI classifications
Classification
Colapinto Maccullum classification
TYPE 1 Stretch only; intact urethra
TYPE 2 Membranous urethra ruptures above UGD and so, contrast extravasates into pelvic extraperitoneal space
TYPE 3 Membranous urethra ruptures in the UGD and so, contrast extravasates into perineum
Pitfalls of Colapinto Maccullum
• Type 3 injury is not a pure posterior urethral injury as it can extend
into bulbar urethra
• Bladder neck injuries are not included
Goldman classification
TYPE 1 Colapinto-Maccullum 1
TYPE 2 Colapinto-Maccullum 2
TYPE 3 Colapinto-Maccullum 3 but extends into bulbar(anterior) urethra
TYPE 4 Bladder neck injury
TYPE 4A Bladder base injury
TYPE 5 Pure anterior urethral injury
AAST
1 Contusion
2 Stretch
3 Partial disruption
4 Complete disruption and <2 cm urethral
distraction
5 Complete disruption and >2 cm urethral
distraction or extension into prostate or vagina
EAU
1 Stretch
2 Contusion
3 Partial disruption
4 Complete disruption
5 Complete/Partial disruption with associated tear
of bladder neck, rectum or vagina
Type 1 injury
Type 2 injury
Type 3 injury
Type 4 injury
In reality…
• Most patients are with polytrauma
• CECT is the preferred 1st line investigation
• CECT is least sensitive for urethral injury
The prostate and peri prostatic space
Urogenital diaphragm and associated fat plane
Bulbo and Ischiocavernosus
Type 1 injury Type 2 injury
Type 3 injury
CT distinction between type 2 and 3 is difficult
Non specific urethral injury indicators
UGD fat plane distortion
Hematoma of ischiocavernosus
Distortion of prostatic contour
Obscuration of ischiocavernosus/bulbocavernosus
Obturator internus hematoma
Correlation with RGU
Distortion of UGD fat plane 88%
Hematoma of ischiocavernosus 88%
Distortion of prostatic contour 59%
Distortion of bulbocavernosus/ischiocavernosus 47%
Obturator internus hematoma 53%
Ali et al, CT signs of urethral injury, Radiographics, July-Aug 2003
Predictors of urethral injury
Predictors of urethral injury
Basta et al, Predicting urethral injury from pelvic fracture patterns in male patients with blunt trauma, J Urol, 2007
Relationship between pubic diastasis and
urethral injury
Basta et al, Predicting urethral injury from pelvic fracture patterns in male patients with blunt trauma, J Urol, 2007
Relationship between inferomedial pubic
ramus fracture and urethral injury
Basta et al, Predicting urethral injury from pelvic fracture patterns in male patients with blunt trauma, J Urol, 2007
Bladder neck incompetence in
PFUI
• Incidence of BN injuries : 4.5%
• In contrast to urethral injuries, sharp edge of bone injures
• Risk greater in young boys
Competent bladder neck Incompetent bladder neck
Primary realignment
Primary realignment(PR) vs Suprapubic
cystostomy-Delayed urethroplasty(SCDU)
Alexander et al, Outcomes following primary realignment versus SPC with delayed urethroplasty for pelvic
fracture associated posterior urethral injury : A systematic review with meta analysis, Curr Urol, 2019
Stricture rates
PR vs SCDU PER vs SCDU
Alexander et al, Outcomes following primary realignment versus SPC with delayed urethroplasty for pelvic
fracture associated posterior urethral injury : A systematic review with meta analysis, Curr Urol, 2019
• Multiple studies showed that the stricture rates following PR are
either higher or equal to SCDU but definitely not lower
• PER had a stricture rate of 71%
• Multiple subsequent procedures and might worsen the actual
stricture
Erectile dysfunction
PR vs SCDU PER vs SCDU
Alexander et al, Outcomes following primary realignment versus SPC with delayed urethroplasty for pelvic
fracture associated posterior urethral injury : A systematic review with meta analysis, Curr Urol, 2019
ED rates
• PR vs SCDU vs PER = 17.5% vs 13.2% vs 71.2%
• More of a consequence of injury than that of management
Urinary incontinence
PR vs SCDU PER vs SCDU
Alexander et al, Outcomes following primary realignment versus SPC with delayed urethroplasty for pelvic
fracture associated posterior urethral injury : A systematic review with meta analysis, Curr Urol, 2019
Urinary incontinence rates
• PR vs SCDU vs PER = 8.5% vs 8.2% vs 5.8%
Arguments
In favour of PER
• Decreased rate of stenosis
• Shorter strictures
• Decreased need for major
reconstruction
Against PER
• High failure rates
• Delay the time to definitive repair
• Subsequent repairs become difficult
ERECTILE DYSFUNCTION POST
PFUI
Is it the injury or the management?
• Urethral diaphragm injury
• Hematoma and nervous
entrapment
• Sacroiliac jt disruption and pelvic
plexus injury
• Internal iliac artery injury
• Internal iliac artery embolization
• Retropelvic dissection
Embolisation and ED
• Selective embolization is the preferred modality
• This is not always the case
• Temporary vessel spasm cloaking an active bleed
• No increased risk of post embolization ED
Ramirez et al. Male sexual function after
bilateral internal iliac artery embolization for pelvic fracture. J Trauma, 2004
Incidence
• Difficult to estimate
• 5-20% with pelvic fracture only
• 42-62% with PFUI also
Shenfeld et al. The incidence and causes of erectile
dysfunction after pelvic fractures associated with posterior
urethral disruption. J Urol 2003
Mark et al. Impotence following pelvic fracture urethral injury:
incidence, aetiology and management. Br J Urol 1995
Predictors of ED post PFUI
• Sacroiliac fractures (OR = 4)1
• Pubic diastasis (OR = 15.89)2
• Lateral prostatic displacement (OR = 6.9)2
• Long urethral gap (OR = 2)2
• Increased risk when pubic diastasis is >1 inch
1Wright et al. Specific fracture configurations predict sexual and excretory
dysfunction in men and women 1 year after pelvic fracture. J Urol 2006
2Koraitim MM. Predictors of erectile dysfunction post pelvic fracture urethral
injuries: a multivariate analysis. Urology 2013
N=120 ( 2009 – 2013)
↓
IIEF questionnaire
↓
NPT
↓ ↓
80% organic ED 20% psychogenic ED
↓
Penile duplex and neurophysiological testing
↓ ↓ ↓
Neural Vascular Mixed
42.7% 30% 27.1%
↓ ↓ ↓
Arterial VOD Mixed
12.7% 56.4% 30.9%
Guan et al. The vascular and neurogenic factors associated with
erectile dysfunction in patients after pelvic fractures. Int Braz J Urol
2015
Management of ED post PFUI
• NPT - ≥1 erection lasting at least 10 minutes with ≥60% rigidity at the
tip of penis as normal1
• ICI – deformities of penis, etiological diagnosis, can be coupled with
duplex(PSV<25 cm/s – arteriogenic; EDV >5 cm/s – veno occlusive)
• Penile angiography – isolated arterial insufficiency in duplex with no
venous leak
1Yaman et al. Effect of aging on quality of nocturnal erections: evaluation with NPTR
testing. Int J Impot Res 2004;16:150-153.
Shenfeld et al. The role of sildenafil in the treatment of erectile dysfunction in patients with pelvic fracture
urethral disruption. J Urol 2004;172:2350-2352.
• PDE5i trial
• Most patients also have psychogenic component of the trauma
Surgical techniques
• Penile revascularisation - 82% success rate1
• Penile implants
1Zuckerman et al. Outcome of penile revascularization for arteriogenic erectile
dysfunction after pelvic fracture urethral injuries; Urology 2012
Surgical management of PFUI
Symphysiotomy vs Pubectomy
Pubectomy and repair in supine position
Pierce JM. Exposure of the membranous and posterior urethra by total pubectomy. J Urol
The perineal
pull through
Badenoch’s pull through
Badenoch AW. A pull-through operation for impassable traumatic stricture of the urethra. Br J Urol
1950;22:404–9.
Paines and
Coombe’s
refinement of
transpubic
urethroplasty
Pierce vs Paines-Coombes
Staged
urethroplasties
Turner Warwick Leadbetter Wells
The
posterior
approach
The
abdominoperineal
approach
Waterhouse Warwick Webster
Perineal
approach
revisited
Urethral
mobilisation
• Step 1
Corporal
body
separation
• Step 2
Inferior
wedge
pubectomy
• Step 3
Supracrural
re routing
• Step 4
3 cm
2 cm
2 cm
2 cm
Koraitim’s
modification
Koraitim
The golden triad of posterior urethroplasty
• Complete scar resection
• Fixation of healthy mucosa of both urethral ends
• Tension free anastomosis
Koraitim MM. On the art of anastomotic posterior urethroplasty: a 27-year
experience. J Urol 2005;173:135–9.
To conclude
• Radiographs can predict incidence of urethral injury
• CECT can predict urethral injury in polytrauma patients
• SPC-DU is the preferred mode of treatment
THANK YOU

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Pelvic fracture and PFUDD.pptx

  • 1. Pelvic fracture and Pelvic Fracture Urethral Injury Sukhdev CMC Vellore
  • 2. Outline • Anatomy of pelvis and associated urinary tract • Pelvic fracture classifications • Pelvic fracture urethral injury classifications • Imaging in PFUI • Management
  • 4.
  • 5. Urethral arterial blood supply External iliac artery Internal iliac artery ↓ ↓ Femoral artery Anterior division ↓ ↓ Superficial External pudendal artery Internal pudendal artery ↓ ↓ Dorsolateral and ventrolateral axial arteries Bulbourethral, cavernosal and dorsal artery of penis ↓ ↓ Supply skin and subcutaneous tissue Bulbourethral – supplies urethra and corpus spongiosum Cavernosal – supplies corpora cavernosa Dorsal artery of penis – supplies tunica and tissue beneath Buck fascia
  • 6. • 1-sacroiliac ligament • 2-sacrospinous ligament • 3-sacrotuberous ligament • *- iliolumbar ligament
  • 7. RTA in India • 16 citizens get killed and 53 injured every hour in India due to road traffic accidents Public health crisis of road traffic accidents in India, J Family Med Prime Care, 2019
  • 9. Young and Burgess classification(1986)
  • 11.
  • 21.
  • 22. Pelvic fracture and Urinary tract
  • 23.
  • 24.
  • 25. Biomechanics of pelvic fracture urethral injury
  • 26. Andrich et al, BJUI, 2007
  • 27. Andrich et al, BJUI, 2007
  • 28. Andrich et al, BJUI, 2007
  • 29. Urological injuries associated with pelvic trauma, J Urol, 1979
  • 30. Clinical features • Hemodynamically stable vs unstable • Polytrauma • Blood at meatus (sensitivity of 37-93%) – does not correlate with severity of injury • Palpable bladder and inability to void • Perineal bruising • DRE – elevated or displaced prostate in 34% of cases or even an impalpable prostate due to pelvic hematoma • Blood on examining finger – rectal injury Lim PHC, Chung HC. Initial management of acute urethral injuries. Br J Urol 1989 Kotkin L, Koch MO. Impotence and incontinence after immediate realignment of posterior urethral trauma: result of injury or management? J Urol1996
  • 31.
  • 33.
  • 34.
  • 35. • Supine • Pelvis elevated 300-450 in horizontal plane • Thigh closest to table is flexed to 900 and upper thigh is straight • Scout film to ensure proper positioning
  • 36. Techniques of contrast injection 1. 60 cc syringe directly into the meatus – exposure to radiographer’s hand more 2. 14F Foley with 2 cc balloon inflation in fossa navicularis
  • 37. • Do not inject lubricant as the catheter may slip out • 30 ml of iodinated contrast agent • Injected slowly under flouro • Injection should continue till contrast gets past the sphincter into the bladder when image acquisition should be started • Spasm of external sphincter can prevent bladder filling – gentle positive pressure will help
  • 38. Urethrography in trauma setting • Foam cushions underneath the left side of patient for a 300-450 tilt • If movement is impossible or a spinal injury is suspected, the II should be rotated to left anterior oblique angulation
  • 41. Limitations of contrast based studies • Poor retrograde filling • Failure of bladder opening • Prostate 3D location in relation to urethra • Secondary passages may be overlooked • Organic causes of post traumatic impotence missed Oh et al. Magnetic resonance urethrography to assess obliterative posterior urethral stricture: comparison to conventional retrograde urethrography with voiding cystourethrography. J Urol. 2010
  • 42.
  • 45. Colapinto Maccullum classification TYPE 1 Stretch only; intact urethra TYPE 2 Membranous urethra ruptures above UGD and so, contrast extravasates into pelvic extraperitoneal space TYPE 3 Membranous urethra ruptures in the UGD and so, contrast extravasates into perineum
  • 46. Pitfalls of Colapinto Maccullum • Type 3 injury is not a pure posterior urethral injury as it can extend into bulbar urethra • Bladder neck injuries are not included
  • 47. Goldman classification TYPE 1 Colapinto-Maccullum 1 TYPE 2 Colapinto-Maccullum 2 TYPE 3 Colapinto-Maccullum 3 but extends into bulbar(anterior) urethra TYPE 4 Bladder neck injury TYPE 4A Bladder base injury TYPE 5 Pure anterior urethral injury
  • 48. AAST 1 Contusion 2 Stretch 3 Partial disruption 4 Complete disruption and <2 cm urethral distraction 5 Complete disruption and >2 cm urethral distraction or extension into prostate or vagina EAU 1 Stretch 2 Contusion 3 Partial disruption 4 Complete disruption 5 Complete/Partial disruption with associated tear of bladder neck, rectum or vagina
  • 53. In reality… • Most patients are with polytrauma • CECT is the preferred 1st line investigation • CECT is least sensitive for urethral injury
  • 54.
  • 55. The prostate and peri prostatic space
  • 56. Urogenital diaphragm and associated fat plane
  • 58. Type 1 injury Type 2 injury
  • 59. Type 3 injury CT distinction between type 2 and 3 is difficult
  • 60. Non specific urethral injury indicators UGD fat plane distortion
  • 65. Correlation with RGU Distortion of UGD fat plane 88% Hematoma of ischiocavernosus 88% Distortion of prostatic contour 59% Distortion of bulbocavernosus/ischiocavernosus 47% Obturator internus hematoma 53% Ali et al, CT signs of urethral injury, Radiographics, July-Aug 2003
  • 67. Predictors of urethral injury Basta et al, Predicting urethral injury from pelvic fracture patterns in male patients with blunt trauma, J Urol, 2007
  • 68. Relationship between pubic diastasis and urethral injury Basta et al, Predicting urethral injury from pelvic fracture patterns in male patients with blunt trauma, J Urol, 2007
  • 69. Relationship between inferomedial pubic ramus fracture and urethral injury Basta et al, Predicting urethral injury from pelvic fracture patterns in male patients with blunt trauma, J Urol, 2007
  • 71. • Incidence of BN injuries : 4.5% • In contrast to urethral injuries, sharp edge of bone injures • Risk greater in young boys
  • 72. Competent bladder neck Incompetent bladder neck
  • 74. Primary realignment(PR) vs Suprapubic cystostomy-Delayed urethroplasty(SCDU) Alexander et al, Outcomes following primary realignment versus SPC with delayed urethroplasty for pelvic fracture associated posterior urethral injury : A systematic review with meta analysis, Curr Urol, 2019
  • 75. Stricture rates PR vs SCDU PER vs SCDU Alexander et al, Outcomes following primary realignment versus SPC with delayed urethroplasty for pelvic fracture associated posterior urethral injury : A systematic review with meta analysis, Curr Urol, 2019
  • 76. • Multiple studies showed that the stricture rates following PR are either higher or equal to SCDU but definitely not lower • PER had a stricture rate of 71% • Multiple subsequent procedures and might worsen the actual stricture
  • 77. Erectile dysfunction PR vs SCDU PER vs SCDU Alexander et al, Outcomes following primary realignment versus SPC with delayed urethroplasty for pelvic fracture associated posterior urethral injury : A systematic review with meta analysis, Curr Urol, 2019
  • 78. ED rates • PR vs SCDU vs PER = 17.5% vs 13.2% vs 71.2% • More of a consequence of injury than that of management
  • 79. Urinary incontinence PR vs SCDU PER vs SCDU Alexander et al, Outcomes following primary realignment versus SPC with delayed urethroplasty for pelvic fracture associated posterior urethral injury : A systematic review with meta analysis, Curr Urol, 2019
  • 80. Urinary incontinence rates • PR vs SCDU vs PER = 8.5% vs 8.2% vs 5.8%
  • 81. Arguments In favour of PER • Decreased rate of stenosis • Shorter strictures • Decreased need for major reconstruction Against PER • High failure rates • Delay the time to definitive repair • Subsequent repairs become difficult
  • 83. Is it the injury or the management? • Urethral diaphragm injury • Hematoma and nervous entrapment • Sacroiliac jt disruption and pelvic plexus injury • Internal iliac artery injury • Internal iliac artery embolization • Retropelvic dissection
  • 84. Embolisation and ED • Selective embolization is the preferred modality • This is not always the case • Temporary vessel spasm cloaking an active bleed • No increased risk of post embolization ED Ramirez et al. Male sexual function after bilateral internal iliac artery embolization for pelvic fracture. J Trauma, 2004
  • 85. Incidence • Difficult to estimate • 5-20% with pelvic fracture only • 42-62% with PFUI also Shenfeld et al. The incidence and causes of erectile dysfunction after pelvic fractures associated with posterior urethral disruption. J Urol 2003 Mark et al. Impotence following pelvic fracture urethral injury: incidence, aetiology and management. Br J Urol 1995
  • 86. Predictors of ED post PFUI • Sacroiliac fractures (OR = 4)1 • Pubic diastasis (OR = 15.89)2 • Lateral prostatic displacement (OR = 6.9)2 • Long urethral gap (OR = 2)2 • Increased risk when pubic diastasis is >1 inch 1Wright et al. Specific fracture configurations predict sexual and excretory dysfunction in men and women 1 year after pelvic fracture. J Urol 2006 2Koraitim MM. Predictors of erectile dysfunction post pelvic fracture urethral injuries: a multivariate analysis. Urology 2013
  • 87. N=120 ( 2009 – 2013) ↓ IIEF questionnaire ↓ NPT ↓ ↓ 80% organic ED 20% psychogenic ED ↓ Penile duplex and neurophysiological testing ↓ ↓ ↓ Neural Vascular Mixed 42.7% 30% 27.1% ↓ ↓ ↓ Arterial VOD Mixed 12.7% 56.4% 30.9% Guan et al. The vascular and neurogenic factors associated with erectile dysfunction in patients after pelvic fractures. Int Braz J Urol 2015
  • 88. Management of ED post PFUI • NPT - ≥1 erection lasting at least 10 minutes with ≥60% rigidity at the tip of penis as normal1 • ICI – deformities of penis, etiological diagnosis, can be coupled with duplex(PSV<25 cm/s – arteriogenic; EDV >5 cm/s – veno occlusive) • Penile angiography – isolated arterial insufficiency in duplex with no venous leak 1Yaman et al. Effect of aging on quality of nocturnal erections: evaluation with NPTR testing. Int J Impot Res 2004;16:150-153.
  • 89. Shenfeld et al. The role of sildenafil in the treatment of erectile dysfunction in patients with pelvic fracture urethral disruption. J Urol 2004;172:2350-2352. • PDE5i trial • Most patients also have psychogenic component of the trauma
  • 90. Surgical techniques • Penile revascularisation - 82% success rate1 • Penile implants 1Zuckerman et al. Outcome of penile revascularization for arteriogenic erectile dysfunction after pelvic fracture urethral injuries; Urology 2012
  • 91.
  • 94. Pubectomy and repair in supine position Pierce JM. Exposure of the membranous and posterior urethra by total pubectomy. J Urol
  • 96. Badenoch’s pull through Badenoch AW. A pull-through operation for impassable traumatic stricture of the urethra. Br J Urol 1950;22:404–9.
  • 102.
  • 106. Urethral mobilisation • Step 1 Corporal body separation • Step 2 Inferior wedge pubectomy • Step 3 Supracrural re routing • Step 4 3 cm 2 cm 2 cm 2 cm
  • 108.
  • 109.
  • 110. Koraitim The golden triad of posterior urethroplasty • Complete scar resection • Fixation of healthy mucosa of both urethral ends • Tension free anastomosis Koraitim MM. On the art of anastomotic posterior urethroplasty: a 27-year experience. J Urol 2005;173:135–9.
  • 111. To conclude • Radiographs can predict incidence of urethral injury • CECT can predict urethral injury in polytrauma patients • SPC-DU is the preferred mode of treatment

Editor's Notes

  1. Membranous urethra unprotected part of urethra
  2. Blood at meatus : spasm of sphincter can prevent blood at meatus or there can be a minor injury which can produce blood at meatus Palpable bladder : due to spasm of bladder neck bladder may be full or bladder may be empty due to decreased renal perfusion and obviously cant be elicited in an unconscious patient. DRE – young males; prostate can be flat
  3. Colapinto – 1977 Goldman - 1997
  4. Dis
  5. 16 patients test group and 32 patients in control group All patients had embolization with gelatin which is temporary
  6. No pre injury IIEF scores
  7. 1- short term follow up. Patients can recover upto 2 years after injury
  8. Young perineal Uncomfortable position Virgin territory
  9. Combine images
  10. MCU picture